Understanding and Treating Persecutory Delusions
Oxford Health Biomedical Research CentreNIHR10.13039/501100000272 (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - February 3, 2024 Category: Psychiatry Source Type: research
Correction to: Spatial and Temporal Abnormalities of Spontaneous Fixational Saccades and Their Correlates With Positive and Cognitive Symptoms in Schizophrenia
National Natural Science Foundation of China10.13039/50110000180962171269821715448200140682101582821513148167133281971251Science and Technology Commission of Shanghai Municipality10.13039/50110000339920ZR144860021S3190310022Y11903600Strategic Priority Research Program of Chinese Academy of SciencesXDB32060203Shanghai Municipal Science and Technology Major Project2018SHZDZX012018SHZDZX05Clinical Research Center at Shanghai Mental Health CenterCRC2018ZD0119MC1911100Clinical Research Plan of SHDC16CR2015ASHDC12022113Clinical Research Center at Shanghai Jiao Tong University School of MedicineDLY201817 (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - December 25, 2023 Category: Psychiatry Source Type: research
Toll-Like Receptor mRNA Levels in Schizophrenia: Association With Complement Factors and Cingulate Gyrus Cortical Thinning
ConclusionsThe study underscores the role of innate immune activation in schizophrenia, indicating a coordinated immune response of TLRs and the complement system. Our results suggest there could be more bacterial influence (based on TLR 4 levels) as opposed to viral influence (based on TLR3 levels) in schizophrenia. Specific TLRs were associated with brain cortical thickness reductions of limbic brain structures. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - December 15, 2023 Category: Psychiatry Source Type: research
Self-Disorder in Schizophrenia: A Revised View (1. Comprehensive Review –Dualities of Self- and World-Experience)
This article presents a state-of-the-art overview of the current self-disturbance model and critically assesses its descriptive adequacy with respect to the clinical variability and heterogeneity of the alterations in self- and world-awareness characteristic of schizophrenia. Special attention is paid to experiences of exaggerated basic self, increased “grip” or “hold” on the world, and paradoxical combinations. The next article proposes a theoretical revision of the self-disturbance model by considering how hyperreflexivity might form the crucial common thread or generating factor that unifies the phenomenological...
Source: Schizophrenia Bulletin - December 9, 2023 Category: Psychiatry Source Type: research
Self-Disorder in Schizophrenia: A Revised View (2. Theoretical Revision —Hyperreflexivity)
AbstractA growing body of research supports the role of self-disorders as core phenotypic features of schizophrenia-spectrum conditions. Self-disorders comprise various alterations of conscious experience whose theoretical understanding continues to present a challenge. This is the second of two articles that aim to clarify the nature of self-disorders in schizophrenia by considering the currently most influential, phenomenological model of schizophrenia: the basic-self-disturbance or ipseity-disorder model (IDM). The previous paper (article 1) presented a state-of-the-art overview of this model and critically assessed its...
Source: Schizophrenia Bulletin - December 9, 2023 Category: Psychiatry Source Type: research
Disease Progression Patterns of Brain Morphology in Schizophrenia: More Progressed Stages in Treatment Resistance
ConclusionsThe brain morphological progressions in schizophrenia can be classified into 3 subtypes, and treatment resistance was associated with more progressed stages, which may suggest a novel biomarker. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - November 25, 2023 Category: Psychiatry Source Type: research
Correction to: Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci
This is a correction to: Piotr Jaholkowski, Guy F L Hindley, Alexey A Shadrin, Markos Tesfaye, Shahram Bahrami, Mari Nerhus, Zillur Rahman, Kevin S O ’Connell, Børge Holen, Nadine Parker, Weiqiu Cheng, Aihua Lin, Linn Rødevand, Naz Karadag, Oleksandr Frei, Srdjan Djurovic, Anders M Dale, Olav B Smeland, Ole A Andreassen, Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Nov el Risk Loci, Schizophrenia Bulletin, 2023;, sbad063,https://doi.org/10.1093/schbul/sbad063 (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - November 22, 2023 Category: Psychiatry Source Type: research
Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia
ConclusionsThese findings suggest that reconfiguration of brain networks via coordinated cortical thinning is related to treatment response in schizophrenia. Further longitudinal studies are warranted to confirm if greater structural covariance could serve as a marker for treatment response in this disease. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - November 18, 2023 Category: Psychiatry Source Type: research
A Transdiagnostic Study of Effort-Cost Decision-Making in Psychotic and Mood Disorders
ConclusionsOur results provide support for ECDM deficits in schizophrenia. Additionally, differences between groups in ECDM suggest a seemingly similar behavioral phenotype, reduced motivation, could arise from disparate mechanisms. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - October 30, 2023 Category: Psychiatry Source Type: research
Up-regulation of the Trace Amine Receptor, TAAR-1, in the Prefrontal Cortex of Individuals Affected by Schizophrenia
ConclusionsThe up-regulation of TAAR1 observed in the SCZ prefrontal cortex supports the development of TAAR1 agonists as new promising drugs in the treatment of SCZ. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - October 28, 2023 Category: Psychiatry Source Type: research
Evidence for Reduced Sensory Precision and Increased Reliance on Priors in Hallucination-Prone Individuals in a General Population Sample
ConclusionsWe replicate the finding that increased CH rates and recent hallucinations correlate with increased prior weighting using a linguistic version of the CH task. Results support a role for reduced sensory precision in the interplay between prior weighting and hallucination-proneness. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - October 13, 2023 Category: Psychiatry Source Type: research
Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation
ConclusionsWe provide genetics-based evidence that schizophrenia is shaped by disruptions of separable biological processes acting at distinct phases of neurodevelopment. The modeling of genetic risk factors that moderate each other ’s effect, informed by the timing of their expression, will aid in a better understanding of the development of schizophrenia. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - October 12, 2023 Category: Psychiatry Source Type: research
Antipsychotic Medication and Risk of Metabolic Disorders in People With Schizophrenia: A Longitudinal Study Using the UK Clinical Practice Research Datalink
ConclusionsAntipsychotic polypharmacy, particularly polypharmacy solely comprised of first-generation antipsychotics, increased the risk of hypertension. Future research employing larger samples, follow-up longer than the current median of 14 months, and more complex methodologies may further elucidate the association reported in this study. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - August 25, 2023 Category: Psychiatry Source Type: research
Medical and Psychiatric Care Preceding the First Psychotic Disorder Diagnosis
ConclusionsIn this insured population of Massachusetts residents with a new psychotic disorder diagnosis, nearly all had some healthcare utilization, visits for injury or trauma were common, and nearly half filled an antipsychotic medication in the preceding 48 months. These patterns of care could represent either pre-disease signals, delays, or both in receiving a formal diagnosis. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - August 22, 2023 Category: Psychiatry Source Type: research
Methodological Characteristics and Feasibility of Ecological Momentary Assessment Studies in Psychosis: a Systematic Review and Meta-Analysis
ConclusionsEMA methods have been widely applied in psychosis studies using a range of protocols. Completion rates are high, providing clear evidence of feasibility in psychosis populations. Recommendations for reporting in future studies are provided. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - August 22, 2023 Category: Psychiatry Source Type: research
