The experiences of cardiac arrest survivors and their key supporters following cardiac arrest: a systematic review and meta-ethnography
To review qualitative studies on the experience of sudden cardiac arrest survival from the perspective of both survivors and their key supporters, including family/close friends. (Source: Resuscitation)
Source: Resuscitation - March 26, 2024 Category: Emergency Medicine Authors: Charlotte Southern, Elizabeth Tutton, Katie N. Dainty, Kate Seers, Nathan A. Pearson, Keith Couper, David R. Ellard, Gavin D. Perkins, Kirstie L. Haywood Tags: Review Source Type: research

Open for business: the blood-brain barrier after cardiac arrest
Better biomarkers of illness severity are needed to improve management of patients with a variety of neurological emergencies, including hypoxic ischemic brain injury (HIBI) after cardiac arrest. When such markers assess well-defined pathophysiological mechanisms of injury, they may be useful not only as prognostic tools but also in research that aims to translate neuroprotective strategies from the bench to bedside. Measures of blood-brain barrier (BBB) integrity offer an appealing target in that they may reflect not only established HIBI severity but also a potentially modifiable pathway of secondary injury. (Source: Resuscitation)
Source: Resuscitation - March 22, 2024 Category: Emergency Medicine Authors: David J. Barton, Jonathan Elmer Tags: Editorial Source Type: research

How Can We Interpret the Unexpected Results in Two Pilot Trials Comparing Thiamine to Placebo after Cardiac Arrest?
Patients managed in the ICU following cardiac arrest suffer from multiple complications, including brain ischaemia resulting from reperfusion injury, circulatory failure and the risk of multiorgan failure [1]. To date, management has been largely supportive, with common ICU interventions aimed at normalising circulation, preventing secondary insults and employing neuroprognostication through a delayed multimodal approach [2]. A common characteristic of these patients is early lactatemia, which relates to whole-body ischaemia occurring during cardiac arrest. (Source: Resuscitation)
Source: Resuscitation - March 22, 2024 Category: Emergency Medicine Authors: Markus B Skrifvars Tags: Editorial Source Type: research

Endotracheal Epinephrine At Standard Versus High Dose For Resuscitation Of Asystolic Newborn Lambs
Globally, birth asphyxia is a major cause of neonatal mortality, resulting in more than 700,000 deaths annually.1 Amongst survivors,>400,000 infants per year are neurologically impaired as a result of birth asphyxia.2 Infants exposed to severe asphyxia are likely to require cardiopulmonary resuscitation (CPR) with chest compressions. Current recommendations advise CPR for infants who are asystolic, or have heart rate (Source: Resuscitation)
Source: Resuscitation - March 22, 2024 Category: Emergency Medicine Authors: Graeme R. Polglase, Yoveena Brian, Darcy Tantanis, Douglas A. Blank, Shiraz Badurdeen, Kelly J. Crossley, Martin Kluckow, Andrew W. Gill, Emily Camm, Robert Galinsky, Nils Thomas Songstad, Claus Klingenberg, Stuart B. Hooper, Calum T. Roberts Tags: Experimental paper Source Type: research

Heroism, Futility, and Lactate Physiology
A profoundly important yet often glanced over task of resuscitationists is to cease attempts at saving someone ’s life when efforts are futile. The quantitative definition of the word futility varies widely throughout the world and even within individuals in a given hospital. Do we cross over the line of futility at 10% survival, 1% survival… 0.1% survival? In the case of ECPR, the difficulty in finding this line is even more apparent. We know that intra-arrest pre-ECMO inclusion variables such as bystander CPR, witnessed arrest, and age are difficult to accurately assess in the chaos of an out of hospital scenario. (S...
Source: Resuscitation - March 22, 2024 Category: Emergency Medicine Authors: Zachary Shinar, Dinis Dos Reis Miranda Tags: Editorial Source Type: research

Reply to Addressing the Need for Bilateral Carotid Evaluation in Doppler Monitoring Studies for Enhanced CPR Outcomes
Thank for the reader's considerations. We have carefully reviewed the correspondence [1] and would like to address the concerns raised. (Source: Resuscitation)
Source: Resuscitation - March 22, 2024 Category: Emergency Medicine Authors: Shuo Wang, Chunsheng Li Tags: Reply to Correspondence Source Type: research

Pediatric Out-of-Hospital Cardiac Arrest Still Needs More Attention
Pediatric out-of-hospital cardiac arrest (OHCA) is relatively infrequent according to epidemiological data from population-based studies, with an incidence ranging from 1-20/100,0001 –4. However, given the devastating effects on patients’ families and the fact that outcomes are quite dismal, it represents a significant public health problem. Survival to hospital discharge after pediatric OHCA ranges from 6-25%1,3,5. The literature on neurologic and neurobehavioral outcomes ( especially via long-term follow-up) is slim, and the existing data shows that these outcomes are poor also. (Source: Resuscitation)
Source: Resuscitation - March 22, 2024 Category: Emergency Medicine Authors: Ivie D. Esangbedo Tags: Editorial Source Type: research

The impact of alternate defibrillation strategies on shock-refractory and recurrent ventricular fibrillation: A secondary analysis of the DOSE VF cluster randomized controlled trial
The DOSE VF randomized controlled trial (RCT) employed a pragmatic definition of refractory ventricular fibrillation (VF after three successive shocks). However, it remains unclear whether the underlying rhythm during the first three shocks was shock-refractory or recurrent VF. (Source: Resuscitation)
Source: Resuscitation - March 22, 2024 Category: Emergency Medicine Authors: Sheldon Cheskes, Ian R. Drennan, Linda Turner, Sandeep V. Pandit, Paul Dorian Tags: Clinical paper Source Type: research

Resuscitation (un-)wanted: Does anyone care? A retrospective real data analysis
In case of out-of-hospital cardiac arrest (OHCA) personnel of the emergency medical services (EMS) are regularly confronted with advanced directives (AD) and do-not-attempt-resuscitation (DNACPR) orders. The authors conducted a retrospective analysis of EMS operation protocols to examine the prevalence of DNACPR in case of OHCA and the influence of a presented DNACPR on CPR-duration, performed Advanced-Life-Support (ALS) measures and decision making. Materials and methods. Retrospective analysis of prehospital medical documentation of all resuscitation incidents in a German county with 250,000 inhabitants from 1 January 20...
Source: Resuscitation - March 22, 2024 Category: Emergency Medicine Authors: Dennis Rupp, Nils Heuser, Martin Christian Sassen, Susanne Betz, Christian Volberg, Susanne Glass Tags: Clinical paper Source Type: research

Strategic Placement of Automated External Defibrillators at City Bicycle-Sharing Stations: Exploring the Potential
To the Editor, (Source: Resuscitation)
Source: Resuscitation - March 22, 2024 Category: Emergency Medicine Authors: Nino Fija čko, Inja Dokl, Špela Metličar, Robert Greif Tags: Letter to the Editor Source Type: research

Together We Save: Uniting Forces in Manual and Mechanical CPR
Mechanical chest compression devices assist rescuers in the delivery of high-quality cardiopulmonary resuscitation (CPR) 1. The initial enthusiasm after the introduction of this technique was followed by reservation following multiple randomized trials demonstrating that mechanical chest compressions do not confer a survival benefit compared to manual chest compressions in out-of-hospital cardiac arrest (OHCA) 2,3. Current CPR guidelines recommend considering mechanical CPR only if high quality manual chest compression is not practical or compromises provider safety 4. (Source: Resuscitation)
Source: Resuscitation - March 14, 2024 Category: Emergency Medicine Authors: Roos Edgar, Judith L. Bonnes Tags: Editorial Source Type: research

Brain computed tomography after resuscitation from in-hospital cardiac arrest
Few data characterize the role of brain computed tomography (CT) after resuscitation from in-hospital cardiac arrest (IHCA). We hypothesized that identifying a neurological etiology of arrest or cerebral edema on brain CT are less common after IHCA than after resuscitation from out-of-hospital cardiac arrest (OHCA). (Source: Resuscitation)
Source: Resuscitation - March 14, 2024 Category: Emergency Medicine Authors: Cecelia Ratay, Jonathan Elmer, Clifton W Callaway, Katharyn L. Flickinger, Patrick J Coppler, on behalf of the University of Pittsburgh Post-Cardiac Arrest, Service Tags: Clinical paper Source Type: research

Not ‘just’ surviving: towards a Quality Standard which meets the care and rehabilitation needs of cardiac arrest survivors and their key supporters
The need for a quality standard for survivors of cardiac arrest and their supporters (Source: Resuscitation)
Source: Resuscitation - March 14, 2024 Category: Emergency Medicine Authors: M. Bradfield, KL. Haywood, M. Mion, A. Kayani, S. Leckey, on behalf of the RCUK Quality Standards Group for, Care, Rehabilitation of Cardiac Arrest Survivors, Key Supporters Tags: Editorial Source Type: research

Corrigendum to “Tyrphostin reduces the organ injury in haemorrhagic shock: Role of inducible nitric oxide synthase” [Resuscitation 58(3) (2003) 349–361]
The authors regret “that the above mentioned article contained an inaccurate version of Fig. 11A showing a histological section of a liver obtained from rats subjected to the surgical procedure without causing a haemorrhage (sham-operation) subjecting to IHC-staining for iNOS. The correct and final version of the im age follows below. The authors sincerely apologize for any inconvenience caused by this error and assure the readers of this article of their commitment to upholding the integrity and accuracy of their research findings. (Source: Resuscitation)
Source: Resuscitation - March 11, 2024 Category: Emergency Medicine Authors: Michelle McDonald, Maha Abdelrahman, Salvatore Cuzzocrea, Christoph Thiemermann Source Type: research

Acknowledgement to 2023 Reviewers
The Editors would like to thank all of the reviewers listed below who do such excellent work for Resuscitation. Without their knowledge, skill and dedication the journal would not achieve the high standard of peer review that we seek to maintain at all times. (Source: Resuscitation)
Source: Resuscitation - March 11, 2024 Category: Emergency Medicine Source Type: research