Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules | Science
Tubulin, one of the most abundant cytoskeletal building blocks, has numerous isotypes in metazoans encoded by different conserved genes. Whether these distinct isotypes form cell type – and context-specific microtubule structures is poorly understood. ... (Source: Science: Current Issue)
Source: Science: Current Issue - April 26, 2024 Category: Science Source Type: research
Sequence basis of transcription initiation in the human genome | Science
Transcription initiation is a process that is essential to ensuring the proper function of any gene, yet we still lack a unified understanding of sequence patterns and rules that explain most transcription start sites in the human genome. By predicting ... (Source: Science: Current Issue)
Source: Science: Current Issue - April 26, 2024 Category: Science Source Type: research
Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts | Science
Organisms exhibit extensive variation in ecological niche breadth, from very narrow (specialists) to very broad (generalists). Two general paradigms have been proposed to explain this variation: (i) trade-offs between performance efficiency and breadth ... (Source: Science: Current Issue)
Source: Science: Current Issue - April 26, 2024 Category: Science Source Type: research
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells | Science
Chemical modulation of proteins enables a mechanistic understanding of biology and represents the foundation of most therapeutics. However, despite decades of research, 80% of the human proteome lacks functional ligands. Chemical proteomics has advanced ... (Source: Science: Current Issue)
Source: Science: Current Issue - April 26, 2024 Category: Science Source Type: research
Science needs neurodiversity | Science
All brains work differently. Individuals process information and engage with the world in ways that are influenced by a multitude of biological, cultural, and social factors. In the world of science, these differences are what spark innovation. This is ... (Source: Science: Current Issue)
Source: Science: Current Issue - April 25, 2024 Category: Science Source Type: research
A sound beginning of life starts before birth | Science
Long-term impact from prenatal noise exposure in birds should raise general concern (Source: Science: Current Issue)
Source: Science: Current Issue - April 25, 2024 Category: Science Source Type: research
How DNA encodes the start of transcription | Science
A deep-learning model reveals the rules that define transcription initiation (Source: Science: Current Issue)
Source: Science: Current Issue - April 25, 2024 Category: Science Source Type: research
Microbes and vitamin D aid immunotherapy | Science
Vitamin D modulates intestinal epithelial cell function to enhance antitumor microbes (Source: Science: Current Issue)
Source: Science: Current Issue - April 25, 2024 Category: Science Source Type: research
Developing future nanomedicines | Science
Quantitative analysis of biodistribution and clearance may improve nanoparticle development (Source: Science: Current Issue)
Source: Science: Current Issue - April 25, 2024 Category: Science Source Type: research
Frans de Waal (1948 –2024) | Science
Primatologist who brought animals and humans “a little closer” (Source: Science: Current Issue)
Source: Science: Current Issue - April 25, 2024 Category: Science Source Type: research
Corporate emissions targets and the neglect of future innovators | Science
Targets can distort competition in favor of incumbent firms (Source: Science: Current Issue)
Source: Science: Current Issue - April 25, 2024 Category: Science Source Type: research
Sustainable justice | Science
The needs of marginalized groups must be central to sustainability goals, argues a sociologist (Source: Science: Current Issue)
Source: Science: Current Issue - April 25, 2024 Category: Science Source Type: research
Data, death, and what comes next | Science
A scholar outlines how to respect the digital traces the dead leave behind (Source: Science: Current Issue)
Source: Science: Current Issue - April 25, 2024 Category: Science Source Type: research
A future to look forward to | Science
HomeScienceVol. 384, No. 6694A future to look forward toBack To Vol. 384, No. 6694 Full accessBooks et al.Podcast Share on A future to look forward toScience25 Apr 2024Vol 384, Issue 6694p. 392DOI: 10.1126/science.adp6426 PREVIOUS ARTICLEData, death, and what comes nextPreviousNEXT ARTICLEDangers of disposable electronic devicesNext ContentsInformation& AuthorsMetrics& CitationsView OptionsRe … (Source: Science: Current Issue)
Source: Science: Current Issue - April 25, 2024 Category: Science Source Type: research
Dangers of disposable electronic devices | Science
HomeScienceVol. 384, No. 6694Dangers of disposable electronic devicesBack To Vol. 384, No. 6694 Full accessLetter Share on Dangers of disposable electronic devicesLaura Young [email protected], Sue Dawson, [...] , David Lavallee, Mark Midownik, [...] , Imogen Napper, Richard Thompson, and Rebecca Wade+4 authors +2 authors fewerAuthors Info& AffiliationsScience25 Apr 2024Vol 384, Issue 6694p. 393 … (Source: Science: Current Issue)
Source: Science: Current Issue - April 25, 2024 Category: Science Source Type: research
