Correlation of florbetaben PET imaging and the amyloid peptide A ß42 in cerebrospinal fluid
Today, the use of biomarkers such as amyloid-specific positron emission tomography (PET) tracers and information derived from cerebrospinal fluid (CSF) can support the diagnosis of Alzheimer ´s disease (AD) as an indicator for the presence of amyloid pathology. We here show that the PET signal of the 18F-labelled tracer florbetaben (NeuraCeqTM), that binds to amyloid-beta plaques, inversely correlates with CSF levels of Aß42, another biomarker for AD. Results from the two biomarkers w ere concordant in 34 out of 38 subjects. (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - November 4, 2016 Category: Psychiatry Authors: Carola G. Schipke, Norman Koglin, Santiago Bullich, Lisa Katharina Joachim, Brigitte Haas, John Seibyl, Henryk Barthel, Osama Sabri, Oliver Peters Source Type: research

Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients
This study aimed to explore the effects of the long-acting antipsychotic drug palmitate paliperidone in resting-state brain activity of schizophrenia patients. Seventeen schizophrenia outpatients were included and received palmitate paliperidone injection (PAL) treatment for 13 weeks. These patients were compared to seventeen matched healthy controls. All subjects underwent two scan sessions of resting-state magnetic resonance imaging (baseline and the 13th week) and regional homogeneity (ReHo) at resting-state where compared. (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - November 4, 2016 Category: Psychiatry Authors: Yan Bai, Weixin Wang, Jian Xu, Fengrui Zhang, Hongjun Yu, Chunrong Luo, Lianzhang Wang, Xianyu Chen, Roeben Munji, Baoci Shan, Lin Xu, Xiufeng Xu, Yuqi Cheng Source Type: research

Distinct Differences in Striatal Dysmorphology Between Attention Deficit Hyperactivity Disorder Boys with and without a Comorbid Reading Disability
There is evidence of greater cognitive deficits in attention deficit hyperactivity disorder with a comorbid reading disability (ADHD/+RD) compared to ADHD alone (ADHD/-RD). Additionally, the striatum has been consistently implicated in ADHD. However, the extent of morphological alterations in the striatum of ADHD/+RD is poorly understood, which is the main purpose of this study. Based on structural MRI images, the surface deformation of the caudate and putamen was assessed in 59 boys matching in age and IQ [19 ADHD/-RD, 15 ADHD/+RD and 25 typically developing controls (TDC)]. (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - November 2, 2016 Category: Psychiatry Authors: Dhruman D. Goradia, Sherry Vogel, Brianne Mohl, Dalal Khatib, Caroline Zajac-Benitez, Usha Rajan, Arthur Robin, David R. Rosenberg, Jeffrey A. Stanley Source Type: research

Volume of Hippocampal Subfields in Patients with Alcohol Dependence
Alcohol-induced hippocampal atrophy has been well documented in many studies and is known to affect various subfields. Given the functional heterogeneity of these subfields, we investigated the precise effects of alcohol-induced damage in these areas. Twenty-six male patients with alcohol dependence (alcohol group) and twenty-six age-matched male healthy social drinkers were recruited from a mental health hospital and the community respectively, with the aim of comparing the hippocampal subfields between groups. (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - November 1, 2016 Category: Psychiatry Authors: Jeonghwan Lee, Sung-Jin Im, Sang-Gu Lee, Alfreda Stadlin, Jung-Woo Son, Chul-Jin Shin, Gawon Ju, Sang-Ick Lee, Siekyeong Kim Source Type: research

DTI microstructural abnormalities in adolescent siblings of patients with childhood-onset schizophrenia
We found microstructural differences between adolescent COS siblings and age-matched control participants with greater mean diffusivity (MD) in the putamen in controls compared to COS siblingsOur data also reveal widespread increased white matter MD, radial diffusivity (RD), and axial diffusivity (AD) throughout the brain in the COS siblings compared to controls.Increases in white matter fractional anisotropy (FA) and decreases in MD, RD, and AD were associated with worse task performance in COS siblings. (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - October 31, 2016 Category: Psychiatry Authors: Dana Waltzman, Barbara Jean Knowlton, Jessica Rachel Cohen, Susan Yost Bookheimer, Robert Martin Bilder, Robert Franklin Asarnow Source Type: research