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[NEWS FOCUS] Death-Bed ProphecyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On the eve of its termination, SAGE KE takes a look at the future of research on aging.
Source: Science of Aging Knowledge Environment - February 5, 2007 Category: Science Authors: Mitch Leslie Source Type: journals

[REVIEW] Targeting the Role of the Endosome in the Pathophysiology of Alzheimer's Disease: A Strategy for TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alzheimer's disease-associated endosomal abnormalities might provide a route for drug-based interventions.
Source: Science of Aging Knowledge Environment - February 5, 2007 Category: Science Authors: Barbara A. Tate and Paul M. Mathews Source Type: journals

[CASE STUDY] Dementia with Cerebrovascular DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A case study.
Source: Science of Aging Knowledge Environment - February 5, 2007 Category: Science Authors: Clinton B. Wright, Jean Paul G. Vonsattel, Karen Bell, and Lawrence S. Honig Source Type: journals

[PERSPECTIVE] WRN's Tenth AnniversaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
What have we learned about RecQ helicase function in a segmental progeroid syndrome and normal aging?
Source: Science of Aging Knowledge Environment - February 5, 2007 Category: Science Authors: Fuki M. Hisama, Vilhelm A. Bohr, and Junko Oshima Source Type: journals

[PERSPECTIVE] The Unusual Genetics of Human LongevityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Centenarians provide a unique opportunity for understanding "longevity genes."
Source: Science of Aging Knowledge Environment - February 5, 2007 Category: Science Authors: Giovanna De Benedictis and Claudio Franceschi Source Type: journals

[PERSPECTIVE] Aging On the JobEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As the population ages, will the workforce decline along with it?
Source: Science of Aging Knowledge Environment - February 5, 2007 Category: Science Authors: James Levine, Justin Heet, and Barbara Burlingame Source Type: journals

[PERSPECTIVE] The Role of Mitochondria in Conserved Mechanisms of AgingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Report from the second "MiMage" symposium describes research on a variety of systems.
Source: Science of Aging Knowledge Environment - February 5, 2007 Category: Science Authors: Christian Scheckhuber and Heinz D. Osiewacz Source Type: journals

[PERSPECTIVE] Developing a Research Agenda in Biogerontology: Physiological SystemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Research supported by the National Institute on Aging aims to understanding the biology of aging tissues.
Source: Science of Aging Knowledge Environment - February 5, 2007 Category: Science Authors: Jill L. Carrington and Francis L. Bellino Source Type: journals

[PERSPECTIVE] From Bedside to Bench: Does Mental and Physical Activity Promote Cognitive Vitality in Late Life?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conference looks at the role of exercise for promoting mental health and delaying dementia.
Source: Science of Aging Knowledge Environment - February 5, 2007 Category: Science Authors: Stephanie Studenski, Michelle C. Carlson, Howard Fillit, William T. Greenough, Arthur Kramer, and George W. Rebok Source Type: journals

[PERSPECTIVE] A Work in Progress: The Metabolic SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Should we diagnose and treat the metabolic syndrome?
Source: Science of Aging Knowledge Environment - February 5, 2007 Category: Science Authors: Jose A. Luchsinger Source Type: journals

[CLASSIC PAPER] Mutation Selection and the Natural History of CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature 255, 197 (1975).
Source: Science of Aging Knowledge Environment - February 5, 2007 Category: Science Authors: John Cairns Source Type: journals

Papers of NoteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
See what the SAGEKE editors selected as the most exciting research in the field of aging.
Source: Science of Aging Knowledge Environment - February 5, 2007 Category: Science Authors: Heather McDonald (mailto:hmcdonal at aaas.org) Source Type: journals

[VIEWPOINT] I Come Not to Bury SAGE KE, but to Appraise ItEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One of the site's creators tells a personal story of its rise and demise.
Source: Science of Aging Knowledge Environment - June 29, 2006 Category: Science Authors: Heather McDonald (mailto:hmcdonal at aaas.org) Evelyn Strauss Source Type: journals

Experimental Rodent StrainsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Check out the biological characteristics of inbred and hybrid strains used to study aging.
Source: Science of Aging Knowledge Environment - June 22, 2006 Category: Science Authors: Heather McDonald (mailto:hmcdonal at aaas.org) Source Type: journals

Classic PapersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
View historical (pre-1990) articles on aging-related topics.
Source: Science of Aging Knowledge Environment - June 21, 2006 Category: Science Source Type: journals

[PERSPECTIVE] Aging at the Interface of Stem Cell Renewal, Apoptosis, Senescence, and CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists apply systems biology approaches to the field of aging-related research.
Source: Science of Aging Knowledge Environment - June 16, 2006 Category: Science Authors: Heather McDonald (mailto:hmcdonal at aaas.org) Almut Nebel, Elke Schaffitzel, and Maren Hertweck Source Type: journals

[CLASSIC PAPER] Pleiotropy, Natural Selection, and the Evolution of SenescenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The author discusses his theory of senescence; Evolution 11, 398 (1957).
Source: Science of Aging Knowledge Environment - June 16, 2006 Category: Science Authors: G. C. Williams Source Type: journals

[NEWS FOCUS] Pushing the EnvelopeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Research blossoms on rare genetic disorders that might be linked to aging.
Source: Science of Aging Knowledge Environment - June 1, 2006 Category: Science Authors: Heather McDonald (mailto:hmcdonal at aaas.org) Mitch Leslie Source Type: journals

[CLASSIC PAPER] The Maintenance of the Accuracy of Protein Synthesis and Its Relevance to AgingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The author discusses the "error catastrophe" hypothesis; Proc. Natl. Acad. Sci. U.S.A. 49, 517 (1963).
Source: Science of Aging Knowledge Environment - May 31, 2006 Category: Science Authors: L. E. Orgel Source Type: journals

[PERSPECTIVE] Stem Cell Aging and CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Do stem cells age? Cancer studies may bring us closer to an answer.
Source: Science of Aging Knowledge Environment - May 30, 2006 Category: Science Authors: Heather McDonald (mailto:hmcdonal at aaas.org) Jennifer Fuller Source Type: journals

[PERSPECTIVE] The Age of Skin CancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Why are older men at greater risk for melanoma than older women?
Source: Science of Aging Knowledge Environment - May 29, 2006 Category: Science Authors: Anu Desai, Richard Krathen, Ida Orengo, and Estela E. Medrano Source Type: journals

[NEWS FOCUS] Shortcut to DeathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stubby protein spurs cancer cells to eat themselves.
Source: Science of Aging Knowledge Environment - May 29, 2006 Category: Science Authors: Mitch Leslie Source Type: journals

Papers of NoteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
See what the SAGEKE editors selected as the most exciting research in the field of aging.
Source: Science of Aging Knowledge Environment - May 29, 2006 Category: Science Source Type: journals