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BF3 ·Et2O Assisted Synthesis of Sulfinylated Spiro[5.5]trienones from Biaryl ynones
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3OB02010J, PaperBarnali Roy, Puspendu Kuila, Sangam Jha, Debayan Sarkar Sulfinyls are valuable structural moieties towards the development of synthetically new pharmaceuticals and agrochemicals. Herein, we disclose a straightforward synthesis of sulfinylated spiro[5.5]trienones proceeding via an unprecedented BF3 ·Et2O promoted spirocyclization... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 26, 2024 Category: Molecular Biology Authors: Barnali Roy Source Type: research

Intermolecular Hydrogen Bonding Behavior of Amino Acid Radical Cations
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00301B, PaperIsabella Moppel, BarbaraAnn Elliott, Shuming Chen Amino acid and peptide radicals are of broad interest due to their roles in biochemical oxidative damage, pathogenesis and protein radical catalysis, among others. Using density functional theory (DFT) calculations... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 26, 2024 Category: Molecular Biology Authors: Isabella Moppel Source Type: research

Total synthesis of jamaicamide B
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Ryosuke Shigeta, Takahiro Suzuki, Kazuki Kaneko, Hiroaki Tanaka, Ibuki Haishima, Kanata Norio, Ayano Tanaka-Yanuma, Toyonobu Usuki Jamaicamide B was isolated from the cyanobacterium Moorea producens in Jamaica and shows neurotoxicity as a sodium channel blocker. This unique mixed peptide-polyketide structure contains a pyrrolinone ring, a β-methoxy... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 26, 2024 Category: Molecular Biology Authors: Ryosuke Shigeta Source Type: research

Synthesis of Acridones via Ir(III)-Catalyzed Amination Annulation of Oxazoles with Anthranils
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00377B, CommunicationLin Dong, Han-Yi Zhou An unprecedented Ir(III)-catalyzed C-H activation/amination/annulation of 2-phenyloxazoles with anthranils for the highly selective preparation of acridone derivatives in one-pot under controlled conditions is reported. This protocol is characterized by atom... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 25, 2024 Category: Molecular Biology Authors: Lin Dong Source Type: research

Me3SiBr-promoted cascade electrophilic thiocyanation/cyclization of ortho-alkynylanilines to synthesize indole derivatives
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00367E, CommunicationQing Wang, Chukai Shao, Ruirui Hua, Hongquan Yin, Fu-Xue Chen A Lewis acid-promoted electrophilic thiocyanation/cyclization of ortho-alkynylanilines for the synthesis of indole derivatives has been developed. The reaction utilizes Me3SiBr as the Lewis acid and N-thiocyanatosuccinimide as the thiocyanating reagent.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 25, 2024 Category: Molecular Biology Authors: Qing Wang Source Type: research

Exploring the mechanism of the reductive amination of acetophenones via the Borch approach: the role of the acid catalyst
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00160E, PaperJo ão P. A. Souza, Amanda K. Jacobs, Leandro Piovan, Renan B. Campos In the reductive amination process, the acid catalyst plays a crucial role not only in the elimination of water but also in the nucleophilic step, particularly when electron-donating groups are installed at the para-position of the acetophenone. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 25, 2024 Category: Molecular Biology Authors: Jo ão P. A. Souza Source Type: research

Microwave-Assisted Synthesis of Highly Sulfated Mannuronate Glycans as Potential Inhibitors against SARS-CoV-2
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00466C, PaperYirong Zhu, Xiaotong Wang, Siqian Lu, Jibin Zheng, Youling Liang, Liangliang Zhang, Pengfei Fang, Peng Xu, Biao Yu, You Yang Algae-based marine carbohydrate drugs are typically decorated with negative ion groups such as carboxylation and sulfation. However, precise synthesis of highly sulfated alginates is challenging, thus impeding their structure –activity relationship... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 25, 2024 Category: Molecular Biology Authors: Yirong Zhu Source Type: research

Photoproperties of favipiravir and its 6-substituted analogues: fluorescence controlled through halogen substitution and tautomerism
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00397G, PaperGerm án Fuentes, Ivan E. Romero, Matías N. Moller, Marcos Couto, Angel H. Romero The photophysical properties of favipiravir and its 6-halogenated analogues are presented, and the origin of fluorescence was interpreted as a function of 3-OH tautomerism. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 24, 2024 Category: Molecular Biology Authors: Germ án Fuentes Source Type: research

A Gram-Scale Synthesis of Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs)
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00536H, PaperChangqing Song, Alexander Wade, Jon D. Rainier This manuscript describes our third generation, gram-scale synthesis of Very Long Chain-Polyunsaturated Fatty Acids (VLC-PUFAs), a unique and increasingly important class of lipids. Critical to this work and what makes... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 24, 2024 Category: Molecular Biology Authors: Changqing Song Source Type: research

Stereoselective synthesis of gem-dihalopiperidines via the halo-aza-Prins cyclization reaction: access to piperidin-4-ones and pyridines
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00338A, PaperSurjya Kumar Bora, Subhamoy Biswas, Bipin Kumar Behera, Anil K. Saikia An efficient synthesis of 4,4-dihalopiperidines fromN-(3-halobut-3-en-1-yl)-4-methylbenzenesulfonamide has been unveiled. 4,4-Dihalopiperidines have been transformed in one step into piperidin-4-ones, pyridines and enol ethers in reasonable yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 24, 2024 Category: Molecular Biology Authors: Surjya Kumar Bora Source Type: research

Synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines and isocoumarins enabled by multi-component reagents system (MCRS)
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00328D, CommunicationXuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei Du The combining use of BnSCF2D,mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of 4-SCF2D-isocoumarins-1-imines/isocoumarinsvia intramolecular cyclization of 2-alkynylbenzamides/2-alkynylbenzoates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 24, 2024 Category: Molecular Biology Authors: Xuemin Li Source Type: research

Facile Synthesis of Diiodoheteroindenes and Understanding Their Sonogashira Cross-Coupling Selectivity for the Construction of Unsymmetrical Enediynes
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Alexander V. Ponomarev, Natalia Danilkina, Julia S. Okuneva, Aleksandra A. Vidyakina, Ekaterina A. Khmelevskaya, Alexander Bunev, Andrey M Rumyantsev, Anastasia I Govdi, Thomas Suarez, Igor Alabugin, Irina Balova Electrophile-promoted cyclizations of functionalized alkynes offer a useful tool for constructing halogen-substituted heterocycles primed for further derivatization. Preinstallation of an iodo-substituent at the alkyne prior to the iodo-cyclization opens access... The content of this RSS Feed (c) The Royal Society of Ch...
Source: RSC - Organic and Biomolecular Chemistry - April 24, 2024 Category: Molecular Biology Authors: Alexander V. Ponomarev Source Type: research

Visible Light-mediated Synthesis of Quinazolinones and Benzothiadiazine-1,1-dioxides Utilizing Aliphatic Alcohols
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00541D, PaperSaloni Kumari, Souvik Roy, Pragya Arora, Sabuj Kundu The activation and utilization of challenging aliphatic alcohols like methanol and ethanol is a very appealing approach to synthesize valuable organic molecules. Using methanol and ethanol as a coupling partner... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 23, 2024 Category: Molecular Biology Authors: Saloni Kumari Source Type: research

Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00479E, CommunicationCao Nguyen Nguyen, Duc Toan Nguyen, Ha An Tran, Dinh Hung Mac, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh Nguyen A cost-effective, practical, straightforward and scalable synthesis of α-pyronesvia base- and sulfur-promoted annulation of phenylacetates and chalcones is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 23, 2024 Category: Molecular Biology Authors: Cao Nguyen Nguyen Source Type: research

Visible light-driven photocatalytic sulfonative oxidation of benzyl secondary amines
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00348A, PaperYong-Xiang L ü, Xinqian Wang, Ying-Ming Pan, Keyume Ablajan A method for the α-oxidation and sulfonation of benzyl secondary amines was developed utilizing Ir(III) or Eosin Y as the photocatalyst in the presence of O2 as a green oxidant.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 23, 2024 Category: Molecular Biology Authors: Yong-Xiang L ü Source Type: research