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Reirradiation to the abdomen for gastrointestinal malignanciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hyperfractionated accelerated reirradiation to the abdomen was well-tolerated with low rates of acute and late toxicity. Reirradiation could play a role in providing a limited duration of local control in gastrointestinal cancer patients with a history of prior abdominal radiotherapy. (Source: Radiation Oncology)
Source: Radiation Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Waqar HaqueChristopher CraneSunil KrishnanMarc DelclosMilind JavleChristopher GarrettRobert WolffPrajnan Das Source Type: journals

[68Ga]-DOTATOC-PET/CT for meningioma IMRT treatment planningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: DOTATOC-PET/CT information may strongly complement patho-anatomical data from MRI and CT in cases with complex meningioma and is thus helpful for improved target volume delineation especially for skull base manifestations and recurrent disease after surgery. (Source: Radiation Oncology)
Source: Radiation Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Barbara GehlerFrank PaulsenMehmet OksuzTill-Karsten HauserSusanne EschmannRoland BaresChristina PfannenbergMichael BambergPeter BartensteinClaus BelkaUte Ganswindt Source Type: journals

Systematisation of spatial uncertainties for comparison between a MR and a CT-based radiotherapy workflow for prostate treatmentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Treatment planning directly on MR images reduce the spatial uncertainty for prostate treatments. (Source: Radiation Oncology)
Source: Radiation Oncology - November 17, 2009 Category: Cancer & Oncology Authors: Tufve NyholmMorgan NybergMagnus KarlssonMikael Karlsson Source Type: journals

Audiological findings in patients treated with radio- and concomitant chemotherapy for head and neck tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Patients with head and neck cancer submitted to the conventional radiotherapy treatment, combined with the chemotherapy with cisplatin, presented a high incidence of decreased hearing by the end of treatment. Strong evidence was observed linking auditory alteration to the amount of radiotherapy treatment. (Source: Radiation Oncology)
Source: Radiation Oncology - November 15, 2009 Category: Cancer & Oncology Authors: Ana Helena Dell'AringaMyrian IsaacGustavo ArrudaMaria Carolina EstevesAlfredo Rafael Dell'AringaJose Luis JuniorAlexandre Rodrigues Source Type: journals

Clinical-Dosimetric Analysis of Measures of Dysphagia including Gastrostomy-tube Dependence among Head and Neck Cancer Patients Treated Definitively by Intensity-Modulated Radiotherapy with Concurrent ChemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our analysis suggests that adhering to the following parameters may decrease the risk of prolonged GT dependence and dysphagia: IPC V65 < 15%, IPC V60 < 40%, IPC Dmean < 55 Gy, and CPI Dmax < 60 Gy. (Source: Radiation Oncology)
Source: Radiation Oncology - November 12, 2009 Category: Cancer & Oncology Authors: Baoqing LiDan LiDerick LauD FarwellQuang LuuDavid RockeKathleen NewmanJean CourquinJames PurdyAllen Chen Source Type: journals

The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The ataxia telangiectasia mutated (ATM) and the ATM- related (ATR) kinases play a central role in facilitating the resistance of cancer cells to genotoxic treatment regimens. The components of the ATM and ATR regulated signaling pathways thus provide attractive pharmacological targets, since their inhibition enhances cellular sensitivity to chemo- and radiotherapy. Caffeine as well as more specific inhibitors of ATM (KU55933) or ATM and ATR (CGK733) have recently been shown to induce cell death in drug-induced senescent tumor cells. Addition of these agents to cancer cells previously rendered senescent by exposure to genot...
Source: Radiation Oncology - November 10, 2009 Category: Cancer & Oncology Authors: John AlaoPer Sunnerhagen Source Type: journals

Image guided dose escalated prostate radiotherapy: still room to improveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: IGRT to 79.8 Gy results in favourable rates of late toxicity compared with published non-IGRT treated cohorts. Future avenues of investigation for toxicity reduction include IMRT, margin reduction, and dose modulation targeted to sites of disease burden. Further work is required to maximize efficacy beyond that achieved through radiation dose escalation alone. (Source: Radiation Oncology)
Source: Radiation Oncology - November 3, 2009 Category: Cancer & Oncology Authors: Jarad MartinAndrew BayleyRobert BristowPeter ChungMary GospodarowiczCynthia MenardMichael MilosevicTara RosewallPadraig WardeCharles Catton Source Type: journals

Combined treatment with lexatumumab and irradiation leads to strongly increased long term tumour control under normoxic and hypoxic conditionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data show that a combination of the pro-apoptotic antibody lexatumumab with irradiation reduces tumour regrowth and leads to a highly increased local tumour control in a nude mouse model. This substantial effect was observed under ambient and more pronounced under hypoxic conditions. (Source: Radiation Oncology)
Source: Radiation Oncology - October 27, 2009 Category: Cancer & Oncology Authors: Patrizia MariniDorothea JungingerStefan SticklWilfried BudachMaximilian NiyaziClaus Belka Source Type: journals

A fast radiotherapy paradigm for anal cancer with volumetric modulated arc therapy (VMAT)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: VMAT provides treatment plans with high conformity and homogeneity equivalent to step-and-shoot-IMRT for this mono-concave treatment volume. Short treatment delivery time and low primary MU are the most important advantages. (Source: Radiation Oncology)
Source: Radiation Oncology - October 25, 2009 Category: Cancer & Oncology Authors: Florian StielerDirk WolffFrank LohrVolker SteilYasser Abo-MadyanFriedlieb LorenzFrederik WenzSabine Mai Source Type: journals

AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data show that AT-101 strongly enhances radiation-induced apoptosis in human leukemic cells and indicate a requirement for the SAPK/JNK pathway in this response. This type of apoptosis modulation may overcome treatment resistance and lead to the development of new effective combination therapies. (Source: Radiation Oncology)
Source: Radiation Oncology - October 22, 2009 Category: Cancer & Oncology Authors: Shuraila ZerpRianne StoterGitta KuipersDajun YangMarc LippmanWim Van BlitterswijkHarry BartelinkRogier RooswinkelVincent LafleurMarcel Verheij Source Type: journals

Pharmacokinetics and biodistribution of Erufosine in nude mice - implications for combination with radiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Alkylphosphocholines represent promising antineoplastic drugs that induce cell death in tumor cells by primary interaction with the cell membrane. Recently we could show that a combination of radiotherapy with Erufosine, a paradigmatic intravenously applicable alkylphosphocholine, in vitro leads to a clear increase of irradiation-induced cell death. In view of a possible combination of Erufosine and radiotherapy in vivo we determined the pharmacokinetics and bioavailability as well as the compatibility of Erufosine in nude mice. Methods: NMRI (nu/nu) nude mice were treated by intraperitoneal or subcutaneous inj...
Source: Radiation Oncology - October 22, 2009 Category: Cancer & Oncology Authors: Guido HenkeLars LindnerMichael VogeserHans-Jorg EiblJurgen WornerArndt MullerMichael BambergKirsten WachholzClaus BelkaVerena Jendrossek Source Type: journals

Radiation-induced Akt activation modulates radioresistance in human glioblastoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that Akt may be a central player in a feedback loop whereby activation of Akt induced by IR increases radioresistance of GBM cells. Targeting the Akt signaling pathway may have important therapeutic implications when used in combination with IR in the treatment of a subset of brain tumor patients. (Source: Radiation Oncology)
Source: Radiation Oncology - October 13, 2009 Category: Cancer & Oncology Authors: Hui-Fang LiJung-Sik KimTodd Waldman Source Type: journals

Remarks on reporting and recording consistent with the ICRU Reference DoseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The authors advocate reporting the PTV median dose or preferably the mean dose of the central dose plateau PTVx as a potential replacement or successor of the ICRU Reference Dose - both usable for CRT and IMRT. (Source: Radiation Oncology)
Source: Radiation Oncology - October 13, 2009 Category: Cancer & Oncology Authors: Klaus BratengeierMarkus OechsnerMark GaineyMichael Flentje Source Type: journals

Radiotherapy and radiosurgery for benign skull base meningiomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Meningiomas located in the region of the base of skull are difficult to access. Complex combined surgical approaches are more likely to achieve complete tumor removal, but frequently at a cost of treatment related high morbidity. Local control following subtotal excision of benign meningiomas can be improved with conventional fractionated external beam radiation therapy with a reported 5-year progression-free survival up to 95%. New radiation techniques, including stereotactic radiosurgery (SRS), fractionated stereotactic radiotherapy (FSRT), and intensity-modulated radiotherapy (IMRT) have been developed as a more accurat...
Source: Radiation Oncology - October 13, 2009 Category: Cancer & Oncology Authors: Giuseppe MinnitiMaurizio AmichettiRiccardo Maurizi Enrici Source Type: journals

Differential protection by wildtype vs. organelle-specific Bcl-2 suggests a combined requirement of both the ER and mitochondria in ceramide-mediated caspase-independent programmed cell deathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest a combined requirement for both mitochondria and the ER in the induction and the signaling pathways of ciPCD mediated by ceramide. (Source: Radiation Oncology)
Source: Radiation Oncology - October 8, 2009 Category: Cancer & Oncology Authors: Andrea DeerbergJustyna SosnaLutz ThonClaus BelkaDieter Adam Source Type: journals

Patient information in radiation oncology: a cross- sectional pilot study using the EORTC QLQ-INFO26 moduleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In a single-center pilot study, radiotherapy patients indicated having received most information about medical tests and their disease. Patients very satisfied with their information had received the largest amount of information. Brochures, television and internet were the most important media. Individual patient needs should be considered in the development of novel information strategies. (Source: Radiation Oncology)
Source: Radiation Oncology - September 27, 2009 Category: Cancer & Oncology Authors: Johannes AdlerYvonne Paelecke-HabermannPatrick JahnMargarete LandenbergerBernd LeplowDirk Vordermark Source Type: journals

Development of a neuro-fuzzy technique for automated parameter optimization of inverse treatment planningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The study demonstrated a feasible way to automatically perform parameter optimization of inverse treatment planning under guidance of prior knowledge without human intervention other than providing a set of constraints that have proven clinically useful in a given setting. (Source: Radiation Oncology)
Source: Radiation Oncology - September 24, 2009 Category: Cancer & Oncology Authors: Florian StielerHui YanFrank LohrFrederik WenzFang-Fang Yin Source Type: journals

The effect of on-line position correction on the dose distribution in focal radiotherapy for bladder cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: On-line position correction does result in an altered target coverage, due to changes in average path length after position correction. An extra margin can be added to prevent underdosage. (Source: Radiation Oncology)
Source: Radiation Oncology - September 23, 2009 Category: Cancer & Oncology Authors: Dominique van RooijenJeroen van de KamerRene PoolMaarten HulshofCaro KoningArjan Bel Source Type: journals

Intensity Modulated Radiotherapy (IMRT) in the treatment of children and adolescents - a single institution's experience and a review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: IMRT in the treatment of children and adolescents is feasible and was applied safely within the last 9 years at our institution. Several reports in literature show the excellent possibilities of IMRT in selective sparing of organs at risk and achieving local control. In selected cases the quality of IMRT plans increases the therapeutic ratio and outweighs the risk of potentially increased rates of secondary malignancies by the augmented low dose exposure. (Source: Radiation Oncology)
Source: Radiation Oncology - September 22, 2009 Category: Cancer & Oncology Authors: Florian SterzingEva StoiberSimeon NillHarald BauerPeter HuberJurgen DebusMarc Munter Source Type: journals

Self-assessed bowel toxicity after external beam radiotherapy for prostate cancer - predictive factors on irritative symptoms, incontinence and rectal bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The aim of the study was to evaluate self-assessed bowel toxicity after radiotherapy (RT) for prostate cancer. In contrast to rectal bleeding, information concerning irritative symptoms (rectal urgency, pain) and incontinence after RT has not been adequately documented and reported in the past. Methods: Patients (n=286) have been surveyed prospectively before (A), at the last day (70.2-72.0Gy; B), a median time of two (C) and 16 months after RT (D) using a validated questionnaire (Expanded Prostate Cancer Index Composite). Bowel domain score changes were analyzed and patient-/dose-volume-related factors tested ...
Source: Radiation Oncology - September 20, 2009 Category: Cancer & Oncology Authors: Michael PinkawaMarc PirothKarin FischedickSandra NussenJens KlotzRichard HolyMichael Eble Source Type: journals

Comparison of CT and integrated PET- based radiation therapy planning in patients with malignant pleural mesotheliomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study demonstrated the usefulness of PET-CT-based target volume delineation in patients with MPM. Co-registration of PET and CT information reduces the likelihood of geographic misses, and additionally, significant reductions observed in target volumes may potentially allow escalation of RT dose beyond conventional limits potential clinical benefits in tumor control rates, which needs to be tested in future studies. (Source: Radiation Oncology)
Source: Radiation Oncology - September 15, 2009 Category: Cancer & Oncology Authors: Berrin PehlivanErkan TopkanCem OnalGul NursalOznur YukselYemliha DolekMelek YavuzAli Yavuz Source Type: journals

RapidArc, intensity modulated photon and proton techniques for recurrent prostate cancer in previously irradiated patients: a treatment planning comparison studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: RA and IMPT showed improvements in conformal avoidance relative to fixed beam IMRT for 7 patients with recurrent prostate cancer. IMPT showed further sparing of organs at risk. (Source: Radiation Oncology)
Source: Radiation Oncology - September 8, 2009 Category: Cancer & Oncology Authors: Damien WeberHui WangLuca CozziGiovanna DipasqualeHaleem KhanOsman RatibMichel RouzaudHansjoerg VeesHabib ZaidiRaymond Miralbell Source Type: journals

Ipsilateral irradiation for well lateralized carcinomas of the oral cavity and oropharynx: results on tumor control and xerostomiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In selected patients with early and moderate stages, well lateralized oral and oropharyngeal carcinomas, ipsilateral irradiation treatment of the primary site and ipsilateral neck spares salivary gland function without compromising loco-regional control. (Source: Radiation Oncology)
Source: Radiation Oncology - August 31, 2009 Category: Cancer & Oncology Authors: Laura CerezoMargarita MartinMario LopezAlicia MarinAlberto Gomez Source Type: journals

Intraoperative radiotherapy (IORT) combined with external beam radiotherapy (EBRT) for soft-tissue sarcomas - a retrospective evaluation of the Homburg experience in the years 1995-2007Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The combination of surgery, IORT, and EBRT yields favourable local control and survival data which are well within the range of the results reported in the literature. The complication rates, however, are considerable although the complications are not severe, they should be taken into account when therapy decisions are made. (Source: Radiation Oncology)
Source: Radiation Oncology - August 25, 2009 Category: Cancer & Oncology Authors: Marcus NiewaldJochen FleckensteinNorbert LichtCaroline BleuzenChristian Ruebe Source Type: journals

High throughput evaluation of gamma-H2AXEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The DNA double-strand break (DSB) is the primary lethal lesion after therapeutic radiation. Thus, the development of assays to detect and to quantitate these lesions could have broad preclinical and clinical impact. Phosphorylation of histone H2AX to form gamma-H2AX is a known marker for irradiation-induced DNA DSBs. However, the first generation assay involves the use of immunofluorescent staining of gamma-H2AX foci. This assay is time consuming, operator dependent and is not scalable for high throughput assay development. Thus, we sought to develop a new assay using a high throughput electrochemiluminescent platform from...
Source: Radiation Oncology - August 23, 2009 Category: Cancer & Oncology Authors: Dane AvondoglioTamalee ScottWhoon Jong KilMary SproullPhilip TofilonKevin Camphausen Source Type: journals

Target splitting in radiation therapy for lung cancer: further developments and exemplary treatment plansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Target splitting is a highly conformal and nontheless non-expensive method with regard to linac and staff time. It enables secure accelerated high-dose treatments of patients with NSCLC. (Source: Radiation Oncology)
Source: Radiation Oncology - August 13, 2009 Category: Cancer & Oncology Authors: Karl WurstbauerHeinz DeutschmannPeter KoppFlorian MerzHelmut SchollerFelix Sedlmayer Source Type: journals

Severe hypoxia induces chemoresistance in clinical cervical tumors through MVP overexpressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The oxygen molecule modulates tumour response to radiotherapy. Higher radiation doses are required under hypoxic conditions to induce cell death. Hypoxia may inhibit the non-homologous end-joining DNA repair through down regulating Ku70/80 expression. Hypoxia induces drug resistance in clinical tumours, although the mechanism is not clearly elucidated. Vaults are ribonucleoprotein particles with a hollow barrel-like structure composed of three proteins: major vault protein (MVP), vault poly(ADP-ribose) polymerase, and telomerase associated protein-1 and small untranslated RNA. Overexpression of MVP has been associated with...
Source: Radiation Oncology - August 5, 2009 Category: Cancer & Oncology Authors: Pedro LaraMarta LloretBernardino ClavoRosa ApolinarioLuis Alberto Henriquez HernandezElisa BordonFausto FontesAgustin Rey Source Type: journals

Conformal radiotherapy for lung cancer: interobservers' variability in the definition of gross tumor volume between radiologists and radiotherapistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: There were no significant differences in the definition of gross tumor volume between radiologists and radiotherapists. (Source: Radiation Oncology)
Source: Radiation Oncology - August 4, 2009 Category: Cancer & Oncology Authors: Chiang TyngRubens ChojniakPaula PintoMarcelle BorbaAlmir BitencourtRicardo FogaroliDouglas CastroPaulo Novaes Source Type: journals

Simultaneous integrated boost radiotherapy for bilateral breast: a treatment planning and dosimetric comparison for volumetric modulated arc and fixed field intensity modulated therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose: A study was performed comparing dosimetric characteristics of volumetric modulated arcs (RapidArc, RA) and fixed field intensity modulated therapy (IMRT) on patients with bilateral breast carcinoma.Methods and Materials: Plans for IMRT and RA, were optimised for 10 patients prescribing 50Gy to the breast (PTVII, 2.0Gy/fraction) and 60Gy to the tumour bed (PTVI, 2.4Gy/fraction). Objectives were: for PTVs V90%>95%, Dmax (Source: Radiation Oncology)
Source: Radiation Oncology - July 23, 2009 Category: Cancer & Oncology Authors: Giorgia NicoliniAlessandro ClivioAntonella FogliataEugenio VanettiLuca Cozzi Source Type: journals

External beam radiation results in minimal changes in post void residual urine volumes during the treatment of clinically localized prostate cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: To evaluate the impact of external beam radiation therapy (XRT) on weekly ultrasound determined post-void residual (PVR) urine volumes in patients with prostate cancer. Methods: 125 patients received XRT for clinically localized prostate cancer. XRT was delivered to the prostate only (n=66) or if the risk of lymph node involvement was greater than 10% to the whole pelvis followed by a prostate boost (n=59). All patients were irradiated in the prone position in a custom hip-fix mobilization device with an empty bladder and rectum. PVR was obtained at baseline and weekly. Multiple clinical and treatment parameter...
Source: Radiation Oncology - July 21, 2009 Category: Cancer & Oncology Authors: Peter OrioGregory MerrickZachariah AllenWayne ButlerKent WallnerBrian KurkoRobert Galbreath Source Type: journals

The radiosensitizer 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide induces DNA damage in EMT-6 mammary carcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Collectively, our findings indicate that radiosensitization by DCQ is mediated by DNA damage and decreased repair and that ROS are at least partially responsible. (Source: Radiation Oncology)
Source: Radiation Oncology - July 13, 2009 Category: Cancer & Oncology Authors: Joelle HaykalFady GearaMakhlouf HaddadinColin SmithHala Gali-Muhtasib Source Type: journals

Concurrent chemo-radiotherapy following neoadjuvant chemotherapy in locally advanced breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This non-conventional multimodal treatment has good loco-regional control for LABC. Randomized clinical trials of preoperative CCRTh following chemotherapy, in patients with LABC are warranted. (Source: Radiation Oncology)
Source: Radiation Oncology - July 10, 2009 Category: Cancer & Oncology Authors: Alberto Alvarado-MirandaOscar ArrietaCarlos Gamboa-VignolleDavid Saavedra-PerezRafael Morales-BarreraEnrique Bargallo-RochaJuan Zinser-SierraVictor Perez-SanchezTeresa Ramirez-UgaldeFernando Lara-Medina Source Type: journals

Implications of a high-definition multileaf collimator (HD-MLC) on treatment planning techniques for stereotactic body radiation therapy (SBRT): a planning studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Data derived from the present comparative assessment suggest dosimetric merit of the high definition MLC system over the millennium MLC system. However, the clinical significance of these results warrants further investigation in order to determine whether the observed dosimetric advantages translate into outcome improvements. (Source: Radiation Oncology)
Source: Radiation Oncology - July 9, 2009 Category: Cancer & Oncology Authors: James TanyiPaige SummersCharles McCrackenYiyi ChenLi-Chung KuMartin Fuss Source Type: journals

Negligible or weak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma: analysis of data from randomized trial between radiation alone versus concurrent chemo-radiation (SQNP-01)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Contrary to literature published on other malignancies, our findings seemed to indicate that over-expression of COX-2 confer a better prognosis in patients with endemic NPC. Larger studies are required to conclusively determine the significance of COX-2 expression in these patients. (Source: Radiation Oncology)
Source: Radiation Oncology - July 9, 2009 Category: Cancer & Oncology Authors: Susan Li Er LoongJacqueline Siok Gek HwangHui Hua LiJoseph Tien Seng WeeSwee Peng YapMelvin Lee Kiang ChuaKam Weng FongTerence Wee Kiat Tan Source Type: journals

Radiation-induced cancer after radiotherapy for non-Hodgkin's lymphoma of the head and neck: a retrospective studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we evaluated the incidence and clinical features of head and neck cancer (HNC) occurring after radiotherapy (RT) for NHL.Material and methodsWe investigated the clinical records of 322 patients who had received RT for early-stage NHL of the head and neck at our institute between 1952 and 2000. Results: There were 4 patients with a second HNC developing in the irradiated field, consisting of 2 patients with gum cancer, 1 case with tongue cancer and 1 case with maxillary sinus cancer. The pathological diagnosis in all the 4 patients was squamous cell carcinoma (SCC). Two of the patients (one with gum cancer an...
Source: Radiation Oncology - July 9, 2009 Category: Cancer & Oncology Authors: Kazuma TodaHitoshi ShibuyaKeiji HayashiFumio Ayukawa Source Type: journals

Extraneural metastases from cranial meningioma: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here on a patient who was treated for an atypical brain meningioma with multiple surgeries and multiple sessions of stereotactic radiosurgery with good control of his brain disease. Thirteen years after diagnosis, he developed bilateral large sacroiliac and abdominal metastases. (Source: Radiation Oncology)
Source: Radiation Oncology - July 5, 2009 Category: Cancer & Oncology Authors: Mirna AbboudGeorge HaddadMireille KattarIbrahim Abu RizkFady Geara Source Type: journals

Clinical outcome of breast cancer occurring after treatment for Hodgkin's lymphoma: case-control analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The previous history of HL does not appear to be a poor prognostic factor for BC occurring thereafter. (Source: Radiation Oncology)
Source: Radiation Oncology - June 29, 2009 Category: Cancer & Oncology Authors: Mohamed Alm El-DinKevin HughesRita RaadSaveli GoldbergAlan AisenbergAndrzej NiemierkoAlphonse Taghian Source Type: journals

Monte Carlo dose verification of prostate patients treated with simultaneous integrated boost intensity modulated radiation therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: MC agrees better with film measurements than SC. Although, on average, SC-calculated doses agreed with MC calculations within the targets within 2%, there were deviations up to 5% for some patient's treatment plans. For some patients, the magnitude of such deviations might decrease the intended target dose levels that are required for the treatment protocol, placing the patients in different dose levels that do not satisfy the protocol dose requirements. (Source: Radiation Oncology)
Source: Radiation Oncology - June 15, 2009 Category: Cancer & Oncology Authors: Nesrin DoganIvaylo MihaylovYan WuPaul KeallJeffrey SiebersMichael Hagan Source Type: journals

Constitutive gene expression profile segregates toxicity in locally advanced breast cancer patients treated with high-dose hyperfractionated radical radiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we have found an association between the constitutive gene expression profile of peripheral blood lymphocytes and the development of acute and late toxicity in consecutive, unselected patients. These observations suggest the possibility of predicting normal tissue response to irradiation in high-dose non-conventional radiation therapy regimens. Prospective studies with higher number of patients are needed to validate these preliminary results. (Source: Radiation Oncology)
Source: Radiation Oncology - June 4, 2009 Category: Cancer & Oncology Authors: Luis Henriquez HernandezPedro LaraBeatriz PinarElisa BordonCarlos Rodriguez GallegoCristina BilbaoLeandro Fernandez PerezAmilcar Flores Morales Source Type: journals

Radiotherapy quality assurance review in a multi-center randomized trial of limited-disease small cell lung cancer: the Japan Clinical Oncology Group (JCOG) trial 0202Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results of the RT QA assessment in JCOG 0202 seemed to be acceptable, providing reliable results. (Source: Radiation Oncology)
Source: Radiation Oncology - June 2, 2009 Category: Cancer & Oncology Authors: Naoko Sanuki-FujimotoSatoshi IshikuraKazushige HayakawaKaoru KubotaYutaka NishiwakiTomohide Tamura Source Type: journals

Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Respiratory tumor movement was modestly suppressed by the BodyFIX system, while the SpO2 level did not decrease. It was considered a simple and effective method for SBRT of lung tumors. Preliminary results were encouraging. (Source: Radiation Oncology)
Source: Radiation Oncology - May 28, 2009 Category: Cancer & Oncology Authors: Fumiya BabaYuta ShibamotoNatsuo TomitaChisa Ikeya-HashizumeKyota OdaShiho AyakawaHiroyuki OginoChikao Sugie Source Type: journals

Comparison of rectal volume definition techniques and their influence on rectal toxicity in patients with prostate cancer treated with 3D conformal radiotherapy: a dose-volume analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Different techniques of rectal contouring significantly influence the calculation of radiation doses to the rectum and the prediction of rectal toxicity. Rectal volume receiving higher doses (>70 Gy) and mean rectal doses may significantly predict rectal bleeding for techniques contouring larger rectal volumes, as was in method 3. (Source: Radiation Oncology)
Source: Radiation Oncology - May 11, 2009 Category: Cancer & Oncology Authors: Cem Onal, Erkan Topkan, Esma Efe, Melek Yavuz, Serhat Sonmez and Aydin Yavuz Source Type: journals

Potentials of on-line repositioning based on implanted fiducial markers and electronic portal imaging in prostate cancer radiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Prostate movement relative to adjacent bony anatomy is significant and contributes substantially to the target position variability. Performing on-line setup correction using implanted radioopaque markers and megavoltage radiography results in reduced treatment margins depending on the online imaging protocol (once a week or more frequently). (Source: Radiation Oncology)
Source: Radiation Oncology - April 27, 2009 Category: Cancer & Oncology Authors: Reinhold Graf, Peter Wust, Volker Budach and Dirk Bohmer Source Type: journals

Concurrent chemoradiotherapy in adjuvant treatment of breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: From the 5 years retrospective investigation we showed similar disease free survival and overall survival in the two concurrent chemo-radiotherapy treatments based on anthracycline and CMF. However in the loco-regional breast cancer the treatment based on anthracycline was significantly better than that of the treatment based on CMF. There was more haematological and skin dermatitis toxicity in the anthracycline group. (Source: Radiation Oncology)
Source: Radiation Oncology - April 7, 2009 Category: Cancer & Oncology Authors: Nabil Ismaili, Nawfel Mellas, Ouafae Masbah, Sanaa Elmajjaoui, Arifi Samia, Imane Bekkouch, Samir Ahid, Zakaria Bazid, Mohammed Adnane Tazi, Abdelouahed Erraki, Omar El Mesbahi, Noureddine Benjaafar, Brahim El Khalil El Gueddari, Mohammed Ismaili, Said Af Source Type: journals

Stereotactic radiosurgery for glioblastoma: retrospective analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: SRS is well tolerated in the treatment of glioblastoma. As there was no difference in survival whether SRS is delivered upfront or at recurrence, the treatment for each patient should be individualized. Future studies are needed to identify patients most likely to respond to SRS. (Source: Radiation Oncology)
Source: Radiation Oncology - March 17, 2009 Category: Cancer & Oncology Authors: Tithi Biswas, Paul Okunieff, Michael C Schell, Therese Smudzin, Webster H Pilcher, Robert S Bakos, G EDWARD Vates, Kevin A Walter, Andrew Wensel, David N Korones and Michael T Milano Source Type: journals

The script concordance test in radiation oncology: validation study of a new tool to assess clinical reasoningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The SCT is reliable and useful to discriminate among participants according to their level of experience in radiation oncology. It appears as a useful tool to document the progression of reasoning during residency training. (Source: Radiation Oncology)
Source: Radiation Oncology - February 9, 2009 Category: Cancer & Oncology Authors: Carole Lambert, Robert Gagnon, David Nguyen and Bernard Charlin Source Type: journals

Job stress and job satisfaction of physicians, radiographers, nurses and physicists working in radiotherapy: a multicenter analysis by the DEGRO Quality of Life Work GroupEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Ongoing changes in cancer care cause an increase in the complexity of cases which is characterized by modern treatment techniques and a higher demand for patient information about the underlying disease and therapeutic options. At the same time, the restructuring of health services and reduced funding have led to the downsizing of hospital care services. These trends strongly influence the workplace environment and are a potential source of stress and burnout among professionals working in radiotherapy. Methods and patients: A postal survey was sent to members of the workgroup "Quality of Life" which is part o...
Source: Radiation Oncology - February 6, 2009 Category: Cancer & Oncology Authors: Susanne Sehlen, Dirk Vordermark, Christof Schafer, Peter Herschbach, Anja Bayerl, Steffi Pigorsch, Jutta Rittweger, Claudia Dormin, Tobias Bolling, Hans Joachim Wypior, Franz Zehentmayr, Wolfgang Schulze and Hans Geinitz Source Type: journals

On the performances of Intensity Modulated Protons, RapidArc and Helical Tomotherapy for selected paediatric casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Five complex pediatric cases were selected as representative examples to compare three advanced radiation delivery techniques. While differences were noted in the metrics examined, all three techniques provided satisfactory conformal avoidance and conformation. (Source: Radiation Oncology)
Source: Radiation Oncology - January 14, 2009 Category: Cancer & Oncology Authors: Antonella Fogliata, Slav Yartsev, Giorgia Nicolini, Alessandro Clivio, Eugenio Vanetti, Rolf Wyttenbach, Glenn Bauman and Luca Cozzi Source Type: journals

Investigation of the usability of conebeam CT data sets for dose calculationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The generation of three HU-D tables specific for the anatomical regions pelvis, thorax and head and specific for the corresponding CBCT image acquisition parameters resulted in accurate dose calculation in CBCT images. Once these HU-D tables are created, direct dose calculation on CBCT datasets is possible without the need of a reference CT images for pixel value calibration. (Source: Radiation Oncology)
Source: Radiation Oncology - December 16, 2008 Category: Cancer & Oncology Authors: Anne Richter, Qiaoqiao Hu, Doreen Steglich, Kurt Baier, Jurgen Wilbert, Matthias Guckenberger and Michael Flentje Source Type: journals