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The secretions of oviduct epithelial cells increase the equine in vitro fertilization rate: are osteopontin, atrial natriuretic peptide A and oviductin involved?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our study shows a beneficial effect of homologous and heterologous oviduct cells on equine IVF rates, though the rates remain low. Furthers studies are necessary to identify the proteins involved. We showed that the surface plasmon resonance technique is efficient and powerful to analyze molecular interactions during fertilization. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - November 19, 2009 Category: Endocrinology Authors: Sylvie MugnierMorgane KervellaCecile DouetSylvie CanepaGeraldine PascalStefan DeleuzeGuy DuchampPhilippe MongetGhylene Goudet Source Type: journals

Gene expression profiles of mouse spermatogenesis during recovery from irradiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The data indicates that recovery of spermatogenesis can be monitored by means of gene expression, which could aid in designing radiation treatment regimes for cancer patients leading to better restoration of spermatogenesis. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - November 19, 2009 Category: Endocrinology Authors: Fozia ShahMasami TanakaJohn NielsenTeruaki IwamotoShinichi KobayashiNiels SkakkebaekHenrik LeffersKristian Almstrup Source Type: journals

Leukocytospermia and sperm preparation - a flow cytometric studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Seminal leukocytes do not seem to influence sperm preparation results. However, for assisted conception, semen samples containing leukocytes should be processed using swim-up method. Although peroxidase-test is recommended by WHO as the standardmethod for determining semen leukocytes, it should not be used in clinical research study. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - November 19, 2009 Category: Endocrinology Authors: Giuseppe RicciSandra PerticarariRita BoscoloRoberto SimeoneMonica MartinelliLeo Fischer-TamaroSecondo GuaschinoGianni Presani Source Type: journals

Enhanced ERbeta immunoexpression and apoptosis in the germ cells of cimetidine-treated ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The presence of ERbeta immunolabeling in the flagellum and residual bodies of spermatids reinforces the role of estrogen in spermiogenesis. The overexpression of ERbeta in the germ cells of CmG could be related to a possible interference of cimetidine on tubular androgenization and/or on the intratubular aromatase due to Sertoli cell damage. The parallelism between ERbeta overexpression and apoptosis indicates a participation of ERbeta on germ cell death. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - November 18, 2009 Category: Endocrinology Authors: Estela Sasso-Cerri Source Type: journals

Up-regulation of CatSper genes family by seleniumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Se treatment in the aging subjects could up-regulate the expression of CatSper genes, and therefore results in elevation of sperm motility. Furthermore, Se treatment improved sperm parameters, especially morphology and viability rates. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - November 16, 2009 Category: Endocrinology Authors: Shabnam MohammadiMansoure MovahedinSeyed Javad Mowla Source Type: journals

Semen molecular and cellular features: these parameters can reliably predict subsequent ART outcome in a goat modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Currently, the assessment of sperm function in a raw or processed semen sample is not able to reliably predict sperm ability to withstand freezing and thawing procedures and in vivo fertility and/or assisted reproductive biotechnologies (ART) outcome. The aim of the present study was to investigate which parameters among a battery of analyses could predict subsequent spermatozoa in vitro fertilization ability and hence blastocyst output in a goat model. Ejaculates were obtained by artificial vagina from 3 adult goats (Capra hircus) aged 2 years (A, B and C). In order to assess the predictive value of viability, computer as...
Source: Reproductive Biology and Endocrinology - November 9, 2009 Category: Endocrinology Authors: Fiammetta BerlinguerManuela MadedduValeria PasciuSara SuccuAntonio SpezziguValentina SattaPaolo MereuGiovanni LeoniSalvatore Naitana Source Type: journals

Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The data demonstrate that E2-regulated endometrial remodeling is rapid in onset ( (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - November 4, 2009 Category: Endocrinology Authors: Louise RussoBryan PeanoShreya TrivediTodd CavalcantoBenjamin OlenchockJoseph CarusoAmanda SmolockOleg VishnevskyRussell Gardner Source Type: journals

Quantity and quality of retrograde menstruation: a case control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: When compared to nonmenstrual phases of the cycle, menstruation is associated with an increased concentration of red and white blood cells in PF. However, the presence of EM cells that are detectable by immunohistochemistry in PF is low during all phases of the cycle, including menstruation. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 30, 2009 Category: Endocrinology Authors: Attila BokorSophie DebrockMaria DrijkoningenWilly GoossensVilmos FulopThomas D'Hooghe Source Type: journals

Expression of nodal signalling components in cycling human endometrium and in endometrial cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The expression of Nodal in normal and malignant endometrial cells that lack Lefty strongly supports an important role for this embryonic morphogen in the tissue remodelling events that occur across the menstrual cycle and in tumourogenesis. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 29, 2009 Category: Endocrinology Authors: Irene PapageorgiouPeter NichollsFang WangMartin LackmannYogeshwar MakanjiLois SalamonsenDavid RobertsonCraig Harrison Source Type: journals

The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in human and ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: D-aspartic acid is a physiological amino acid occurring principally in the pituitary gland and testes and has a role in the regulation of the release and synthesis of LH and testosterone in humans and rats. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 27, 2009 Category: Endocrinology Authors: Enza TopoAndrea SoricelliAntimo D'AnielloSalvatore RonsiniGemma D'Aniello Source Type: journals

Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental developmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These observations support a role for the endocannabinoid system during the period of decidualization and placental development. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 27, 2009 Category: Endocrinology Authors: Bruno FonsecaGeorgina Correia-da-SilvaAnthony TaylorJustin KonjeStephen BellNatercia Teixeira Source Type: journals

The measurement of reactive oxygen species in human neat semen and in suspended spermatozoa: a comparisonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Measurement of ROS production in neat semen better reflects actual oxidative status because it detects only the overproduction of ROS which are not effectively scavenged by antioxidant capacity of seminal fluid. The results of our study shows a good commutability of both measurements for identification of semen samples with high ROS production. The measurement in neat semen is even less time consuming and therefore easier to implement into laboratory routine. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 27, 2009 Category: Endocrinology Authors: Helena FingerovaIvana ObornaJiri NovotnyMagda SvobodovaJana BrezinovaLenka Radova Source Type: journals

The BSA-induced Ca(2+) influx during sperm capacitation is CATSPER channel-dependentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We conclude that the initial phase of the increases in intracellular calcium concentration induced by BSA requires the CATSPER channel, but not the voltage-gated calcium channel. Our findings identify the molecular conduit responsible for the calcium entry required for the sperm motility changes that occur during capacitation. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 27, 2009 Category: Endocrinology Authors: Jingsheng XiaDejian Ren Source Type: journals

Tissue-specific cytokine release from human extra-placental membranes stimulated by lipopolysaccharide in a two-compartment tissue culture systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The amnion and choriodecidua exhibited distinct patterns of response to LPS with evidence of inflammatory signaling across the layers of the gestational membranes. These results suggest a complicated network of signaling within the gestational membranes, in which cytokine- and tissue-specific responses to inflammatory stimulation may have important implications for maintaining pregnancy in the challenge of microbial invasion of the uterine compartment. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 26, 2009 Category: Endocrinology Authors: Natalie ThiexMark ChamesRita Loch-Caruso Source Type: journals

Prostaglandin treatment is associated with a withdrawal of progesterone and androgen at the receptor level in the uterine cervixEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Treatment with prostaglandin(PG)-E2 is clinically efficient for cervical priming. The aim of this study was to evaluate the impact of PG-E2 on the expression of the progesterone (PR), androgen (AR) and glucocorticoid (GR) receptors in human uterine cervix in prolonged pregnancy.The study groups were postterm nulliparous women with unripe cervices undergoing cervical priming with PG-E2 before labor induction. Responders (n=12) who delivered vaginally were compared with non-responders (n=10), who underwent cesarean section due to failure to progress to the active phase of labor. Controls (n=18) with vaginal partus at a norma...
Source: Reproductive Biology and Endocrinology - October 22, 2009 Category: Endocrinology Authors: Ylva Vladic StjernholmTomislav VladicBlesson SelvanesanGunvor Ekman-OrdebergLena Sahlin Source Type: journals

Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hazardous health effects stemming from exposure to radiofrequency electromagnetic waves (RF-EMW) emitted from cell phones have been reported in the literature. However, the cellular target of RF-EMW is still controversial. This review identifies the plasma membrane as a target of RF-EMW. In addition, the effects of RF-EMW on plasma membrane structures (i.e. NADH oxidase, phosphatidylserine, ornithine decarboxylase) and voltage-gated calcium channels are discussed. We explore the disturbance in reactive oxygen species (ROS) metabolism caused by RF-EMW and delineate NADH oxidase mediated ROS formation as playing a central ro...
Source: Reproductive Biology and Endocrinology - October 21, 2009 Category: Endocrinology Authors: Nisarg DesaiKavindra KesariAshok Agarwal Source Type: journals

Leptin interferes with 3',5'-Cyclic Adenosine Monophosphate (cAMP) signaling to inhibit steroidogenesis in human granulosa cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Obesity has been linked to an increased risk of female infertility. Leptin, an adipocytokine which is elevated during obesity, may influence gonadal function through modulating steroidogenesis in granulosa cells. Methods: The effect of leptin on progesterone production in simian virus 40 immortalized granulosa (SVOG) cells was examined by Enzyme linked immunosorbent assay (ELISA). The effect of leptin on the expression of the steroidogenic enzymes (StAR, P450scc, 3betaHSD) in SVOG cells was examined by real-time PCR and Western blotting. The mRNA expression of leptin receptor isoforms in SVOG cells were examine...
Source: Reproductive Biology and Endocrinology - October 21, 2009 Category: Endocrinology Authors: Qing LinSong PoonJunling ChenLinan ChengBasil Ho YuenPeter Leung Source Type: journals

Effects of leptin on in vitro maturation, fertilization and embryonic cleavage after ICSI and early developmental expression of leptin (Ob) and leptin receptor (ObR) proteins in the horseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was conducted to determine whether leptin supplementation during in vitro maturation (IVM) to horse oocytes could have effects on their developmental capacity after fertilization by IntraCytoplasmic Sperm Injection (ICSI). Methods: Compact and expanded-cumulus horse oocytes were matured in medium containing different concentrations (1, 10, 100, 1000 ng/ml) of recombinant human leptin and the effects on maturation, fertilization and embryo cleavage were evaluated. Furthermore, early developmental expression of Ob and leptin receptor (Ob-R) was investigated by immunocytochemical staining. Results: In expanded-cumu...
Source: Reproductive Biology and Endocrinology - October 15, 2009 Category: Endocrinology Authors: Anna Lange ConsiglioMaria Elena Dell'AquilaNadia FiandaneseBarbara AmbruosiYoon ChoGiampaolo BosiSilvana ArrighiGiovanni LacalandraFausto Cremonesi Source Type: journals

A comparison of menotropin, highly-purified menotropin and follitropin alfa in cycles of intracytoplasmic sperm injectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although similar live birth rates were achieved, markedly lower doses of r-hFSH were required compared with hMG or HP-hMG. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 13, 2009 Category: Endocrinology Authors: Sandro EstevesJoan SchertzSidney VerzaDanielle SchneiderSilval Zabaglia Source Type: journals

Predicting lung maturity in preterm rupture of membranes via lamellar bodies count from a vaginal pool: a cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Counting of lamellar bodies in amniotic fluid from a vaginal pool may be used to predict fetal lung maturity. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 13, 2009 Category: Endocrinology Authors: Raed SalimNoah ZafranZohar NachumGali GarmiEliezer Shalev Source Type: journals

Early hCG addition to rFSH for ovarian stimulation in IVF provides better results and the cDNA copies of the hCG receptor may be an indicator of successful stimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study has also determined, for the first time to our best knowledge, m-RNA for LH/hCG receptors in the lymphocytes of peripheral blood 40 h before ovum pick-up. cDNA levels of the hCG receptor after ovarian stimulation were significantly higher among women receiving hCG compared to those receiving LH. In addition, higher levels were encountered among women with pregnancy compared to those without, although this was not statistically significant due to the small number of pregnancies. It seems that hCG permits a highly effective and more stable occupancy of rLH/hCG receptors and gives more follicles and more oocytes. T...
Source: Reproductive Biology and Endocrinology - October 12, 2009 Category: Endocrinology Authors: Peter DrakakisDimitris LoutradisAntonis BeloukasVana SypsaVasiliki AnastasiadouGeorge KalofoliasHelen ArabatziErasmia KiapekouKonstantinos StefanidisDimitris ParaskevisAntonis MakrigiannakisAngelos HatzakisAris Antsaklis Source Type: journals

Laparoscopic conservative management of ureteral endometriosis: a survey of eighty patients submitted to ureterolysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: laparoscopic ureterolysis is effective and well tolerated in most cases of ureteral endometriosis. Ureteroneocystostomy is a better strategy for patients with extended (more than 4 cm) ureteral involvement or with severe stenosis with or without hydronephrosis. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 11, 2009 Category: Endocrinology Authors: Marco CamanniLuca BoninoElena Maria DelpianoPaola BerchiallaGiuseppe MigliarettiAlberto RevelliFrancesco Deltetto Source Type: journals

Miscarriage rates after dehydroepiandrosterone (DHEA) supplementation in women with diminished ovarian reserve: a case control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionSince DOR patients in the literature are reported to experience significantly higher miscarriage rates than average IVF patients, the here observed reduction in miscarriages after DHEA supplementation exceeds, however, all expectations. Miscarriage rates after DHEA not only were lower than in an average national IVF population but were comparable to rates reported in normally fertile populations. Low miscarriage rates, comparable to those of normal fertile women, are statistically impossible to achieve in DOR patients without assumption of a DHEA effect on embryo ploidy. Beyond further investigations in infertile...
Source: Reproductive Biology and Endocrinology - October 6, 2009 Category: Endocrinology Authors: Norbert GleicherEddy RyanAndrea WeghoferSonia Blanco-MejiaDavid Barad Source Type: journals

The absorption and uptake of recombinant human follicle-stimulating hormone through vaginal subcutaneous injections - a pharmacokinetic studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The vaginal injection mode elicited a rapid and highly extended absorption of rhFSH injected compared to conventional abdominal injection. These data indicate that the rate and extent of FSH absorption from the injection site can vary depending on the route of the FSH administration. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 6, 2009 Category: Endocrinology Authors: Chao-Chin HsuHsin-Chih KuoChao-Tien HsuQing Gu Source Type: journals

Influence of obstetric factors on osteogenic potential of umbilical cord-derived mesenchymal stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Wharton's jelly from the umbilical cord is a noncontroversial source of mesenchymal stem cells (WJMSCs) with high plasticity, proliferation rate and ability to differentiate towards multiple lineages. WJMSCs from different donors have been characterized for their osteogenic potential. Although there is large evidence of WJMSCs plasticity, recently scientific debate has focused on MSCs selection, establishing predictable elements to discriminate the cells with most promising osteoprogenitor cell potential.In the present study a comparative study between the presence of osteoblastic markers and different parameters that pert...
Source: Reproductive Biology and Endocrinology - October 4, 2009 Category: Endocrinology Authors: Letizia PenolazziRenata VecchiatiniStefania BignardiElisabetta LambertiniElena TorreggianiAlessandro CanellaTiziana FranceschettiGiorgio CaluraFortunato VesceRoberta Piva Source Type: journals

Intra- and inter-observer analysis in the morphological assessment of early-stage embryosEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In conclusion, assessment of morphological characteristics of early stage embryos using multilevel images was marked by a high intra-observer and a moderate inter-observer agreement. Training sessions were useful to increase inter-observer agreement. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - September 28, 2009 Category: Endocrinology Authors: Goedele PaternotJohanna DevroeSophie DebrockThomas D'HoogheCarl Spiessens Source Type: journals

Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We previously demonstrated that the androgenic and anti-androgenic effects of endocrine disruptors (EDs) alter reproductive function and exert distinct effects on developing male reproductive organs. To further investigate these effects, we used an immature rat model to examine the effects of di-(2 ethylhexyl) phthalate (DEHP) and flutamide (Flu) on the male reproductive system. Immature male SD rats were treated daily with DEHP and Flu on postnatal days (PNDs) 21 to 35, in a dose-dependent manner. As results, the weights of the testes, prostate, and seminal vesicle and anogenital distances (AGD) decreased significantly in...
Source: Reproductive Biology and Endocrinology - September 25, 2009 Category: Endocrinology Authors: Thuy VoEui-Man JungVu Hoang DangYeong-Min YooKyung-Chul ChoiFrank YuEui-Bae Jeung Source Type: journals

Impact of GnRH analogues on oocyte/embryo quality and embryo development in in vitro fertilization/intracytoplasmic sperm injection cycles: a case control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Despite the clinical outcomes of ovarian stimulation with either GnRH-agonist or GnRH-antagonist analogues for in vitro fertilization (IVF) being well analysed, the effect of analogues on oocyte/embryo quality and embryo development is still not known in detail. The aim of this case-control study was to compare the efficacy of a multiple-dose GnRH antagonist protocol with that of the GnRH agonist long protocol with a view to oocyte and embryo quality, embryo development and IVF treatment outcome. Methods: Between October 2001 and December 2008, 100 patients were stimulated with human menopausal gonadotrophin (H...
Source: Reproductive Biology and Endocrinology - September 24, 2009 Category: Endocrinology Authors: Akos MurberPeter FancsovitsNora LedoZsuzsa TothneJanos RigoJanos Urbancsek Source Type: journals

A novel variant of ER-alpha, ER-alpha36 mediates testosterone-stimulated ERK and Akt activation in endometrial cancer Hec1A cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Testosterone induces ERK and Akt phosphorylation via the membrane-initiated signaling pathways mediated by ER-alpha36, suggesting a possible involvement of ER-alpha 36 in testosterone carcinogenesis. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - September 23, 2009 Category: Endocrinology Authors: Sheng-Li LinLi-Ying YanXing-Wei LiangZhen-Bo WangZhao-Yi WangJie QiaoHeide SchattenQing-Yuan Sun Source Type: journals

Biological versus chronological ovarian age: implications for assisted reproductive technologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Patients with biologically older ovaries may benefit from a tailored approach based on individual patient characteristics. Among the most promising adjuvant therapies for improving ART outcomes in women of advanced reproductive age are the administration of exogenous LH or GH. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - September 21, 2009 Category: Endocrinology Authors: Carlo AlviggiPeter HumaidanColin HowlesDonald TredwayStephen Hillier Source Type: journals

Impact of female age and male infertility on ovarian reserve markers to predict outcome of assisted reproduction technology cyclesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to assess the capability of ovarian reserve markers, including baseline FSH levels, baseline anti-Mullerian hormone (AMH) levels, and antral follicle count (AFC), as predictors of live births during IVF cycles, especially for infertile couples with advanced maternal age and/or male factors. Methods: A prospective cohort of 336 first IVF/ICSI cycles undergoing a long protocol with GnRH agonist was investigated. Patients with endocrine disorders or unilateral ovaries were excluded. Results: Among the ovarian reserve tests, AMH and age had a greater area under the receiving operating characteristic cur...
Source: Reproductive Biology and Endocrinology - September 16, 2009 Category: Endocrinology Authors: Tsung-Hsien LeeChung-Hsien LiuChun-Chia HuangKung-Chen HsiehPi-Mei LinMaw-Sheng Lee Source Type: journals

Factors affecting the outcome of human blastocyst vitrificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
With single blastocyst transfer practice becoming more common in ART, there is a greater demand for a convenient and reliable cryostorage of surplus blastocysts. Vitrification has emerged in the last decade as an alternative promising substitute for slow freezing. Blastocysts represent a unique challenge in cryostorage due to their size, multicellular structure and presence of blastocoele. The continuous acquisition of experience and introduction of many different technological developments has led to the improvement of vitrification as a technology and improved the results of its application in blastocyst cryostorage. The...
Source: Reproductive Biology and Endocrinology - September 15, 2009 Category: Endocrinology Authors: Amr KaderAudrey ChoiYasser OriefAshok Agarwal Source Type: journals

Laser capture microdissection of gonads from juvenile zebrafishEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The study presents a protocol for isolation of individual juvenile zebrafish gonads, which will enable future investigations of gonadal gene expression during the critical period of sex differentiation. Furthermore, the presented staining method is applicable to other species as it is directed towards alkaline phosphatase that is expressed in gonocytes and embryonic stem cells, which is conserved among vertebrate species. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - September 13, 2009 Category: Endocrinology Authors: Anne JorgensenJohn NielsenJane MorthorstPoul BjerregaardHenrik Leffers Source Type: journals

Function of caspase-14 in trophoblast differentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Since expression of these molecules is normally increased with trophoblast differentiation, our results imply that caspase-14 inhibits trophoblast differentiation. This is the first functional study of this unusual member of the caspase family in the trophoblast, where it has a different function than in the epidermis. This knowledge of the molecular underpinnings of trophoblast differentiation may instruct future therapies of trophoblast disease. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - September 13, 2009 Category: Endocrinology Authors: Lloyd WhiteWim DeclercqFrank ArfusoAdrian CharlesArun Dharmarajan Source Type: journals

Participation of ezrin in bacterial uptake by trophoblast giant cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Ezrin associates with Hsc70 that locates on the membrane of TG cells and participates in the bacterial uptake by TG cells. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - September 8, 2009 Category: Endocrinology Authors: Kenta WatanabeMasato TachibanaSuk KimMasahisa Watarai Source Type: journals

Rapidly evolving marmoset MSMB genes are differently expressed in the male genital tractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Callitrichide monkeys have four functional MSMB that are all expressed in the male genital tract, but the product from one gene, MSMB3, will predominate in seminal plasma. This gene and MSMB2, the predominating testicular gene, have accumulated mutations that affect different parts of the translation products, suggesting an ongoing molecular specialization that presumably yields functional differences in accessory sex glands and testis. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - September 8, 2009 Category: Endocrinology Authors: Ake LundwallOlivia LarnePenelope NayuduYvonne CederCamilla Valtonen-Andre Source Type: journals

A cross-study gene set enrichment analysis identifies critical pathways in endometriosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The study of complex diseases through pathway analysis is able to highlight genes weakly connected to the phenotype which may be difficult to detect by using classical univariate statistics. By standardised microarray preprocessing and GSEA, we have increased the concordance in identifing many biological mechanisms involved in endometriosis. The identified gene pathways will shed light on the understanding of endometriosis and promote the development of novel therapies. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - September 7, 2009 Category: Endocrinology Authors: Hongbo ZhaoQishan WangChunyan BaiKan HeYuchun Pan Source Type: journals

Increased NO bioavailability in aging male rats by genistein and exercise training: using 4, 5-diaminofluorescein diacetateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Several kinds of anti-oxidants have drawn a lot of intension for their benefits on vascular protection. In addition, it has been demonstrated that exercise training could improve endothelial function by up-regulating endothelial nitric oxide synthase (eNOS) protein. Therefore, the present study aims to investigate the effects of genistein, a potent phyto-antioxidant, and exercise training on age-induced endothelial dysfunction in relation to NO bioavailability using in situ NO-sensitive fluorescent dye detection. Methods: Male Wistar rats (20-22-month old) were divided into four groups: aged rats treated with c...
Source: Reproductive Biology and Endocrinology - September 6, 2009 Category: Endocrinology Authors: Sukanya EksakulklaDaroonwan SuksomPrasong SiriviriyakulSuthiluk Patumraj Source Type: journals

Modulation of Apolipoprotein D levels in human pregnancy and association with gestational weight gainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: It is speculated that the decrease in plasma ApoD concentration during pregnancy is an adaptive response aimed at maintaining fetal lipid homeostasis. The exact mechanism of this adaptation is not known. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - September 1, 2009 Category: Endocrinology Authors: Sonia Do CarmoJean-Claude ForestYves GiguereAndre MasseJulie LafondEric Rassart Source Type: journals

Comparative structure analyses of cystine knot-containing molecules with eight aminoacyl ring including glycoprotein hormones (GPH) alpha and beta subunits and GPH-related A2 (GPA2) and B5 (GPB5) moleculesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionThe comparison indicated that the common GPH alpha subunit exhibits a SS bridge organization ressembling that of DAN and GPA2 but possesses a unique bridge linking an additional cysteine inside the ring to the most N-terminal cysteine residue. The specific GPHbeta subunits also exhibit a SS bridge organization close to that of DAN but it has two additional C-terminal cysteine residues which are involved in the formation of the "seat belt" fastened by a SS "buckle" that ensures the stability of the heterodimeric structure of GPHs. GPA2 and GPB5 exhibit no cys residue potentially involved in interchain SS bridge an...
Source: Reproductive Biology and Endocrinology - August 30, 2009 Category: Endocrinology Authors: Eva AlvarezClaire CahoreauYves Combarnous Source Type: journals

"hCG priming" effect in controlled ovarian stimulation through a long protocolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: All the above clinical observations, in conjunction with previous data, suggest a point towards a beneficial "hCG priming" effect in controlled ovarian hyperstimulation through a long GnRH-a down-regulation protocol, particularly in patients with previous ART failures. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - August 30, 2009 Category: Endocrinology Authors: Panagiotis BeretsosGeorge PartsinevelosEleni ArabatziPeter DrakakisDepy MavrogianniElli AnagnostouKostas StefanidisAris AntsaklisDimitris Loutradis Source Type: journals

Distribution and hormonal regulation of membrane progesterone receptors beta and gamma in ciliated epithelial cells of mouse and human fallopian tubesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings show the presence and hormonal regulation of two distinct mPRs associated with the cilia of the fallopian tubes in both mice and women. It is hypothesized that these receptors are involved in the control of ciliary movement and, thus, gamete transport in the fallopian tubes of mammals. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - August 27, 2009 Category: Endocrinology Authors: Magdalena NutuBirgitta WeijdegardPeter ThomasAnn Thurin-KjellbergHakan BilligD G Joakim Larsson Source Type: journals

Occurrence of testicular microlithiasis in androgen insensitive hypogonadal miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We have identified a mouse model of TM and show that lack of endocrine stimulation is a cause of TM. Importantly, this model will provide a means with which to identify the mechanisms of TM development and the underlying changes in protein and gene expression. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - August 26, 2009 Category: Endocrinology Authors: Peter O'ShaughnessyAna MonteiroGuido VerhoevenKarl De GendtMargaret Abel Source Type: journals

Comparison of follicular fluid and serum levels of Inhibin A and Inhibin B with calculated indices used as predictive markers of ovarian hyperstimulation syndrome in IVF patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Ovarian Hyperstimulation Syndrome (OHSS) is a severe health complication observed in some patients undergoing hormonal stimulation during IVF. Presence of OHSS is often associated with a high count of growing follicles responding to FSH hyperstimulation. However, the number of responding follicles may not be sufficient enough to predict the onset and severity of OHSS. The aim of this study was to find whether follicular fluid (FF) and serum concentrations of Inhibin A and Inhibin B in patients undergoing IVF treatment may serve as a predictor of OHSS status independent of the growing follicles count. Methods: S...
Source: Reproductive Biology and Endocrinology - August 23, 2009 Category: Endocrinology Authors: Jiri MoosKarel RezabekVanda FilovaMartina MoosovaJana PavelkovaJana Peknicova Source Type: journals

Prolactin signaling through the short isoform of the mouse prolactin receptor regulates DNA binding of specific transcription factors, often with opposite effects in different reproductive issuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results clearly indicate that PRL does signal through PRL-RS in the decidua as well as the ovary, independently of PRL-RL, and activates/represses transcription factors in a tissue specific manner. This is the first report showing PRL/PRL-RS regulation of specific transcription factors. Many of these transcription factors were not previously known to be PRL targets, suggesting novel physiological roles for this hormone. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - August 23, 2009 Category: Endocrinology Authors: Y. Sangeeta DeviAurora ShehuJulia HalperinCarlos StoccoJamie LeAnita SeiboldGeula Gibori Source Type: journals

Matrix metalloproteinase-2 is elevated in midtrimester amniotic fluid prior to the development of preeclampsiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ObjectiveTo evaluate levels of matrix metalloproteinases (MMP) and their inhibitors (TIMP) in second trimester amniotic fluid of women with hypertensive disorders compared to normotensive women.Study Design: Amniotic fluid was obtained from 133 women undergoing genetic second trimester amniocentesis. Zymography was performed for MMP characterization and an MMP-2 ELISA kit was used to determine MMP-2 levels. TIMP-2 expression was evaluated using western blot. Results: Mean amniotic fluid MMP-2 and TIMP-2 levels were significantly higher in women who developed a hypertensive disorder compared to normotensive women (P (Source...
Source: Reproductive Biology and Endocrinology - August 22, 2009 Category: Endocrinology Authors: Michal LaveeShlomit GoldmanEtty Daniel-SpiegelEliezer Shalev Source Type: journals

Modulation of cytokines and transcription factors (T-Bet and GATA3) in CD4 enriched cervical cells of Chlamydia trachomatis infected fertile and infertile women upon stimulation with chlamydial inclusion membrane proteins B and CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Chlamydial Inclusion membrane proteins (Incs), are involved in biochemical interactions with host cells and infecting Chlamydiae. We have previously reported the role of two Chlamydia trachomatis (CT) Incs, namely IncB and IncC in generating host immunity in CT infected women. Emerging data shows involvement of Inc stimulated CD4 positive T cells in aiding host immunity in infected fertile and infertile women through the secretion of interferon gamma. However the lack of data on the intra-cytokine interplay to these Incs in infected cell milieu prompted us to investigate further. Methods: A total of 14 CT-posit...
Source: Reproductive Biology and Endocrinology - August 21, 2009 Category: Endocrinology Authors: Rishein GuptaHarsh VardhanPragya SrivastavaSudha SalhanAruna Mittal Source Type: journals

Isolation and characterization of bovine herpesvirus 4 (BoHV-4) from a cow affected by post partum metritis and cloning of the genome as a bacterial artificial chromosomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The analysis of genome strain variation is a key method for investigating genes associated with disease. A resource for dissection of the interactions between BoHV-4 and host endometrial cells was generated by cloning the genome of BoHV-4 as a BAC. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - August 18, 2009 Category: Endocrinology Authors: Gaetano DonofrioValentina FranceschiAntonio CapocefaloSandro CaviraniIain Sheldon Source Type: journals

Male mice with deleted Wolframin (Wfs1) gene have reduced fertilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The impaired fertility of Wfs1KO male mice is most likely due to changes in sperm morphology and reduced number of spermatogenic cells. The exact mechanism through which the Wfs1 gene influences sperm morphology needs to be clarified in further studies. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - August 9, 2009 Category: Endocrinology Authors: Klari NoormetsSulev KoksAnts KavakAndres ArendMarina AunapuuAivi KeldrimaaEero VasarVallo Tillmann Source Type: journals

Transforming growth factor beta isoforms regulation of Akt activity and XIAP levels in rat endometrium during estrous cycle, in a model of pseudopregnancy and in cultured decidual cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Those results suggest that TGF-beta might play an important role in the remodelling endometrium during the estrous cycle and in the regulation of apoptosis in rat decidual cells, in which inhibition of Akt survival pathway might be an important mechanism involved in the regulation of apoptosis. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - August 4, 2009 Category: Endocrinology Authors: Pierre-Luc CaronGuylaine Frechette-FrigonCarl ShoonerValerie LeblancEric Asselin Source Type: journals