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Source: Seminars in Diagnostic Pathology - May 1, 2009 Category: Pathology Source Type: journals

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Source: Seminars in Diagnostic Pathology - May 1, 2009 Category: Pathology Source Type: journals

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Source: Seminars in Diagnostic Pathology - May 1, 2009 Category: Pathology Source Type: journals

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Source: Seminars in Diagnostic Pathology - May 1, 2009 Category: Pathology Source Type: journals

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Source: Seminars in Diagnostic Pathology - May 1, 2009 Category: Pathology Source Type: journals

Vasculitides of the gastrointestinal tractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Systemic vasculitis is often not considered as a possible diagnosis by clinicians because of its low prevalence compared with other more common diseases. Vasculitis can affect any end organ, and it is therefore often missed early on in disease progression. Gastrointestinal (GI) manifestations of vasculitis are considered rare and the presentation is often nonspecific. However, if there is significant involvement of the major vessels of the gastrointestinal system, life-threatening sequelae, including perforation and bowel ischemia, may occur. This makes early and immediate management crucial to improve long-term morbidity ...
Source: Seminars in Diagnostic Pathology - May 1, 2009 Category: Pathology Authors: Eric Ahn, Adriana Luk, Runjan Chetty, Jagdish Butany Source Type: journals

Vasculitis affecting the kidneyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vasculitis refers to vessel wall leukocyte infiltration, often with necrosis, and can involve any of one or more vessels in the body. The kidney is commonly affected by vasculitis. Vasculitis is best classified based on the size of the involved vessels into large, medium, and small vessel disease. Small vessel vasculitis (SVV) that includes glomerulonephritis is by far the most frequent vasculitic lesion in the kidney, and the defining renal lesion is a necrotizing crescentic glomerulonephritis. Medium vessel vasculitis occasionally involves the kidney as necrotizing arteritis, and large vessel vasculitis only rarely affec...
Source: Seminars in Diagnostic Pathology - May 1, 2009 Category: Pathology Authors: Rohan John, Andrew M. Herzenberg Source Type: journals

Neuropathology of cerebrovascular diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cerebrovascular disease (CVD) is one of the commonest causes of disability and mortality worldwide. It includes all disorders in which an area of the brain is transiently or permanently affected by ischemia or bleeding. In this review, we describe the neuropathological changes associated with the most common entities leading to brain ischemia and hemorrhage.
Source: Seminars in Diagnostic Pathology - May 1, 2009 Category: Pathology Authors: Lili-Naz Hazrati, Catherine Bergeron, Jagdish Butany Source Type: journals

Vascular and glomerular manifestations of viral hepatitis B and C: a reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Secondary vasculopathies have varied etiologies that include paraneoplastic processes (eg, migratory thrombophlebitis, urticarial vasculitis); direct invasion by tumors (eg, superior and inferior vena cava syndrome); metabolic diseases (eg, diabetes mellitus); and infections, among others. The infective causes of vasculitides could result from direct involvement of vessels by a vasculo-tropic agent (eg, mucor infection); adjacent inflammation nonspecifically affecting nearby vessels; or from infection-induced immune-mediated vasculitis. Viruses represent a major group in the development of the latter, and many human viruse...
Source: Seminars in Diagnostic Pathology - May 1, 2009 Category: Pathology Authors: Oyedele A. Adeyi Source Type: journals

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Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Source Type: journals

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Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Source Type: journals

TopicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Source Type: journals

IntroductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The field of medical toxicology is a widely diverse field in which the clinical laboratory plays an integral role. The term “toxicology” can be thought of as the assault, absorption and adverse effects of foreign substances to the human body. In this way, the areas of drug overdose, drug interactions, allergic reactions, illicit drug abuse, hazardous chemical exposures, radiation, psychiatry, wilderness/environmental medicine, infectious agents, food safety, botany, virology, zoology, parasitology, mycology, teratology and of course, pharmacology. The articles in this special toxicology/environmental medicine issue of ...
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Authors: Jerrold B. Leikin Source Type: journals

Preventing errors in patient management: the emergency department clinician and the toxicology laboratoryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Poor communication between the clinical toxicologist and the toxicology laboratory can result in a variety of problems. Clinicians must familiarize themselves with the toxicology assays that are available in their hospital and how to interpret assay results. Toxicology tests ordered in the emergency department should provide useful information for patient management and disposition. Toxicology laboratory personnel should have a good working relationship with emergency department clinicians and clinical toxicologists to maximize the usefulness of the laboratory in patient management.
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Authors: Michele Zell Kanter Source Type: journals

Hepatotoxicity in an infant following supratherapeutic dosing of acetaminophen for twenty-four hoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Severe hepatotoxicity in acute acetaminophen overdose in children is uncommon. This apparent protection does not extend to chronic or repeated high dose acetaminophen administration. The Illinois Poison Center (IPC) was consulted on a case involving a 7 month old 17 lb infant, who had presented the day prior to an emergency department with complaint of febrile illness. Patient had been prescribed acetaminophen for symptoms, and the mother called IPC when she realized that she had been incorrectly giving the patient concentrated infant acetaminophen (80 mg per 0.8 mL) totalling 42.3 mg/kg/dose or 234 mg/kg/24 hours instead ...
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Authors: Arthur Kubic, Anthony M. Burda, Elizabeth Bockewitz, Michael Wahl Source Type: journals

Cocaine: history, social implications, and toxicity: a reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article describes the history and pharmacology of illicit cocaine use.
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Authors: Rachel A. Goldstein, Carol DesLauriers, Anthony Burda, Kelly Johnson-Arbor Source Type: journals

A review of the use of ethyl glucuronide as a marker for ethanol consumption in forensic and clinical medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ethyl glucuronide (EtG) is a direct phase-II metabolite of ethanol formed through the UDP-glucuronosyl transferase catalyzed conjugation of ethanol with glucuronic acid. It has been detected in many antemortem and postmortem biological matrices using a variety of analytical methods. Due to its long urinary elimination time, detectability in hair, specificity for ethanol exposure, and low detection limits of assays, the use of EtG has been proposed as a marker of recent ethanol intake in a variety of clinical and legal settings, including medical monitoring for relapse, emergency department patient evaluation, postmortem as...
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Authors: Robert B. Palmer Source Type: journals

Clinical approach to clinical herbal toxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article is a review of the history and current status of herbs in the United States. The clinical effects of herbs and herbal medicine will be reviewed with respect to side effects and clinical toxicity. Treatment of herbal toxicity will be described where indicated.
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Authors: Richard T. Tovar Source Type: journals

The effect of complimentary and alternative medicine products on laboratory testingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A multi-billion dollar industry has evolved over the last decade based on herbal product sales with an underlying belief that herbals are natural and therefore safe. The herbal product industry is essentially unregulated and producers are not required to follow good manufacturing practices (GMP). Batch to batch product variation, heavy metal and pesticide contamination, and even therapeutic drug contamination are problematic. Compounding these manufacturing issues are drug to drug and drug to herbal interactions that can cause cytochrome induction or inhibition. It is important for physicians to query their patients on her...
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Authors: Robert Rosecrans, James C. Dohnal Source Type: journals

Laboratory interferences with the newer cyanide antidote: hydroxocobalaminEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article briefly discusses acute cyanide poisoning and treatment, and summarizes laboratory interferences that have been reported with the use of hydroxocobalamin.
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Authors: Nathan Beckerman, Scott M. Leikin, Robert Aitchinson, May Yen, Brandon K. Wills Source Type: journals

Normal reference value of red blood cell count of Chinese young men and geographical factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: If geographical values are obtained in a certain area, the normal reference value of red blood cell count of young men in this area can be reckoned by using the regression equation. Furthermore, according to the geographical factors, China can be divided into eight districts: Northeast China District, North China District, Shanxi-Shaanxi-Inner Mongolia District, Middle and Lower reaches of the Changjiang River District, Southeast China District, Northwest China District, Southwest China District, and Qinghai-Tibet Plateau District.
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Authors: Ge Miao, Zhang Yaping, He Jinwei, Yan Yanchun, Wang Xin, Cao Lixia, Fu Haiyan Source Type: journals

Death by Polonium-210: lessons learned from the murder of former Soviet spy Alexander LitvinenkoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The medical response to radiation—whether the result of radiological warfare, terrorist deployment of improvised radiation dispersal weapons, political assassination, occupational or industrial accidents or the medically radiated patient remains one of the least taught among all disciplines within medical education. In the aftermath of 9/11 among medical vulnerabilities to toxicant threats, of all the categories of weapons of mass destruction (WMD)—whether using the CBRNE (chemical, biological, radiological, nuclear, explosive) or NBC (nuclear, biological, chemical) acronym—radiation is the least taught in profession...
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Authors: Robin B. McFee, Jerrold B. Leikin Source Type: journals

American Academy of Clinical Toxicology: “Question of the Day”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The following is a list of 68 questions formulated as a member benefit for the American Academy of Clinical Toxicology (AACT). One question/answer is e-mailed daily to members under the title “AACT Tox Question of the Day.” Each answer is appropriately referenced. As the reader can see from the scope of these questions, the field of Clinical Toxicology is extremely diverse and encompasses virtually every medical specialty.
Source: Seminars in Diagnostic Pathology - February 1, 2009 Category: Pathology Authors: Michael I. Greenberg, John A. Curtis, James Madsen, David Vearrier, David Haggerty, Joseph D'Orazio Source Type: journals