Evaluation of MRI Post-Processing Methods Combined with PET in Detecting Focal Cortical Dysplasia Lesions for Patients with MRI-Negative Epilepsy
This study aimed to enhance MRI post-processing by incorporating positron emission tomography (PET) analysis. We sought to compare the diagnostic efficacy of diverse image post-processing methodologies in patients presenting MRI-negative FCD. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - March 28, 2024 Category: Neurology Authors: Zhe Qian, Jiuluan Lin, Rifeng Jiang, St éphane Jean, Yihai Dai, Donghuo Deng, Panashe Tevin Tagu, Lin Shi, Shiwei Song Source Type: research

Early Onset Absence Epilepsy of childhood: epidemiologic data, treatment and outcome in a sample of 56 patients born between 2000 and 2018
Childhood Absence Epilepsy (CAE) is a generalized, age-related epilepsy syndrome [1] affecting school-age children. The mean age of onset is 6-7 years; it usually presents before the age of 10 years, and only in rare cases before the age of 4 years [2;3]. CAE is characterized by the appearance of generalized spike-wave discharges with a frequency of approximately 3 Hz, associated with psychomotor arrest that lasts 4-30 seconds. Usually, neurological examination is normal and the prognosis is good [4]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - March 27, 2024 Category: Neurology Authors: C. Filippi, S. Damioli, P. Accorsi, E. Crotti, E.M. Fazzi, J. Galli, P. Martelli, A. Morandi, A. Muda, S. Pinghini, S. Saottini, S.E. Sforza, G. Milito, L. Giordano Source Type: research

Applicability of the International League Against Epilepsy (ILAE) 2022 Diagnostic Criteria for Epilepsy Syndromes in children: A retrospective review of 1550 children with epilepsy
An epilepsy syndrome is defined by an electroclinical constellation of characteristic clinical and electroencephalographic (EEG) features, supported by specific etiologies. [1] Epilepsy syndromes typically present in an age-dependent manner and are associated with distinctive comorbidities. It is crucial to identify epilepsy syndromes as they carry specific implications for treatment and prognosis. [2] In May 2022, the International League Against Epilepsy (ILAE) Nosology and Definitions Task Force published four papers that defined diagnostic criteria for epilepsy syndromes with onset in neonates and infants, [3] onset in...
Source: Seizure: European Journal of Epilepsy - March 27, 2024 Category: Neurology Authors: Bhavya Kansal, Aakanksha Anand, Divyani Garg, Anshika Gupta, Ashna Kumar, Suvasini Sharma Source Type: research

Using scalp EEG to predict seizure recurrence and electrical status epilepticus in children with idiopathic focal epilepsy
Idiopathic focal epilepsy (IFE), which is characterized by focal-onset seizures, often has a genetic component and frequently occurs in the absence of structural brain lesions (1989, [14,50]). IFE comprises several syndromes, including benign epilepsy with occipital paroxysms (early and late onset), benign childhood epilepsy with centrotemporal spikes (BECT), and idiopathic photosensitive occipital epilepsy, along with several undefined syndromes [15]. The prevalence of IFE is high during childhood, and BECT accounts for 15% of epilepsy syndromes in children under the age of 15 [36]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - March 27, 2024 Category: Neurology Authors: Xiaofei Ye, Panpan Hu, Bin Yang, Yang Yang, Ding Gao, Ginger Qinghong Zeng, Kai Wang Source Type: research

PETSurfer-Based Brain Segmentation in Patients with Temporal Lobe Epilepsy and Associated Hippocampal Sclerosis
In a homogeneous cohort of mesial temporal lobe epilepsy (mTLE) patients with hippocampal sclerosis (HS), this study utilizes the PETSurfer method to quantify and localize areas of cerebral hypometabolism. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - March 26, 2024 Category: Neurology Authors: Zorica Jokovi ć, Aleksa Pejović, Vera Miler Jerković, Dragoslav Sokić, Nikola Vojvodić, Marija Mijaljević, Vladimir Baščarević, Leposava Brajković, Aleksandar J. Ristić Tags: Short communication Source Type: research

Neuropsychology of late-onset epilepsies
In an increasingly ageing society, patients ageing with epilepsy and those with late-onset epilepsies (LOE) represent a challenge for epilepsy care and treatment. Senescence itself bears risks of pathologies which in the form of acute focal damage (e.g. stroke) or slowly progressive degenerative damage can cause seizures and substantial cognitive impairment. There is converging evidence from studies in LOE that cognitive impairments are present from epilepsy onset before treatment is initiated and may even precede the emergence of seizures. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - March 25, 2024 Category: Neurology Authors: C. Helmstaedter, C. Tailby, J-A. Witt Tags: Review Source Type: research

Reprint of: Recessive APC2 missense variants associated with epilepsies without neurodevelopmental disorders
The APC2 gene (OMIM *612034, also known as APCL) is widely expressed in the brain, predominantly in the cortex and hippocampus. It encodes adenomatous polyposis coli protein-2 (APC2), primarily distributed along actin fibers and microtubules throughout the neurites, growth cones, and cell bodies [1]. As involved in promoting microtubule dynamics and controlling dendritic development [1,2], APC2 plays an important role in regulating neuronal migration and axon guidance. In mice, homozygous knock-out of Apc2 caused impaired neuronal migration, growth retardation, and resulted in seizure behaviors [3], suggesting pathogenic r...
Source: Seizure: European Journal of Epilepsy - March 21, 2024 Category: Neurology Authors: Liang Jin, Yun Li, Sheng Luo, Qian Peng, Qiong-Xiang Zhai, Jin-Xia Zhai, Liang-Di Gao, Jia-Jun Guo, Wang Song, Yong-Hong Yi, Na He, Yong-Jun Chen Source Type: research

Real-world safety of Levetiracetam: Mining and analysis of its adverse drug reactions based on FAERS database
Epilepsy is a prevalent chronic neurological disorder characterized by the abnormal discharge of brain neurons, stemming from various causes. This condition can affect individuals of all ages and income levels [1, 2]. Over 5 million new cases are diagnosed each year, impacting over 65 million people worldwide. Around 80% of individuals with epilepsy reside in underdeveloped countries, and epilepsy contributes to approximately 0.5% of the global burden of diseases. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - March 21, 2024 Category: Neurology Authors: Zhimin He, Cuimin Liu, Lin Lin, Guowen Feng, Gang Wu Source Type: research

Optimizing EEG monitoring in critically ill children at risk for electroencephalographic seizures
Electroencephalographic seizures (ES) and electroencephalographic status epilepticus (ESE) are common in critically ill children with acute encephalopathy who undergo continuous EEG monitoring (CEEG) in the pediatric intensive care unit (PICU).1-17 Excessive ES exposure is associated with adverse neurobehavioral outcomes5,6,10,14,15,18 and may be mitigated by anti-seizure medication treatment.19,20 Thus, guidelines and consensus statements recommend that critically ill children with acute encephalopathy undergo 24-48 hours of CEEG for ES identification and management. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - March 19, 2024 Category: Neurology Authors: Kyle Coleman, France W. Fung, Alexis Topjian, Nicholas S. Abend, Rui Xiao Source Type: research

Human rights and support groups to improve quality of life, self-care and disability in epilepsy
Epilepsy is one of the most common neuropsychiatric disorders [33]. The majority of people with epilepsy live in low- and middle-income countries, where there are significant gaps in accessing effective treatment [34]. Furthermore, people diagnosed with epilepsy and their family members frequently suffer stigmatization and discrimination from those around them [34], which is associated with greater disability [18]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - March 16, 2024 Category: Neurology Authors: Felipe Agudelo-Hern ández, Gloria Inés Saldarriaga Toro, Laura Inés Plata-Casas Source Type: research

Perceived and Self-Stigma in People with Epilepsy in East Africa: Systematic Review and Meta-analysis
People with stigmatizing conditions associated with epilepsy encounter many difficulties in their daily lives and are more likely to have low self-esteem, low levels of hope, internalize negative attitudes, decrease adherence to treatment, and experience unemployment. The purpose of this study was to quantify the extent of perceived stigma and self-stigma among people with epilepsy. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - March 11, 2024 Category: Neurology Authors: Techilo Tinsae, Shegaye Shumet, Girmaw Medifu, Gidey Eriteby, Setegn Fentahun, Wondale Getinet Source Type: research

Predictors of medical intractability in children with epilepsy onset during the first two years of life, excluding infantile epileptic spasm syndrome
Epilepsy is one of the most common neurological disorders in childhood. Approximately 30% of children with epilepsy have treatment that fails to control seizures [1,2]. Knowledge of long-term outcomes is critical for treating children with epilepsy. Early childhood-onset epilepsy may have a worse outcome, leading to physical, behavioral, and psychosocial morbidities [3,4]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - March 8, 2024 Category: Neurology Authors: Mira ç Yıldırım, Mert Altıntaş, Ece Uysal, Ömer Bektaş, Serap Teber Source Type: research

Posttraumatic epilepsy in chronic disorders of consciousness due to severe traumatic brain injury after traffic accidents
The incidence of posttraumatic epilepsy (PTE) is estimated at 10 –20% [1,2], and various risk factors have been noted [2–9]. Approximately 90% of the patients develop PTE within two years during the chronic phase [10,11], but prevalence has been shown to increase over the following ten years [4,5,9,12]. The risk increases with more severe traumatic brain inju ries (STBIs) [6,13], with some reports suggesting an incidence as high as 40% [14]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - March 7, 2024 Category: Neurology Authors: Shoji Yasuda, Hirohito Yano, Yuka Ikegame, Morio Kumagai, Toru Iwama, Jun Shinoda, Tsuyoshi Izumo Source Type: research

Neurostimulation targeting the epileptic focus: current understanding and perspectives for treatment
Despite the present-day availability of over 30 anti-seizure medications, more than one-third of people with epilepsy do not achieve seizure control with medications alone [1]. For individuals with drug-resistant focal epilepsy, localization of the epileptic focus can open up non-medical treatment options, in particular resective epilepsy surgery or laser interstitial thermal ablation, with a high chance to achieve complete seizure control [2]. While generally safe, these destructive, irreversible procedures necessarily involve some risk of resulting neurological deficits, and they may not be feasible when seizures arise f...
Source: Seizure: European Journal of Epilepsy - March 2, 2024 Category: Neurology Authors: Andreas Schulze-Bonhage, Michael A. Nitsche, Stefan Rotter, Niels K. Focke, Vikram R. Rao Source Type: research

Teratogenicity of zonisamide and other little-used antiseizure medications
Over more than two decades, a very considerable majority of the pregnancies of Australian women with epilepsy that have been enrolled in the Raoul Wallenberg Australian Pregnancy Register of Antiepileptic Drugs (APR) have been managed with a relatively small number of the antiseizure medications (ASMs) that are available in the country. The most frequently used ASMs have been carbamazepine (CBZ), lamotrigine (LTG), levetiracetam (LEV) and valproate (VPA) ([8]b). Topiramate (TPM) and clonazepam (CZP) have had less extensive use ([8]b). (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - March 2, 2024 Category: Neurology Authors: Frank J.E. Vajda, Terence J. O'Brien, Janet E. Graham, Alison A. Hitchcock, Piero Perucca, Cecilie M. Lander, Mervyn J. Eadie Source Type: research