Opioid tapering in patients with prescription opioid use disorder: A retrospective study
Conclusions With comprehensive treatments, 27.9% of patients had successful opioid tapering with opioid abstinence for over a year. The use of mirtazepine, topiramate, or likely bupropion was associated with successful opioid tapering in the medication assisted treatment with temporary use of methadone. Opioid tapering may be a practical option and should be considered for managing prescription OUD. Implications For patients with OUD, indefinite opioid maintenance treatment may not be necessary. Considering the ethical values of autonomy, nonmaleficence, and beneficence, clinicians should provide patients with OUD the opt...
Source: Scandinavian Journal of Pain - December 15, 2017 Category: Anesthesiology Source Type: research
Lateral Cutaneous Nerve Entrapment Syndrome (LACNES): A previously unrecognized cause of intractable flank pain
Conclusions and implications LACNES should be considered in patients with chronic flank pain. Injection therapy is long term effective in more than half of the population. (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - December 15, 2017 Category: Anesthesiology Source Type: research
A new treatable chronic pain diagnosis? Flank pain caused by entrapment of posterior cutaneous branch of intercostal nerves, lateral ACNES coined LACNES
Publication date: October 2017 Source:Scandinavian Journal of Pain, Volume 17 Author(s): Harald Breivik, Audun Stubhaug (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - December 15, 2017 Category: Anesthesiology Source Type: research
PhKv a toxin isolated from the spider venom induces antinociception by inhibition of cholinesterase activating cholinergic system
Conclusions Our findings provide, to our knowledge, the first evidence that PhKv caused inhibition of AChE, it increased the ACh content at the neuronal synapses, leading to an activation of the cholinergic system and an antinociceptive response. Implications Studies regarding the nociceptive mechanisms and the identification of potential targets for the treatment of pain have become top priorities. PhKv, by its action of stimulating the cholinergic receptors muscarinic and nicotinic system, reduces pain it may be an alternative for controlling the pain processes. (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - December 15, 2017 Category: Anesthesiology Source Type: research
The burden of central anticholinergic drugs increases pain and cognitive dysfunction. More knowledge about drug-interactions needed
Publication date: October 2017 Source:Scandinavian Journal of Pain, Volume 17 Author(s): Harald Breivik (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - December 15, 2017 Category: Anesthesiology Source Type: research
Sleep, widespread pain and restless legs – What is the connection?
Publication date: October 2017 Source:Scandinavian Journal of Pain, Volume 17 Author(s): Stephen Butler (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - December 15, 2017 Category: Anesthesiology Source Type: research
Why can multimodal, multidisciplinary pain clinics not help all chronic pain patients?
Publication date: October 2017 Source:Scandinavian Journal of Pain, Volume 17 Author(s): Harald Breivik (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - December 9, 2017 Category: Anesthesiology Source Type: research
A case-history illustrates importance of knowledge of drug-interactions when pain-patients are prescribed non-pain drugs for co-morbidities
Publication date: October 2017 Source:Scandinavian Journal of Pain, Volume 17 Author(s): Harald Breivik (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - December 9, 2017 Category: Anesthesiology Source Type: research
Individual variability in clinical effect and tolerability of opioid analgesics – Importance of drug interactions and pharmacogenetics
Conclusions and implications Drug interactions and pharmacogenetic differences may lead to therapeutic failure or serious side effects of opioid analgesics. Many interactions involve combinations with antidepressants and antiepileptics, which are highly relevant drugs in patients suffering from pain. To prevent unfavourable drug interactions it is important that clinicians pay close attention and use electronic drug interaction checkers when treatments are initiated or discontinued. For the management of issues related to pharmacogenetic differences, blood-based CYP genotyping is available as routine test at many laborator...
Source: Scandinavian Journal of Pain - December 9, 2017 Category: Anesthesiology Source Type: research
Exploring patient experiences of a pain management centre: A qualitative study
Conclusion The findings suggest that the main reasons that patients recommended the centre were: (i) support and validation provided by the staff; (ii) provision of detailed information about the treatment choices available; (iii) personalized management plan and strategies to improve overall quality of life alongside pain control. None of the letters criticized the care provided, but eight of seventy reported long waiting times for the first appointment as a problem. Implications Patient views are central to improving care. However, satisfaction questionnaires or checklists can be intimidating, and restrictive in their c...
Source: Scandinavian Journal of Pain - December 9, 2017 Category: Anesthesiology Source Type: research
Basics of Anesthesia, 7th edition, M.C. Pardo Jr., R.D. Miller (Eds.). Elsevier (2018), ISBN: 978-0-323-40115-9
Publication date: Available online 18 October 2017 Source:Scandinavian Journal of Pain Author(s): Harald Breivik (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - December 9, 2017 Category: Anesthesiology Source Type: research
Sedation: A Guide to Patient Management, 6th edition, S.F. Malamed. Elsevier (2018), ISBN: 978-0-323-40053-4
Publication date: Available online 18 October 2017 Source:Scandinavian Journal of Pain Author(s): Harald Breivik (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - December 9, 2017 Category: Anesthesiology Source Type: research
Initial validation of the exercise chronic pain acceptance questionnaire
Conclusions This study offers preliminary support for the factorial and predictive validity of the CPAQ-E among exercising individuals with arthritis. Implications This measure could help researchers increase the specificity and sensitivity of pain acceptance responses to exercising among individuals with arthritis. A more sensitive measure might help clinicians interpret patient responses to exercise for pain self-management. (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - December 9, 2017 Category: Anesthesiology Source Type: research
Narratives of life with long-term low back pain: A follow up interview study
Conclusions The challenge for people with low back pain was to find ways of getting on with life, and this included their ability to configure an understandable narrative that opened up for a future, implying new understandings of the self and how life could be lived. When healthcare professionals offered personal and realistic suggestions to the informants’ configuration of narratives of life with low back pain, they supported a positive change in the informants’ ways of coping with their situation. Implications Health professionals can play an important role in low back pain sufferers’ configuration of meaningful ...
Source: Scandinavian Journal of Pain - December 9, 2017 Category: Anesthesiology Source Type: research
Pain catastrophizing, perceived injustice, and pain intensity impair life satisfaction through differential patterns of physical and psychological disruption
Conclusions The current findings highlight the distinct affective and behavioural mediators of pain and maladaptive cognitive appraisal processes in chronic pain, and highlight their importance in both perceptions of pain-related interference and longer-term quality of life. (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - December 9, 2017 Category: Anesthesiology Source Type: research
