30 years of (re)productive biology a symposium honoring professor Martin M. Matzuk, MD, PhD
Biol Reprod. 2024 Apr 17:ioae051. doi: 10.1093/biolre/ioae051. Online ahead of print.NO ABSTRACTPMID:38629590 | DOI:10.1093/biolre/ioae051 (Source: Reproductive Biology)
Source: Reproductive Biology - April 17, 2024 Category: Reproduction Medicine Authors: T Rajendra Kumar Kathleen H Burns Wei Yan Source Type: research
Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach
Syst Biol Reprod Med. 2024 Dec;70(1):101-112. doi: 10.1080/19396368.2024.2325699. Epub 2024 Apr 17.ABSTRACTMDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and appropriate DDR regulation. There haven't been systematic investigations of MDC1 mutations that induce cancer and genomic instability. Variations in nsSNPs have the potential to modify the protein chemistry and their function. Describing functional SNPs in disease-associated genes ...
Source: Reproductive Biology - April 17, 2024 Category: Reproduction Medicine Authors: Vaishnavee Thote Susha Dinesh Sameer Sharma Source Type: research
Correlation between standard sperm parameters and sperm DNA fragmentation from 11,339 samples
Syst Biol Reprod Med. 2024 Dec;70(1):91-100. doi: 10.1080/19396368.2024.2333285. Epub 2024 Apr 17.ABSTRACTConventional semen parameters have long been considered fundamental in male fertility analyses. However, doubts have been raised regarding the clinical utility of the assessment of spermatozoa (sperm) DNA damage. In this retrospective study, we investigated the potential correlation between conventional semen parameters and semen DNA fragmentation (SDF) assessed as sperm DNA damage, in 11,339 semen samples collected between January 2019 and June 2022. We observed significant negative correlations between the DNA fragme...
Source: Reproductive Biology - April 17, 2024 Category: Reproduction Medicine Authors: Tingting Yang Lin Yu Jinyan Xu Lijuan Ying Yelin Jia Yan Zheng Bin Zhou Fuping Li Source Type: research
Sodium oligomannate's amelioration of reproductive and metabolic phenotypes in a letrozole-induced PCOS-like mouse model depends on the gut microbiome
In conclusion, the hyperinsulinemia and hyperandrogenemia of PCOS-like mice were alleviated by GV-971 intervention, which was associated with mitigating bile acid metabolism and modulating gut microbiota.PMID:38630889 | DOI:10.1093/biolre/ioae058 (Source: Reproductive Biology)
Source: Reproductive Biology - April 17, 2024 Category: Reproduction Medicine Authors: Zhi Li Yan Liu Yang Wang Qingqing Cai Yuhui Wang Yixuan Bai Haiou Liu Congjian Xu Feifei Zhang Source Type: research
30 years of (re)productive biology a symposium honoring professor Martin M. Matzuk, MD, PhD
Biol Reprod. 2024 Apr 17:ioae051. doi: 10.1093/biolre/ioae051. Online ahead of print.NO ABSTRACTPMID:38629590 | DOI:10.1093/biolre/ioae051 (Source: Reproductive Biology)
Source: Reproductive Biology - April 17, 2024 Category: Reproduction Medicine Authors: T Rajendra Kumar Kathleen H Burns Wei Yan Source Type: research
Trajectory of primordial follicle depletion is accelerated in obese mice in response to 7,12-dimethylbenz[a]anthracene exposure
This study indicates that obesity influences ovotoxicity caused by a genotoxicant, potentially involving accelerated primordial follicle activation and hampering normal follicular dynamics.PMID:38625059 | DOI:10.1093/biolre/ioae059 (Source: Reproductive Biology)
Source: Reproductive Biology - April 16, 2024 Category: Reproduction Medicine Authors: Jaspreet K Rishi Kelsey Timme Hunter E White Karl C Kerns Aileen F Keating Source Type: research
Endocan: A biomarker for endothelial dysfunction and inflammation, linking maternal obesity and pediatric obesity in a cohort of preterm neonates
CONCLUSIONS: In our cohort of preterm neonates, elevated serum endocan at birth was associated with both maternal obesity and downstream pediatric obesity. More research is needed to understand intergenerational transmission of obesity. A large focus has been on epigenetic modification. Endothelial dysfunction and inflammation may play important roles in these pathways. Effective biomarkers, including endocan, may also serve as intermediate outcomes in future pregnancy research.PMID:38626514 | DOI:10.1016/j.ejogrb.2024.04.013 (Source: Reproductive Biology)
Source: Reproductive Biology - April 16, 2024 Category: Reproduction Medicine Authors: E Holthaus M O'Neill W Jeske P DeChristopher J Goodman L Glynn S Levin J Muraskas Source Type: research
Brief Communication: A case report of dilation and evacuation for cephalopagus conjoined twin pregnancy at 22 weeks
Eur J Obstet Gynecol Reprod Biol. 2024 Apr 10:S0301-2115(24)00175-1. doi: 10.1016/j.ejogrb.2024.04.008. Online ahead of print.NO ABSTRACTPMID:38627165 | DOI:10.1016/j.ejogrb.2024.04.008 (Source: Reproductive Biology)
Source: Reproductive Biology - April 16, 2024 Category: Reproduction Medicine Authors: Megan Masten Paige Kendall Rebecca Cohen Source Type: research
Uretrovaginal reflux as a cause of daytime intermitent urinary incontinency in a 14-year old girl
Eur J Obstet Gynecol Reprod Biol. 2024 Mar 31:S0301-2115(24)00165-9. doi: 10.1016/j.ejogrb.2024.03.043. Online ahead of print.NO ABSTRACTPMID:38627166 | DOI:10.1016/j.ejogrb.2024.03.043 (Source: Reproductive Biology)
Source: Reproductive Biology - April 16, 2024 Category: Reproduction Medicine Authors: Dubravko Habek Source Type: research
Correction: Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data
Reprod Biol Endocrinol. 2024 Apr 17;22(1):45. doi: 10.1186/s12958-024-01218-6.NO ABSTRACTPMID:38627739 | DOI:10.1186/s12958-024-01218-6 (Source: Reproductive Biology)
Source: Reproductive Biology - April 16, 2024 Category: Reproduction Medicine Authors: Qunying Fang Zonghui Qiao Lei Luo Shun Bai Min Chen Xiangjun Zhang Lu Zong Xian-Hong Tong Li-Min Wu Source Type: research
Impact of dehydroepiandrosterone sulfate and free androgen index on pregnancy and neonatal outcomes in PCOS patients
CONCLUSION: In conclusion, PCOS patients with biochemical hyperandrogenism show unsatisfactory clinical PR and CLBR when undergoing assisted reproductive technology (ART). This may be attributed to the influence of both adrenal-derived DHEAS and ovarian-derived FAI on the unfavorable pregnancy outcomes.PMID:38627777 | DOI:10.1186/s12958-024-01212-y (Source: Reproductive Biology)
Source: Reproductive Biology - April 16, 2024 Category: Reproduction Medicine Authors: Wen Zhao Zeting Li Bing Cai Canquan Zhou Qingyun Mai Source Type: research
Uterine infusion strategies for infertile patients with recurrent implantation failure: a systematic review and network meta-analysis
CONCLUSIONS: Intrauterine infusion of HCG, PBMC, G-CSF, and PRP are promising strategies for improving pregnancy outcomes for infertile patients with recurrent implantation failure. Among these treatments, PRP may be the best. More researches are required to explore the effect of drug combinations and less commonly used drugs as well.TRIAL REGISTRATION: Our study was registered in PROSPERO and the ID was CRD42023467188.PMID:38627790 | DOI:10.1186/s12958-024-01221-x (Source: Reproductive Biology)
Source: Reproductive Biology - April 16, 2024 Category: Reproduction Medicine Authors: Qin Xie Xiaozhen Quan Yanli Lan Xuezhou Yang Source Type: research
A simulation study to assess the potential benefits of MRI-based fetal weight estimation as a second-line test for suspected macrosomia
CONCLUSION: The superior accuracy of MRI-EFW over US-EFW for the diagnosis of macrosomia could result in lower rates of IOL without compromising the relative advantages of the intervention but fails to demonstrate a significant benefit to justify a replication of the original trial using MRI-EFW as a second-line test.PMID:38615575 | DOI:10.1016/j.ejogrb.2024.04.009 (Source: Reproductive Biology)
Source: Reproductive Biology - April 14, 2024 Category: Reproduction Medicine Authors: Dominique A Badr Andrew Carlin Michel Boulvain Caroline Kadji Mieke M Cannie Jacques C Jani Leonardo Gucciardo Source Type: research
Successful management of fetal hypoxia due to amniotic banding at 26 weeks of pregnancy: A case report of a rare survival
CONCLUSION: This case presents the first reported survival of an extremely preterm fetus in hypoxic distress as a cause of amniotic banding of the umbilical cord, with a rare degree of incidental timing. Ultrasound diagnosis remains the gold standard. Obstetrical vigilance is warranted, with fetal rescue proven to be feasible.PMID:38616145 | DOI:10.1016/j.ejogrb.2024.04.010 (Source: Reproductive Biology)
Source: Reproductive Biology - April 14, 2024 Category: Reproduction Medicine Authors: Florian Waerlop Isabelle Dehaene Kristien Roelens Source Type: research
Corrigendum to 'Transcriptomic profile of GLCs of PCOS women highlights metabolic dysregulation as a plausible contributor to PCOS pathophysiology' Reproductive Biology, Volume 23, Issue 3 (2023), 100787
Reprod Biol. 2024 Apr 13:100885. doi: 10.1016/j.repbio.2024.100885. Online ahead of print.NO ABSTRACTPMID:38614814 | DOI:10.1016/j.repbio.2024.100885 (Source: Reproductive Biology)
Source: Reproductive Biology - April 13, 2024 Category: Reproduction Medicine Authors: Krutika Patil Aalaap Naigaonkar Indira Hinduja Srabani Mukherjee Source Type: research
