Association between schizophrenia polygenic risk and neural correlates of emotion perception
Schizophrenia (SCZ) is a highly debilitating and heritable mental illness, characterized by impairment in diverse abilities spanning perception, reasoning, and social cognition (de Jong et al., 2013; Green et al., 2004). Evidence suggests that the SCZ-related impairment in these abilities may be due to the dynamic interplay between genes and brain (Martin et al., 2014; Roffman et al., 2006). Current estimates from twin and family studies put the heritability of SCZ at 81% (Wahlst rom et al., 1986), which has led to large collaborative efforts to identify genes able to explain this heritability. (Source: Psychiatry R...
Source: Psychiatry Research: Neuroimaging - April 24, 2018 Category: Psychiatry Authors: Ilvana Dzafic, Hana Burianov á, Sathish Periyasamy, Bryan Mowry Source Type: research
Association between schizophrenia polygenic risk and neural correlates of emotion perception.
Schizophrenia (SCZ) is a highly debilitating and heritable mental illness, characterized by impairment in diverse abilities spanning perception, reasoning, and social cognition (de Jong et al., 2013; Green et al., 2004). Evidence suggests that the SCZ-related impairment in these abilities may be due to the dynamic interplay between genes and brain (Martin et al., 2014; Roffman et al., 2006). Current estimates from twin and family studies put the heritability of SCZ at 81% (Wahlst rom et al., 1986), which has led to large collaborative efforts to identify genes able to explain this heritability. (Source: Psychiatry R...
Source: Psychiatry Research: Neuroimaging - April 24, 2018 Category: Psychiatry Authors: Ilvana Dzafic, Hana Burianov á, Sathish Periyasamy, Bryan Mowry Source Type: research
Alterations in Anterior Cingulate Cortex Myoinositol and Aggression in Veterans with Suicidal Behavior: A Proton Magnetic Resonance Spectroscopy Study
Suicide is the tenth leading cause of death and is a significant public health issue in the United States (CDC, 2015). Suicide is also prevalent among veterans with an average of 18 individuals dying by suicide every day in the United States, which is approximately 18% of suicides in individuals 18 or older (Department of Veterans Affairs, 2009). The high rate of suicide among veterans coupled with limite d number of pharmacological treatments highlight the fact that there is an urgent need to investigate the neurobiological underpinnings of suicide in veterans, with the overall goal of identifying objective biomarkers...
Source: Psychiatry Research: Neuroimaging - April 24, 2018 Category: Psychiatry Authors: Chandni Sheth, Andrew Prescot, Elliott Bueler, Jennifer DiMuzio, Margaret Legarreta, Perry F. Renshaw, Deborah Yurgelun-Todd, Erin McGlade Source Type: research
Association between schizophrenia polygenic risk and neural correlates of emotion perception.
Schizophrenia (SCZ) is a highly debilitating and heritable mental illness, characterized by impairment in diverse abilities spanning perception, reasoning, and social cognition (de Jong et al., 2013; Green et al., 2004). Evidence suggests that the SCZ-related impairment in these abilities may be due to the dynamic interplay between genes and brain (Martin et al., 2014; Roffman et al., 2006). Current estimates from twin and family studies put the heritability of SCZ at 81% (Wahlst rom et al., 1986), which has led to large collaborative efforts to identify genes able to explain this heritability. (Source: Psychiatry R...
Source: Psychiatry Research: Neuroimaging - April 24, 2018 Category: Psychiatry Authors: Ilvana Dzafic, Hana Burianov á, Sathish Periyasamy, Bryan Mowry Source Type: research
Alterations in Anterior Cingulate Cortex Myoinositol and Aggression in Veterans with Suicidal Behavior: A Proton Magnetic Resonance Spectroscopy Study
Suicide is the tenth leading cause of death and is a significant public health issue in the United States (CDC, 2015). Suicide is also prevalent among veterans with an average of 18 individuals dying by suicide every day in the United States, which is approximately 18% of suicides in individuals 18 or older (Department of Veterans Affairs, 2009). The high rate of suicide among veterans coupled with limite d number of pharmacological treatments highlight the fact that there is an urgent need to investigate the neurobiological underpinnings of suicide in veterans, with the overall goal of identifying objective biomarkers...
Source: Psychiatry Research: Neuroimaging - April 24, 2018 Category: Psychiatry Authors: Chandni Sheth, Andrew Prescot, Elliott Bueler, Jennifer DiMuzio, Margaret Legarreta, Perry F. Renshaw, Deborah Yurgelun-Todd, Erin McGlade Source Type: research
Manual dexterity and brain structure in patients with schizophrenia: A whole-brain magnetic resonance imaging study
Patients with schizophrenia exhibit impairments in a variety of cognitive functions, including fine motor (e.g., manual) dexterity (Ayesa-Arriola et al., 2013; Gonzalez-Blanch et al., 2007; Heinrichs and Zakzanis, 1998; Midorikawa et al., 2008; Sponheim et al., 2010). The Purdue Pegboard Test (PPT) is a bimanual coordination task that can be used to assess psychomotor abilities (i.e., motor speed and coordination) in subjects, such as patie nts with schizophrenia (Lee et al., 2013). PPT scores are consistently lower in patients with schizophrenia compared with healthy controls (Docx et al., 2013; Fuller and Jahansh...
Source: Psychiatry Research: Neuroimaging - April 14, 2018 Category: Psychiatry Authors: Shinsuke Hidese, Miho Ota, Daimei Sasayama, Junko Matsuo, Ikki Ishida, Moeko Hiraishi, Toshiya Teraishi, Kotaro Hattori, Hiroshi Kunugi Source Type: research
Manual dexterity and brain structure in patients with schizophrenia: a whole-brain magnetic resonance imaging study
Patients with schizophrenia exhibit impairments in a variety of cognitive functions, including fine motor (e.g., manual) dexterity (Ayesa-Arriola et al., 2013; Gonzalez-Blanch et al., 2007; Heinrichs and Zakzanis, 1998; Midorikawa et al., 2008; Sponheim et al., 2010). The Purdue Pegboard Test (PPT) is a bimanual coordination task that can be used to assess psychomotor abilities (i.e., motor speed and coordination) in subjects, such as patients with schizophrenia (Lee et al., 2013). PPT scores are consistently lower in patients with schizophrenia compared with healthy controls (Docx et al., 2013; Fuller and Jahanshahi, 1999...
Source: Psychiatry Research: Neuroimaging - April 14, 2018 Category: Psychiatry Authors: Shinsuke Hidese, Miho Ota, Daimei Sasayama, Junko Matsuo, Ikki Ishida, Moeko Hiraishi, Toshiya Teraishi, Kotaro Hattori, Hiroshi Kunugi Source Type: research
Higher 5-HT1A autoreceptor binding as an endophenotype for major depressive disorder identified in high risk offspring – A pilot study
Depressive disorders are estimated to be 40% heritable (Uhl and Grow, 2004), and offspring of individuals with early-onset depression are at higher risk of developing these disorders (Mann et al., 2005). The serotonin (5-HT) system has been implicated in major depressive disorder (MDD) (Blier et al., 1990), and offspring of MDD patients report transie nt depression after serotonin depletion by acute tryptophan depletion (Klaassen et al., 1999). An endophenotype of MDD may help to identify persons at elevated risk of developing MDD (HR or high risk) while still healthy (no history of a mood disorder). (Source: Psyc...
Source: Psychiatry Research: Neuroimaging - April 13, 2018 Category: Psychiatry Authors: Matthew S. Milak, Spiro Pantazatos, Rain Rashid, Francesca Zanderigo, Christine DeLorenzo, Natalie Hesselgrave, R. Todd Ogden, Maria A. Oquendo, Stephanie T. Mulhern, Jeffrey M. Miller, Ainsley K. Burke, Ramin V. Parsey, J. John Mann Source Type: research
Higher 5-HT1A Autoreceptor Binding as an Endophenotype for Major Depressive Disorder Identified in High Risk Offspring. A Pilot Study
Depressive disorders are estimated to be 40% heritable (Uhl and Grow, 2004), and offspring of individuals with early-onset depression are at higher risk of developing these disorders (Mann et al., 2005). The serotonin (5-HT) system has been implicated in major depressive disorder (MDD) (Blier et al., 1990), and offspring of MDD patients report transient depression after serotonin depletion by acute tryptophan depletion (Klaassen et al., 1999). An endophenotype of MDD may help to identify persons at elevated risk of developing MDD (HR or high risk) while still healthy (no history of a mood disorder). (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - April 13, 2018 Category: Psychiatry Authors: Matthew S. Milak, Spiro Pantazatos, Rain Rashid, Francesca Zanderigo, Christine DeLorenzo, Natalie Hesselgrave, R. Todd Ogden, Maria A. Oquendo, Stephanie T. Mulhern, Jeffrey M. Miller, Ainsley K. Burke, Ramin V. Parsey, J. John Mann Source Type: research
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(Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - April 12, 2018 Category: Psychiatry Source Type: research
Neural correlates of top-down regulation and generation of negative affect in major depressive disorder
Individuals with major depressive disorder (MDD) are impaired in regulating negative affect in two important ways: they have difficulty reducing negative emotions and they generate negative affect in the absence of external cues (Mathews and MacLeod, 2005). Several neuroimaging studies investigating MDD-associated dysfunction in reducing negative affect have used tasks in which participants are asked to reappraise negative stimuli in order to alter their affective experience, typically to decrease negative affect (e.g., Ochsner e t al., 2012; Rive et al., 2013). (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - April 7, 2018 Category: Psychiatry Authors: Elena Goetz Davis, Lara C. Foland-Ross, Ian H. Gotlib Source Type: research
Neural Correlates of Top-Down Regulation and Generation of Negative Affect in Major Depressive Disorder
Individuals with major depressive disorder (MDD) are impaired in regulating negative affect in two important ways: they have difficulty reducing negative emotions and they generate negative affect in the absence of external cues (Mathews and MacLeod, 2005). Several neuroimaging studies investigating MDD-associated dysfunction in reducing negative affect have used tasks in which participants are asked to reappraise negative stimuli in order to alter their affective experience, typically to decrease negative affect (e.g., Ochsner et al., 2012; Rive et al., 2013). (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - April 7, 2018 Category: Psychiatry Authors: Elena Goetz Davi s, Lara C. Foland-Ross, Ian H. Gotlib Source Type: research
Cerebellar abnormalities in first-episode, drug-naive schizophrenia at rest
As one of the most severe psychiatric disorders, schizophrenia affects about 1% of populations across the world. It presents with a collection of signs and symptoms, primarily starting paranoid delusions and auditory hallucinations in adolescence or early adulthood (Insel, 2010). Despite that studies of schizophrenia have been conducted over a century, the mechanism of schizophrenia is still unclear. (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - March 29, 2018 Category: Psychiatry Authors: Wenbin Guo, Fengyu Zhang, Feng Liu, Jindong Chen, Renrong Wu, Danny Q Chen, Zhikun Zhang, Jinguo Zhai, Jingping Zhao Source Type: research
Cerebellar abnormalities in first-episode, drug-naive schizophrenia at rest
As one of the most severe psychiatric disorders, schizophrenia affects about 1% of populations across the world. It presents with a collection of signs and symptoms, primarily starting paranoid delusions and auditory hallucinations in adolescence or early adulthood (Insel, 2010). Despite that studies of schizophrenia have been conducted over a century, the mechanism of schizophrenia is still unclear. (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - March 29, 2018 Category: Psychiatry Authors: Wenbin Guo, Fengyu Zhang, Feng Liu, Jindong Chen, Renrong Wu, Danny Q Chen, Zhikun Zhang, Jinguo Zhai, Jingping Zhao Source Type: research
Altered grey matter volume and cortical thickness in patients with schizo-obsessive comorbidity
Schizo-obsessive comorbidity (SOC) has been proposed to delineate the subgroup of schizophrenia (SCZ) patients who also have significant obsessive-compulsive (OC) symptoms (Attademo et al., 2016; Cunill and Castells, 2011; Swets et al., 2014). In previous studies, the incidence of OC symptoms in SCZ patients has been found to be 10 times higher than the general population (Esslinger et al., 2015; Peng et al., 2014; Tonna et al., 2015). Patients with SOC are characterized by earlier onset, higher hospitalization rate (Owashi et al., 2010), more severe cognitive deficits (Cunill et al., 2013; Schirmbeck et al., 201...
Source: Psychiatry Research: Neuroimaging - March 28, 2018 Category: Psychiatry Authors: Yong-ming Wang, Lai-quan Zou, Wen-lan Xie, Zhuo-ya Yang, Xiong-zhao Zhu, Eric F.C. Cheung, Thomas Alrik S ørensen, Arne Møller, Raymond C.K. Chan Source Type: research
