Paediatric and adult bronchiectasis: Vaccination in prevention and management
ABSTRACTBronchiectasis has received increased attention recently, including an emphasis on preventing infective exacerbations that are associated with disease progression and lung function decline. While there are several bacteria and viruses associated with bronchiectasis, licensed vaccines are only currently available forStreptococcus pneumoniae,Haemophilus influenzae (H. influenzae protein D as a conjugate in a pneumococcal vaccine),Mycobacterium tuberculosis, Bordetella pertussis and influenza virus. The evidence for the efficacy and effectiveness of these vaccines in both preventing and managing bronchiectasis in chil...
Source: Respirology - November 26, 2018 Category: Respiratory Medicine Authors: Kerry ‐Ann F. O'Grady,
Allan W. Cripps,
Keith Grimwood Tags: Invited Review Series: Paediatric and Adult Bronchiectasis Source Type: research
Radiofrequency spectral analysis of EBUS for peripheral pulmonary lesions
ConclusionRF analysis might be capable of demonstrating aspects of the lesion's pathological heterogeneity rather than precisely differentiating between benign and malignant lesions. (Source: Respirology)
Source: Respirology - November 23, 2018 Category: Respiratory Medicine Authors: Kei Morikawa,
Noriaki Kurimoto,
Takeo Inoue,
Teruomi Miyazawa,
Masamichi Mineshita Tags: Original Article Source Type: research
Non ‐invasive ventilation: Essential requirements and clinical skills for successful practice
This article addresses the different skills needed in a team to provide an effective NIV service. Some detail is given in each of the key areas but it is not comprehensive and should stimulate further learning (reading, attendance on courses, e‐learning, etc.), determined by the needs of the individual. (Source: Respirology)
Source: Respirology - November 23, 2018 Category: Respiratory Medicine Authors: Mark W. Elliott Tags: Invited Review Series: Non ‐invasive ventilation Source Type: research
Acute respiratory distress syndrome and the promise of driving pressure
Respirology, EarlyView. (Source: Respirology)
Source: Respirology - November 22, 2018 Category: Respiratory Medicine Authors: Rebecca E. Sell,
Atul Malhotra Tags: Editorial Source Type: research
Pulmonary rehabilitation for chronic obstructive pulmonary disease: Has it peaked?
Respirology, EarlyView. (Source: Respirology)
Source: Respirology - November 22, 2018 Category: Respiratory Medicine Authors: Anne E. Holland Tags: Commentary Source Type: research
Remarkable progress in cystic fibrosis —But why?
Respirology, EarlyView. (Source: Respirology)
Source: Respirology - November 22, 2018 Category: Respiratory Medicine Authors: Catherine Rang,
John Wilson Tags: Commentary Source Type: research
Effect of CPAP on airway reactivity and airway inflammation in children with moderate –severe asthma
ConclusionWe found that the 4 ‐week treatment with nocturnal CPAP did not produce a twofold suppression of airway reactivity in children with moderate–severe asthma. (Source: Respirology)
Source: Respirology - November 16, 2018 Category: Respiratory Medicine Authors: Eduardo Praca,
Hasnaa Jalou,
Nadia Krupp,
Angela Delecaris,
Joseph Hatch,
James Slaven,
Susan J. Gunst,
Robert S. Tepper Tags: Original Article Source Type: research
Issue Information
Respirology, Volume 23, Issue 12, Page 1079-1083, December 2018. (Source: Respirology)
Source: Respirology - November 15, 2018 Category: Respiratory Medicine Tags: Issue Information Source Type: research
Lumpers versus splitters: What to do with suspected idiopathic pulmonary fibrosis?
Respirology, EarlyView. (Source: Respirology)
Source: Respirology - November 15, 2018 Category: Respiratory Medicine Authors: Christopher J. Ryerson Tags: Editorial Source Type: research
Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma
ConclusionRepeated exposure to temperature variation exacerbated experimental ‘asthma’ and TRPA1 mediated this temperature‐dependent inflammatory effect. (Source: Respirology)
Source: Respirology - November 15, 2018 Category: Respiratory Medicine Authors: Chenqiu Du,
Jun Kang,
Wei Yu,
Mingqing Chen,
Baizhan Li,
Hong Liu,
Han Wang Tags: Original Article Source Type: research
Respiratory muscle weakness increases dead ‐space ventilation ratio aggravating ventilation–perfusion mismatch during exercise in patients with chronic heart failure
ConclusionRespiratory muscle weakness was associated with an increased dead ‐space ventilation ratio aggravating ventilation–perfusion mismatch during exercise in patients with CHF. (Source: Respirology)
Source: Respirology - November 14, 2018 Category: Respiratory Medicine Authors: Nobuaki Hamazaki,
Takashi Masuda,
Kentaro Kamiya,
Ryota Matsuzawa,
Kohei Nozaki,
Emi Maekawa,
Chiharu Noda,
Minako Yamaoka ‐Tojo,
Junya Ako Tags: Original Article Source Type: research
Genetic risk factors for the development of pulmonary disease identified by genome ‐wide association
ABSTRACTChronic respiratory diseases are a major cause of morbidity and mortality. Asthma and chronic obstructive pulmonary disease (COPD) combined affect over 500 million people worldwide. While environmental factors are important in disease progression, asthma and COPD have long been known to be heritable with genetic components playing an important role in the risk of developing disease. Identification of genetic variation contributing to disease progression is important for a number of reasons including identification of risk alleles, understanding underlying disease mechanisms and development of novel therapies. Genom...
Source: Respirology - November 13, 2018 Category: Respiratory Medicine Authors: Robert Hall,
Ian P. Hall,
Ian Sayers Tags: Invited Review Series: Molecular Techniques for Respiratory Diseases Source Type: research
Spectrum of mutations of cystic fibrosis in the 22 Arab countries: A systematic review
This study aimed to reveal the spectrum ofCFTR gene mutations in Arab CF patients and their corresponding clinical phenotypes among the 22 Arab countries. We searched four literature databases (PubMed, Science Direct, Web of Science and Scopus) from their times of inception to January 2018. All possible search terms were used to encompass the different clinical phenotypes, disease incidences,CFTR mutations, ages and consanguinity rates of CF patients in the 22 Arab countries. Our search strategy identified 678 articles; of these, 72 were eligible for this systematic review. We retrieved data from 18 Arab countries; only 17...
Source: Respirology - November 12, 2018 Category: Respiratory Medicine Authors: Duaa Al ‐Sadeq,
Taghreed Abunada,
Rajaa Dalloul,
Sara Fahad,
Sara Taleb,
Kholoud Aljassim,
Fatima Alzahra Al Hamed,
Hatem Zayed Tags: Systematic Review Source Type: research
Measuring the effects of bronchial thermoplasty using oscillometry
ConclusionLung impedance measured with oscillometry did not change following BT despite marked clinical improvements in patients with severe asthma. (Source: Respirology)
Source: Respirology - November 12, 2018 Category: Respiratory Medicine Authors: David Langton,
Alvin Ing,
Joy Sha,
Kim Bennetts,
Nicole Hersch,
McKinny Kwok,
Virginia Plummer,
Francis Thien,
Claude Farah Tags: Original Article Source Type: research
Respiratory adjuncts to NIV in neuromuscular disease
ABSTRACTMuscle weakness is an intrinsic feature of neuromuscular diseases (NMD). When the respiratory muscles are involved, the ability to take a deep breath is compromised, leading to reduced lung volumes and a restrictive ventilatory impairment. Inspiratory, expiratory and bulbar muscle weakness can also impair cough, which may impede secretion clearance. Non ‐invasive ventilation (NIV) is an established and indispensable therapy to manage hypoventilation and respiratory failure. The role of other therapies that support respiratory health is less clearly defined, and the evidence of efficacy is also harder to summarize...
Source: Respirology - November 8, 2018 Category: Respiratory Medicine Authors: Nicole Sheers,
Mark E. Howard,
David J. Berlowitz Tags: Invited Review Series: Non ‐invasive ventilation Source Type: research
