PsychopharmacologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26

1270 records returned

Developmental vitamin D deficiency alters dopamine-mediated behaviors and dopamine transporter function in adult female ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined locomotor responses of male and female juvenile and adult rats to a dose range of amphetamine. We also measured dopamine receptor and monoamine transporter densities in adult brain. Results Female DVD-deficient adult rats displayed an enhanced sensitivity to amphetamine-induced locomotion, an increased dopamine transporter density in the caudate–putamen and increased affinity in the nucleus accumbens compared with control females. By contrast, there were no differences between control and DVD-deficient male rats. Discussion Taken together, this suggests an...
Source: Psychopharmacology - November 18, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Gestational exposure to the organophosphate chlorpyrifos alters social–emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Overall, the present results confirm a specific and sex-dependent vulnerability of affective/emotional domains to developmental CPF exposure. Furthermore, data provide clear indication on the disrupting effects of prenatal CPF on serotoninergic transmission. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1713-2Authors Aldina Venerosi, Istituto Superiore di Sanità Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences V.le Regina Elena 299 Rome ItalyLaura Ricceri, Istituto Superiore di Sanità Section of Neurotoxico...
Source: Psychopharmacology - November 18, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Amphetamine analogs methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) differentially affect speechEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Methamphetamine improved verbal fluency and MDMA adversely affected fluency. This pattern of effects is consistent with the effects of these drugs on functioning in other cognitive domains. In general, methamphetamine effects on speech were inconsistent with effects popularly attributed to this drug, while MDMA-related effects were in agreement with some anecdotal reports and discordant with others. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1715-0Authors Gina F. Marrone, New York State Psychiatric Institute Division of Substance Abuse 1051 Riverside...
Source: Psychopharmacology - November 16, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Decreases in recollective experience following acute alcohol: a dose–response studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Alcohol-induced impairments in recognition memory occur in a dose-dependent manner, specifically driven by reductions in recognition associated with conscious awareness. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1709-yAuthors James A. Bisby, University College London Clinical Psychopharmacology Unit Gower Street London UKJulie R. Leitz, University College London Clinical Psychopharmacology Unit Gower Street London UKCelia J. A. Morgan, University College London Clinical Psychopharmacology Unit Gower Street London UKH. Valerie Curran, University Colleg...
Source: Psychopharmacology - November 12, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Dose-dependent effects of the CRF1 receptor antagonist R317573 on regional brain activity in healthy male subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions R317573 appears to produce acute dose-dependent changes in rCMglu. Effects occurred in regions that may be behaviorally relevant to mood and anxiety disorders. In some regions, these effects may be related to the receptor (target) density. Measuring acute effects on rCMglu with FDG-PET may offer a method for defining pharmacologically active doses for central nervous system targets for which selective radiotracers are lacking. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1714-1Authors Mark E. Schmidt, Johnson & Johnson Pharmaceutical Research and Devel...
Source: Psychopharmacology - November 12, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Histaminergic neurotransmission seems to be necessary for the stimulatory effect of ethanol to occur, whereas lack of histamine leads to changes that enhance the conditioned reward by ethanol. Our findings also suggest a role for histamine H3 receptor in modulation of the ethanol stimulation and reward. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1710-5Authors Saara Nuutinen, University of Helsinki Neuroscience Center, Institute of Biomedicine/Anatomy, Biomedicum Helsinki P.O. Box 63 Haartmaninkatu 8 Helsinki FIN-00014 FinlandKaj Karlstedt, University...
Source: Psychopharmacology - November 12, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Discriminative stimulus functions of methanandamide and ∆9-THC in rats: tests with aminoalkylindoles (WIN55,212-2 and AM678) and ethanolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Data are congruent with the general observation that there is substantial overlap in the discriminative stimulus effects of CB1R ligands across different chemical classes. However, the quantitative differences in the interactions between the two aminoalkylindoles and rimonabant in the two discrimination groups suggest subtle variations in the ligand–receptor activation(s). Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1708-zAuthors Torbjörn U. C. Järbe, Temple University Department of Psychology 265-67 Weiss Hall, 1701 North 13th Street Philadelphia P...
Source: Psychopharmacology - November 9, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We conclude that the daily administration of 20 mg of rimonabant for 2 weeks has no effect on alcohol consumption in nontreatment-seeking heavy alcohol drinkers. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1704-3Authors David Ted George, National Institute on Alcohol Abuse and Alcoholism Laboratory of Clinical and Translational Studies 10 Center Drive, 10 CRC-Hatfield Center, Rm. 1-5330, MSC 1108 Bethesda MD 20892-1108 USADavid W. Herion, National Institute on Alcohol Abuse and Alcoholism Laboratory of Clinical and Translational Studies 10 Cent...
Source: Psychopharmacology - November 9, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Activation of 5-HT6 receptors facilitates attentional set shiftingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Through use of a novel 5-HT agonist, these experiments reveal a previously unrecognised role for 5-HT activation in PFC-dependent executive function, mediated by 5-HT6 receptor activation. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1701-6Authors Katherine E. Burnham, University of Oxford Department of Pharmacology Mansfield Road Oxford OX1 3QT UKMark G. Baxter, University of Oxford Department of Experimental Psychology Oxford OX1 3UD UKJohn R. Bainton, University of Oxford Department of Pharmacology Mansfield Road Oxford OX1 3QT UKEric Southam, GlaxoSm...
Source: Psychopharmacology - November 9, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanismsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Results suggest that the capacity of kappa opioid agonists to increase extracellular 5-HT levels may at least partially underlie kappa agonist-induced modulation of cocaine seeking. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1705-2Authors Daniela Rüedi-Bettschen, Harvard Medical School New England Primate Research Center One Pine Hill Drive P.O. Box 9102 Southborough MA 01772-9102 USAJames K. Rowlett, Harvard Medical School New England Primate Research Center One Pine Hill Drive P.O. Box 9102 Southborough MA 01772-9102 USARoger D. Spealman, Harvard ...
Source: Psychopharmacology - October 26, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Evaluation of potential sex differences in the subjective and analgesic effects of morphine in normal, healthy volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These data suggest that, in humans, there are sex differences in the subjective mood-altering effects of morphine but, based on this limited sample, there is little evidence for sex differences in its analgesic effects. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1703-4Authors Sandra D. Comer, College of Physicians and Surgeons of Columbia University Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry 1051 Riverside Dr., Unit 120 New York NY 10032 USAZiva D. Cooper, College of Physicians and Surgeons of Columbia U...
Source: Psychopharmacology - October 26, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

A randomised trial of glucose tablets to aid smoking cessationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions No significant effect of glucose tablets over and above sweet tasting tablets could be detected overall, but the possibility of an effect as an adjunct to NRT or bupropion merits further investigation. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1692-3Authors Robert West, University College London Cancer Research UK Health Behaviour Research Centre, Department of Epidemiology and Public Health London WC1E 6BT UKSylvia May, University College London Health Behaviour Research Centre London UKAndy McEwen, University College London Health Behaviour Research...
Source: Psychopharmacology - October 26, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT6 and 5-HT2A receptor mechanismsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The efficacies of selective 5-HT2A and 5-HT6 receptor antagonists suggest potential mechanisms mediating the effects of sertindole, which has high affinity for these 5-HT receptor subtypes. The sertindole-induced improvement in cognitive function in this animal model suggests relevance for the management of cognitive deficit symptoms in schizophrenia. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1702-5Authors Nagi Idris, The University of Bradford Bradford School of Pharmacy Bradford West Yorkshire BD7 1DP UKJo Neill, The University of Bradford Bradford ...
Source: Psychopharmacology - October 22, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Impulsive choice and response in dopamine agonist-related impulse control behaviorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Greater impulsive choice, faster RT, faster decision conflict RT, and executive dysfunction may contribute to ICDs in PD. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1697-yAuthors Valerie Voon, National Institutes of Health 10 Center Drive, Bldg 10/Rm 7D37 Bethesda MD 20892-1428 USABrady Reynolds, Ohio State University Columbus OH USAChristina Brezing, National Institutes of Health 10 Center Drive, Bldg 10/Rm 7D37 Bethesda MD 20892-1428 USACecile Gallea, National Institutes of Health 10 Center Drive, Bldg 10/Rm 7D37 Bethesda MD 20892-1428 USAMeliha Skalji...
Source: Psychopharmacology - October 21, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Stimulation of mGluR1s in the DH is necessary for incentive motivational and/or memory processes that contribute to drug context-induced cocaine-seeking behavior. These findings indicate that the mGluR1 is an interesting target from an addiction treatment perspective. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1700-7Authors Xiaohu Xie, University of North Carolina Department of Psychology CB# 3270 Davie Hall Chapel Hill NC USADonna R. Ramirez, University of North Carolina Department of Psychology CB# 3270 Davie Hall Chapel Hill NC USAHeather C. Lassete...
Source: Psychopharmacology - October 21, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This phase II study provides preliminary evidence of a possible therapeutic effect of saffron extract in the treatment of patients with mild-to-moderate Alzheimer’s disease. This trial is registered with the Iranian Clinical Trials Registry (IRCT138711051556N1). Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1706-1Authors Shahin Akhondzadeh, Tehran University of Medical Sciences Psychiatric Research Center, Roozbeh Psychiatric Hospital South Kargar Street Tehran 13337 IranMehdi Shafiee Sabet, Tehran University of Medical Sciences Department of Neurology T...
Source: Psychopharmacology - October 21, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Administration of neurotoxic doses of MDMA reduces sensitivity to ethanol and increases GAT-1 immunoreactivity in mice striatumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These findings indicate that mice with a MDMA-induced dopaminergic lesion show increased expression of striatal GAT-1 that may contribute to the lower sensitivity to EtOH-induced sedative effects and the resistance to the development of rapid tolerance to hypothermia produced by EtOH. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1699-9Authors María Izco, Universidad Complutense Departamento de Farmacologia, Facultad de Medicina Madrid 28040 SpainMaria Dolores Gutierrez-Lopez, Universidad Complutense Departamento de Farmacologia, Facultad de Medicina Mad...
Source: Psychopharmacology - October 20, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Effect of acute and chronic treatment with milnacipran potentiates the anticonvulsant activity of conventional antiepileptic drugs in the maximal electroshock-induced seizures in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Acute, but not chronic, treatment with MLN can increase the effectiveness of some AEDs against MES-induced seizures in mice. It seems that MLN may also be considered as a candidate drug for clinical trials in patients with epilepsy and depressive disorders. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1698-xAuthors Kinga K. Borowicz, Lublin Medical University Experimental Neuropathophysiology Unit, Department of Pathophysiology Jaczewskiego 8 Lublin PolandKamila Furmanek-Karwowska, Lublin Medical University Experimental Neuropathophysiology Unit, Depart...
Source: Psychopharmacology - October 20, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Comparative study of five antiepileptic drugs on a translational cognitive measure in the rat: relationship to antiepileptic propertyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These results highlight somewhat similar effects of phenytoin, valproate, pregabalin and lacosamide on attention and reaction time, and comparison to efficacious doses from the seizure tests support the view that there may be a better separation with the newer AEDs. Levetiracetam had no detrimental effect in the 5-CSRTT, which may be consistent with clinical experience where the drug is considered to be well tolerated amongst the AED class. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1682-5Authors Guy A. Higgins, NPS Pharmaceuticals 101 College Street...
Source: Psychopharmacology - October 20, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Effect of apomorphine on cognitive performance and sensorimotor gating in humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The apomorphine challenge test appears a useful tool to assess dopamine receptor functioning at the forebrain level. Modulation of the effect of apomorphine by baseline performance levels may be explained by an inverted U-shape relation between prefrontal dopamine functioning and cognitive performance, and mesolimbic dopamine functioning and sensorimotor gating. Future apomorphine challenge tests preferentially use multiple outcome measures, after subcutaneous administration of apomorphine. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1686-1Authors Arnt...
Source: Psychopharmacology - October 15, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Restoration of amphetamine-induced locomotor sensitization in dopamine D1 receptor-deficient miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions D1 receptors were necessary for induction, but may not be necessary for expression of amphetamine-induced sensitization at low doses. The manifestation of amphetamine sensitization depended on the duration of treatment and length of the withdrawal period. Cholinergic–nicotinic stimulation restored amphetamine-induced sensitization in D1−/− mice. Enhanced basal expression of p-CREB in D1−/− mice may represent an adaptive mechanism related to lack of D1 receptors. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1690-5Authors Mufida B. El-Ghundi, Un...
Source: Psychopharmacology - October 15, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Light and intermittent cigarette smokers: a review (1989–2009)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In contrast to daily smokers, LITS show few or no signs of dependence as currently defined by DSM-IV criteria, appear to exercise more self-control, seem to be less impulsive, and their smoking experience is primarily associated with positive rather than negative reinforcement. Conclusions drawn from the reviewed literature highlight the multivariate factors that must be taken into account when defining LITS and emphasize the importance of further research on this increasing fraction of smokers. The potential implications of increased LITS prevalence on smoking-related disease risks remain to be ...
Source: Psychopharmacology - October 14, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Effects of paroxetine on emotional functioning and treatment awareness: a 4-week randomized placebo-controlled study in healthy cliniciansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This is the first study assessing the impact of a 4-week paroxetine treatment on emotional functioning in healthy psychiatrists and psychologists. The DBPX group was distinguishable from both SBPX and DBPO groups by a decrease in internal emotional experience, suggesting that two factors could be involved in the clinical response to paroxetine: a decrease in emotional feeling and treatment awareness. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1691-4Authors Nathalie Besnier, Hôpital Sainte Marguerite Pôle de Psychiatrie Adultes-Assistance Publique-H...
Source: Psychopharmacology - October 13, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Effect of topiramate treatment on ethanol consumption in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The results from this study establish in a rodent model that topiramate effectively and persistently reduces ethanol consumption and suggests that its efficacy may depend on genetic vulnerability but not level of drinking. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1683-4Authors Florence J. Breslin, University of Virginia Health System Department of Psychiatry and Neurobehavioral Sciences 1670 Discovery Drive Charlottesville VA 22911 USABankole A. Johnson, University of Virginia Health System Department of Psychiatry and Neurobehavioral Sciences 1670 D...
Source: Psychopharmacology - October 13, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Long-term neuropsychological effects of ecstasy in middle-aged ecstasy/polydrug usersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study in middle-aged ecstasy/polydrug users replicated findings of studies in younger ecstasy users, showing a harmful effect of ecstasy on verbal memory. There was no clear support for an interaction between harmful effects of ecstasy use and age-related memory decline or mid-life depression. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1688-zAuthors Thelma Schilt, University of Amsterdam Department of Psychonomics Roetersstraat 15 1018 WB Amsterdam The NetherlandsMaarten W. J. Koeter, University of Amsterdam Department of Psychiatry, Amsterdam Ins...
Source: Psychopharmacology - October 13, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Botulinum toxin B as an effective and safe treatment for neuroleptic-induced sialorrheaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Like for PD, botulinum toxin type B represents an effective and safe treatment for neuroleptic-induced sialorrhea with a treatment effect of 8 to 16 weeks. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1689-yAuthors Susanne Steinlechner, University of Luebeck Department of Psychiatry and Psychotherapy Ratzeburger Allee 160 23538 Luebeck GermanyChristine Klein, University of Luebeck Department of Neurology Luebeck GermanyAndreas Moser, University of Luebeck Department of Neurology Luebeck GermanyRebekka Lencer, University of Luebeck Department of Psyc...
Source: Psychopharmacology - October 13, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

The serotonin 5-HT2A receptor agonist TCB-2: a behavioral and neurophysiological analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The current studies are important, as they are the first to assess the effects of TCB-2 in mice, and are among the first to report the behavioral and neurophysiological effects of this conformationally restricted phenethylamine analog compound, which has 65-fold greater effects on signaling via the phosphoinositide versus arachidonic acid pathways. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1694-1Authors Meredith A. Fox, National Institute of Mental Health, National Institutes of Health Laboratory of Clinical Science 10 Center Drive, Building 10-3D41,...
Source: Psychopharmacology - October 13, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Rapid tryptophan depletion following cognitive behavioural therapy for panic disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We suggest that the partial return of symptoms in response to flumazenil reflects a vulnerability to RTD in this group of panic disorder patients who had responded to treatment with CBT. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1696-zAuthors Caroline Bell, University of Otago Christchurch New ZealandSean Hood, University of Western Australia School of Psychiatry & Clinical Neurosciences Perth AustraliaJohn Potokar, University of Bristol Psychopharmacology Unit Bristol UKJon Nash, University of Bristol Psychopharmacology Unit Bristol UKMariona Adrover,...
Source: Psychopharmacology - October 13, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In contrast to anxiogenic-like effects induced by acute fluoxetine, leptin elicits anxiolytic-like effects after acute administration. These results suggest that leptin has both antidepressant-like and anxiolytic-like properties. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1684-3Authors Jing Liu, University of Texas Health Science Center at San Antonio Department of Pharmacology 7703 Floyd Curl Drive San Antonio TX 78229 USAJacob C. Garza, University of Texas Health Science Center at San Antonio Department of Pharmacology 7703 Floyd Curl Drive San Anton...
Source: Psychopharmacology - October 13, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The anxiolytic-like effect of chlorpheniramine is produced, at least in part, by the facilitation of serotonergic neurotransmission in the PFC. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1695-0Authors Shigeo Miyata, Hoshi University Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences Tokyo 142-8501 JapanShoko Hirano, Hoshi University Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences Tokyo 142-8501 JapanMasahiro Ohsawa, Hoshi University Department of Pathophysiology a...
Source: Psychopharmacology - October 13, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Increased amphetamine-induced locomotor activity, sensitization, and accumbal dopamine release in M5 muscarinic receptor knockout miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we show here for the first time that amphetamine-induced hyperactivity and dopamine release as well as amphetamine sensitization are enhanced in mice lacking the M5 receptor. These results support the concept that the M5 receptor modulates effects of addictive drugs. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1685-2Authors Lene S. Schmidt, Rigshospitalet Laboratory of Neuropsychiatry, Psychiatric Center O-6102, Blegdamsvej 3 2100 Copenhagen DenmarkAnthony D. Miller, University of Memphis Department of Psychology Memphis TN USADeranda B. Lester, University of M...
Source: Psychopharmacology - October 10, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Impact of dopamine–glutamate interactions on striatal neuronal nitric oxide synthase activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These studies show for the first time that ongoing NMDA receptor activation is necessary for the modulation of striatal NOS activity by both facilitatory (D1 receptor activation) and inhibitory (D2 receptor activation) dopaminergic signaling mechanisms. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1687-0Authors Kristina E. Hoque, The Chicago Medical School at Rosalind Franklin University of Medicine and Science Department of Neuroscience 3333 Green Bay Road North Chicago IL 60064 USARaksha P. Indorkar, The Chicago Medical School at Rosalind Franklin Univ...
Source: Psychopharmacology - October 9, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Dosing protocol and analgesic efficacy determine opioid tolerance in the mouseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Taken together, intermittent and acute opioid agonist administration produces minimal tolerance compared to continuous infusion. Furthermore, there is an inverse relationship between analgesic efficacy and tolerance following continuous infusion. These results suggest that opioid analgesic tolerance may be increased when sustained release dosing formulations or continuous infusions are employed clinically. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1673-6Authors Priyanka A. Madia, St. John’s University Department of Pharmaceutical Sciences, College ...
Source: Psychopharmacology - October 9, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Alterations to pre-pulse inhibition (PPI) in chronic cannabis users are secondary to sustained attention deficitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Cannabis users showed an attention-dependant alteration in PPI, which appeared to reflect a deficit in sustain attention, and which was different to that which has been observed in schizophrenia using the same methodology. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1679-0Authors Kirsty Elizabeth Scholes, Graylands Hospital Centre for Clinical Research in Neuropsychiatry Post Office Private Bag No. 1 Claremont WA Australia 6910Mathew Thomas Martin-Iverson, Graylands Hospital Centre for Clinical Research in Neuropsychiatry Post Office Private Bag No. 1 Cl...
Source: Psychopharmacology - October 9, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Low-dose tryptophan depletion in recovered depressed women induces impairments in autobiographical memory specificityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, 24 previously depressed women underwent low-dose ATD or sham depletion and completed tests of initial and delayed memory, recollection- and familiarity-based recognition, and AMS. Results ATD did not differentially affect state mood. Compared with sham depletion, ATD impaired immediate recall on the Auditory Verbal Learning Test. Although ATD did not differentially impair recollection- and familiarity-based recognition, it did slow recognition of positive words. ATD also reduced autobiographical memory specificity in response to negative cue words. Discussion The result...
Source: Psychopharmacology - October 8, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Repeated amphetamine administration in rats revealed consistency across days and a complete dissociation between locomotor and hypothalamic-pituitary-adrenal axis effects of the drugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Dissociation exists between HPA and locomotor activation induced by AMPH, which seemed to be both reliable individual traits. Locomotor reactivity to novelty was related neither to HPA nor to locomotor responses to AMPH. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1676-3Authors Humberto Gagliano, Autonomous University of Barcelona Institute of Neurosciences Bellaterra Barcelona 08193 SpainRaül Andero, Autonomous University of Barcelona Institute of Neurosciences Bellaterra Barcelona 08193 SpainAntonio Armario, Autonomous University of Barcelona Institu...
Source: Psychopharmacology - October 7, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Nicotine withdrawal and κ-opioid receptorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These observations suggest that KOPr coupling and function are impaired in NAc and CPU during nicotine withdrawal, and imply receptor desensitization. KOPr desensitization might be a mechanism to ameliorate aversive behavioral symptoms, as nicotine withdrawal evolves. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1674-5Authors Michael J. McCarthy, The Ohio State University College of Medicine Department of Psychiatry 5038 Graves Hall, 333 West 10th Ave Columbus OH 43210 USAHailing Zhang, The Ohio State University College of Medicine Department of Psychia...
Source: Psychopharmacology - October 6, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Residual effects of hypnotic drugs in aging drivers submitted to simulated accident scenarios: an exploratory studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This study did not reveal any major residual effects of the hypnotics studied on driving performance in aging drivers. However, the urban driving situations used here for the first time in the evaluation of drugs revealed some modifications in driving habits which could lead to risky behavior. It thus appears that urban driving simulations are useful for gaining knowledge about the effects of drugs on driving behavior. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1677-2Authors Mohamed Meskali, INRETS (French National Institute for Transport and Safety ...
Source: Psychopharmacology - October 1, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Social experiences affect reinstatement of cocaine-induced place preference in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Social experiences modify vulnerability to reinstatement, acting as prevention or risk factors in the development of drug addiction. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1678-1Authors Bruno Ribeiro Do Couto, Universidad de Murcia Departamento de Anatomía Humana y Psicobiología, Facultad de Psicología Campus de Espinardo 30100 Murcia SpainMaria A. Aguilar, Universitat de Valencia Unidad de Investigación Psicobiología de las Drogodependencias. Departamento de Psicobiología, Facultad de Psicología Avda. Blasco Ibáñez, 21 46010 Valencia Spai...
Source: Psychopharmacology - October 1, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

The effects of thioperamide on extracellular levels of glutamate and GABA in the rat prefrontal cortexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These data indicate that H3 receptors in the prefrontal cortex can enhance stimulated GABA release, but do not regulate basal levels of glutamate or GABA. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1670-9Authors Natalie Welty, Neuroscience Johnson and Johnson Pharmaceutical Research and Development, L.L.C. 3210 Merryfield Row San Diego CA 92121 USAJames R. Shoblock, Neuroscience Johnson and Johnson Pharmaceutical Research and Development, L.L.C. 3210 Merryfield Row San Diego CA 92121 USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0...
Source: Psychopharmacology - September 30, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Decreased levels of serum brain-derived neurotrophic factor in drug-naïve first-episode schizophrenia: relationship to clinical phenotypesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Low BDNF levels at the onset of psychosis suggest that it may contribute to the pathogenesis of schizophrenia and perhaps, could be a candidate biological marker for positive symptoms. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1665-6Authors Da Chun Chen, Beijing Huilongguan Hospital Beijing People’s Republic of ChinaJing Wang, Guangxi Normal University College of Life Science Guilin 541004 People’s Republic of ChinaBo Wang, Jilin Agricultural University College of Chinese Medicinal Material ChangChun 130118 People’s Republic of ChinaSheng Chang Y...
Source: Psychopharmacology - September 29, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Motivational effects of opiates in conditioned place preference and aversion paradigm—a study in three inbred strains of miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We suggest that motivational homeostasis can be modulated by mu opioid receptors in mice, with the C57 mice representing a genotype that is more sensitive to processes related to rewards, whereas the genotype of DBA is more sensitive to aversion. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1672-7Authors Wojciech Solecki, Institute of Pharmacology, Polish Academy of Science Department of Molecular Neuropharmacology 12 Smetna Street 31-343 Krakow PolandAnna Turek, Institute of Pharmacology, Polish Academy of Science Department of Molecular Neuropharmacolo...
Source: Psychopharmacology - September 29, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Extended access to amphetamine self-administration increases impulsive choice in a delay discounting task in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results show that extended AMPH self-administration produces a transient loss of inhibitory control, which may play a role in the escalating pattern of drug intake that characterizes the addiction process. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1667-4Authors Cassandra D. Gipson, University of Kentucky Department of Psychology Lexington KY 40536-0509 USAMichael T. Bardo, University of Kentucky Department of Psychology Lexington KY 40536-0509 USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology)
Source: Psychopharmacology - September 28, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Ethanol seeking triggered by environmental context is attenuated by blocking dopamine D1 receptors in the nucleus accumbens core and shell in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These findings suggest a critical role for dopamine acting via D1 receptors in the nucleus accumbens in the reinstatement of responding for ethanol cues triggered by placement into an ethanol-associated context. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1657-6Authors Nadia Chaudhri, University of California at San Francisco Ernest Gallo Clinic and Research Center, Department of Neurology 5858 Horton Street Suite 200 Emeryville CA 94608 USALacey L. Sahuque, University of California at San Francisco Ernest Gallo Clinic and Research Center, Department of ...
Source: Psychopharmacology - September 24, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Repeated aripiprazole administration attenuates cocaine seeking in a rat model of relapseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion These findings support the possibility that repeated aripiprazole may be an effective therapeutic agent for the prevention of relapse in abstinent cocaine users. Based on its antipsychotic profile, aripiprazole may be particularly useful for individuals diagnosed with comorbid psychoses, such as schizophrenia or bipolar disorder. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1671-8Authors Matthew W. Feltenstein, Medical University of South Carolina Department of Neurosciences 173 Ashley Avenue Charleston SC 29425 USAPhong H. Do, Medical University of Sout...
Source: Psychopharmacology - September 24, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Determining the subjective and physiological effects of BZP on human femalesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion/interpretation Physiological and subjective data reflected a clear similarity between the effects of BZP and those of other commonly known stimulants such as amphetamine and 3,4-methylenedioxymethamphetamine. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1669-2Authors Joanne C. Lin, University of Auckland School of Pharmacy, Faculty of Medical and Health Sciences Private Bag 92019 Auckland New ZealandNisha Bangs, University of Auckland School of Pharmacy, Faculty of Medical and Health Sciences Private Bag 92019 Auckland New ZealandHeeSeung Lee, University ...
Source: Psychopharmacology - September 24, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

A comparison of the effects of caffeine following abstinence and normal caffeine useEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Although improvements in mood and reaction time may best explained as relief from withdrawal symptoms, other performance measures showed no evidence of withdrawal and were equally sensitive to an acute dose of caffeine in the normal caffeinated state. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1668-3Authors Merideth A. Addicott, Wake Forest University School of Medicine Department of Radiology Medical Center Blvd. Winston-Salem NC 27157 USAPaul J. Laurienti, Wake Forest University School of Medicine Department of Radiology Medical Center Blvd. Winston-...
Source: Psychopharmacology - September 24, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Cocaine craving and use during daily lifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Cocaine craving is tightly coupled to cocaine use in users’ normal environments. Our findings provide previously unavailable support for a relationship that has been seriously questioned in some theoretical accounts. We discuss what steps will be needed to determine whether craving causes use. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1655-8Authors Kenzie L. Preston, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health Treatment Section Baltimore MD USAM...
Source: Psychopharmacology - September 24, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Response to, “Cognitive, psychomotor and subjective effects of sodium oxybate and triazolam in healthy volunteers,” 2009; 206(1):141–154Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorsDOI 10.1007/s00213-009-1662-9Authors Deborah L. Zvosec, Hennepin County Medical Center Department of Emergency Medicine Minneapolis MN USAStephen W. Smith, Hennepin County Medical Center Department of Emergency Medicine Minneapolis MN USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology)
Source: Psychopharmacology - September 24, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

A verification of previously identified QTLs for cocaine-induced activation using a panel of B6.A chromosome substitution strains (CSS) and A/J x C57Bl/6J F2 miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Collectively, chromosome 5 and 18 QTL have now been replicated in multiple independent crosses derived from the A/J and C57BL/6J progenitors. The use of an in silico analysis highlighted potential candidate genes on chromosomes 5 and 18. The present results complement the targeted gene approach currently prevalent in the study of cocaine and provide a broader empirically based focus for subsequent candidate gene studies. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1656-7Authors Alan E. Boyle, Research Institute, McGill University Health Centre Departm...
Source: Psychopharmacology - September 23, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals