Reviews in Gynaecological and Perinatal Practice
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Editorial Board and Aims and Scope
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Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Source Type: journals
Contents
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Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Source Type: journals
Genetic mutations in gynaecological cancers
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Abstract: Approximately 10% of cancer deaths in women in Westernised countries are due to gynaecological malignancy. Cancer results from the accumulation of multiple genetic alterations. Some alterations occur in the germline and increase susceptibility to disease during an individual's lifetime. Such alterations often manifest themselves as a clustering of cancer cases within families. However, these are relatively rare. Most genetic changes are spontaneous, occurring in somatic cells, and are associated with a progressive tumour development. It is likely that the compliment of genetic changes that initiate and accumulate...
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: Karim Elmasry, Simon A. Gayther Source Type: journals
Treatment and follow-up of women with microinvasive cervical cancer
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Abstract: Until recently, the treatment of choice for Stage 1A cervical cancer has been simple or radical hysterectomy. With excellent survival rates and an increasing desire to conserve fertility, conservative surgical methods are being used. The object of this review is to discuss prognostic factors, treatment options and methods of follow-up for women with microinvasive cervical cancer.
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: Mary Cairns, Margaret Cruickshank Source Type: journals
Postpartum bladder dysfunction
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Abstract: The development of postpartum urinary symptoms such as incontinence and voiding dysfunction are not uncommon and often difficult to resolve. The urinary tract undergoes both structural and functional changes during pregnancy and after delivery. These changes may be specific in response to pregnancy and in some women may be compounded by pathological changes that persist after delivery. In labour, factors such as prolonged labour, assisted vaginal delivery, and perineal laceration have been associated with development of bladder dysfunction. Anatomical and functional changes to the pelvic floor may occur secondary...
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: Charlotte Chaliha Source Type: journals
Management of postpartum urinary retention
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This article reviews the etiology, prevention, management and long-term implications of retention for bladder functions.
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: Raheela M. Rizvi, Javed Rizvi Source Type: journals
The investigation and management of the hirsute woman
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Abstract: Female hirsutism is a distressing and embarrassing problem although there is rarely a sinister underlying pathology. It is characterised by excessive coarse terminal hairs in a male-like pattern and is due to increased androgen production or increased sensitivity of androgen receptors. Polycystic ovary syndrome (PCOS) is by far the commonest cause of hirsutism. A systematic evaluation of the patient will readily identify any serious underlying cause. Therapeutic options often include a combination of medical treatments targeting different sites of action, apart from mechanical ablation, cosmetic measures, or use ...
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: Nadia F. Soliman, Peter G. Wardle Source Type: journals
Optimising in vitro fertilisation (IVF) outcome in women with endometriosis
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Abstract: The etiology of endometriosis remains unclear and at the moment most of the therapeutic options are directed towards the relief of symptoms. In this context, in vitro fertilisation (IVF) overcomes anatomical distortion but our ability to influence environmental factors still seems to be limited. The improvement in pregnancy rates in endometriosis associated infertility is as important as the reduction in complications, and a careful analysis for the indications of each treatment option should be guaranteed. The use of gonadotropin releasing hormone agonists (GnRHa) for 3–6 months has shown to improve IVF outcom...
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: Alejandro Chavez-Badiola, Andrew Drakeley Source Type: journals
A systematic review to determine the effectiveness of medical therapies at causing disease regression in endometriosis
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Abstract: Endometriosis is a common condition affecting around 2–10% of women of reproductive age. Various medical therapies are in widespread use for control of symptoms, however, very little is known of the effect of these therapies on the disease itself. In addition, the natural history of the condition when left untreated is far from clearly understood. If one uses medical therapies for symptom control it is possible the underlying disease may progress insidiously such that, if surgery is required in the future, may be increasingly difficult and hazardous. We reviewed the literature to assess the efficacy of any medi...
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: T.T. Carpenter, A.S.H. Kent, R. Lawrenson Source Type: journals
Endometriosis: A general review and rationale for surgical therapy
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Abstract: This review article aims to give a comprehensive insight into both the historical and current thoughts on all aspects of endometriosis including aetiology, diagnosis, and medical and surgical treatments. The prevalence of endometriosis is about 6–8%, and may affect up to two million women in the United Kingdom. It causes, through pain and infertility, a significant problem for sufferers, their families and society as a whole. There is no conclusive evidence to explain its aetiology although our understanding of the basic pathophysiology is improving. However, there remains a substantial lack of understanding in...
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: P. Barton-Smith, K. Ballard, A.S.H. Kent Source Type: journals
Chronic pelvic pain: Aetiology and therapy
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Abstract: Gynaecologists are frequently referred women with chronic pelvic pain. These women are often frustrated as they seek to understand their pain and how to manage it. The investigation of women with chronic pelvic pain hinges on taking a full history including social and psychological issues and usually involves laparoscopy and transvaginal ultrasound. Management is often complex and includes taking a multidisciplinary approach as well as using hormonal agents, surgery and psychological interventions.
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: Cynthia Farquhar, Pallavi Latthe Source Type: journals
Pelvic inflammatory disease and pelvic abscesses
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Abstract: Pelvic inflammatory disease and pelvic abscesses have been reported as a major complication following a wide variety of obstetrical, gynaecological and surgical procedures. The aim of this review article is to emphasize the need for a more aggressive approach to detect and to treat what can be a debilitating condition that if inadequately treated may result in mortality. The large numbers of options available are discussed under the headings of: conservative management, interventional radiological management and surgical treatment. Lastly, preventive strategies are discussed, as pelvic inflammatory disease may re...
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: Zeenat Eva Khan, Javed H. Rizvi Source Type: journals
Religious aspects of contraception
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Abstract: After an introduction recounting the pronatalist views of the world's religions, the article goes on to explore each of the major religions, Judaism, Christianity, Islam, Hinduism, Sikhism and Buddhism and their belief systems in relation to contraception and abortion. This is followed by a discussion of the practical consequences of these beliefs and of the role of the professional in helping women and couples of the varied faiths in their choice of methods. How these choices may affect religious practices and vice versa is also considered.
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: Elphis Christopher Source Type: journals
Factors affecting the early embryonic environment
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Abstract: The early human embryo develops in a tightly controlled, relatively protected environment. During the first 8–12 weeks of human gestation, the delivery of maternal blood, and therefore the amount of oxygen to the developing embryo is limited and the embryo is supplied with essential nutrients in part via the decidual uterine glands, the placental trophoblast and the secondary yolk sac. Factors that interfere with this process may well result in spontaneous miscarriage or adverse outcome later in pregnancy. There is mounting evidence for the presence of transporter systems for many substances including drugs and...
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: Jemma Johns, Eric Jauniaux, Graham Burton Source Type: journals
Intrauterine origins of metabolic disease
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Abstract: It is well established that there is a strong relationship between fetal growth and the subsequent development of type 2 diabetes and other features of the metabolic syndrome. The importance of the fetal environment has been shown in both human and rodent studies. Twin studies suggest that the relationship can be independent of genotype, and studies of individuals in gestation during famine clearly indicate the importance of the fetal environment. However the mechanistic basis of the relationship is as yet unknown. To investigate the underlying mechanisms behind this relationship, a number of animal models have b...
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: N.H. Smith, S.E. Ozanne Source Type: journals
Antenatal prevention of neonatal group B streptococcal infection
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We present an overview of vaginal group B streptococcal isolation methods and antenatal strategies for prevention of neonatal infection.
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: Sophie Beal, Stephanie Dancer Source Type: journals
The evidence for the use of cervical cerclage
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Abstract: Cervical incompetence is an important factor in the aetiology of preterm birth and mid-trimester miscarriage. Its diagnosis usually relies on clinical history, but recent studies have investigated the role of transvaginal ultrasound scanning, with the finding of shortened cervical length being associated with an increased risk of preterm delivery.Cervical incompetence can be treated using MacDonald and Shirodkar cervical sutures. The largest study to date found a significant reduction in preterm delivery in those women who had a suggestive clinical history. This finding has been supported by the insertion of sutu...
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: Jennifer A. Brewster, James J. Walker Source Type: journals
Repeat Caesarean section or induction of labour
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Abstract: Obstetricians frequently need to decide whether to induce a woman who has previously been delivered by Caesarean section (LSCS). There is very little evidence from randomised controlled trials to aid their decision making. Observational studies, with their inherent flaws, suggest a 3.6% maternal complication rate in women undergoing repeat elective LSCS, and approximately 66% vaginal delivery rate and 1% uterine rupture rate in women who were induced. There is little evidence to guide the choice of induction agent. Various factors have been suggested to predict a successful vaginal delivery, but a previous vagina...
Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Authors: Sarah Vause, Stelios Christodoulou Source Type: journals
Author Index of Volume 6
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Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Source Type: journals
Subject Index of Volume 6
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Source: Reviews in Gynaecological and Perinatal Practice - September 1, 2006 Category: OBGYN Source Type: journals
