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Important ESTRO datesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 30, 2009 Category: Radiology Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 30, 2009 Category: Radiology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 30, 2009 Category: Radiology Source Type: journals

Justification for inter-fraction correction of catheter movement in fractionated high dose-rate brachytherapy treatment of prostate cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Inter-fraction correction for catheter movement using pre-treatment imaging is critical to maintain the quality of an implant. Without movement correction there is significant risk of tumour under-dosage and normal tissue over-dosage. The findings of this study justify additional imaging between fractions in order to carry out correction. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 26, 2009 Category: Radiology Authors: Tania Simnor, Sonia Li, Gerry Lowe, Peter Ostler, Linda Bryant, Caroline Chapman, Dave Inchley, Peter J. Hoskin Tags: Original articles Source Type: journals

New inverse planning technology for image-guided cervical cancer brachytherapy: Description and evaluation within a clinical frameEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Inverse planning based on the HIPO algorithm can produce treatment plans for cervical cancer brachytherapy which are comparable to plans based on manual optimisation as applied in clinical practice. It is essential to take into account the spatial dose distribution in addition to the DVH-based constraints. The proposed inverse planning concept is feasible for improving the therapeutic ratio and limiting substantial high-dose regions around needles. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 21, 2009 Category: Radiology Authors: Petra Trnková, Richard Pötter, Dimos Baltas, Andreas Karabis, Elena Fidarova, Johannes Dimopoulos, Dietmar Georg, Christian Kirisits Tags: Original articles Source Type: journals

Quadrimodal treatment of high-risk T1 and T2 bladder cancer: Transurethral tumor resection followed by concurrent radiochemotherapy and regional deep hyperthermiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The quadrimodal treatment was feasible and well tolerated. Local control and bladder-preserving rates were encouraging. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 19, 2009 Category: Radiology Authors: Michael Wittlinger, Claus M. Rödel, Christian Weiss, Steffen F. Krause, Reinhard Kühn, Rainer Fietkau, Rolf Sauer, Oliver J. Ott Tags: Original articles Source Type: journals

Clinical and dosimetric predictors of late rectal toxicity after conformal radiation for localized prostate cancer: Results of a large multicenter observational studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The application of rectal dose–volume constraints limited the incidence of rectal bleeding. The risk of bleeding may be further reduced by limiting V75Gy (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 15, 2009 Category: Radiology Authors: Gianni Fellin, Claudio Fiorino, Tiziana Rancati, Vittorio Vavassori, Micaela Baccolini, Carla Bianchi, Emanuela Cagna, Pietro Gabriele, Floranna Mauro, Loris Menegotti, Angelo Filippo Monti, Michele Stasi, Riccardo Valdagni Tags: Original articles Source Type: journals

Lipiodol injection for target volume delineation and image guidance during radiotherapy for bladder cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A technique was developed for bladder tumour demarcation with lipiodol injection through a flexible cystoscope. The technique proved to be simple and useful for image-guided radiotherapy in bladder cancer as well as a helpful aid in the tumour delineation process. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 5, 2009 Category: Radiology Authors: Floris Pos, Axel Bex, Hermina Maria Dees-Ribbers, Anja Betgen, Marcel van Herk, Peter Remeijer Tags: Original articles Source Type: journals

MR-guided simultaneous integrated boost in preoperative radiotherapy of locally advanced rectal cancer following neoadjuvant chemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Tumor volume reduction for rectal cancer patients following neoadjuvant chemotherapy allows for increased tumor dose using a SIB strategy without increased OAR toxicity. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 5, 2009 Category: Radiology Authors: Therese Seierstad, Knut Håkon Hole, Erik Sælen, Anne Hansen Ree, Kjersti Flatmark, Eirik Malinen Tags: Original articles Source Type: journals

Is ad-hoc plan adaptation based on 2-Step IMRT feasible?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The first results for adaptation of interfractional changes using the 2-Step IMRT algorithm are encouraging. The plans were superior to plans with optimized isocentre position and only marginally inferior to a newly optimized plan. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 5, 2009 Category: Radiology Authors: Klaus Bratengeier, Bülent Polat, Mark Gainey, Patricia Grewenig, Jürgen Meyer, Michael Flentje Tags: Original articles Source Type: journals

Radical prostatectomy vs. intensity-modulated radiation therapy in the management of localized prostate adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and purpose: To determine whether radical prostatectomy (RP) or intensity-modulated radiation therapy (IMRT) to ⩾72Gy, plus hormonal therapy if indicated, results in improved biochemical disease-free survival (BDFS) in localized prostate adenocarcinoma.Materials and methods: Between 1997 and 2005, a consecutive sample of 556 patients who underwent RP (n=204) or IMRT (n=352) at two referral centers was analyzed. The patients were stratified into prognostic groups based on clinical stage, Gleason score, and pretreatment prostate-specific antigen (PSA). The outcome measure was BDFS.Results: IMRT patient...
Source: Radiotherapy and Oncology - October 5, 2009 Category: Radiology Authors: Ayal A. Aizer, James B. Yu, John W. Colberg, Anne M. McKeon, Roy H. Decker, Richard E. Peschel Tags: Original articles Source Type: journals

Important ESTRO datesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 28, 2009 Category: Radiology Tags: Original articles Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 28, 2009 Category: Radiology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 28, 2009 Category: Radiology Source Type: journals

Modeling set-up error by daily MVCT for prostate adjuvant treatment delivered in 20 fractions: Implications for the assessment of the optimal correction strategiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Purpose: To optimise image-guided radiotherapy (IGRT) approaches in set-up error correction for hypofractionated adjuvant treatment of prostate cancer using helical tomotherapy (HT).Methods and materials: HT unit provides megavoltage – CT (MVCT) imaging capability for daily patient set-up. The intrinsic uncertainty of the available image registration techniques was first investigated on a pelvic phantom.To optimise different set-up correction strategies, MVCT data of 37 patients treated with 58Gy delivered in 20 fractions were analyzed. 620 MVCT images were globally available for the analysis. Daily on-line set...
Source: Radiotherapy and Oncology - September 22, 2009 Category: Radiology Authors: Sara Broggi, Cesare Cozzarini, Claudio Fiorino, Eleonora Maggiulli, Filippo Alongi, Giovanni Mauro Cattaneo, Nadia Di Muzio, Riccardo Calandrino Tags: Original articles Source Type: journals

Carbon-11 acetate PET/CT based dose escalated IMRT in prostate cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our study indicates that [11C]acetate can be used to define the IPL’s and in combination with SIBIMRT the defined areas can theoretically be treated to ultra high doses without increasing the treatment toxicity. These results motivate the formal validation of [11C]acetate PET for biological dose planning in prostate cancer. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 22, 2009 Category: Radiology Authors: Jan Seppälä, Marko Seppänen, Eveliina Arponen, Paula Lindholm, Heikki Minn Tags: Original articles Source Type: journals

18F-fluorocholine PET-guided target volume delineation techniques for partial prostate re-irradiation in local recurrent prostate cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Semi-automated segmentation techniques for 18F-choline PET-guided GTV delineation resulted in substantially higher GTVs compared to manual delineation and might replace the latter for determination of recurrent prostate cancer for partial prostate re-irradiation. The selection of the most appropriate segmentation algorithm still needs to be determined. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 22, 2009 Category: Radiology Authors: Hui Wang, Hansjörg Vees, Raymond Miralbell, Michael Wissmeyer, Charles Steiner, Osman Ratib, Srinivasan Senthamizhchelvan, Habib Zaidi Tags: Original articles Source Type: journals

IMRT significantly reduces acute toxicity of whole-pelvis irradiation in patients treated with post-operative adjuvant or salvage radiotherapy after radical prostatectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The risk of acute toxicity following post-operative WPRT delivered by means of IMRT was reduced compared to that of 3DCRT. The most significant reduction concerned uGI, mainly owing to better bowel sparing with IMRT. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 22, 2009 Category: Radiology Authors: Filippo Alongi, Claudio Fiorino, Cesare Cozzarini, Sara Broggi, Lucia Perna, Giovanni Mauro Cattaneo, Riccardo Calandrino, Nadia Di Muzio Tags: Original articles Source Type: journals

Late toxicity after postprostatectomy salvage radiation therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Salvage EBRT for a detectable PSA level after RP is the only curative treatment in this setting. This treatment can be administered in a manner that results in a low likelihood of late complications. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 22, 2009 Category: Radiology Authors: Jennifer L. Peterson, Steven J. Buskirk, Michael G. Heckman, Julia E. Crook, Stephen J. Ko, Michael J. Wehle, Todd C. Igel, Karin A. Prussak, Thomas M. Pisansky Tags: Original articles Source Type: journals

Volumetric modulated arc therapy (VMAT) vs. serial tomotherapy, step-and-shoot IMRT and 3D-conformal RT for treatment of prostate cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: All approaches yield treatment plans of improved quality when compared to 3D-conformal treatments, with serial tomotherapy providing best OAR sparing and VMAT being the most efficient treatment option in our comparison. Plans which were calculated with 3D-CRT provided good target coverage but resulted in higher dose to the rectum. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 18, 2009 Category: Radiology Authors: Dirk Wolff, Florian Stieler, Grit Welzel, Friedlieb Lorenz, Yasser Abo-Madyan, Sabine Mai, Carsten Herskind, Martin Polednik, Volker Steil, Frederik Wenz, Frank Lohr Tags: Original articles Source Type: journals

Dose–volume effects for normal tissues in external radiotherapy: PelvisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A great deal of quantitative information regarding the dose–volume relationships of pelvic organs at risk has been collected and analysed over the last 10 years. The need to improve our knowledge in the modelling of late and acute toxicity has become increasingly important, due to the rapidly increasing use of inverse-planned intensity-modulated radiotherapy (IMRT) and the consequent need of a quantitative assessment of dose–volume or biological-based cost functions. This comprehensive review concerns most organs at risk involved in planning optimisation for prostate and other types of pelvic cancer. The rect...
Source: Radiotherapy and Oncology - September 18, 2009 Category: Radiology Authors: Claudio Fiorino, Riccardo Valdagni, Tiziana Rancati, Giuseppe Sanguineti Tags: Systematic reviews Source Type: journals

Twinning partnerships through International Atomic Energy Agency (IAEA) to improve radiotherapy in common paediatric cancers in low- and mid-income countriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: RT remains an essential component of the multidisciplinary management of many paediatric cancers. Excessive variations in outcome are inappropriate and call for action on harmonising training programmes and compliance with evidence-based recommendations. Training projects targeting paediatric cancer care are being implemented and clinical studies comparing new technologies against evidence-based approaches are needed to achieve this goal. The IAEA has an important role in these activities and has commenced prospective data collection in 13 LMICs to monitor trends in treatment techniques and outcomes. (Source: R...
Source: Radiotherapy and Oncology - September 14, 2009 Category: Radiology Authors: Eeva Salminen, Yavuz Anacak, Siddartha Laskar, Rolf-Dieter Kortmann, Elsa Raslawski, Graham Stevens, Raul C. Ribeiro Tags: Original articles Source Type: journals

MRI-guided treatment-planning optimisation in intracavitary or combined intracavitary/interstitial PDR brachytherapy using tandem ovoid applicators in locally advanced cervical cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Purpose: To study the impact of MRI-guided treatment planning on dose/volume parameters in pulsed dose rate (PDR) brachytherapy (BT) for cervical cancer. Additionally, we investigated the potential benefit of an intracavitary/interstitial (IC/IS) modification of the classical tandem ovoid applicator.Material and methods: For 24 patients we compared Standard PDR BT plans, Scaled Standard plans and MRI-guided Optimised plans. The total EBRT/BT prescribed dose to Manchester point A or to 90% of the HR-CTV (D90 HR-CTV) expressed in EQD2 was 80Gyαβ10 in 17 patients (Period I) and 84Gyαβ10 in 7 patients (Period II)...
Source: Radiotherapy and Oncology - September 14, 2009 Category: Radiology Authors: Ina M. Jürgenliemk-Schulz, Robbert J.H.A. Tersteeg, Judith M. Roesink, Stefan Bijmolt, Christel N. Nomden, Marinus A. Moerland, Astrid A.C. de Leeuw Tags: Original articles Source Type: journals

Postoperative morbidity and mortality in relation to leukocyte counts and time to surgery after short-course preoperative radiotherapy for rectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: Preoperative radiotherapy for rectal cancer decreases local recurrence rates, but increases postoperative complications. Impaired postoperative leukocyte reaction after preoperative short-course radiotherapy has been reported. The aim was to assess postoperative morbidity and mortality in relation to leukocyte reaction and the time interval between radiotherapy and surgery.Materials and methods: A retrospective analysis of patients included in the Stockholm I and II trials, randomising patients to surgery alone or to 5×5Gy with immediate surgery, identified pre- and postoperative leukocyte values for...
Source: Radiotherapy and Oncology - September 14, 2009 Category: Radiology Authors: Tone Fokstuen, Torbjörn Holm, Bengt Glimelius Tags: Original articles Source Type: journals

Target volume shape variation during irradiation of rectal cancer patients in supine position: Comparison with prone positionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Shape variation of the MesoRect is substantial, heterogeneous and different between male and female patients. Differences between supine and prone orientation, however, are small. Clinical margins should be differentiated in position along the cranio–caudal axis, in anterior–posterior direction and for gender. Margins should also be increased, even when online setup correction is used. Due to the small margin differences between prone and supine treatments, the setup choice should be determined on dose to the organs at risk. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 14, 2009 Category: Radiology Authors: Jasper Nijkamp, Rianne de Jong, Jan-Jakob Sonke, Corine van Vliet, Corrie Marijnen Tags: Original articles Source Type: journals

Is a single arc sufficient in volumetric-modulated arc therapy (VMAT) for complex-shaped target volumes?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The complexity of the target volume determined whether single arc VMAT was equivalent to ss-IMRT. Multiple arc VMAT improved results compared to single arc VMAT at cost of increased delivery times, increased monitor unites and increased spread of low doses. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 14, 2009 Category: Radiology Authors: Matthias Guckenberger, Anne Richter, Thomas Krieger, Juergen Wilbert, Kurt Baier, Michael Flentje Tags: Original articles Source Type: journals

MRI before and after external beam intensity-modulated radiotherapy of patients with prostate cancer: The feasibility of monitoring of radiation-induced tissue changes using a dynamic contrast-enhanced inversion-prepared dual-contrast gradient echo sequenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Purpose: To identify and quantify suitable pharmacokinetic MRI parameters for monitoring tissue changes after external beam intensity-modulated radiotherapy of prostate cancer.Material and methods: Six patients with biopsy-proven prostate cancer (initial PSA, 6.0–81.4ng/ml) underwent MRI at 1.5T using a combined endorectal/body phased-array coil and a dynamic contrast-enhanced inversion-prepared dual-contrast gradient echo sequence (T1/T2∗w; 1.65s temporal resolution). MRI was performed before and immediately after radiotherapy, at 3months and at 1year. Perfusion, blood volume, mean transit time, delay, dispe...
Source: Radiotherapy and Oncology - September 14, 2009 Category: Radiology Authors: Tobias Franiel, Lutz Lüdemann, Matthias Taupitz, Dirk Böhmer, Dirk Beyersdorff Tags: Original articles Source Type: journals

Comparison of three radiotherapy modalities on biochemical control and overall survival for the treatment of prostate cancer: A systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The combination of external beam radiotherapy and HDR brachytherapy results in a superior biochemical control and overall survival found in a systematic review on radiotherapy for prostate cancer. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 14, 2009 Category: Radiology Authors: Bradley R. Pieters, Djuna Z. de Back, Caro C.E. Koning, Aeilko H. Zwinderman Tags: Systematic reviews Source Type: journals

Double blind randomized phase II study with radiation+5-fluorouracil±celecoxib for resectable rectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Addition of celecoxib to preoperative chemoradiation is feasible for patients with locally advanced rectal cancer. To study the individual effect of COX-2 inhibitors on pathological response phase III studies are required. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 11, 2009 Category: Radiology Authors: Annelies Debucquoy, Sarah Roels, Laurence Goethals, Louis Libbrecht, Eric Van Cutsem, Karel Geboes, Freddy Penninckx, André D’Hoore, William H. McBride, Karin Haustermans Tags: Original articles Source Type: journals

Dosimetric consequences of uncorrected setup errors in helical Tomotherapy treatments of breast-cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Tomotherapy’s rotational delivery provides sufficient photon fluence extending beyond the skin surface to allow an up to 7-mm uncorrected setup error in the anterolateral direction. However, the steep dose falloff that conforms to the lung surface leads to compromised dose distributions with uncorrected posteromedial shifts. Therefore, daily image guidance and consequent patient repositioning is warranted for breast-cancer patients. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 6, 2009 Category: Radiology Authors: S. Murty Goddu, Sridhar Yaddanapudi, Olga L. Pechenaya, Summer R. Chaudhari, Eric E. Klein, Divya Khullar, Issam El Naqa, Sasa Mutic, Sasha Wahab, Lakshmi Santanam, Imran Zoberi, Daniel A. Low Tags: Original articles Source Type: journals

Time and motion study of radiotherapy delivery: Economic burden of increased quality assurance and IMRTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Time measurements were performed on daily treatment delivery with the aim to quantify the impact of quality assurance (QA) using an electronic portal imaging device (EPID) on RT delivery time and to validate the time burden of intensity modulated radiation therapy (IMRT) as an example of advanced technology.Both increased QA and the delivery of IMRT were found to be significant parameters determining daily treatment time (TT), which in turn translates in increased treatment costs. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 3, 2009 Category: Radiology Authors: Evelyn Van de Werf, Yolande Lievens, Jan Verstraete, Kris Pauwels, Walter Van den Bogaert Tags: Original articles Source Type: journals

Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Despite inherent weaknesses, PET-hypoxia imaging is able to generate quantitative tumor maps that accurately reflect the underlying microscopic reality (i.e., hypoxic cell density) in an animal model with a clinical realistic image contrast. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 2, 2009 Category: Radiology Authors: Morten Busk, Michael R. Horsman, Steen Jakobsen, Kim V. Hansen, Johan Bussink, Albert van der Kogel, Jens Overgaard Tags: Original articles Source Type: journals

3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data demonstrate TAE226 as potent FAK inhibitor that enhances the cellular radiosensitivity particularly of HNSCC cells grown in a 3D cell culture model. Future in vitro and in vivo investigations will clarify, to which extent this approach might be clinically relevant for radiotherapy of HNSCC. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 2, 2009 Category: Radiology Authors: Stephanie Hehlgans, Inga Lange, Iris Eke, Nils Cordes Tags: Original articles Source Type: journals

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data identify LAMP3 as a novel hypoxia-inducible gene regulated by the UPR. LAMP3 is a new candidate biomarker of UPR activation by hypoxia in tumours and is a potential mediator of hypoxia-induced metastasis. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 1, 2009 Category: Radiology Authors: Hilda Mujcic, Tomasz Rzymski, Kasper M.A. Rouschop, Marianne Koritzinsky, Manuela Milani, Adrian L. Harris, Bradly G. Wouters Tags: Original articles Source Type: journals

Molecular radiation biology: Perspectives for radiation oncologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Molecular radiation biology has become a powerful discipline and tool for detailed investigations into biological mechanisms of problems and aspects of modern radiation oncology. In this context special emphasis is given to the mechanisms of DNA-repair and their relevance for radiation therapy, to the relevance of radiation-induced signal transduction for normal and tumour cell response, to the role of the micro-environment for the modification of tumour as well as normal tissue responses to radiation, and last but not the least to the aspects of individualization and molecular targeting in radiation therapy. These topics ...
Source: Radiotherapy and Oncology - September 1, 2009 Category: Radiology Authors: H. Peter Rodemann Tags: Editorial Source Type: journals

A multi-institutional acute gastrointestinal toxicity analysis of anal cancer patients treated with concurrent intensity-modulated radiation therapy (IMRT) and chemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Using previous dosimetric analysis methods, we identified the volume of bowel receiving 30Gy (V30) correlated with acute gastrointestinal (GI) toxicity in anal cancer patients treated with intensity-modulated radiation therapy and concurrent chemotherapy. For V30>450cc and⩽450cc, acute GI toxicity was 33% and 8%, respectively (p=0.003). (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 1, 2009 Category: Radiology Authors: Kiran Devisetty, Loren K. Mell, Joseph K. Salama, David A. Schomas, Robert. C. Miller, Ashesh B. Jani, John C. Roeske, Bulent Aydogan, Steven J. Chmura Tags: Original articles Source Type: journals

Dose-escalation using intensity-modulated radiotherapy for prostate cancer – Evaluation of the dose distribution with and without 18F-choline PET-CT detected simultaneous integrated boostEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and purpose: The aim of the study was to evaluate the impact of a dose escalation to an 18F-choline PET-CT defined simultaneous integrated boost (IB) on the dose distribution and changes of the equivalent uniform dose (EUD).Materials and methods: PET-CT was performed in 12 consecutive patients for treatment planning. An intraprostatic lesion was defined by a tumour-to-background uptake value ratio >2 (GTVPET). Dose escalation was focused only on the intraprostatic lesion. Two comparisons were evaluated: whole prostate irradiation to 76Gy±boost to 80Gy (C1) and whole prostate irradiation to 66.6Gy±boo...
Source: Radiotherapy and Oncology - September 1, 2009 Category: Radiology Authors: Michael Pinkawa, Charbel Attieh, Marc D. Piroth, Richard Holy, Sandra Nussen, Jens Klotz, Robert Hawickhorst, Wolfgang Schäfer, Michael J. Eble Tags: Original articles Source Type: journals

Important ESTRO datesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - August 31, 2009 Category: Radiology Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - August 31, 2009 Category: Radiology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - August 31, 2009 Category: Radiology Source Type: journals

Difficulties and potential of correlating local recurrences in prostate cancer with the delivered local doseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In the previous decades the distinction between a local relapse and distant metastases was difficult to accomplish in an early stage. As a consequence, a failure could only be coarsely related to the original radiotherapy treatment. Currently, due to better imaging and position verification techniques, the actual dose within the prostate can be estimated, taking position uncertainties into account. Furthermore, advanced functional MRI techniques, such as MR spectroscopy (MRS) and dynamic contrast-enhanced MRI (DCE-MRI), increase the chance of localizing a local recurrence within the prostate. With this informatio...
Source: Radiotherapy and Oncology - August 25, 2009 Category: Radiology Authors: Marco van Vulpen, Cornelis A.T. van den Berg, Maaike R. Moman, Uulke A. van der Heide Tags: Original articles Source Type: journals

Initial validations for pursuing irradiation using a gimbals tracking systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Our newly designed image-guided radiotherapy (IGRT) system enables the dynamic tracking irradiation with a gimbaled X-ray head and a dual on-board kilovolt imaging subsystem for real-time target localization. Examinations using a computer-controlled three-dimensionally movable phantom demonstrated that our gimbals tracking system significantly reduced motion blurring effects in the dose distribution compared to the non-tracking state. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - August 24, 2009 Category: Radiology Authors: Kenji Takayama, Takashi Mizowaki, Masaki Kokubo, Noriyuki Kawada, Hiroshi Nakayama, Yuichiro Narita, Kazuo Nagano, Yuichiro Kamino, Masahiro Hiraoka Tags: Original articles Source Type: journals

CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell lines HCT-116Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and purpose: CD133 is controversially discussed as putative (surrogate) marker for cancer stem/tumor-initiating cell populations (CSC/TIC) in epithelial tumors including colorectal carcinomas (CRCs). We studied CD133 expression in established CRC cell lines and examined in vitro behavior, radioresponse and in vivo tumor formation of CD133+/− subpopulations of one cell line of interest.Materials and methods: Ten CRC cell lines were analyzed for CD133 expression using flow cytometry and Western blotting. CD133+ and CD133− HCT-116 subpopulations were separated by FACS and studied in 2-D and 3-D cultur...
Source: Radiotherapy and Oncology - August 24, 2009 Category: Radiology Authors: Claudia Dittfeld, Antje Dietrich, Susann Peickert, Sandra Hering, Michael Baumann, Marian Grade, Thomas Ried, Leoni A. Kunz-Schughart Tags: Original articles Source Type: journals

Intrafraction motion in patients with cervical cancer: The benefit of soft tissue registration using MRIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Considerable intrafraction CTV motion is observed in cervical cancer patients. Intrafraction MRI-guided soft tissue registration using an MRI-accelerator will correct for this motion. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - August 19, 2009 Category: Radiology Authors: Ellen M. Kerkhof, Richard W. van der Put, Bas W. Raaymakers, Uulke A. van der Heide, Ina M. Jürgenliemk-Schulz, Jan J.W. Lagendijk Tags: Original articles Source Type: journals

Image quality and stability of image-guided radiotherapy (IGRT) devices: A comparative studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: Reasonable differences in image quality between CT and CBCT were observed. Further research and development are necessary to increase image quality of commercially available CBCT devices in order for them to serve the needs for adaptive and/or online planning. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - August 19, 2009 Category: Radiology Authors: Markus Stock, Marlies Pasler, Wolfgang Birkfellner, Peter Homolka, Richard Poetter, Dietmar Georg Tags: Original articles Source Type: journals

Enhanced response to C225 of A431 tumor xenografts growing in irradiated tumor bedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and purpose: We recently demonstrated that C225 maintenance therapy after completion of radiotherapy further increased tumor radiocurability. The present study assessed mechanisms underlying the observed improvement in C225 efficacy in pre-irradiated tissue (tumor bed).Materials and methods: A431 xenografts growing in pre-irradiated and non-irradiated tissue were treated with C225. Tumors were assessed for growth delay, cell proliferation, hypoxia, EGFR and VEGF expressions. In vitro clonogenic survival of cells derived from these tumors was also assayed.Results: Pre-irradiation of tumor bed induced gr...
Source: Radiotherapy and Oncology - August 19, 2009 Category: Radiology Authors: Oliver Riesterer, Kathryn A. Mason, Uma Raju, Qiuan Yang, Li Wang, Walter N. Hittelman, K. Kian Ang, Luka Milas Tags: Original articles Source Type: journals

Dosimetric assessment of static and helical TomoTherapy in the clinical implementation of breast cancer treatmentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study concentrates on the evaluation of the planning protocol for the TomoTherapy and TomoDirect TPS, dose verification and the implementation of in vivo dosimetry.Materials and methods: Eight patients with different breast cancer indications (left/right tumor, axillary nodes involvement (N+)/no nodes (N0), tumorectomy/mastectomy) were enrolled. TomoTherapy, TomoDirect and conventional plans were generated for prone and supine positions leading to six or seven plans per patient. Dose prescription was 42Gy in 15 fractions over 3weeks. Dose verification of a TomoTherapy plan is performed using TLDs and EDR2 film inside ...
Source: Radiotherapy and Oncology - August 16, 2009 Category: Radiology Authors: Truus Reynders, Koen Tournel, Peter De Coninck, Steve Heymann, Vincent Vinh-Hung, Hilde Van Parijs, Michaël Duchateau, Nadine Linthout, Thierry Gevaert, Dirk Verellen, Guy Storme Tags: Original articles Source Type: journals

Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A single pre-treatment core needle biopsy may provide valid results for parameters of the tumour micromilieu, however the accuracy is limited by significant intratumoural heterogeneity in the parameters and sampling error. The needle biopsy procedure does not significantly affect local tumour control rates after fractioned irradiation and may therefore be integrated for longitudinal studies in radiobiological experiments. Pre-treatment histological parameters measured in the biopsy did not correlate with the outcome of fractionated irradiation within the UT-SCC-5 tumour line. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - August 16, 2009 Category: Radiology Authors: Ala Yaromina, Anja Eckardt, Daniel Zips, Wolfgang Eicheler, Christina Schuetze, Howard Thames, Michael Baumann Tags: Original articles Source Type: journals

Genetic variants and normal tissue toxicity after radiotherapy: A systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here an overview of these studies with information on the genetic variants, tumour type, number of patients included, the endpoint studied, the mechanism(s) by which the candidate genes are involved in the pathogenesis of normal tissue toxicity, and odds ratios (ORs) for candidate variants. Though many positive results have been reported, inconsistent findings and non-replication of previous results have frequently occurred. This can presumably be attributed to certain methodological shortcomings including lack of statistical power to detect small effect sizes. Based on theoretical considerations and experiences ...
Source: Radiotherapy and Oncology - August 16, 2009 Category: Radiology Authors: Christian Nicolaj Andreassen, Jan Alsner Tags: Systematic review Source Type: journals