Long-term second-generation antipsychotics decreases bone formation and resorption in male patients with schizophrenia
ConclusionLong-term SGAs medication inhibited osteogenesis in a dose- and time-dependent manner and damaged the balance of bone formation and bone resorption. (Source: Psychopharmacology)
Source: Psychopharmacology - April 22, 2024 Category: Psychiatry Source Type: research
A rat model of operant negative reinforcement in opioid-dependent males and females
ConclusionsWe introduce an operant negative reinforcement procedure where a subset of opioid-dependent rats learned to lever-press to escape withdrawal-inducing naloxone infusions. The procedure can be used to study mechanisms of individual differences in opioid negative reinforcement-related behaviors in opioid-dependent rats. (Source: Psychopharmacology)
Source: Psychopharmacology - April 20, 2024 Category: Psychiatry Source Type: research
L-DOPA and oxytocin influence the neural correlates of performance monitoring for self and others
ConclusionsThese different behavioral and neural patterns after oxytocin compared to L-DOPA administration highlight a divergent role of each neurochemical in modulating the neural mechanisms underlying social performance monitoring. (Source: Psychopharmacology)
Source: Psychopharmacology - April 19, 2024 Category: Psychiatry Source Type: research
N-(3-((3-(trifluoromethyl)phenyl)selanyl)prop-2-yn-1-yl) benzamide induces antidepressant-like effect in mice: involvement of the serotonergic system
ConclusionThis study pointed a new compound with antidepressant-like effect, and it could be considered for the development of new antidepressants. (Source: Psychopharmacology)
Source: Psychopharmacology - April 18, 2024 Category: Psychiatry Source Type: research
Coenzyme Q10 and exercise training reinstate middle cerebral artery occlusion-induced behavioral deficits and hippocampal long-term potentiation suppression in aging rats
ConclusionCollectively, the findings of the present study imply that 12 weeks of aerobic training and Q10 supplementation alone can simultaneously reverse cerebral ischemia induced neurobehavioral deficits via amelioration of synaptic plasticity and a reduction in cerebral infarction volume in senescent rats. (Source: Psychopharmacology)
Source: Psychopharmacology - April 17, 2024 Category: Psychiatry Source Type: research
Teneurin C-terminal associated peptide (TCAP)-1 attenuates the development and expression of naloxone-precipitated morphine withdrawal in male Swiss Webster mice
ConclusionsThese findings establish TCAP-1 as a potential therapeutic candidate for the prevention and treatment of morphine withdrawal. (Source: Psychopharmacology)
Source: Psychopharmacology - April 17, 2024 Category: Psychiatry Source Type: research
Coenzyme Q10 and exercise training reinstate middle cerebral artery occlusion-induced behavioral deficits and hippocampal long-term potentiation suppression in aging rats
ConclusionCollectively, the findings of the present study imply that 12 weeks of aerobic training and Q10 supplementation alone can simultaneously reverse cerebral ischemia induced neurobehavioral deficits via amelioration of synaptic plasticity and a reduction in cerebral infarction volume in senescent rats. (Source: Psychopharmacology)
Source: Psychopharmacology - April 17, 2024 Category: Psychiatry Source Type: research
Teneurin C-terminal associated peptide (TCAP)-1 attenuates the development and expression of naloxone-precipitated morphine withdrawal in male Swiss Webster mice
ConclusionsThese findings establish TCAP-1 as a potential therapeutic candidate for the prevention and treatment of morphine withdrawal. (Source: Psychopharmacology)
Source: Psychopharmacology - April 17, 2024 Category: Psychiatry Source Type: research
Leveraging meta-regression to test if medication effects on cue-induced craving are associated with clinical efficacy
ConclusionsThe preliminary results of the current study challenge the assumption that alcohol cue-reactivity alone can be used as an early efficacy indicator for AUD pharmacotherapy development. These findings suggest that a wider range of early efficacy indicators and experimental paradigms be considered for Phase II testing of novel compounds. (Source: Psychopharmacology)
Source: Psychopharmacology - April 13, 2024 Category: Psychiatry Source Type: research
Dysregulations of amino acid metabolism and lipid metabolism in urine of children and adolescents with major depressive disorder: a case-control study
ConclusionsOur research suggests dysregulated amino acid metabolism and lipid metabolism in the urine of children and adolescents with MDD, similar to results in plasma metabolomics studies. This contributes to the comprehension of mechanisms underlying children and adolescents with MDD. (Source: Psychopharmacology)
Source: Psychopharmacology - April 12, 2024 Category: Psychiatry Source Type: research
5-HT 2A and 5-HT 2C receptor antagonism differentially modulate reinforcement learning and cognitive flexibility: behavioural and computational evidence
ConclusionsThese data indicate that 5-HT2A and 5-HT2CRs both modulate different aspects of flexibility, with 5-HT2ARs modulating learning from negative feedback as measured using RL parameters and 5-HT2CRs for learning from positive feedback assessed through conventional measures. (Source: Psychopharmacology)
Source: Psychopharmacology - April 10, 2024 Category: Psychiatry Source Type: research
