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SIRS membershipEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Schizophrenia Research)
Source: Schizophrenia Research - November 11, 2009 Category: Psychiatry Source Type: journals

SIRS conferenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Schizophrenia Research)
Source: Schizophrenia Research - November 11, 2009 Category: Psychiatry Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Schizophrenia Research)
Source: Schizophrenia Research - November 11, 2009 Category: Psychiatry Source Type: journals

Impact of real-world ziprasidone dosing on treatment discontinuation rates in patients with schizophrenia or bipolar disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: The purpose of this study is to evaluate the relationship between maximum dose of ziprasidone and time to discontinuation in the treatment of schizophrenia/schizoaffective disorder and bipolar disorder in clinical practice.Method: The 2001–2006 MarketScan Commercial and Medicare Databases were analyzed for maximum ziprasidone doses achieved in patients with schizophrenia/schizoaffective disorder or bipolar disorder. Ziprasidone maximum-dose groups were defined as low (20–60mg/d), medium (61–119mg/d), or high (120–160mg/d). Patients receiving >160mg/d were excluded. Mean time to discontinuation...
Source: Schizophrenia Research - October 30, 2009 Category: Psychiatry Authors: Leslie Citrome, Christopher Reist, Liisa Palmer, Leslie B. Montejano, Gregory Lenhart, Brian Cuffel, James Harnett, Kafi N. Sanders Tags: Treatment Source Type: journals

Using virtual reality to evaluate executive functioning among persons with schizophrenia: A validity studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Persons with Schizophrenia experience difficulties with Executive Functioning (EF) that affect independence and participation in activities. Specifically, EF impacts performance in Instrumental Activities of Daily Living (IADL) that require flexible thinking and accommodation to complex environments. However, less is known how schizophrenia affects EF and individuals' performance in activities. IADL performance can be tested using a virtual reality (VR) environment that simulates real life activities. The purpose of this study was: 1) to examine the feasibility and validity of the Virtual Action Planning-Supermar...
Source: Schizophrenia Research - October 23, 2009 Category: Psychiatry Authors: Naomi Josman, Anat Elbaz Schenirderman, Evelyne Klinger, Eynat Shevil Tags: Cognition Source Type: journals

Low-frequency EEG oscillations associated with information processing in schizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined event-related evoked and induced delta and theta activity in 17 people with schizophrenia and 17 healthy controls in two go/no-go task variants. We analyzed stimulus-related and response-related oscillations associated with correct-hits, correct-rejects and false-alarms. Our results reveal a pattern of reduced delta and theta activity for task-relevant events in schizophrenia. The findings indicate that while low-frequency oscillations are increased in amplitude at rest, they are not coordinated effectively in schizophrenia during various information processing tasks including target-detection, response-inhibit...
Source: Schizophrenia Research - October 23, 2009 Category: Psychiatry Authors: Alan T. Bates, Kent A. Kiehl, Kristin R. Laurens, Peter F. Liddle Tags: Electrophysiology Source Type: journals

Biochemical risk factors for development of obesity in first-episode schizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Obesity is a serious health issue for many patients with schizophrenia. There is a lack of predictors for and understanding of the development of obesity in the early phase of the illness. Therefore we investigated a set of routine biochemistry variables in blood as predictors of the development of obesity and weight gain over 5years in an observational cohort study of patients with first-episode schizophrenia (n=59). Twelve percent of the patients were obese at baseline and 37% were obese at the 5-year follow-up. The mean body mass index (BMI) change over 5years was a 4.1kg/m2 increase (4.5 SD). Obesity was pred...
Source: Schizophrenia Research - October 22, 2009 Category: Psychiatry Authors: Robert Bodén, Arvo Haenni, Leif Lindström, Johan Sundström Tags: The metabolic syndrome Source Type: journals

The relationship between prepulse inhibition and general psychopathology in patients with schizophrenia treated with long-acting risperidoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Patients with schizophrenia exhibit impairments in prepulse inhibition (PPI) of the startle response. Available data suggest that atypical antipsychotics may be more effective than typical antipsychotics in improving PPI deficits in schizophrenia. However, previous studies have used between-subjects rather than longitudinal within-subjects designs to demonstrate superiority of particular atypical antipsychotics over typical antipsychotics in improving PPI in patients with schizophrenia. This longitudinal within-subjects test–retest study was designed to evaluate changes in PPI and clinical symptoms in patients ...
Source: Schizophrenia Research - October 21, 2009 Category: Psychiatry Authors: Isabel Martinez-Gras, Gabriel Rubio, Blanca Alvarez del Manzano, Roberto Rodriguez-Jimenez, Fernando Garcia-Sanchez, Alexandra Bagney, Juan Carlos Leza, José Borrell Tags: Electrophysiology Source Type: journals

Acetyl-coenzyme A carboxylase α gene variations may be associated with the direct effects of some antipsychotics on triglyceride levelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Acetyl-coenzyme A carboxylase α (ACACA) single-nucleotide polymorphism (SNP) (rs2229416) was significantly associated with hypertriglyceridemia, during exploration of antipsychotic direct effects on lipids. Neuropeptide Y (NPY) gene (rs1468271) and ACACB gene (rs2241220) SNPs were significantly associated with severe hypercholesterolemia. In the same sample (173 patients on olanzapine, quetiapine, chlorpromazine or mirtazapine [increasing the risk of hyperlipidemia] and 184 controls taking other antipsychotics), three (rs1266175, rs12453407 and rs9906543) of eight additional ACACA SNPs were significantly associa...
Source: Schizophrenia Research - October 21, 2009 Category: Psychiatry Authors: Francisco J. Diaz, Alexander Meary, Maria J. Arranz, Gualberto Ruaño, Andreas Windemuth, Jose de Leon Tags: The metabolic syndrome Source Type: journals

Beyond symptom dimensions: Schizophrenia risk factors for patient groups derived by latent class analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:: A data-driven subgroup of schizophrenia patients, characterized as lacking co-morbid depressive symptoms, is less heterogeneous with respect to neurodevelopmental etiology. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 20, 2009 Category: Psychiatry Authors: S.J. Leask, J.K. Vermunt, D.J. Done, T.J. Crow, M. Blows, M.P. Boks Tags: Miscellaneous Source Type: journals

Five-year stability of ICD-10 diagnoses among Chinese patients presented with first-episode psychosis in Hong KongEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Schizophrenia and bipolar affective disorder were diagnostically stable and could be reliably classified at intake in a Chinese first-episode psychosis sample using the ICD-10 criteria. Diagnostic instability in the least prevalent categories of functional psychosis highlights the limitations of current taxonomies and calls for ongoing revision of diagnostic criteria. In the absence of biological marker, longitudinal validation across consecutive episodes is necessary for accurate diagnostic ascertainment. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 19, 2009 Category: Psychiatry Authors: Wing Chung Chang, Shirley Lai Kwan Pang, Dicky Wai Sau Chung, Sandra Sau Man Chan Tags: Miscellaneous Source Type: journals

Smoking expectancies and intention to quit in smokers with schizophrenia, schizoaffective disorder and non-psychiatric controlsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we compared positive and negative smoking expectancies, and examined relationships between expectancies and intention to quit smoking, in smokers with schizophrenia (n=46), smokers with schizoaffective disorder (n=35), and smokers without psychiatric illness (n=71). In all three groups, reduction of negative affect was rated as the most important smoking expectancy and intention to quit smoking was systematically related to concerns about the health effects and social consequences of smoking. Compared to the other groups of smokers, those with schizoaffective disorder were more concerned with social expectan...
Source: Schizophrenia Research - October 19, 2009 Category: Psychiatry Authors: Jennifer W. Tidey, Damaris J. Rohsenow Tags: Smoking Source Type: journals

Verbal fluency deficits and altered lateralization of language brain areas in individuals genetically predisposed to schizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Alterations of verbal fluency may correlate with deficits of gray matter volume and hemispheric lateralization of language brain regions like the pars triangularis (PT) in schizophrenia. Examining non-psychotic individuals at high genetic risk (HR) for schizophrenia may clarify if these deficits represent heritable trait markers or state dependent phenomena. We assessed adolescent and young adult HR subjects (N=60) and healthy controls (HC; N=42) using verbal fluency tests and Freesurfer to process T1-MRI scans. We hypothesized volumetric and lateralization alterations of the PT and their correlation with verbal ...
Source: Schizophrenia Research - October 19, 2009 Category: Psychiatry Authors: Tejas S Bhojraj, Alan N Francis, Rajaprabhakaran Rajarethinam, Shaun Eack, Shreedhar Kulkarni, Konasale M Prasad, Debra M Montrose, Diana Dworakowski, Vaibhav Diwadkar, Matcheri S Keshavan Tags: Brain structure and development Source Type: journals

Deviant trajectories of cortical maturation in 22q11.2 deletion syndrome (22q11DS): A cross-sectional and longitudinal studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: 22q11.2 deletion syndrome (22q11DS) is associated with an increased susceptibility to develop schizophrenia. Despite a large body of literature documenting abnormal brain structure in 22q11DS, cerebral changes associated with brain maturation in 22q11DS remained largely unexplored. To map cortical maturation from childhood to adulthood in 22q11.2 deletion syndrome, we used cerebral MRI from 59 patients with 22q11DS, aged 6 to 40, and 80 typically developing controls; three year follow-up assessments were also available for 32 patients and 31 matched controls. Cross-sectional cortical thickness trajectories during...
Source: Schizophrenia Research - October 19, 2009 Category: Psychiatry Authors: Marie Schaer, Martin Debbané, Meritxell Bach Cuadra, Marie-Christine Ottet, Bronwyn Glaser, Jean-Philippe Thiran, Stephan Eliez Tags: Brain structure and development Source Type: journals

Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Spatial working memory (SWM) dysfunction has been suggested as a trait marker of schizophrenia and implicates a diffuse network involving prefrontal, temporal and parietal cortices. However, structural abnormalities in both grey and white matter in relation to SWM deficits are largely unexplored. The current magnetic resonance imaging (MRI) study examined this relationship in a sample of young first-episode schizophrenia (FES) patients using a whole-brain voxel-based method.SWM ability of 21 FES patients and 41 comparable controls was assessed by the CANTAB SWM task. Using an automated morphometric analysis of br...
Source: Schizophrenia Research - October 19, 2009 Category: Psychiatry Authors: Luca Cocchi, Mark Walterfang, Renée Testa, Stephen J. Wood, Marc L. Seal, John Suckling, Tsutomu Takahashi, Tina-Marie Proffitt, Warrick J. Brewer, Christopher Adamson, Bridget Soulsby, Dennis Velakoulis, Patrick D. McGorry, Christos Pantelis Tags: Brain structure and development Source Type: journals

Motivational deficits as the central link to functioning in schizophrenia: A pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Negative symptoms have consistently been found to contribute to functional impairment in schizophrenia. In this pilot study, we sought to delineate the core negative symptoms that contribute to this functional impairment. Adult outpatients with schizophrenia were evaluated for the severity of positive, negative, cognitive, and depressive symptoms. The Quality of Life Scale was used to assess current functioning. Results from 21 participants revealed that amotivation was the sole predictor of functioning, accounting for 74% of the variance in current functioning. This suggests that motivational deficits are the ce...
Source: Schizophrenia Research - October 16, 2009 Category: Psychiatry Authors: G. Foussias, S. Mann, K.K. Zakzanis, R. van Reekum, G. Remington Tags: Miscellaneous Source Type: journals

Two-dimensional assessment of cytoarchitecture in the superior temporal white matter in schizophrenia, major depressive disorder and bipolar disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we performed a cytoarchitectural assessment of the white matter adjacent to the planum temporale (PT), an auditory association region located within the superior temporal gyrus, in subjects with schizophrenia, bipolar disorder, major depressive disorder and controls (15 subjects per group). Using two-dimensional measures, we recorded the cell density, distribution and size of all neurons and glial nuclei within this region. Glial density was lower in the schizophrenia group, relative to the control group. Neuronal density, neuronal size, and glial nuclear size did not differ between groups. No significant dif...
Source: Schizophrenia Research - October 16, 2009 Category: Psychiatry Authors: Clare L. Beasley, Mrinalini Honavar, Ian P. Everall, David Cotter Tags: Brain structure and development Source Type: journals

Family-level predictors and correlates of the duration of untreated psychosis in African American first-episode patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Whereas family strengths and coping likely account for a significant portion of variability in DUP, both insight and caregiver strain probably evolve as a consequence of DUP. Efforts to strengthen families and tap into existing strengths of families in specific cultural groups would likely enhance early treatment-seeking for psychotic disorders. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 15, 2009 Category: Psychiatry Authors: Michael T. Compton, Sandra M. Goulding, Tynessa L. Gordon, Paul S. Weiss, Nadine J. Kaslow Tags: Miscellaneous Source Type: journals

An examination of neuroticism as a moderating factor in the association of positive and negative schizotypy with psychopathology in a nonclinical sampleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Personality traits such as neuroticism are associated with schizophrenia and schizotypy. However, studies thus far have not clarified the differential association of neuroticism with individual schizotypy dimensions and the role it plays in the expression of schizophrenia-spectrum psychopathology. 204 nonclinically ascertained participants completed self-report questionnaires assessing neuroticism and the positive and negative schizotypy dimensions, and underwent structured interviews assessing schizophrenia-spectrum psychopathology (psychotic-like experiences, negative symptoms, cluster A personality disorders a...
Source: Schizophrenia Research - October 12, 2009 Category: Psychiatry Authors: Neus Barrantes-Vidal, Agnès Ros-Morente, Thomas R. Kwapil Tags: Schizotypal personality Source Type: journals

Meta-analysis of magnetic resonance imaging studies in chromosome 22q11.2 deletion syndrome (velocardiofacial syndrome)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Many regions extensively studied in schizophrenia were not covered in the existing VCFS literature. However, the studies considered support volumetric abnormalities which may help explain why VCFS is associated with a greatly increased risk of psychosis and other psychiatric disorders. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 12, 2009 Category: Psychiatry Authors: Giles M. Tan, Danilo Arnone, Andrew M. McIntosh, Klaus P. Ebmeier Tags: Brain structure and development Source Type: journals

Correlates of cognitive impairment in first episode schizophrenia: The EUFEST studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A moderate/severe impairment of processing speed, motor dexterity, verbal memory and cognitive flexibility was found in the largest sample of FE patients analyzed so far. The impairment was largely independent from psychopathology and not associated with DUP. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 12, 2009 Category: Psychiatry Authors: Silvana Galderisi, Michael Davidson, René S. Kahn, Armida Mucci, Han Boter, Mihai D. Gheorghe, Janusz K. Rybakowski, Jan Libiger, Sonia Dollfus, Juan J. López-Ibor, Joseph Peuskens, Luchezar G. Hranov, Wolfgang W. Fleischhacker, EUFEST group Tags: Results from the EUFEST study Source Type: journals

Effectiveness of antipsychotics in first-episode schizophrenia and schizophreniform disorder on response and remission: An open randomized clinical trial (EUFEST)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Substantial proportions of first-episode patients with schizophrenia showed clinically meaningful response and remission rates within 12months. The proportions of response and remission were higher for most SGAs as compared to haloperidol. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 12, 2009 Category: Psychiatry Authors: Han Boter, Joseph Peuskens, Jan Libiger, W. Wolfgang Fleischhacker, Michael Davidson, Silvana Galderisi, René S. Kahn, for the EUFEST study group Tags: Results from the EUFEST study Source Type: journals

‘Theory’ of mind impairment in patients affected by schizophrenia and in their parentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: “Theory of mind” (ToM) is the ability to judge the mental states of the self and others. It is currently considered as a part of the broader concept of social cognition, known to influence the social behaviour of patients affected by schizophrenia. Recently it has been hypothesized that the impairment of ToM is a trait that can be detected both in patients with schizophrenia and in non-psychotic relatives of patients, but it still not clear what the contribution of the familial patterns of cognitive impairment is.The aim of this study is to assess parental impairments of ToM performance considering the effect...
Source: Schizophrenia Research - October 9, 2009 Category: Psychiatry Authors: S. Anselmetti, M. Bechi, M. Bosia, C. Quarticelli, E. Ermoli, E. Smeraldi, R. Cavallaro Tags: Cognition Source Type: journals

SIRS MembershipEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Schizophrenia Research)
Source: Schizophrenia Research - October 5, 2009 Category: Psychiatry Source Type: journals

SIRS ConferenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Schizophrenia Research)
Source: Schizophrenia Research - October 5, 2009 Category: Psychiatry Source Type: journals

Determinants of everyday outcomes in schizophrenia: The influences of cognitive impairment, functional capacity, and symptomsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the relative importance of cognitive impairments measured with a neuropsychological battery, performance-based measures of social and everyday living skills, and positive and negative symptoms for the prediction of real-world outcomes in social and residential domains. In contrast to most previous studies, we examined the importance of individual symptoms, as well as total subscale scores, for predicting clinician rated outcomes in 194 older outpatients with schizophrenia. Symptoms were rated with the Positive and Negative Syndrome Scale; everyday living skills were measured by the UCSD Performance-base...
Source: Schizophrenia Research - October 5, 2009 Category: Psychiatry Authors: Feea R. Leifker, Christopher R. Bowie, Philip D. Harvey Tags: Outcome in schizophrenia Source Type: journals

The Impact of developmental instability on voxel-based morphometry analyses of neuroanatomical abnormalities in SchizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The etiologic factors underlying schizophrenia have been conceptualized as reflecting two largely genetic components — those unique to schizophrenia and those representing vulnerability to neurodevelopmental deviation in general. The Developmental Instability (DI) approach suggests that the latter can be indexed by minor physical anomalies (MPAs), which assess early prenatal growth abnormalities, and fluctuating anatomic asymmetries (FA), which reflects later deviations. Individuals with schizophrenia (N=19) had elevated scores on both measures as compared to healthy controls (N=23). Further, MPAs and FA were v...
Source: Schizophrenia Research - October 5, 2009 Category: Psychiatry Authors: Matthew Euler, Robert J. Thoma, Steven W. Gangestad, Jose M. Cañive, Ronald A. Yeo Tags: Neurodevelopment and schizophrenia Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Schizophrenia Research)
Source: Schizophrenia Research - October 5, 2009 Category: Psychiatry Source Type: journals

Newer conceptualizations of schizophrenia demand a name changeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In their review, “Schizophrenia “just the facts” 4. Clinical features and conceptualization”, review the conceptualization of schizophrenia but state that the value of changing the name is “questionable” and “semantics”. I strongly disagree with this. The name schizophrenia needs to be urgently changed in the service of doctor patient communication, education and stigma reduction. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 5, 2009 Category: Psychiatry Authors: Tomer Trevor Levin Tags: Letters to the Editors Source Type: journals

Schizophrenia and the incidence of cardiovascular morbidity: A population-based longitudinal study in Ontario, CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Given the elevated risk of cardiovascular morbidity among individuals with schizophrenia, our findings add to the importance of screening and intervention programs for metabolic disorders and known cardiovascular risk factors among patients with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 5, 2009 Category: Psychiatry Authors: Russell C. Callaghan, Matthew D. Boire, Roberto G. Lazo, Kwame McKenzie, Tony Cohn Tags: Miscellaneous Source Type: journals

NPY mRNA expression in the prefrontal cortex: Selective reduction in the superficial white matter of subjects with schizoaffective disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings suggest that the alterations in SST-containing interneurons in schizophrenia and schizoaffective disorder are selective for the subset that do not express NPY mRNA, and that lower NPY mRNA expression in the superficial white matter may distinguish subjects with schizoaffective disorder from those with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 5, 2009 Category: Psychiatry Authors: Harvey M. Morris, Rachelle E. Stopczynski, David A. Lewis Tags: Genetics Source Type: journals

The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sampleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: DTNBP1 is associated with schizophrenia in many studies, but the associated alleles and haplotypes vary between samples.Method: We assessed nine single nucleotide polymorphisms (SNPs) in this gene for association with schizophrenia in a new sample of 1021 cases and 626 controls from Ireland.Results: Four SNPs give evidence of association (0.000018 (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 5, 2009 Category: Psychiatry Authors: Brien Riley, Po-Hsiu Kuo, Brion S. Maher, Ayman H. Fanous, Jingchun Sun, Brandon Wormley, F. Anthony O'Neill, Dermot Walsh, Zhongming Zhao, Kenneth S. Kendler Tags: Genetics Source Type: journals

Specific brain structural abnormalities in first-episode schizophrenia. A comparative study with patients with schizophreniform disorder, non-schizophrenic non-affective psychoses and healthy volunteers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigates the specificity of brain structural abnormalities in schizophrenia by using region-of-interest method of volumetric analysis in a heterogeneous sample of schizophrenia spectrum patients at their first break of the illness. 225 subjects, comprising 82 schizophrenia patients, 36 schizophreniform disorder patients and 24 patients with non-schizophrenic non-affective psychoses, and 83 healthy individuals underwent a magnetic resonance imaging brain scan. Quantitative brain morphometric variables were assessed: cortical CSF, lateral ventricle, total brain tissue, white matter and cortical and subcortical...
Source: Schizophrenia Research - October 5, 2009 Category: Psychiatry Authors: Benedicto Crespo-Facorro, Roberto Roiz-Santiáñez, Rocío Pérez-Iglesias, Diana Tordesillas-Gutiérrez, Ignacio Mata, José Manuel Rodríguez-Sánchez, Enrique Marco de Lucas, José Luis Vázquez-Barquero Tags: Brain structure and development Source Type: journals

Twin study of illness history variables in psychosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Illness history variables in psychosis show a broad range of familial aggregation. It is likely that familial influences are predominantly modifying effects, independent of susceptibility factors for psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 29, 2009 Category: Psychiatry Authors: Charlotte L. Allan, Alastair G. Cardno, Frühling V. Rijsdijk, Sridevi Kalidindi, Anne Farmer, Robin M. Murray, Peter McGuffin Tags: Genetics Source Type: journals

Symptomatic and functional outcome in youth at ultra-high risk for psychosis: A longitudinal studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The current report assesses the clinical, functioning and demographic data of a cohort enrolled in the P3 prevention program for psychosis; a Spanish National Health System and Ministry of Science funded program. Comparisons are made between those individuals who had converted to psychosis and those who had not at 3years after an average of 24 treatment sessions. Subjects included 61 participants meeting Structured Interview for Prodromal Syndromes criteria, with ages ranging from 17 to 31, and all meeting criteria for ultra-high risk of psychosis. Prospective follow-up data are reported for patients re-evaluated...
Source: Schizophrenia Research - September 29, 2009 Category: Psychiatry Authors: Serafín Lemos-Giráldez, Oscar Vallina-Fernández, Purificación Fernández-Iglesias, Guillermo Vallejo-Seco, Eduardo Fonseca-Pedrero, Mercedes Paíno-Piñeiro, Susana Sierra-Baigrie, Pilar García-Pelayo, Clara Pedrejón-Molino, Sandra Alonso-Bada, Ana Tags: Outcome studies Source Type: journals

Maternal age and paternal age are associated with distinct childhood behavioural outcomes in a general population birth cohortEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: Recent studies show that advanced paternal age (APA) is associated with an increased risk of neurodevelopmental disorders such as autism, bipolar disorder and schizophrenia. A body of evidence also suggests that individuals who develop schizophrenia show subtle deviations in a range of behavioural domains during their childhood. The aim of the study was to examine the relationship between paternal and maternal ages and selected behavioural measures in children using a large birth cohort.Method: Participants were singleton children (n=21,753) drawn from the US Collaborative Perinatal Project. The outco...
Source: Schizophrenia Research - September 25, 2009 Category: Psychiatry Authors: Sukanta Saha, Adrian G. Barnett, Stephen L. Buka, John J. McGrath Tags: Outcome studies Source Type: journals

Motivation and its Relationship to Neurocognition, Social Cognition, and Functional Outcome in SchizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Findings in the present study indicate that motivation plays a significant and mediating role between neurocognition, social cognition, and functional outcome. Potential psychosocial treatment implications are discussed, especially those that emphasize social cognitive and motivational enhancement. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 23, 2009 Category: Psychiatry Authors: David E. Gard, Melissa Fisher, Coleman Garrett, Alexander Genevsky, Sophia Vinogradov Tags: Outcome in schizophrenia Source Type: journals

Depth of the olfactory sulcus: A marker of early embryonic disruption in schizophrenia?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Embryonic insults during early gestation increase the risk of schizophrenia. Abnormal forebrain development during this period is often characterized by a shallow olfactory sulcus. The adjacent orbital sulcus does not develop until the third trimester and so is immune to early intrauterine insults. We measured olfactory and orbital sulcal depths in 36 patients and 28 control subjects. Patients had shallower olfactory sulci, but normal orbital sulci. Olfactory and orbital sulcal depths were correlated in controls, but not in patients. Olfactory sulcal depth may therefore be a biomarker denoting an early embryonic ...
Source: Schizophrenia Research - September 22, 2009 Category: Psychiatry Authors: Bruce I. Turetsky, Patrick Crutchley, Jeffrey Walker, Raquel E. Gur, Paul J. Moberg Tags: Neurodevelopment and schizophrenia Source Type: journals

The effects of antipsychotic medications on emotion perception in patients with chronic schizophrenia in the CATIE trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Few pharmacological intervention studies have examined the impact of medication on social cognition, particularly emotion perception. The goal of this randomized, double-blind study is to compare the effects of several second generation antipsychotics and a first generation antipsychotic, perphenazine, on emotion perception in individuals with schizophrenia. Patients were assigned to receive treatment with olanzapine, queitapine fumarate, risperidone, ziprasidone or perphenazine for up to 18months. Eight hundred and seventy three patients completed an emotion perception test immediately prior to randomization and...
Source: Schizophrenia Research - September 21, 2009 Category: Psychiatry Authors: David L. Penn, Richard S.E. Keefe, Sonia M. Davis, Piper S. Meyer, Diana O. Perkins, Diane Losardo, Jeffrey A. Lieberman Tags: Effects of neuroleptics Source Type: journals

Striatal metabolic alterations in non-psychotic adolescent offspring at risk for schizophrenia: A 1H spectroscopy studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In vivo proton (1H) Magnetic Resonance spectroscopy (1H MRS) has shown abnormalities in young first-episode patients with schizophrenia. It is unclear whether these abnormalities reflect trait related vs. state related alterations in schizophrenia. We compared young first-degree relatives of schizophrenia patients and healthy controls using 1H MRS. We hypothesized alterations in the 1H MRS metabolites N-acetyl aspartate (NAA) and glutamate in corticostriatal and thalamic brain regions. We obtained multi-voxel, short-TE 1H MRS measurements at 1.5 Tesla in 40 consenting adolescent offspring at risk for schizophreni...
Source: Schizophrenia Research - September 13, 2009 Category: Psychiatry Authors: Matcheri S. Keshavan, Rachel M. Dick, Vaibhav A. Diwadkar, Debra M. Montrose, Konasale M. Prasad, Jeffrey A. Stanley Tags: High-risk cohort studies Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Schizophrenia Research)
Source: Schizophrenia Research - September 11, 2009 Category: Psychiatry Source Type: journals

Corrigendum to “Extended release metfomin for metabolic control assistance during prolonged clozapine administration: A 14week, double-blind, parallel group, placebo-controlled study” [Schizophr. Res. 113 (1) (2009) 19–26]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors recently reported that extended release metformin administration for 14weeks significantly decreased body weight, serum insulin and the trygliceride/HDL-C ratio in patients undergoing prolonged clozapine administration (). We did not provide the gender distribution in this study, and it is a relevant data by itself, and for future comparisons. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 9, 2009 Category: Psychiatry Authors: Edgardo Carrizo, Virginia Fernández, Ignacio Sandia, Dexy Prieto, Johana Mogollón, Lisette Connel, Dennys Valbuena, Iliana Fernández, Enma Araujo de Baptista, Trino Baptista Tags: Corrigendum Source Type: journals

Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Bi-acetylated l-stepholidine (l-SPD-A), a novel derivate of l-stepholidine (l-SPD), possesses a pharmacological profile of D1/5-HT1A agonism and D2 antagonism. In the present study, we examined the potential antipsychotic effect of l-SPD-A in a phencyclidine (PCP)-induced rat model of schizophrenia. Pretreatment with l-SPD-A blocked acute PCP-induced hyperlocomotion and reversed prepulse inhibition (PPI) deficits. Chronic l-SPD-A administration (i.p., 10mg/kg/day for 14days) improved social interaction and novel object recognition impairments in rats that were pretreated with PCP (i.p., 5mg/kg/day for 14days). Mo...
Source: Schizophrenia Research - September 9, 2009 Category: Psychiatry Authors: Yang Guo, Hai Zhang, Xuetao Chen, Wenxian Cai, Jianjun Cheng, Yushe Yang, Guozhang Jin, Xuechu Zhen Tags: Effects of neuroleptics Source Type: journals

Listing of metabolic changes in healthy volunteers receiving orally dissolving olanzapine or oral olanzapine: Data from a clinical study that was terminated earlyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Weight loss has been reported in patients switching treatment from olanzapine (OLZ) in the standard oral tablet formulation to OLZ in the orally disintegrating tablet formulation. (). Significant differences in weight change between patients treated with the standard oral tablets and patients treated with the orally disintegrating tablets have also been observed (). However, results from the Placebo and Active Comparator Trial of Olanzapine Zydis Pills Used Sublingually (PLATYPUS), a larger double-blind, double-dummy study comparing these 2 formulations, found no significant difference between treatment groups in mean weig...
Source: Schizophrenia Research - September 7, 2009 Category: Psychiatry Authors: Vicki Poole Hoffmann, Michael Case, Jennie G. Jacobson, Jennie Lin Francis Tags: Letters to the Editors Source Type: journals

Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Grey matter volume of the frontal, temporal, parietal and cerebellar areas that are known to be involved in the co-ordination of mental activity, cognitive flexibility, and verbal learning and memory predict responsiveness to CBTp in patients with psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 7, 2009 Category: Psychiatry Authors: Preethi Premkumar, Dominic Fannon, Elizabeth Kuipers, Emmanuelle R. Peters, Ananatha P.P. Anilkumar, Andrew Simmons, Veena Kumari Tags: The metabolic syndrome Source Type: journals

Abnormal thalamic glutamate and liability to psychosis: State or trait marker?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with interest the article by recently published in Schizophrenia Research. The authors used proton magnetic resonance spectroscopy (H-MRS) to acquire absolute concentrations of brain metabolites in subjects with a high genetic risk of schizophrenia to investigate the potential relationship between genetic liability to schizophrenia and neuronal dysfunction. Relative to the controls, the high genetic risk group showed significant reduction in absolute metabolite levels in the N-acetylaspartate (NAA), creatine, and choline spectra of the thalamus, while no differences in metabolite concentrations were observed in the...
Source: Schizophrenia Research - September 6, 2009 Category: Psychiatry Authors: J.M. Stone, P. Fusar-Poli Tags: Letter to the Editors Source Type: journals

General absence of abnormal cortical asymmetry in childhood-onset schizophrenia: A longitudinal studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present findings do not support asymmetry differences for this severe, early form of schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 6, 2009 Category: Psychiatry Authors: Jennifer L. Bakalar, Deanna K. Greenstein, Liv Clasen, Julia W. Tossell, Rachel Miller, Alan C. Evans, Anand A. Mattai, Judith L. Rapoport, Nitin Gogtay Tags: Neurodevelopment and schizophrenia Source Type: journals

Recovery from schizophrenia: Results from a 1-year follow-up observational study of patients in symptomatic remissionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The proportion of patients in recovery increased among those fulfilling SR criteria. After 1year, in addition to known factors like shorter DUP and better PA, social cognitive abilities and depressive symptoms were found to correlate with recovery. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 2, 2009 Category: Psychiatry Authors: Julio Bobes, Antonio Ciudad, Enric Álvarez, Luis San, Pepa Polavieja, Inmaculada Gilaberte Tags: Outcome in schizophrenia Source Type: journals

Resequencing and association study of vesicular glutamate transporter 1 gene (VGLUT1) with schizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we searched for genetic variants in the putative core promoter region and 12 exons (including UTR ends) of the VGLUT1 gene using direct sequencing in a sample of Han Chinese schizophrenic patients (n=376) and non-psychotic controls (n=368) from Taiwan, and conducted a case-control association study. We identified two common SNPs (g.-248G>C (ss159695612) and c.2697C>A (rs1043558)) in the VGLUT1 gene. No differences in the allele and genotype frequencies were detected between the patients and control subjects. Besides, we identified eight patient-specific rare variants in 16 out of 376 patients, including two ...
Source: Schizophrenia Research - September 1, 2009 Category: Psychiatry Authors: Yu-Chih Shen, Ding-Lieh Liao, Jen-Yeu Chen, Ying-Chieh Wang, I-Ching Lai, Ying-Jay Liou, Yu-Jun Chen, Sy-Ueng Luu, Chia-Hsiang Chen Tags: Genetics Source Type: journals

Increased unconscious semantic activation in schizophrenia patients with formal thought disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Formal thought disorder (TD) is a core symptom in schizophrenia, but the underlying neurocognitive mechanisms have yet to be determined. This pilot study tested the hypothesis that unconscious semantic activation in conceptual memory is increased in thought disordered patients with schizophrenia. Twenty-eight right-handed individuals with a DSM-IV diagnosis of schizophrenia or schizophreniform disorder (2 patients) and 14 healthy comparison participants performed lexical decisions on target words that were preceded by semantically related and unrelated unconsciously perceived masked prime words (masked priming pa...
Source: Schizophrenia Research - August 27, 2009 Category: Psychiatry Authors: Markus Kiefer, Ulla Martens, Matthias Weisbrod, Leo Hermle, Manfred Spitzer Tags: Cognition Source Type: journals