Radiation Biological Toximetry Using Circulating Cell-Free DNA (cfDNA) for Rapid Radiation/Nuclear Triage
Radiat Res. 2024 Apr 25. doi: 10.1667/RADE-23-00159.1. Online ahead of print.ABSTRACTOptimal triage biodosimetry would include risk stratification within minutes, and it would provide useful triage despite heterogeneous dosimetry, cytokine therapy, mixed radiation quality, race, and age. For regulatory approval, the U.S. Food and Drug Administration (FDA) Biodosimetry Guidance requires suitability for purpose and a validated species-independent mechanism. Circulating cell-free DNA (cfDNA) concentration assays may provide such triage information. To test this hypothesis, cfDNA concentrations were measured in unprocessed mon...
Source: Radiation Research - April 25, 2024 Category: Physics Authors: Paul Okunieff Steven G Swarts Bruce Fenton Stephen B Zhang Zhenhuan Zhang Lori Rice Daohong Zhou France Carrier Lurong Zhang Source Type: research
Updated Analysis of Radon Exposure and Lung Cancer Mortality in the Cohort of Newfoundland Fluorspar Miners (1950-2016)
Radiat Res. 2024 Apr 23. doi: 10.1667/RADE-23-00114.1. Online ahead of print.ABSTRACTThe commercial mining of fluorspar in St. Lawrence Newfoundland began in 1933. Miners who worked underground were exposed to high levels of radon progeny, especially before ventilation was introduced into the mines in 1960. The mean cumulative radon exposure for underground miners in this cohort was 380.9 working level months (WLM). A series of studies of this cohort have characterized the increased risks of lung cancer mortality due to radon. We have extended the follow-up of this cohort an additional 15 years to provide additional insigh...
Source: Radiation Research - April 22, 2024 Category: Physics Authors: Paul J Villeneuve Howard I Morrison Rachel Lane Source Type: research
Updated Analysis of Radon Exposure and Lung Cancer Mortality in the Cohort of Newfoundland Fluorspar Miners (1950-2016)
Radiat Res. 2024 Apr 23. doi: 10.1667/RADE-23-00114.1. Online ahead of print.ABSTRACTThe commercial mining of fluorspar in St. Lawrence Newfoundland began in 1933. Miners who worked underground were exposed to high levels of radon progeny, especially before ventilation was introduced into the mines in 1960. The mean cumulative radon exposure for underground miners in this cohort was 380.9 working level months (WLM). A series of studies of this cohort have characterized the increased risks of lung cancer mortality due to radon. We have extended the follow-up of this cohort an additional 15 years to provide additional insigh...
Source: Radiation Research - April 22, 2024 Category: Physics Authors: Paul J Villeneuve Howard I Morrison Rachel Lane Source Type: research
Effects of Partial-Body, Continuous/Pulse Irradiation at Dose Rates from Flash to Conventional Rates on The Level of Surviving Blood Lymphocytes: Modeling Approach II. Two- and Multiple-Pulse Irradiation
Radiat Res. 2024 Apr 16. doi: 10.1667/RADE-23-00221.1. Online ahead of print.ABSTRACTMathematical models, which describe effects of partial-body, two- and multiple-pulse irradiation at high total doses D and at average dose rates N from FLASH to conventional rates on the level of surviving blood lymphocytes in humans and mice, have been developed originating in the previously proposed approach. These models predict that levels of surviving blood lymphocytes in humans and mice increase with increasing the dose rate from N = D / TR (TR is the time of the blood flowing into or out of the irradiated segment of the blood circul...
Source: Radiation Research - April 16, 2024 Category: Physics Authors: Francis A Cucinotta Olga A Smirnova Source Type: research
Effects of Partial-Body, Continuous/Pulse Irradiation at Dose Rates from Flash to Conventional Rates on The Level of Surviving Blood Lymphocytes: Modeling Approach II. Two- and Multiple-Pulse Irradiation
Radiat Res. 2024 Apr 16. doi: 10.1667/RADE-23-00221.1. Online ahead of print.ABSTRACTMathematical models, which describe effects of partial-body, two- and multiple-pulse irradiation at high total doses D and at average dose rates N from FLASH to conventional rates on the level of surviving blood lymphocytes in humans and mice, have been developed originating in the previously proposed approach. These models predict that levels of surviving blood lymphocytes in humans and mice increase with increasing the dose rate from N = D / TR (TR is the time of the blood flowing into or out of the irradiated segment of the blood circul...
Source: Radiation Research - April 16, 2024 Category: Physics Authors: Francis A Cucinotta Olga A Smirnova Source Type: research
Effects of Partial-Body, Continuous/Pulse Irradiation at Dose Rates from Flash to Conventional Rates on The Level of Surviving Blood Lymphocytes: Modeling Approach II. Two- and Multiple-Pulse Irradiation
Radiat Res. 2024 Apr 16. doi: 10.1667/RADE-23-00221.1. Online ahead of print.ABSTRACTMathematical models, which describe effects of partial-body, two- and multiple-pulse irradiation at high total doses D and at average dose rates N from FLASH to conventional rates on the level of surviving blood lymphocytes in humans and mice, have been developed originating in the previously proposed approach. These models predict that levels of surviving blood lymphocytes in humans and mice increase with increasing the dose rate from N = D / TR (TR is the time of the blood flowing into or out of the irradiated segment of the blood circul...
Source: Radiation Research - April 16, 2024 Category: Physics Authors: Francis A Cucinotta Olga A Smirnova Source Type: research
Effects of Partial-Body, Continuous/Pulse Irradiation at Dose Rates from Flash to Conventional Rates on the Level of Surviving Blood Lymphocytes: Modeling Approach. I. Continuous Irradiation
Radiat Res. 2024 Apr 15. doi: 10.1667/RADE-23-00222.1. Online ahead of print.ABSTRACTA mathematical model developed by Cucinotta and Smirnova is extended to describe effects of continuous, partial-body irradiation at high doses D and at dose N rates from FLASH to conventional rates on the level of surviving blood lymphocytes in humans and small laboratory animals (mice). Specifically, whereas the applicability of the model is limited to the exposure times shorter than a single cardiac cycle T0, the extended model is capable of describing such effects for the aforementioned and longer exposure times. The extended model is i...
Source: Radiation Research - April 14, 2024 Category: Physics Authors: Francis A Cucinotta Olga A Smirnova Source Type: research
Gastrointestinal Acute Radiation Syndrome: Mechanisms, Models, Markers, and Medical Countermeasures
This report provides an overview of information that was presented during the conference, and important discussions surrounding a broad range of topics that are critical for the research, development, licensure, and use of MCMs for GI-ARS.PMID:38616048 | DOI:10.1667/RADE-23-00196.1 (Source: Radiation Research)
Source: Radiation Research - April 14, 2024 Category: Physics Authors: Thomas A Winters Libero Marzella Olivia Molinar-Inglis Paul W Price Nyun Calvin Han Jonathan E Cohen Sue-Jane Wang Anthony F Fotenos Julie M Sullivan John Esker Paula J Lapinskas Andrea L DiCarlo Source Type: research
Steven Anthony Marino Sr. 1946-2024
Radiat Res. 2024 Apr 1;201(4):366-367. doi: 10.1667/RADE-23-00SAM.1.NO ABSTRACTPMID:38588379 | DOI:10.1667/RADE-23-00SAM.1 (Source: Radiation Research)
Source: Radiation Research - April 8, 2024 Category: Physics Authors: David Brenner Tom Hei Sally Amundson Guy Garty Source Type: research
C. Norman Coleman, M.D.(1945-2024)1
Radiat Res. 2024 Apr 1;201(4):271-274. doi: 10.1667/RADE-24-00CNC.1.NO ABSTRACTPMID:38588380 | DOI:10.1667/RADE-24-00CNC.1 (Source: Radiation Research)
Source: Radiation Research - April 8, 2024 Category: Physics Authors: Jeffrey C Buchsbaum Frank S Govern Pataje Prasanna Source Type: research
Connexin 43 Prevents Radiation-Induced Intestinal Damage via the Ca2+-Dependent PI3K/Akt Signaling Pathway
This study aimed to investigate the expression and role of connexins in RIID and underlying mechanism. In this study, a calcein-AM fluorescence probe was used to detect changes in gap junctional intercellular communication in intestinal epithelial IEC-6 cells. Our results show that gap junctional intercellular communication of IEC-6 cells was reduced at 6, 12, 24, and 48 h after irradiation, with the most pronounced effect at 24 h. Western blotting and immunofluorescence results showed that the expression of Cx43, but not other connexins, was reduced in irradiated intestinal epithelial cells. Silencing of Cx43 reduced gap ...
Source: Radiation Research - April 8, 2024 Category: Physics Authors: Yue Zhu Jun Dai Bin Song Yuehua Zhang Tingyi Yang Hongwei Xu Xiaopeng Xu Yi Gao Tao Yan Weidong Shen Wenhao Zhang Shuyu Zhang Pengfei Liu Source Type: research
Steven Anthony Marino Sr. 1946-2024
Radiat Res. 2024 Apr 1;201(4):366-367. doi: 10.1667/RADE-23-00SAM.1.NO ABSTRACTPMID:38588379 | DOI:10.1667/RADE-23-00SAM.1 (Source: Radiation Research)
Source: Radiation Research - April 8, 2024 Category: Physics Authors: David Brenner Tom Hei Sally Amundson Guy Garty Source Type: research
C. Norman Coleman, M.D.(1945-2024)1
Radiat Res. 2024 Apr 1;201(4):271-274. doi: 10.1667/RADE-24-00CNC.1.NO ABSTRACTPMID:38588380 | DOI:10.1667/RADE-24-00CNC.1 (Source: Radiation Research)
Source: Radiation Research - April 8, 2024 Category: Physics Authors: Jeffrey C Buchsbaum Frank S Govern Pataje Prasanna Source Type: research
Connexin 43 Prevents Radiation-Induced Intestinal Damage via the Ca2+-Dependent PI3K/Akt Signaling Pathway
This study aimed to investigate the expression and role of connexins in RIID and underlying mechanism. In this study, a calcein-AM fluorescence probe was used to detect changes in gap junctional intercellular communication in intestinal epithelial IEC-6 cells. Our results show that gap junctional intercellular communication of IEC-6 cells was reduced at 6, 12, 24, and 48 h after irradiation, with the most pronounced effect at 24 h. Western blotting and immunofluorescence results showed that the expression of Cx43, but not other connexins, was reduced in irradiated intestinal epithelial cells. Silencing of Cx43 reduced gap ...
Source: Radiation Research - April 8, 2024 Category: Physics Authors: Yue Zhu Jun Dai Bin Song Yuehua Zhang Tingyi Yang Hongwei Xu Xiaopeng Xu Yi Gao Tao Yan Weidong Shen Wenhao Zhang Shuyu Zhang Pengfei Liu Source Type: research
Steven Anthony Marino Sr. 1946-2024
Radiat Res. 2024 Apr 1;201(4):366-367. doi: 10.1667/RADE-23-00SAM.1.NO ABSTRACTPMID:38588379 | DOI:10.1667/RADE-23-00SAM.1 (Source: Radiation Research)
Source: Radiation Research - April 8, 2024 Category: Physics Authors: David Brenner Tom Hei Sally Amundson Guy Garty Source Type: research
