Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology
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Advanced kernel methods vs. Monte Carlo-based dose calculation for high energy photon beams.
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CONCLUSION: All TPS investigated in this study demonstrated accurate dose calculation in homogenous and heterogeneous phantoms. Commercially available TPS with Monte Carlo option performed best in heterogeneous phantoms. However, the difference between the CC and the MC algorithms was found to be small.
PMID: 19926153 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 17, 2009 Category: Radiology Authors: Fotina I, Winkler P, Künzler T, Reiterer J, Simmat I, Georg D Tags: Radiother Oncol Source Type: journals
Optimal gantry angles and field sizes in kilovoltage cone-beam tomosynthesis for set-up of women with breast cancer undergoing radiotherapy treatment.
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Optimal beam geometry for kilovoltage cone-beam tomosynthesis (CB-TS) imaging for the set-up of 20 patients with breast cancer was analyzed and presented for prone and supine scenarios. Gantry angles and field sizes that allow maximum clearance and minimum dose to normal organs from kilovoltage imaging were determined for medial and lateral arcs. Optimal CB-TS arc span may vary depending on patient geometry, particularly on the separation between the cavity and the chest wall. CB-TS arc angles 40 degrees were found to be optimal for the cavity to chest wall separation d>3cm for supine set-up and d>7cm for prone s...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 16, 2009 Category: Radiology Authors: Lyatskaya Y, Buehler A, Ng SK, Wong J, Bellon JR, Zygmanski P Tags: Radiother Oncol Source Type: journals
Low rate of thoracic toxicity in palliative paraspinal single-fraction stereotactic body radiation therapy.
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CONCLUSIONS: High-dose single-fraction SBRT is well tolerated to the thoracic region, with most patients tolerating high doses to central structures without significant toxicity.
PMID: 19923027 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 16, 2009 Category: Radiology Authors: Gomez DR, Hunt MA, Jackson A, O'Meara WP, Bukanova EN, Zelefsky MJ, Yamada Y, Rosenzweig KE Tags: Radiother Oncol Source Type: journals
Intensity-modulated radiotherapy for recurrent and second primary head and neck cancer in previously irradiated territory.
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CONCLUSIONS: High-dose IMRT for recurrent and second primary head and neck cancer in previously irradiated territory leads to approximately 20% long-term survival in a non-selected patient population. Identification of patients who would benefit most of curative IMRT is warranted.
PMID: 19919885 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 16, 2009 Category: Radiology Authors: Duprez F, Madani I, Bonte K, Boterberg T, Vakaet L, Derie C, De Gersem W, De Neve W Tags: Radiother Oncol Source Type: journals
Three-dimensional conformal radiation therapy for squamous cell carcinoma of the esophagus: A prospective phase I/II study.
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CONCLUSIONS: Although 3-DCRT to 66Gy for esophageal SCC was well tolerated, the local control was disappointing. The result supports the use of chemoradiation as the standard care for esophageal SCC.
PMID: 19919886 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 16, 2009 Category: Radiology Authors: Wu KL, Chen GY, Xu ZY, Fu XL, Qian H, Jiang GL Tags: Radiother Oncol Source Type: journals
Robotic system-based fractionated stereotactic radiotherapy in locally recurrent nasopharyngeal carcinoma.
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CONCLUSIONS: With regard to OS and LFFS, our study provided favorable outcomes. The incidence of severe late toxicities was acceptable in our study. FSRT would be considered as the alternative treatment of choice in re-irradiation for locally recurrent NPC.
PMID: 19919887 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 16, 2009 Category: Radiology Authors: Seo Y, Yoo H, Yoo S, Cho C, Yang K, Kim MS, Choi C, Shin Y, Lee D, Lee G Tags: Radiother Oncol Source Type: journals
KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy.
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CONCLUSION: We are the first to report the mutation status of KRAS and BRAF in pre-therapeutic biopsies from locally advanced rectal cancers. The high number of KRAS mutations in codons 61 and 146 emphasizes the importance to expand current mutation analyses, whereas BRAF mutations are not relevant for rectal carcinogenesis. Although the KRAS mutation status was not correlated with response, the subtle difference between G12V and G13D mutations warrants analysis of a larger patient population.
PMID: 19913317 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for The...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 11, 2009 Category: Radiology Authors: Gaedcke J, Grade M, Jung K, Schirmer M, Jo P, Obermeyer C, Wolff HA, Herrmann MK, Beissbarth T, Becker H, Ried T, Ghadimi M Tags: Radiother Oncol Source Type: journals
HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer.
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CONCLUSIONS: HPV/p16-expression significantly improved outcome after radiotherapy in HNSCC. Hypoxic modification improved outcome in HPV/p16-negative tumours but was of no significant benefit in HPV/p16-positive tumours, suggesting that hypoxic radioresistance may not be clinically relevant in these tumours.
PMID: 19910068 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 10, 2009 Category: Radiology Authors: Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J, Tags: Radiother Oncol Source Type: journals
Endogenous and radiation-induced expression of gammaH2AX in biopsies from patients treated for carcinoma of the uterine cervix.
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CONCLUSIONS: Endogenous gammaH2AX foci are enriched in hypoxic tumour regions. Small differences in delivered dose can produce quantifiable differences in residual DNA damage that can overshadow inter-tumour differences in response.
PMID: 19903578 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 9, 2009 Category: Radiology Authors: Olive PL, Banuelos CA, Durand RE, Kim JY, Aquino-Parsons C Tags: Radiother Oncol Source Type: journals
Radiotherapy for pituitary adenomas: Long-term efficacy and toxicity.
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CONCLUSIONS: This treatment is effective with good local control rates at 20years. A significant proportion developed hypo-pituitarism. The risk of optic neuropathy was low but risk of stroke increased, particularly in women who had slight increased risk of intra-cranial tumours.
PMID: 19900729 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2009 Category: Radiology Authors: Erridge SC, Conkey DS, Stockton D, Strachan MW, Statham PF, Whittle IR, Grant R, Kerr GR, Gregor A Tags: Radiother Oncol Source Type: journals
Radiotherapy of malignant gliomas: Comparison of volumetric single arc technique (RapidArc), dynamic intensity-modulated technique and 3D conformal technique.
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CONCLUSIONS: If PTV is distant to OAR, the use of 3D conformal technique is sufficient. Otherwise an intensity-modulated technique should be used. RapidArc was faster than conventional IMRT and should be preferred if PTV coverage is adequate.
PMID: 19897266 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 6, 2009 Category: Radiology Authors: Wagner D, Christiansen H, Wolff H, Vorwerk H Tags: Radiother Oncol Source Type: journals
Evaluation of the impact of dental artefacts on intensity-modulated radiotherapy planning for the head and neck.
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CONCLUSIONS: Use of an extended CT/density look-up table together with a simple manual bulk density correction reduces the impact of dental artefacts on head and neck IMRT planning to acceptable levels.
PMID: 19897267 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 6, 2009 Category: Radiology Authors: Webster GJ, Rowbottom CG, Mackay RI Tags: Radiother Oncol Source Type: journals
Quantitative evaluation of cone-beam computed tomography in target volume definition for offline image-guided radiation therapy of prostate cancer.
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CONCLUSIONS: It is feasible to use CBCT for target definition in offline image guidance, thereby eliminating the separate helical CT scan process.
PMID: 19897268 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 6, 2009 Category: Radiology Authors: Wang W, Wu Q, Yan D Tags: Radiother Oncol Source Type: journals
A treatment planning study comparing helical tomotherapy with intensity-modulated radiotherapy for the treatment of anal cancer.
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CONCLUSIONS: HT and IMRT techniques achieved comparable target dose coverage and organ sparing, whereas HT plans were more homogeneous for both men and women.
PMID: 19896229 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 4, 2009 Category: Radiology Authors: Joseph KJ, Syme A, Small C, Warkentin H, Quon H, Ghosh S, Field C, Pervez N, Tankel K, Patel S, Usmani N, Severin D, Nijjar T, Fallone G, Pedersen J Tags: Radiother Oncol Source Type: journals
Impact of target volumes and radiation technique on loco-regional control and survival for patients with unilateral cervical lymph node metastases from an unknown primary.
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CONCLUSIONS: Retrospective comparisons between bilateral and unilateral neck radiotherapies did not show differences in terms of loco-regional control and survival. However, patient's local regional control and survival are significantly improved after 3D-CRT or IMRT.
PMID: 19892420 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 4, 2009 Category: Radiology Authors: Ligey A, Gentil J, Créhange G, Montbarbon X, Pommier P, Peignaux K, Truc G, Maingon P Tags: Radiother Oncol Source Type: journals
High doses per fraction and the linear-quadratic model.
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PMID: 19892421 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 3, 2009 Category: Radiology Authors: Courdi A Tags: Radiother Oncol Source Type: journals
Correlation between dose to the pharyngeal constrictors and patient quality of life and late dysphagia following chemo-IMRT for head and neck cancer.
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CONCLUSION: This study did not find a statistically significant correlation between radiation dose to the PC and observer-assessed dysphagia grade or patient-reported MDADI questionnaire at 1year.
PMID: 19883951 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 31, 2009 Category: Radiology Authors: Bhide SA, Gulliford S, Kazi R, El-Hariry I, Newbold K, Harrington KJ, Nutting CM Tags: Radiother Oncol Source Type: journals
Comparison between CT- and FDG-PET-defined target volumes for radiotherapy planning in head-and-neck cancers.
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Nine patients with head-and-neck cancer underwent computerized tomography (CT) simulation and [(18)F]-fluorodeoxyglucose positron emission tomography (FDG-PET) to compare the radiotherapy target volumes. The PET volumes were delineated with an automatic segmentation based on the source-to-background ratio. The volume comparison showed a reduction and qualitative discrepancies between the PET- and CT-volumes.
PMID: 19880207 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 30, 2009 Category: Radiology Authors: Henriques de Figueiredo B, Barret O, Demeaux H, Lagarde P, De-Mones-Del-Pujol E, Kantor G, de Clermont-Gallerande H, Richaud P, Fernandez P Tags: Radiother Oncol Source Type: journals
Justification for inter-fraction correction of catheter movement in fractionated high dose-rate brachytherapy treatment of prostate cancer.
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CONCLUSIONS: Inter-fraction correction for catheter movement using pre-treatment imaging is critical to maintain the quality of an implant. Without movement correction there is significant risk of tumour under-dosage and normal tissue over-dosage. The findings of this study justify additional imaging between fractions in order to carry out correction.
PMID: 19854524 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 23, 2009 Category: Radiology Authors: Saxby T, Li S, Lowe G, Ostler P, Bryant L, Chapman C, Inchley D, Hoskin PJ Tags: Radiother Oncol Source Type: journals
HDR endobronchial brachytherapy (HDRBT) in the management of advanced lung cancer - Comparison of two different dose schedules.
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CONCLUSIONS: The two treatment protocols showed similar efficiency in overcoming difficulties in breathing. Prognostic factors that significantly correlated with survival length were: grade of remission after treatment, clinical stage and performance status.
PMID: 19854525 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 23, 2009 Category: Radiology Authors: Skowronek J, Kubaszewska M, Kanikowski M, Chicheł A, Młynarczyk W Tags: Radiother Oncol Source Type: journals
Feasibility of the use of the Active Breathing Co ordinator (ABC) in patients receiving radical radiotherapy for non-small cell lung cancer (NSCLC).
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CONCLUSION: The use of ABC in patients receiving radical radiotherapy for NSCLC is feasible. It was not possible to predict a patient's ability to hold breath. A minimum tolerated breath hold time of 15 s is recommended prior to commencing treatment.
PMID: 19854526 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 23, 2009 Category: Radiology Authors: McNair HA, Brock J, Symonds-Tayler JR, Ashley S, Eagle S, Evans PM, Kavanagh A, Panakis N, Brada M Tags: Radiother Oncol Source Type: journals
Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf>MEK>ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK.
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CONCLUSIONS: These data suggest that radiosensitization by lapatinib is mediated largely through inhibition of MEK/ERK and that direct inhibition of this pathway may provide an additional avenue of radiosensitization in EGFR+ or HER2+ breast cancers.
PMID: 19853943 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 22, 2009 Category: Radiology Authors: Sambade MJ, Camp JT, Kimple RJ, Sartor CI, Shields JM Tags: Radiother Oncol Source Type: journals
A study of middle ear function in the treatment of nasopharyngeal carcinoma with IMRT technique.
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CONCLUSIONS: IMRT may have better protected the middle ear function compared with the CRT technique, even with larger fraction sizes than for the conventional CRT technique.
PMID: 19853315 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 21, 2009 Category: Radiology Authors: Wang SZ, Li J, Miyamoto CT, Chen F, Zhou LF, Zhang HY, Yang G, Wang WF, Guo M, Ni XC, Wang L Tags: Radiother Oncol Source Type: journals
Delineation guidelines for organs at risk involved in radiation-induced salivary dysfunction and xerostomia.
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CONCLUSIONS: The provided OAR guidelines are accompanied by CT-based illustrations presenting examples of the delineated structures and their corresponding anatomic boundaries. The parts of the tongue bearing minor salivary glands could not be outlined. Difficulties and uncertainties in defining these minor salivary glands on CT remain to be resolved. Implementation of these guidelines in practice should lead to a reduction in inter- and intra-observer variability and therefore unambiguous reporting of possible dose-volume effect relationships.
PMID: 19853316 [PubMed - as supplied by publisher] (Source: Radiotherapy an...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 21, 2009 Category: Radiology Authors: van de Water TA, Bijl HP, Westerlaan HE, Langendijk JA Tags: Radiother Oncol Source Type: journals
Accelerated partial breast irradiation as part of breast conserving therapy of early breast carcinoma: A systematic review.
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PMID: 19853317 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 21, 2009 Category: Radiology Authors: Nairz O, Sedlmayer F Tags: Radiother Oncol Source Type: journals
Radiosensitivity of squamous cell carcinoma metastases to the neck assessed by immunocytochemical profiling of fine-needle aspiration biopsy cell specimens: A pilot study.
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CONCLUSIONS: FNAB is a non-invasive, simple and cheap procedure, which could serve simultaneously for diagnostic purposes and for radiosensitivity testing. Immunocytochemical determination of cyclin D1 and Ki-67 in FNAB cell samples from neck metastases of SCCHN seems to be a valuable marker for predicting regional response to radiotherapy and might assist when deciding on appropriate primary therapy.
PMID: 19850367 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 19, 2009 Category: Radiology Authors: Fležar MS, Kirbiš IS, Popović KS, Strojan P Tags: Radiother Oncol Source Type: journals
ExacTrac X-ray 6 degree-of-freedom image-guidance for intracranial non-invasive stereotactic radiotherapy: Comparison with kilo-voltage cone-beam CT.
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CONCLUSIONS: This study indicates that there is a general agreement between ExacTrac system and CBCT.
PMID: 19846229 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 18, 2009 Category: Radiology Authors: Ma J, Chang Z, Wang Z, Jackie Wu Q, Kirkpatrick JP, Yin FF Tags: Radiother Oncol Source Type: journals
New inverse planning technology for image-guided cervical cancer brachytherapy: Description and evaluation within a clinical frame.
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CONCLUSIONS: Inverse planning based on the HIPO algorithm can produce treatment plans for cervical cancer brachytherapy which are comparable to plans based on manual optimisation as applied in clinical practice. It is essential to take into account the spatial dose distribution in addition to the DVH-based constraints. The proposed inverse planning concept is feasible for improving the therapeutic ratio and limiting substantial high-dose regions around needles.
PMID: 19846230 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 18, 2009 Category: Radiology Authors: Trnková P, Pötter R, Baltas D, Karabis A, Fidarova E, Dimopoulos J, Georg D, Kirisits C Tags: Radiother Oncol Source Type: journals
Risk factors for voice quality after radiotherapy for early glottic cancer.
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CONCLUSIONS: After the successful irradiation for T1 glottic carcinoma, the great majority of the patients have at least a slightly hoarse voice. A better voice outcome could be achieved if radiotherapy was followed by the patient's cessation of smoking and the appropriate voice therapy.
PMID: 19846231 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 18, 2009 Category: Radiology Authors: Hočevar-Boltežar I, Zargi M, Strojan P Tags: Radiother Oncol Source Type: journals
Quadrimodal treatment of high-risk T1 and T2 bladder cancer: Transurethral tumor resection followed by concurrent radiochemotherapy and regional deep hyperthermia.
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CONCLUSIONS: The quadrimodal treatment was feasible and well tolerated. Local control and bladder-preserving rates were encouraging.
PMID: 19837472 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 15, 2009 Category: Radiology Authors: Wittlinger M, Rödel CM, Weiss C, Krause SF, Kühn R, Fietkau R, Sauer R, Ott OJ Tags: Radiother Oncol Source Type: journals
Clinical and dosimetric predictors of late rectal toxicity after conformal radiation for localized prostate cancer: Results of a large multicenter observational study.
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CONCLUSION: The application of rectal dose-volume constraints limited the incidence of rectal bleeding. The risk of bleeding may be further reduced by limiting V75Gy<5% and, in the case of patients previously submitted to abdominal/pelvic surgery, V70Gy<15-20%. Faecal incontinence seems to be mainly a consequential effect after acute toxicity.
PMID: 19828205 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 11, 2009 Category: Radiology Authors: Fellin G, Fiorino C, Rancati T, Vavassori V, Baccolini M, Bianchi C, Cagna E, Gabriele P, Mauro F, Menegotti L, Monti AF, Stasi M, Valdagni R Tags: Radiother Oncol Source Type: journals
Comparison of gating around end-expiration and end-inspiration in radiotherapy for lung cancer.
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CONCLUSIONS: With amplitude-based gating, gating around end-inspiration (P3) produced a greater decrease in the lung dose, however, the treatment time was longest among the four gated protocols. There was no significant difference between the two phase-based gating protocols (P4 and P5) with respect to the radiation dose to the lungs and the treatment time.
PMID: 19822373 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 9, 2009 Category: Radiology Authors: Saito T, Sakamoto T, Oya N Tags: Radiother Oncol Source Type: journals
Radical prostatectomy vs. intensity-modulated radiation therapy in the management of localized prostate adenocarcinoma.
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CONCLUSIONS: BDFS is similar between RP and IMRT for patients with a favorable or intermediate prognosis. Patients with a poor prognosis display higher BDFS when treated with IMRT to 72Gy plus hormonal therapy.
PMID: 19800702 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 30, 2009 Category: Radiology Authors: Aizer AA, Yu JB, Colberg JW, McKeon AM, Decker RH, Peschel RE Tags: Radiother Oncol Source Type: journals
Lipiodol injection for target volume delineation and image guidance during radiotherapy for bladder cancer.
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A technique was developed for bladder tumour demarcation with lipiodol injection through a flexible cystoscope. The technique proved to be simple and useful for image-guided radiotherapy in bladder cancer as well as a helpful aid in the tumour delineation process.
PMID: 19800703 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 30, 2009 Category: Radiology Authors: Pos F, Bex A, Dees-Ribbers HM, Betgen A, van Herk M, Remeijer P Tags: Radiother Oncol Source Type: journals
MR-guided simultaneous integrated boost in preoperative radiotherapy of locally advanced rectal cancer following neoadjuvant chemotherapy.
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CONCLUSIONS: Tumor volume reduction for rectal cancer patients following neoadjuvant chemotherapy allows for increased tumor dose using a SIB strategy without increased OAR toxicity.
PMID: 19800704 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 30, 2009 Category: Radiology Authors: Seierstad T, Hole KH, Sælen E, Ree AH, Flatmark K, Malinen E Tags: Radiother Oncol Source Type: journals
Chromosomal aberrations in peripheral blood lymphocytes of prostate cancer patients treated with IMRT and carbon ions.
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CONCLUSION: The investigation showed no higher aberration yield induced by treatment with a carbon-ion boost. In contrast, the reduced integral dose to the normal tissue is reflected in a lower chromosomal aberration yield when a carbon-ion boost is used instead of IMRT alone. No cytogenetic "signature" of exposure to densely ionizing carbon ions could be detected in vivo.
PMID: 19800142 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 29, 2009 Category: Radiology Authors: Hartel C, Nikoghosyan A, Durante M, Sommer S, Nasonova E, Fournier C, Lee R, Debus J, Schulz-Ertner D, Ritter S Tags: Radiother Oncol Source Type: journals
Is ad-hoc plan adaptation based on 2-Step IMRT feasible?
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CONCLUSIONS: The first results for adaptation of interfractional changes using the 2-Step IMRT algorithm are encouraging. The plans were superior to plans with optimized isocentre position and only marginally inferior to a newly optimized plan.
PMID: 19796833 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 28, 2009 Category: Radiology Authors: Bratengeier K, Polat B, Gainey M, Grewenig P, Meyer J, Flentje M Tags: Radiother Oncol Source Type: journals
Unintended exposure in radiotherapy: Identification of prominent causes.
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CONCLUSION: With this knowledge of high frequency of occurrences, the identified four prominent initiating events and the 10 most prominent contributing factors must be checked and dealt with as a matter of priority when assessing the safety of a radiotherapy facility. A simple checklist for checking the quality assurance programmes of a radiotherapy department for every aspect of the design and delivery of radiation have been provided.
PMID: 19783058 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 24, 2009 Category: Radiology Authors: Boadu M, Rehani MM Tags: Radiother Oncol Source Type: journals
Recurrence pattern after [(18)F]Fluoroethyltyrosine-Positron Emission Tomography-guided radiotherapy for high-grade glioma: A prospective study.
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CONCLUSIONS: The observed failure pattern after FET-PET planning and chemo-RT is primarily central. The target mismatch-survival data suggest that using FET-PET planning may counteract the possibility of BTV-related progression, which may have a detrimental effect on survival.
PMID: 19782417 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 23, 2009 Category: Radiology Authors: Weber DC, Casanova N, Zilli T, Buchegger F, Rouzaud M, Nouet P, Vees H, Ratib O, Dipasquale G, Miralbell R Tags: Radiother Oncol Source Type: journals
4D-CT-based target volume definition in stereotactic radiotherapy of lung tumours: Comparison with a conventional technique using individual margins.
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CONCLUSIONS: In SBRT of lung tumours the mere use of individual margins for target volume definition cannot compensate for the additional effects that the implementation of 4D-CT phases can offer.
PMID: 19782418 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 23, 2009 Category: Radiology Authors: Hof H, Rhein B, Haering P, Kopp-Schneider A, Debus J, Herfarth K Tags: Radiother Oncol Source Type: journals
A randomized phase II study of CEOP with or without semustine as induction chemotherapy in patients with stage I(E)/II(E) extranodal NK/T-cell lymphoma, nasal type in the upper aerodigestive tract.
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CONCLUSIONS: The addition of semustine to CEOP regimen was not associated with improved efficacy. More effective treatment needs to be explored in patients with intermediate or high risk.
PMID: 19782419 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 23, 2009 Category: Radiology Authors: Ma X, Guo Y, Pang Z, Wang B, Lu H, Gu YJ, Guo X Tags: Radiother Oncol Source Type: journals
The effect of planning algorithms in oesophageal radiotherapy in the context of the SCOPE 1 trial.
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CONCLUSIONS: Plan optimization with the type b algorithm results in improved PTV V95%. Using our suggested optimization rules, equivalent OAR doses can be maintained with both types. For type b, this requires a measured level of compromise to PTV in low density tissue, quantified by the relationship between PTV V95% and the percentage of PTV in lung.
PMID: 19782420 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 23, 2009 Category: Radiology Authors: Wills L, Millin A, Paterson J, Crosby T, Staffurth J Tags: Radiother Oncol Source Type: journals
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Radiother Oncol. 2009 Sep 24;
Authors: Poortmans P, Bartelink H, Collette L
PMID: 19782421 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 23, 2009 Category: Radiology Authors: Poortmans P, Bartelink H, Collette L Tags: Radiother Oncol Source Type: journals
(18)F-fluorocholine PET-guided target volume delineation techniques for partial prostate re-irradiation in local recurrent prostate cancer.
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CONCLUSIONS: Semi-automated segmentation techniques for (18)F-choline PET-guided GTV delineation resulted in substantially higher GTVs compared to manual delineation and might replace the latter for determination of recurrent prostate cancer for partial prostate re-irradiation. The selection of the most appropriate segmentation algorithm still needs to be determined.
PMID: 19767115 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 17, 2009 Category: Radiology Authors: Wang H, Vees H, Miralbell R, Wissmeyer M, Steiner C, Ratib O, Senthamizhchelvan S, Zaidi H Tags: Radiother Oncol Source Type: journals
An international review of patient safety measures in radiotherapy practice: Shafiq J, Barton M, Noble D, Lemer C, Donaldson LJ. Radiother Oncol. 2009 Jul;92(1):15-21.
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PMID: 19767116 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 17, 2009 Category: Radiology Authors: Clark BG, Grimard L Tags: Radiother Oncol Source Type: journals
Dose-volume histogram and dose-surface histogram analysis for skin reactions to carbon ion radiotherapy for bone and soft tissue sarcoma.
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CONCLUSIONS: The area irradiated with over 60GyE (S(60)>20cm(2)) on DSH was found to be a parameter for use as a predictor of late skin reactions.
PMID: 19767117 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 17, 2009 Category: Radiology Authors: Yanagi T, Kamada T, Tsuji H, Imai R, Serizawa I, Tsujii H Tags: Radiother Oncol Source Type: journals
Role of the linear-quadratic model in high doses per fraction.
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PMID: 19767118 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 17, 2009 Category: Radiology Authors: Gay H Tags: Radiother Oncol Source Type: journals
Carbon-11 acetate PET/CT based dose escalated IMRT in prostate cancer.
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CONCLUSIONS: Our study indicates that [(11)C]acetate can be used to define the IPL's and in combination with SIB(IMRT) the defined areas can theoretically be treated to ultra high doses without increasing the treatment toxicity. These results motivate the formal validation of [(11)C]acetate PET for biological dose planning in prostate cancer.
PMID: 19766336 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 16, 2009 Category: Radiology Authors: Seppälä J, Seppänen M, Arponen E, Lindholm P, Minn H Tags: Radiother Oncol Source Type: journals
Late toxicity after postprostatectomy salvage radiation therapy.
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CONCLUSIONS: Salvage EBRT for a detectable PSA level after RP is the only curative treatment in this setting. This treatment can be administered in a manner that results in a low likelihood of late complications.
PMID: 19766337 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 16, 2009 Category: Radiology Authors: Peterson JL, Buskirk SJ, Heckman MG, Crook JE, Ko SJ, Wehle MJ, Igel TC, Prussak KA, Pisansky TM Tags: Radiother Oncol Source Type: journals
IMRT significantly reduces acute toxicity of whole-pelvis irradiation in patients treated with post-operative adjuvant or salvage radiotherapy after radical prostatectomy.
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CONCLUSIONS: The risk of acute toxicity following post-operative WPRT delivered by means of IMRT was reduced compared to that of 3DCRT. The most significant reduction concerned uGI, mainly owing to better bowel sparing with IMRT.
PMID: 19766338 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 16, 2009 Category: Radiology Authors: Alongi F, Fiorino C, Cozzarini C, Broggi S, Perna L, Cattaneo GM, Calandrino R, Di Muzio N Tags: Radiother Oncol Source Type: journals
