Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease
Little is known about the relationships between human genetics and the airway microbiome. Deeply sequenced airway metagenomics, by simultaneously characterizing the microbiome and host genetics, provide a uniq... (Source: Respiratory Research)
Source: Respiratory Research - April 16, 2024 Category: Respiratory Medicine Authors: Jingyuan Gao, Yuqiong Yang, Xiaopeng Xiang, Huimin Zheng, Xinzhu Yi, Fengyan Wang, Zhenyu Liang, Dandan Chen, Weijuan Shi, Lingwei Wang, Di Wu, Shengchuan Feng, Qiaoyun Huang, Xueping Li, Wensheng Shu, Rongchang Chen & hellip; Tags: Research Source Type: research
Decreased serpin C1 in extracellular vesicles predicts response to methotrexate treatment in patients with pulmonary sarcoidosis
Sarcoidosis is a systemic granulomatous disease of unknown etiology primarily affecting the lungs. Treatment is needed when disease symptoms worsen and organ function deteriorates. In pulmonary sarcoidosis, pr... (Source: Respiratory Research)
Source: Respiratory Research - April 16, 2024 Category: Respiratory Medicine Authors: Raisa Kraaijvanger, Montse Janssen Bon ás, Jan C. Grutters, Ioanna Paspali, Marcel Veltkamp, Dominique P. V. de Kleijn and Coline H. M. van Moorsel Tags: Research Source Type: research
Feasibility and acceptability of remotely monitoring spirometry and pulse oximetry as part of interstitial lung disease clinical care: a single arm observational study
Remote monitoring of patient-recorded spirometry and pulse oximetry offers an alternative approach to traditional hospital-based monitoring of interstitial lung disease (ILD). Remote spirometry has been observ... (Source: Respiratory Research)
Source: Respiratory Research - April 15, 2024 Category: Respiratory Medicine Authors: Sarah Barth, Colin Edwards, Gauri Saini, Yussef Haider, Nicholas Paul Williams, Will Storrar, Gisli Jenkins, Iain Stewart and Melissa Wickremasinghe Tags: Research Source Type: research
Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen
Interleukin (IL)-26 is produced by T helper type 17 (Type 17) cells and exerts immunomodulatory plus antimicrobial effects. Previous studies show that local IL-26 concentrations in the airways are higher in pa... (Source: Respiratory Research)
Source: Respiratory Research - April 15, 2024 Category: Respiratory Medicine Authors: Melissa A. Kovach, Ulrika K äck, Karlhans F Che, Bettina Brundin, Jon R. Konradsen and Anders Lindén Tags: Research Source Type: research
Effects of right ventricular remodeling in chronic thromboembolic pulmonary hypertension on the outcomes of balloon pulmonary angioplasty: a 2D-speckle tracking echocardiography study
Balloon pulmonary angioplasty (BPA) improves the prognosis of chronic thromboembolic pulmonary hypertension (CTEPH). Right ventricle (RV) is an important predictor of prognosis in CTEPH patients. 2D-speckle tr... (Source: Respiratory Research)
Source: Respiratory Research - April 15, 2024 Category: Respiratory Medicine Authors: Yaning Ma, Dichen Guo, Jianfeng Wang, Juanni Gong, Huimin Hu, Xinyuan Zhang, Yeqing Wang, Yuanhua Yang, Xiuzhang Lv and Yidan Li Tags: Comment Source Type: research
Early-life house dust mite aeroallergen exposure augments cigarette smoke-induced myeloid inflammation and emphysema in mice
Longitudinal studies have identified childhood asthma as a risk factor for obstructive pulmonary disease (COPD) and asthma-COPD overlap (ACO) where persistent airflow limitation can develop more aggressively. ... (Source: Respiratory Research)
Source: Respiratory Research - April 13, 2024 Category: Respiratory Medicine Authors: Nok Him Fung, Quynh Anh Nguyen, Catherine Owczarek, Nick Wilson, Nadeem Elahee Doomun, David De Souza, Kylie Quinn, Stavros Selemidis, Jonathan McQualter, Ross Vlahos, Hao Wang and Steven Bozinovski Tags: Research Source Type: research
Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis
No effective therapies for pulmonary fibrosis (PF) exist because of the unclear molecular pathogenesis and the lack of effective therapeutic targets. Zinc finger protein 451 (ZNF451), a transcriptional regulat... (Source: Respiratory Research)
Source: Respiratory Research - April 10, 2024 Category: Respiratory Medicine Authors: Hong Peng, Yu Zhang, Jiali Min, Yuexin Tan and Shanshan Liu Tags: Research Source Type: research
Phenotypes and outcome of diffuse pulmonary non-amyloid light chain deposition disease
Light chain deposition disease (LCDD) is a very rare entity. Clinical manifestations of LCDD vary according to the organs involved. Data on pulmonary LCDD are scarce and limited to small series or case reports... (Source: Respiratory Research)
Source: Respiratory Research - April 10, 2024 Category: Respiratory Medicine Authors: Fran çois Lestelle, Catherine Beigelman, David Rotzinger, Salim Si-Mohamed, Mouhamad Nasser, Lidwine Wemeau, Sandrine Hirschi, Grégoire Prevot, Antoine Roux, Vincent Bunel, Emmanuel Gomez, Laurent Sohier, Helene Morisse Pradier, Martine Reynaud Gaubert, Tags: Research Source Type: research
Targeting transitioning lung monocytes/macrophages as treatment strategies in lung disease related to environmental exposures
Environmental/occupational exposures cause significant lung diseases. Agricultural organic dust extracts (ODE) and bacterial component lipopolysaccharide (LPS) induce recruited, transitioning murine lung monoc... (Source: Respiratory Research)
Source: Respiratory Research - April 9, 2024 Category: Respiratory Medicine Authors: Aaron D. Schwab, Todd A. Wyatt, Grace Moravec, Geoffrey M. Thiele, Amy J. Nelson, Angela Gleason, Oliver Schanze, Michael J. Duryee, Debra J. Romberger, Ted R. Mikuls and Jill A. Poole Tags: Research Source Type: research
GLUT3-mediated cigarette smoke-induced epithelial-mesenchymal transition in chronic obstructive pulmonary disease through the NF-kB/ZEB1 pathway
Airway remodelling plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Epithelial –mesenchymal transition (EMT) is a significant process during the occurrence of airway ... (Source: Respiratory Research)
Source: Respiratory Research - April 9, 2024 Category: Respiratory Medicine Authors: Yu Ding, Ziteng Wang, Zheming Zhang, Rong You, Yan Wu and Tao Bian Tags: Research Source Type: research
Use of non-small cell lung cancer multicellular tumor spheroids to study the impact of chemotherapy
Lung cancers represent the main cause of cancer related-death worldwide. Recently, immunotherapy alone or in combination with chemotherapy has deeply impacted the therapeutic care leading to an improved overal... (Source: Respiratory Research)
Source: Respiratory Research - April 5, 2024 Category: Respiratory Medicine Authors: Pauline Hulo, Sophie Deshayes, Judith Fresquet, Anne-Laure Ch éné, Stéphanie Blandin, Nicolas Boisgerault, Jean-François Fonteneau, Lucas Treps, Marc G Denis, Jaafar Bennouna, Delphine Fradin, Elvire Pons-Tostivint and Christophe Blanquart Tags: Research Source Type: research
Updated reference values for static lung volumes from a healthy population in Austria
Reference values for lung volumes are necessary to identify and diagnose restrictive lung diseases and hyperinflation, but the values have to be validated in the relevant population. Our aim was to investigate... (Source: Respiratory Research)
Source: Respiratory Research - April 3, 2024 Category: Respiratory Medicine Authors: Tobias Mraz, Shervin Asgari, Ahmad Karimi, Marie-Kathrin Breyer, Sylvia Hartl, Owat Sunanta, Alina Ofenheimer, Otto C. Burghuber, Angela Zacharasiewicz, Bernd Lamprecht, Caspar Schiffers, Emiel F. M. Wouters and Robab Breyer-Kohansal Tags: Research Source Type: research
A WNT mimetic with broad spectrum FZD-specificity decreases fibrosis and improves function in a pulmonary damage model
Wnt/ β-catenin signaling is critical for lung development and AT2 stem cell maintenance in adults, but excessive pathway activation has been associated with pulmonary fibrosis, both in animal models and human d... (Source: Respiratory Research)
Source: Respiratory Research - April 2, 2024 Category: Respiratory Medicine Authors: Mehaben Patel, Yorick Post, Natalie Hill, Asmiti Sura, Jay Ye, Trevor Fisher, Nicholas Suen, Mengrui Zhang, Leona Cheng, Ariel Pribluda, Hui Chen, Wen-Chen Yeh, Yang Li, H élène Baribault and Russell B. Fletcher Tags: Research Source Type: research
NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal, and aging-associated interstitial lung disease with a poor prognosis and limited treatment options, while the pathogenesis remains elusive.... (Source: Respiratory Research)
Source: Respiratory Research - April 2, 2024 Category: Respiratory Medicine Authors: Ruyan Wan, Siqi Long, Shuaichen Ma, Peishuo Yan, Zhongzheng Li, Kai Xu, Hui Lian, Wenwen Li, Yudi Duan, Miaomiao Zhu, Lan Wang and Guoying Yu Tags: Research Source Type: research
The safety and potential efficacy of exosomes overexpressing CD24 (EXO-CD24) in mild-moderate COVID-19 related ARDS
EXO-CD24 are exosomes genetically manipulated to over-express Cluster of Differentiation (CD) 24. It consists of two breakthrough technologies: CD24, the drug, as a novel immunomodulator that is smarter than s... (Source: Respiratory Research)
Source: Respiratory Research - April 1, 2024 Category: Respiratory Medicine Authors: Ioannis Grigoropoulos, Georgios Tsioulos, Artemis Kastrissianakis, Shiran Shapira, Orr Green, Vasiliki Rapti, Maria Tsakona, Thomas Konstantinos, Athina Savva, Dimitra Kavatha, Dimitrios Boumpas, Konstantinos Syrigos, Ioannis Xynogalas, Konstantinos Leont Tags: Research Source Type: research
