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Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - October 16, 2009 Category: Neurology Source Type: journals

Language assessment in Wada test: Comparison of methohexital and amobarbitalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of our study was to compare the use of methohexital and amobarbital during Wada testing regarding language and memory lateralization quotients as well as speech arrest times.Methods: A chart review of 582 consecutive patients undergoing 1041 Wada-procedures was performed (left=60, right=63, bilateral=459). Language lateralization was calculated based on duration of speech arrest using a laterality index, defined as (L−R)/(L+R). Memory lateralization was expressed as percentage of retained objects and laterality quotient.Results: Language and memory lateralization revealed a similar distribution with amobarb...
Source: Seizure: European Journal of Epilepsy - October 4, 2009 Category: Neurology Authors: Tobias Loddenkemper, Gabriel Möddel, Dudley S. Dinner, Hyunmi Kim, Stephan U. Schuele, Andreas V. Alexopoulos, Prakash Kotagal, Hans O. Lüders Tags: Short Communications Source Type: journals

Patients visiting the emergency room for seizures: Insurance status and clinic follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: Repeated use of the ER for seizures was more common in the county hospital, where the proportion of uninsured patients was also higher. Patients visiting the county hospital ER repeatedly tend not to follow-up in the neurology clinic. This element of disparity of care requires further attention. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - September 23, 2009 Category: Neurology Authors: Fariba Farhidvash, Pradumna Singh, Bassel Abou-Khalil, Amir Arain Tags: Regular Articles Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - September 7, 2009 Category: Neurology Source Type: journals

Preoperative IQ predicts seizure outcomes after anterior temporal lobectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In our study, IQ tests were unable to lateralize seizure foci but may serve as an independent predictor of postoperative seizure outcomes. Since a longer duration of epilepsy had deleterious effects on intelligence, earlier surgical intervention might better preserve neuropsychological function and, consequently, allow better seizure control after ATL. Nonetheless, patients with lower IQ scores could still benefit from ATL. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - August 25, 2009 Category: Neurology Authors: Hsiang-Yu Yu, Yang-Hsin Shih, Tung-Ping Su, Ker-Nen Lin, Chun-Hin Yiu, Yung-Yang Lin, Shang- Yeong Kwan, Chien Chen, Der-Jen Yen Tags: Regular Articles Source Type: journals

Analysis of factors influencing admission to intensive care following convulsive status epilepticus in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Younger age at presentation, administration of more than two doses of benzodiazepines and deviation from the CSE protocol appear to be factors which influence admission of children to ICU. Recognition of pre-hospital administration of benzodiazepines and adherence to therapeutic guidelines may reduce the need for ventilatory support in this group. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - August 24, 2009 Category: Neurology Authors: Sandya Tirupathi, Joseph B. McMenamin, David W. Webb Tags: Regular Articles Source Type: journals

Juvenile myoclonic epilepsy with photosensitivity in a female with Velocardiofacial syndrome (del(22)(q11.2))—Causal relationship or coincidence?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on an adolescent female with Velocardiofacial syndrome (del(22)(q11.2)) and an epilepsy phenotype resembling juvenile myoclonic epilepsy (JME). Clinically, the patient has characteristic signs of both disorders. JME has been linked to several chromosomes, but has not been related to 22q11.2 and is rarely observed in other genetic syndromes. We discuss possible explanations for a relationship between the chromosomal aberration and epilepsy as well as the importance of precise delineation of both epilepsy phenotypes and genetic defects in chromosomal disorders. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - August 19, 2009 Category: Neurology Authors: Johannes R. Lemke, Stefanie Beck-Wödl, Andreas Zankl, Mariluce Riegel, Günter Krämer, Thomas Dorn Tags: Case Study Source Type: journals

Outcome of surgical treatment in non-lesional intractable childhood epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In children with intractable epilepsy and a MRI demonstrating no abnormal lesions, epileptic surgery should be strongly considered when cortical pathology can be identified from other studies. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - August 16, 2009 Category: Neurology Authors: Joo Hee Seo, Byoung Ho Noh, Joon Soo Lee, Dong Suk Kim, Seung Koo Lee, Tae Seung Kim, Se Hoon Kim, Hoon Chul Kang, Heung Dong Kim Tags: Regular Articles Source Type: journals

Psychogenic non-epileptic seizures—Definition, etiology, treatment and prognostic issues: A critical reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In this review we systematically assess our currently available knowledge about psychogenic non-epileptic seizures (PNES) with an emphasis on the psychological mechanisms that underlie PNES, possibilities for psychological treatment as well as prognosis. Relevant studies were identified by searching the electronic databases. Case reports were not considered. 93 papers were identified; 65 of which were studies. An open non-randomized design, comparing patients with PNES to patients with epilepsy is the dominant design. A working definition for PNES is proposed. With respect to psychological etiology, a heterogeneo...
Source: Seizure: European Journal of Epilepsy - August 16, 2009 Category: Neurology Authors: N.M.G. Bodde, J.L. Brooks, G.A. Baker, P.A.J.M. Boon, J.G.M. Hendriksen, O.G. Mulder, A.P. Aldenkamp Tags: Reviews Source Type: journals

Microscopic mild focal cortical dysplasia in temporal lobe dual pathology: An electrocorticography studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Intraoperative electrocorticographic interictal spike frequency recorded in the neocortical inferior temporal gyrus may help to characterize the histopathologic subtypes of mild Palmini Type-I FCD in patients with temporal lobe epilepsy (TLE) and a dual pathology. Our data support the epileptogenicity of neocortical mild FCD in TLE and assessments of ECoG patterns are relevant to determine the extent of the resection in these patients which can influence the electroclinical outcome. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - August 12, 2009 Category: Neurology Authors: L. Morales Chacón, B. Estupiñán, L. Lorigados Pedre, O. Trápaga Quincoses, I. García Maeso, A. Sanchez, J. Bender del Busto, M.E. Garcia, M. Baez Martin, M. Zaldivar, A. Gómez, S. Orozco, L. Rocha Arrieta Tags: Regular Articles Source Type: journals

Retention rate of pregabalin in drug-resistant epilepsy: 1-year follow-up, single-centre observation in 105 consecutive, adult patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PGB is a new therapeutic option as add-on therapy for patients with highly refractory focal epilepsies although the therapeutic success that can be expected in this group of patients is limited. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - August 11, 2009 Category: Neurology Authors: Christian Brandt, Theodor W. May, Bernd Pohlmann-Eden, Esther Nieder, Heike Elsner, Karin Witte-Boelt, Inka Schuermann, Alois Ebner Tags: Regular Articles Source Type: journals

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(Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - August 11, 2009 Category: Neurology Source Type: journals

Seizures and EEG findings in an adult patient with DiGeorge syndrome: A case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: This is the first case report to describe the EEG findings in a patient with DiGeorge syndrome who survived into adulthood. The patient developed generalized tonic–clonic seizures when she was 9 years old and these were associated with hypocalcemia. Despite treatment with calcium, seizures persisted and the patient required antiepileptic medications. She was eventually controlled with oxcarbazepine. An MRI of the head was normal. An EEG showed independent spike and wave discharges emanating from the left temporal and right frontal region. The presence of focal findings on EEG, the lack of complete response to c...
Source: Seizure: European Journal of Epilepsy - August 9, 2009 Category: Neurology Authors: Walter González, Ramon Edmundo D. Bautista Tags: Short Communications Source Type: journals

Toward a definition of MEG spike: Parametric description of spikes recorded simultaneously by MEG and depth electrodesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides a parametric description and definition of clear-cut MEG spikes recorded simultaneously by MEG and depth electrodes (iEEG). A total number of 367 simultaneous MEG/iEEG spikes were selected for analysis. Distribution of morphologic spike parameters and detailed quantitative analysis of the basic morphologic characteristics of MEG spikes is provided. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - August 4, 2009 Category: Neurology Authors: Rafal Nowak, Marta Santiuste, Antonio Russi Tags: Short Communications Source Type: journals

Response to sequential treatment schedules in childhood epilepsy: Risk for development of refractory epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: After failing a first drug, a significant proportion of children can still be controlled with subsequent therapeutic schedules. Only a small proportion develops refractory epilepsy. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - August 4, 2009 Category: Neurology Authors: J. Ramos-Lizana, P. Aguilera-López, J. Aguirre-Rodríguez, E. Cassinello-García Tags: Regular Articles Source Type: journals

Levetiracetam has a time- and stimulation-dependent effect on synaptic transmissionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We recently reported that rodent hippocampal slices incubated with levetiracetam for 3h had altered responses to repetitive stimulation and reduced neurotransmitter release. However, our experiments failed to determine the actual time course of diminished transmission in individual slices followed over time. We have now been able to record from the same slices for up to 3h to determine the latency of the levetiracetam effect after the onset of exposure. Within 30min of levetiracetam exposure, the later field potentials of a burst were reduced. Between 60 and 180min the relative size of later field potentials rema...
Source: Seizure: European Journal of Epilepsy - August 2, 2009 Category: Neurology Authors: Xiao-Feng Yang, Steven M. Rothman Tags: Regular Articles Source Type: journals

Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed so as to characterize the interactions between levetiracetam (LEV) and the conventional antiepileptic drugs (AEDs) clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice by use of type II isobolographic analysis. Adverse-effect profiles of the drugs in combination were determined and brain AED concentrations were measured. The combinations of VPA and ETS with LEV at the fixed-ratio of 1:2, CZP with LEV (1:20,000), and PB with LEV (1:20) were supra-additive (synergistic) in suppressing seizures. In contrast...
Source: Seizure: European Journal of Epilepsy - July 23, 2009 Category: Neurology Authors: Monika Dudra-Jastrzebska, Marta M. Andres-Mach, Neville Ratnaraj, Philip N. Patsalos, Stanislaw J. Czuczwar, Jarogniew J. Luszczki Tags: Regular Articles Source Type: journals

Impact of Lennox-Gastaut Syndrome (LGS) on health-related quality of life (HRQL) of patients and caregivers: Literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The aim of this study was to conduct a review of the literature to evaluate the impact of LGS on the HRQL of children with LGS and their caregivers. The literature search revealed that there is limited published research on the impact of LGS on the HRQL of the child or caregiver. LGS has a major physical impact on a child, with a high frequency of seizures, and a high rate of seizure-related injuries. It interferes with all aspects of the child's intellectual and social development. The patient, and also his/her entire family are affected. Caring for a child with LGS is described as a ‘burden’, with increased...
Source: Seizure: European Journal of Epilepsy - July 9, 2009 Category: Neurology Authors: Katy Gallop, Diane Wild, Annabel Nixon, Lara Verdian, Joyce A. Cramer Tags: Reviews Source Type: journals

Seizure frequency in children with epilepsy: Factors influencing accuracy and parental awarenessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to ascertain the accuracy of clinical reports to determine the seizure frequency in children diagnosed with epilepsy.Methods: We reviewed the clinical record of 78 children (January–May of 2006) admitted to the EEG–video monitoring with epilepsy diagnosis. Clinical reports of parents and the files of EEG–video monitoring were reviewed to determine parents’ awareness for seizures.Results: During video–EEG monitoring, 1244 were recorded on 78 children. Seizures were confirmed in 1095 of which 472 were correctly reported (38%) by parents whereas 623 remained under-reported (50%). Pare...
Source: Seizure: European Journal of Epilepsy - July 9, 2009 Category: Neurology Authors: Cigdem Inan Akman, Maria A. Montenegro, Susan Jacob, Karen Eck, Claudia Chiriboga, Frank Gilliam Tags: Regular Articles Source Type: journals

Lamotrigine and twin pregnancy, incidental event or possible correlation?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is a case series report on 20 epileptic women who were receiving lamotrigine in their pregnancy. Apart from the normal pregnancies and births, in our study three patients gave birth to healthy twins, two vanished twin syndromes occurred and one patient had abortion. Twin pregnancy in association with lamotrigine therapy has not been clearly described before. Our observational study raises the idea that lamotrigine may induce twin pregnancy but larger studies need to investigate the presence or absence of such association more decently. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - July 8, 2009 Category: Neurology Authors: Mahmoud Motamedi, Sanaz Ahmadi Karvigh, Mohammad Ali Sahraian, Amir Reza Azimi, Samira Navardi Tags: Regular Articles Source Type: journals

Seizures in encephalitis: Predictors and outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In encephalitis, seizures occur in 42.6% patients especially in children with low GCS score and having cortical involvement on MRI. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - July 7, 2009 Category: Neurology Authors: U.K. Misra, J. Kalita Tags: Regular Articles Source Type: journals

Essential oils as a cause of breakthrough seizure after temporal lobectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a breakthrough seizure after temporal lobectomy secondary to topical administration of essential oils. We recommend inquiring about the use of essential oils in patients with well-controlled epilepsy who experience breakthrough seizures. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - July 5, 2009 Category: Neurology Authors: Ali M. Bozorg, Selim R. Benbadis Tags: Case Study Source Type: journals

The 1674+11C>T polymorphism of CHRNA4 is associated with juvenile myoclonic epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to explore an association of four polymorphisms of the CHRNA4 with JME in Polish children and young patients. The study included 92 JME patients and 222 unrelated healthy individuals. In each group the frequencies of the CHRNA4 c.555C>T, c.594C>T, 1674+11C>T, and 1674+14A>G polymorphisms were determined using PCR-RFLP analyses. An association between the 1674+11C>T polymorphism of the CHRNA4 and JME was evidenced. Allele T (the risk factor) appeared with a significantly higher frequency in the JME patients than in the controls (p=0.0299). The patients harboring the 1674+11CT+TT genotypes showed an i...
Source: Seizure: European Journal of Epilepsy - July 5, 2009 Category: Neurology Authors: Agata Rozycka, Barbara Steinborn, Wieslaw H. Trzeciak Tags: Short Communication Source Type: journals

Centro-median stimulation yields additional seizure frequency and attention improvement in patients previously submitted to callosotomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: All patients benefit from the procedure. The CM seems to play a role in modulating the epileptic discharges and attention in these patients. On the other hand, it is not the generator of the epileptic abnormality and appeared not to be involved in non-REM sleep-related interictal spiking modulation. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - July 5, 2009 Category: Neurology Authors: Arthur Cukiert, Jose Augusto Burattini, Cristine Mella Cukiert, Meire Argentoni-Baldochi, Carla Baise-Zung, Cássio Roberto Forster, Valeria Antakli Mello Tags: Regular Articles Source Type: journals

Antiepileptic drug treatment of children at a referral centre for epilepsy—Does admission make a difference?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Close comprehensive follow-up of children admitted to the referral centre, with main focus on optimalization of the pharmacological treatment, is of importance regarding quality of life aspects both to the children and their families. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - July 2, 2009 Category: Neurology Authors: Elisif Rytter, Cecilie Johannessen Landmark, Svein I. Johannessen Tags: Regular Articles Source Type: journals

Continuous bilateral infusion of GABA in the dorsomedian nucleus of the thalamus elevates the generalized seizure threshold in amygdala-kindled ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In order to assess the role of continuous intracerebral infusion of GABA over the propagation of generalized seizures from the amygdala, Wistar rats were subjected to a kindling procedure at the left basolateral amygdala. Subsequently, they were implanted with miniosmotic pumps filled with 100mg/mL of GABA in saline, connected to catheters whose tips were placed bilaterally at both dorsomedian nuclei of the thalamus (DMNT). The threshold intensity to provoke local afterdischarges (ADT) and generalized seizures (GST) were measured before, during and after GABA infusion, as well as seizure intensity and signs of at...
Source: Seizure: European Journal of Epilepsy - June 24, 2009 Category: Neurology Authors: José M. Gallego, Laura Ortiz, Rafael Gutiérrez, Juan A. Barcia Tags: Short Communication Source Type: journals

Rasmussen's encephalitis: Experience from a developing country based on a group of medically and surgically treated patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study from a developing country, in addition to substantiating the well known characteristics of RE, noted the following unusual findings: isolated lingual EPC abolished by focal cortical resection, bilateral RE, putaminal atrophy and absence of hemiparesis despite long standing disease. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - June 21, 2009 Category: Neurology Authors: K.N. Ramesha, B. Rajesh, R. Ashalatha, C. Kesavadas, M. Abraham, V.V. Radhakrishnan, P.S. Sarma, K. Radhakrishnan Tags: Regular Articles Source Type: journals

Differences in self-reported depressive symptoms between patients with epileptic and psychogenic nonepileptic seizuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study compared the self-reported depressive symptomatology of patients (n=60 ES and 59 PNES) who underwent video-EEG monitoring and completed self-reported objective measures of psychopathology (PAI and BDI-II). Differences in depressive symptoms were also compared by gender and among several subgroups with ES. Results revealed the PNES group, particularly PNES females, endorsed a significantly higher level of physiological symptoms of depression as measured by the PAI DEP-P subscale than the ES group; the BDI-II did not differ between groups. These findings have potential clinical implications for the identification ...
Source: Seizure: European Journal of Epilepsy - June 21, 2009 Category: Neurology Authors: Sarah B. Asmussen, Kristin A. Kirlin, Shawn D. Gale, Steve S. Chung Tags: Regular Articles Source Type: journals

Levetiracetam in children with refractory epilepsy: Lack of correlation between plasma concentration and efficacyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Levetiracetam given twice a day in children with refractory epilepsy reduces seizure frequency in all types of epilepsy. In children, LEV is a broad spectrum anticonvulsant with a favourable safety profile. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - June 21, 2009 Category: Neurology Authors: Patricia C. Giroux, Milagros Salas-Prato, Yves Théorêt, Lionel Carmant Tags: Regular Articles Source Type: journals

Manic/hypomanic symptoms and quality of life measures in patients with epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: MHS are associated with poor QoL measures in patients with epilepsy, though without differences in educational achievements, employment status and independent living. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - June 21, 2009 Category: Neurology Authors: Marco Mula, Regina Jauch, Andrea Cavanna, Laura Collimedaglia, Davide Barbagli, Verena Gaus, Rebekka Kretz, Michele Viana, Roberto Cantello, Francesco Monaco, Bettina Schmitz Tags: Regular Articles Source Type: journals

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(Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - June 17, 2009 Category: Neurology Source Type: journals

Gamma knife radiosurgery for the treatment of recurrent seizures after incomplete anterior temporal lobectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the safety and clinical efficacy of GKS make it a reasonable and suitable therapeutic alternative for patients with recurrent seizures after incomplete ATL. A higher marginal dose of >25Gy and wider coverage may be more clinically beneficial but warrant further investigation. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - June 7, 2009 Category: Neurology Authors: Der-Jen Yen, Wen-Yuh Chung, Yang-Hsin Shih, Chien Chen, Jiing-Feng Lirng, Chun-Hing Yiu, Hsiang-Yu Yu, Tung-Ping Su, David Hung-Chi Pan Tags: Regular Articles Source Type: journals

Calcineurin-mediated GABAA receptor dephosphorylation in rats after kainic acid-induced status epilepticusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Calcineurin (CaN) is a neuronally enriched, calcium-dependent phosphatase, which plays an important role in a number of neuronal processes including development of learning and memory, and modulation of receptor's function and neuronal excitability as well as induction of apoptosis. It has been established in kindling model that the status epilepticus (SE)-induced increase in CaN activity is involved in the development of seizures through down-regulation of γ-aminobutyric acid A receptor (GABAAR) activation. However, the mechanism by which CaN mediates GABAA receptor dephosphorylation in SE is not fully understo...
Source: Seizure: European Journal of Epilepsy - June 3, 2009 Category: Neurology Authors: Aihua Wang, Zhaofu Chi, Shengjun Wang, Shuhua Wang, Qinjian Sun Tags: Regular Articles Source Type: journals

Outcome after cortico-amygdalo-hippocampectomy in patients with severe bilateral mesial temporal sclerosis submitted to invasive recordingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present our experience while treating patients with severe bilateral MTS submitted to invasive recordings.Methods: Nine adult patients were studied. All patients had simple and complex partial seizures. All patients had bilateral independent interictal temporal lobe spiking and non-lateralizing video-EEG findings. MRI showed severe bilateral MTS and no other brain lesion. All patients had severe verbal and non-verbal memory deficits. All patients were submitted to invasive recordings after bilateral subdural grids implantation. Cortico-amygdalo-hippocampectomy (CAH) was performed in all patients on the side suggested by...
Source: Seizure: European Journal of Epilepsy - June 3, 2009 Category: Neurology Authors: Arthur Cukiert, Cristine Mella Cukiert, Meire Argentoni, Carla Baise-Zung, Cássio Roberto Forster, Valeria Antakli Mello, José Augusto Burattini, Pedro Paulo Mariani Tags: Regular Articles Source Type: journals

Postnatal caffeine treatment affects differently two pentylenetetrazol seizure models in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Effects of repeated postnatal administration of caffeine (10 and 20mg/kg s.c. daily from P7 to P11) were studied in two models of epileptic seizures characterized by spike-and-wave EEG rhythm in 18- and 25-day-old rats. Rhythmic metrazol activity (RMA, model of human absences) was induced by low dose of pentylenetetrazol (PTZ, 20mg/kg or 40mg/kg, i.p.) and minimal clonic seizures (model of human myoclonic seizures) by two successive doses of PTZ (20 and 40mg/kg i.p.). Early postnatal caffeine treatment resulted in significant changes of RMA only in 18-day-old rats. Anticonvulsant effects were observed in RMA epis...
Source: Seizure: European Journal of Epilepsy - June 2, 2009 Category: Neurology Authors: Jana Tchekalarova, Hana Kubová, Pavel Mareš Tags: Regular Articles Source Type: journals

Comment on: Linguistic and cognitive abnormalities in children with benign partial epilepsy with centro-temporal spikes (BCECTS)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We enjoyed reading the article by Völkl-Kernstock et al. entitled “Speech and school performance in children with benign partial epilepsy with centro-temporal spikes (BCECTS)”. The authors have evaluated a group of 20 children suffering from BCECTS with typical features both during the active disease and again 1 year after remission. A total of 8 patients (40%) had never received antiepileptic drug (AED) treatment, 12 (60%) were treated with sulthiame (STM). A group of healthy controls matched by age and gender was included in the statistical analysis. During the active phase, the patients showed impairments both in e...
Source: Seizure: European Journal of Epilepsy - May 31, 2009 Category: Neurology Authors: Alberto Verrotti, Sergio Agostinelli, Francesco Chiarelli Tags: Correspondence Source Type: journals

FLIP&FLAP—A training programme for children and adolescents with epilepsy, and their parentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: FLIP&FLAP is an effective child- and family-centred programme. It is currently being established in Northern Germany to test its usefulness in routine care. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 27, 2009 Category: Neurology Authors: S. Jantzen, E. Müller-Godeffroy, T. Hallfahrt-Krisl, F. Aksu, B. Püst, B. Kohl, A. Redlich, J. Sperner, U. Thyen Tags: Regular Articles Source Type: journals

Variable neurologic phenotype in a GEFS+ family with a novel mutation in SCN1AEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A novel missense mutation in the pore-forming region of the sodium channel gene SCN1A causes GEFS+ with a variable phenotype that includes mood and anxiety disorders, as well as ataxia, expanding the GEFS+ spectrum to include neuropsychiatric disease. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 21, 2009 Category: Neurology Authors: Krista Mahoney, Susan J. Moore, David Buckley, Muhammed Alam, Patrick Parfrey, Sharon Penney, Nancy Merner, Kathy Hodgkinson, Terry-Lynn Young Tags: Regular Articles Source Type: journals

Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: It has been described that febrile seizures during infancy increase risk of subsequent non-febrile seizures during the adulthood. However, latency period between febrile seizure and the onset of the first spontaneous seizure has not been evaluated. The present study was designed to investigate the susceptibility to subsequent seizures in immature rats that had experienced early-life hyperthermic seizures and before they achieved the adult age. The results were compared with those induced by hyperthermia alone. Pentylenetetrazol (PTZ) was applied 24h or 20 days after hyperthermic seizures or hyperthermia were indu...
Source: Seizure: European Journal of Epilepsy - May 17, 2009 Category: Neurology Authors: M. Gonzalez-Ramirez, H. Salgado-Ceballos, S.A. Orozco-Suarez, L. Rocha Tags: Regular Articles Source Type: journals

Comparison of various imaging modalities in localization of epileptogenic lesion using epilepsy surgery outcome in pediatric patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: MRI was invariably reliable in all cases. PET results were as reliable in lateralizing the temporal epileptic area, while its efficacy was lower for extratemporal cases. SISCOM effectively localized lesions in extratemporal cases, but its efficacy was lower in temporal lesions. In cases of conflicting pre-surgical results, MRI, with supplementary data from PET, helped to establish correct decisions in temporal epilepsies, while utilization of SISCOM and MRI data is advised for extratemporal cases. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 13, 2009 Category: Neurology Authors: Jeong Tae Kim, Sun Joon Bai, Keum Ok Choi, Yoon Jin Lee, Hae-Jeong Park, Dong Seok Kim, Heung Dong Kim, Joon Soo Lee Tags: Regular Articles Source Type: journals

Predictors of quality of life after resective extratemporal epilepsy surgery in adults in long-term follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: HRQOL after extratemporal epilepsy surgery has multiple determinants. Medical comorbidities should be considered a negative risk factor for QOL during preoperative and postoperative evaluation process. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 11, 2009 Category: Neurology Authors: Alaa Eldin Elsharkawy, Theodor May, Rupprecht Thorbecke, Alois Ebner Tags: Regular Articles Source Type: journals

Health concerns predicts poor quality of life in well-controlled epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: The findings that substantial health concerns predict poor QOL may have clinical implications, as seizure-free epilepsy is a relatively benign condition, and careful information and counselling about this may alleviate health concerns and improve quality of life. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 11, 2009 Category: Neurology Authors: Erik Hessen, Morten I. Lossius, Leif Gjerstad Tags: Regular Articles Source Type: journals

Cerebrospinal fluid tau as a marker of neuronal damage after epileptic seizureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Epileptic seizures with unknown etiology did not increase CSF tau levels. Abnormal tau levels were associated with either acute or remote symptomatic seizures with known etiology. The presence of elevated CSF tau increases the probability of symptomatic cause in a patient with a seizure. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 11, 2009 Category: Neurology Authors: Johanna Palmio, Jaana Suhonen, Tapani Keränen, Janne Hulkkonen, Jukka Peltola, Tuula Pirttilä Tags: Regular Articles Source Type: journals

Diagnostic usefulness and duration of the inpatient long-term video-EEG monitoring: Findings in patients extensively investigated before the monitoringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Inpatient long-term video-EEG monitoring (LTM) is an important diagnostic tool for patients with seizures and other paroxysmal behavioural events. The main referral categories are diagnosis (epileptic versus non-epileptic disorder), seizure classification and presurgical evaluation. The diagnostic usefulness of the LTM varies considerably (19–75%) depending on how this was defined and on the selection of the patients. The purpose of this study was to assess the diagnostic usefulness and the necessary duration of the LTM for the referral groups, in patients extensively investigated before the monitoring. An LTM ...
Source: Seizure: European Journal of Epilepsy - May 11, 2009 Category: Neurology Authors: Jørgen Alving, Sándor Beniczky Tags: Regular Articles Source Type: journals

Seizure control and biochemical profile on the ketogenic diet in young children with refractory epilepsy—Indian experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: KD is an effective and well-tolerated treatment option in young Indian children with refractory epilepsy. However, careful ongoing medical supervision is needed. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 8, 2009 Category: Neurology Authors: Suvasini Sharma, Sheffali Gulati, Veena Kalra, Anuja Agarwala, Madhulika Kabra Tags: Regular Articles Source Type: journals

A health literacy assessment of the epilepsy.com websiteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Current healthcare guidelines identify low health literacy as a major barrier to optimal health communication. Health literacy is defined as the degree to which individuals can obtain, process and understand basic health information and services needed to make appropriate health decisions. An estimated 90 million people in the U.S. have marginal health literacy. The Institute of Medicine and the U.S. Department of Education recommend that health related information be written at the 6th–8th grade level to address low health literacy. Epidemiological studies demonstrate that persons with epilepsy have significan...
Source: Seizure: European Journal of Epilepsy - May 8, 2009 Category: Neurology Authors: John O. Elliott, Bassel F. Shneker Tags: Regular Articles Source Type: journals

A study of 63 cases with eyelid myoclonia with or without absences: Type of seizure or an epileptic syndrome?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In the first group, EMA should be considered as a photosensitive idiopathic epileptic syndrome. A subgroup of early-onset of EMA refractory to AEDs, associated or not with GTCS and mental retardation should also be considered as a variant or a distinct photosensitive idiopathic epileptic syndrome. Finally, in the second group EMA may correspond to a type of seizures in idiopathic generalized epilepsies. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 6, 2009 Category: Neurology Authors: Roberto H. Caraballo, Elena Fontana, Francesca Darra, Santiago Chacon, Nicolas Ross, Elena Fiorini, Natalio Fejerman, Bernardo Dalla Bernardina Tags: Regular Articles Source Type: journals

Ictal asystole—Late manifestation of partial epilepsy and importance of cardiac pacemakerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with medically intractable cryptogenic partial epilepsy for 27 years who presented with new onset drop attacks. During the epilepsy monitoring unit stay he was found to have a left fronto-temporal partial onset seizures which triggered brady-arrhythmia followed by asystole for 20s. A cardiac pacemaker was implanted and the patient was followed for 2 years. He continued to have simple and complex partial seizures but did not have drop attacks anymore. He still occasionally feels the activation of his pacemaker during simple partial phase of his seizures but the characteristic loss of muscle tone never ha...
Source: Seizure: European Journal of Epilepsy - May 5, 2009 Category: Neurology Authors: Salman Zubair, Ahmed B. Arshad, Bilal Saeed, Shoaib Luqman, Kalarickal J. Oommen Tags: Case Report Source Type: journals

Evaluation of efficacy and safety of anterior corpus callosotomy with keyhole in refractory seizuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Anterior corpus callosotomy with a keyhole approach produces highly favorable outcomes for both GTCS and atonic or tonic seizures with a low risk for complications. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 4, 2009 Category: Neurology Authors: Zheng Ping, Xu Ji-Wen, Wang Gui-Song, Zhou Hong-Yu, Tian Xin Tags: Regular Articles Source Type: journals

Identifying depression in epilepsy in a busy clinical setting is enhanced with systematic screeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Purpose: Depression is a highly prevalent, relatively underdiagnosed and undertreated comorbid condition in epilepsy. The purpose of this study was to determine the effect of using a validated self-reporting depression scale on the ability to detect depression in people with epilepsy receiving care in a busy clinical setting.Methods: The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a 6-item questionnaire validated to screen for depression in people with epilepsy. We performed a retrospective chart review of 192 consecutive patients who had completed the NDDI-E while receiving care at a sei...
Source: Seizure: European Journal of Epilepsy - May 1, 2009 Category: Neurology Authors: David E. Friedman, Doris H. Kung, Somchai Laowattana, Joseph S. Kass, Richard A. Hrachovy, Harvey S. Levin Tags: Regular Articles Source Type: journals