EGFR-dependent endocytosis of Wnt9a and Fzd9b promotes β-catenin signaling during hematopoietic stem cell development in zebrafish
Sci Signal. 2024 Apr 16;17(832):eadf4299. doi: 10.1126/scisignal.adf4299. Epub 2024 Apr 16.ABSTRACTCell-to-cell communication through secreted Wnt ligands that bind to members of the Frizzled (Fzd) family of transmembrane receptors is critical for development and homeostasis. Wnt9a signals through Fzd9b, the co-receptor LRP5 or LRP6 (LRP5/6), and the epidermal growth factor receptor (EGFR) to promote early proliferation of zebrafish and human hematopoietic stem cells during development. Here, we developed fluorescently labeled, biologically active Wnt9a and Fzd9b fusion proteins to demonstrate that EGFR-dependent endocytos...
Source: Science Signaling - April 16, 2024 Category: Biomedical Science Authors: Nicole Nguyen Kelsey A Carpenter Jessica Ensing Carla Gilliland Emma J Rudisel Emily M Mu Kate E Thurlow Timothy J Triche Stephanie Grainger Source Type: research
Taking down tumors takes atypical integrins
Sci Signal. 2024 Apr 16;17(832):eadp7684. doi: 10.1126/scisignal.adp7684. Epub 2024 Apr 16.ABSTRACTAn unexpected integrin pairing enhances T cell receptor signaling and cytotoxicity in antitumor T cells.PMID:38626008 | DOI:10.1126/scisignal.adp7684 (Source: Science Signaling)
Source: Science Signaling - April 16, 2024 Category: Biomedical Science Authors: John F Foley Source Type: research
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens
Sci Signal. 2024 Apr 16;17(832):eadl4738. doi: 10.1126/scisignal.adl4738. Epub 2024 Apr 16.ABSTRACTCocaine use disorder (CUD) is a chronic neuropsychiatric condition that results from enduring cellular and molecular adaptations. Among substance use disorders, CUD is notable for its rising prevalence and the lack of approved pharmacotherapies. The nucleus accumbens (NAc), a region that is integral to the brain's reward circuitry, plays a crucial role in the initiation and continuation of maladaptive behaviors that are intrinsic to CUD. Leveraging advancements in neuroproteomics, we undertook a proteomic analysis that spanne...
Source: Science Signaling - April 16, 2024 Category: Biomedical Science Authors: Philipp Mews Lucas Sosnick Ashik Gurung Simone Sidoli Eric J Nestler Source Type: research
EGFR-dependent endocytosis of Wnt9a and Fzd9b promotes β-catenin signaling during hematopoietic stem cell development in zebrafish
Sci Signal. 2024 Apr 16;17(832):eadf4299. doi: 10.1126/scisignal.adf4299. Epub 2024 Apr 16.ABSTRACTCell-to-cell communication through secreted Wnt ligands that bind to members of the Frizzled (Fzd) family of transmembrane receptors is critical for development and homeostasis. Wnt9a signals through Fzd9b, the co-receptor LRP5 or LRP6 (LRP5/6), and the epidermal growth factor receptor (EGFR) to promote early proliferation of zebrafish and human hematopoietic stem cells during development. Here, we developed fluorescently labeled, biologically active Wnt9a and Fzd9b fusion proteins to demonstrate that EGFR-dependent endocytos...
Source: Science Signaling - April 16, 2024 Category: Biomedical Science Authors: Nicole Nguyen Kelsey A Carpenter Jessica Ensing Carla Gilliland Emma J Rudisel Emily M Mu Kate E Thurlow Timothy J Triche Stephanie Grainger Source Type: research
Taking down tumors takes atypical integrins
Sci Signal. 2024 Apr 16;17(832):eadp7684. doi: 10.1126/scisignal.adp7684. Epub 2024 Apr 16.ABSTRACTAn unexpected integrin pairing enhances T cell receptor signaling and cytotoxicity in antitumor T cells.PMID:38626008 | DOI:10.1126/scisignal.adp7684 (Source: Science Signaling)
Source: Science Signaling - April 16, 2024 Category: Biomedical Science Authors: John F Foley Source Type: research
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens
Sci Signal. 2024 Apr 16;17(832):eadl4738. doi: 10.1126/scisignal.adl4738. Epub 2024 Apr 16.ABSTRACTCocaine use disorder (CUD) is a chronic neuropsychiatric condition that results from enduring cellular and molecular adaptations. Among substance use disorders, CUD is notable for its rising prevalence and the lack of approved pharmacotherapies. The nucleus accumbens (NAc), a region that is integral to the brain's reward circuitry, plays a crucial role in the initiation and continuation of maladaptive behaviors that are intrinsic to CUD. Leveraging advancements in neuroproteomics, we undertook a proteomic analysis that spanne...
Source: Science Signaling - April 16, 2024 Category: Biomedical Science Authors: Philipp Mews Lucas Sosnick Ashik Gurung Simone Sidoli Eric J Nestler Source Type: research
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition
Sci Signal. 2024 Apr 9;17(831):eadh1922. doi: 10.1126/scisignal.adh1922. Epub 2024 Apr 9.ABSTRACTAndrogen deprivation therapy (ADT) is the primary treatment for prostate cancer; however, resistance to ADT invariably develops, leading to castration-resistant prostate cancer (CRPC). Prostate cancer progression is marked by increased de novo synthesis of fatty acids due to overexpression of fatty acid synthase (FASN), making this enzyme a therapeutic target for prostate cancer. Inhibition of FASN results in increased intracellular amounts of ceramides and sphingomyelin, leading to DNA damage through the formation of DNA doubl...
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Caroline Fidalgo Ribeiro Silvia Rodrigues Debora Campanella Bastos Giuseppe Nicol ò Fanelli Hubert Pakula Marco Foiani Giorgia Zadra Massimo Loda Source Type: research
Sensing stretch to suppress appetite
Sci Signal. 2024 Apr 9;17(831):eadp6031. doi: 10.1126/scisignal.adp6031. Epub 2024 Apr 9.ABSTRACTFood intake activates a mechanosensitive ion channel that inhibits ghrelin production and reduces appetite.PMID:38593155 | DOI:10.1126/scisignal.adp6031 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wei Wong Source Type: research
Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection
This study reveals a previously unrecognized function of Miz1 in regulating antiviral defense and a potential mechanism for influenza viruses to evade host immune defense.PMID:38593156 | DOI:10.1126/scisignal.adg7867 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wenjiao Wu Vinothini Arunagiri Hanh Chi Do-Umehara Cong Chen Shuyin Gu Indrani Biswas Karen M Ridge G R Scott Budinger Shuwen Liu Jing Liu Source Type: research
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition
Sci Signal. 2024 Apr 9;17(831):eadh1922. doi: 10.1126/scisignal.adh1922. Epub 2024 Apr 9.ABSTRACTAndrogen deprivation therapy (ADT) is the primary treatment for prostate cancer; however, resistance to ADT invariably develops, leading to castration-resistant prostate cancer (CRPC). Prostate cancer progression is marked by increased de novo synthesis of fatty acids due to overexpression of fatty acid synthase (FASN), making this enzyme a therapeutic target for prostate cancer. Inhibition of FASN results in increased intracellular amounts of ceramides and sphingomyelin, leading to DNA damage through the formation of DNA doubl...
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Caroline Fidalgo Ribeiro Silvia Rodrigues Debora Campanella Bastos Giuseppe Nicol ò Fanelli Hubert Pakula Marco Foiani Giorgia Zadra Massimo Loda Source Type: research
Sensing stretch to suppress appetite
Sci Signal. 2024 Apr 9;17(831):eadp6031. doi: 10.1126/scisignal.adp6031. Epub 2024 Apr 9.ABSTRACTFood intake activates a mechanosensitive ion channel that inhibits ghrelin production and reduces appetite.PMID:38593155 | DOI:10.1126/scisignal.adp6031 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wei Wong Source Type: research
Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection
This study reveals a previously unrecognized function of Miz1 in regulating antiviral defense and a potential mechanism for influenza viruses to evade host immune defense.PMID:38593156 | DOI:10.1126/scisignal.adg7867 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wenjiao Wu Vinothini Arunagiri Hanh Chi Do-Umehara Cong Chen Shuyin Gu Indrani Biswas Karen M Ridge G R Scott Budinger Shuwen Liu Jing Liu Source Type: research
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition
Sci Signal. 2024 Apr 9;17(831):eadh1922. doi: 10.1126/scisignal.adh1922. Epub 2024 Apr 9.ABSTRACTAndrogen deprivation therapy (ADT) is the primary treatment for prostate cancer; however, resistance to ADT invariably develops, leading to castration-resistant prostate cancer (CRPC). Prostate cancer progression is marked by increased de novo synthesis of fatty acids due to overexpression of fatty acid synthase (FASN), making this enzyme a therapeutic target for prostate cancer. Inhibition of FASN results in increased intracellular amounts of ceramides and sphingomyelin, leading to DNA damage through the formation of DNA doubl...
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Caroline Fidalgo Ribeiro Silvia Rodrigues Debora Campanella Bastos Giuseppe Nicol ò Fanelli Hubert Pakula Marco Foiani Giorgia Zadra Massimo Loda Source Type: research
Sensing stretch to suppress appetite
Sci Signal. 2024 Apr 9;17(831):eadp6031. doi: 10.1126/scisignal.adp6031. Epub 2024 Apr 9.ABSTRACTFood intake activates a mechanosensitive ion channel that inhibits ghrelin production and reduces appetite.PMID:38593155 | DOI:10.1126/scisignal.adp6031 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wei Wong Source Type: research
Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection
This study reveals a previously unrecognized function of Miz1 in regulating antiviral defense and a potential mechanism for influenza viruses to evade host immune defense.PMID:38593156 | DOI:10.1126/scisignal.adg7867 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wenjiao Wu Vinothini Arunagiri Hanh Chi Do-Umehara Cong Chen Shuyin Gu Indrani Biswas Karen M Ridge G R Scott Budinger Shuwen Liu Jing Liu Source Type: research
