Molecular Genealogy of Metabolic-associated Hepatocellular Carcinoma
In conclusion, deciphering the intricate interactions among metabolic processes, genetic predispositions, inflammatory responses, immune regulation, and microbial ecology is imperative for the development of novel therapeutic and preventative measures against metabolic-associated HCC. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - April 18, 2024 Category: Gastroenterology Authors: Kodama, Takahiro Takehara, Tetsuo Tags: Review Article Source Type: research
Is There a Safe Alcohol Consumption Limit for the General Population and in Patients with Liver Disease?
Semin Liver Dis DOI: 10.1055/s-0044-1785228 Excessive alcohol consumption represents an important burden for health systems worldwide and is a major cause of liver- and cancer-related deaths. Alcohol consumption is mostly assessed by self-report that often underestimates the amount of drinking. While alcohol use disorders identification test - version C is the most widely used test for alcohol use screening, in patients with liver disease the use of alcohol biomarker could help an objective assessment. The amount of alcohol that leads to significant liver disease depends on gender, genetic background, and coexistence of co...
Source: Seminars in Liver Disease - April 4, 2024 Category: Gastroenterology Authors: Romero-G ómez, Manuel Arab, Juan Pablo Oliveira, Claudia P. Hern ández, María Arrese, Marco Cortez-Pinto, Helena Bataller, Ram ón Tags: Review Articles Source Type: research
New Nomenclature for Nonalcoholic Fatty Liver Disease: Understanding Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction- and Alcohol-Associated Liver Disease, and Their Implications in Clinical Practice
Semin Liver Dis DOI: 10.1055/s-0044-1785196 In June 2023, under the patronage of the American Association for Study of Liver Disease, the European Association for Study of the Liver, and the Asociación Latinoamericana para el Estudio del Hígado with the involvement of 236 participants from around the world, a new nomenclature and definition for nonalcoholic fatty liver disease (NAFLD) has been proposed. Metabolic dysfunction-associated steatotic liver disease (MASLD) was defined as presence of hepatic steatosis and at least one of the cardiometabolic risk factors with alcohol intake less than 140 g/wk for women and 210...
Source: Seminars in Liver Disease - March 26, 2024 Category: Gastroenterology Authors: Canivet, Cl émence M. Boursier, J érôme Loomba, Rohit Tags: Review Article Source Type: research
GAS6/TAM Axis as Therapeutic Target in Liver Diseases
In conclusion, the TAM system is becoming an interesting pharmacological target in liver pathology and a focus of future biomedical research in this field. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - March 21, 2024 Category: Gastroenterology Authors: Tutusaus, Anna Morales, Albert Garc ía de Frutos, Pablo Mar í, Montserrat Tags: Review Article Source Type: research
Gestational and Developmental Contributors of Pediatric MASLD
In conclusion, investigating gestational and developmental contributors to MASLD is critical and may identify future interventional targets for disease prevention. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - February 29, 2024 Category: Gastroenterology Authors: Mouzaki, Marialena Woo, Jessica G. Divanovic, Senad Tags: Review Article Source Type: research
Tailored Model of Care for Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease
Semin Liver Dis DOI: 10.1055/a-2253-9181 Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is increasing globally, creating a growing public health concern. However, this disease is often not diagnosed, and accurate data on its epidemiology are limited in many geographical regions, making it challenging to provide proper care and implement effective national plans. To combat the increasing disease burden, screening and diagnosis must reach a significant number of high-risk subjects. Addressing MASLD as a health care challenge requires a multidiscip...
Source: Seminars in Liver Disease - February 21, 2024 Category: Gastroenterology Authors: El-Kassas, Mohamed Awad, Abeer Elbadry, Mohamed Arab, Juan Pablo Tags: Review Article Source Type: research
UDCA for Drug-Induced Liver Disease: Clinical and Pathophysiological Basis
Semin Liver Dis DOI: 10.1055/s-0044-1779520 Drug-induced liver injury (DILI) is an adverse reaction to medications and other xenobiotics that leads to liver dysfunction. Based on differential clinical patterns of injury, DILI is classified into hepatocellular, cholestatic, and mixed types; although hepatocellular DILI is associated with inflammation, necrosis, and apoptosis, cholestatic DILI is associated with bile plugs and bile duct paucity. Ursodeoxycholic acid (UDCA) has been empirically used as a supportive drug mainly in cholestatic DILI, but both curative and prophylactic beneficial effects have been observed for he...
Source: Seminars in Liver Disease - February 20, 2024 Category: Gastroenterology Authors: Bessone, Fernando Hillotte, Geraldine L. Ahumada, Natalia Jaureguizahar, Fernanda Medeot, Anabela C. Roma, Marcelo G. Tags: Review Article Source Type: research
Liver Transplantation for Hepatocellular Carcinoma: A Narrative Review and A Glimpse into The Future
Semin Liver Dis DOI: 10.1055/a-2242-7543 Liver transplantation (LT) is a highly effective treatment for carefully selected patients with hepatocellular carcinoma (HCC). In this review, we explored the development of LT selection criteria and organ allocation policies, comparing original data to underscore their historical progression into the intricate task of quantitatively estimating pre- and post-LT survivals. We emphasized the role of biomarkers such as serum alpha-fetoprotein, Des-gamma-carboxy-prothrombin, circulating tumor cells, and circulating tumor DNA in predicting patient outcomes. Additionally, we examined the...
Source: Seminars in Liver Disease - February 12, 2024 Category: Gastroenterology Authors: Liu, Hao Sethi, Vrishketan Li, Xingjie Xiao, Yao Humar, Abhinav Tags: Review Article Source Type: research
Algorithms for Early Detection of Silent Liver Fibrosis in the Primary Care Setting
Semin Liver Dis DOI: 10.1055/s-0043-1778127 More than one-third of the adult world population has steatotic liver disease (SLD), with a few percent of individuals developing cirrhosis after decades of silent liver fibrosis accumulation. Lack of systematic early detection causes most patients to be diagnosed late, after decompensation, when treatment has limited effect and survival is poor. Unfortunately, no isolated screening test in primary care can sufficiently predict advanced fibrosis from SLD. Recent efforts, therefore, combine several parameters into screening algorithms, to increase diagnostic accuracy. Besides pati...
Source: Seminars in Liver Disease - January 23, 2024 Category: Gastroenterology Authors: Bech, Katrine Tholstrup Lindvig, Katrine Prier Thiele, Maja Castera, Laurent Tags: Review Article Source Type: research
Biliary Tract Cancer: Molecular Biology of Precursor Lesions
In conclusion, this review summarizes the known molecular features of precancerous lesions in biliary tract cancer and highlights our fragmentary knowledge of the molecular pathogenesis of tumor initiation. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - December 15, 2023 Category: Gastroenterology Authors: Manzano-N úñez, Fátima Prates Tiago Aguilar, Lara Sempoux, Christine Lemaigre, Fr édéric P. Tags: Review Article Source Type: research
The Ploidy State as a Determinant of Hepatocyte Proliferation
Semin Liver Dis 2023; 43: 460-471 DOI: 10.1055/a-2211-2144 The liver's unique chromosomal variations, including polyploidy and aneuploidy, influence hepatocyte identity and function. Among the most well-studied mammalian polyploid cells, hepatocytes exhibit a dynamic interplay between diploid and polyploid states. The ploidy state is dynamic as hepatocytes move through the “ploidy conveyor,” undergoing ploidy reversal and re-polyploidization during proliferation. Both diploid and polyploid hepatocytes actively contribute to proliferation, with diploids demonstrating an enhanced proliferative capacity. This enhanced pot...
Source: Seminars in Liver Disease - December 15, 2023 Category: Gastroenterology Authors: Wilson, Sierra R. Duncan, Andrew W. Tags: Review Article Source Type: research
Novel Therapeutic Approaches in Treatment of Acute-on-Chronic Liver Failure
In conclusion, this review aims to summarize the current understanding of the pathophysiological processes involved in the onset, progression, and recovery of ACLF and discuss novel therapies under development. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - December 15, 2023 Category: Gastroenterology Authors: Saeidinejad, MohammadMahdi Elshabrawi, Ahmed Sriphoosanaphan, Supachaya Andreola, Fausto Mehta, Gautam Agarwal, Banwari Jalan, Rajiv Tags: Review Article Source Type: research
Immune Checkpoint Inhibitor-Induced Liver Injury
Semin Liver Dis 2023; 43: 402-417 DOI: 10.1055/s-0043-1776761 In recent years cancer treatment has been revolutionized by the development and wide application of checkpoint inhibitor (CPI) drugs, which are a form of immunotherapy. CPI treatment is associated with immune-related adverse events, off-target tissue destructive inflammatory complications, which may affect a range of organs, with liver inflammation (hepatitis) being one of the more commonly noted events. This is a novel form of drug-induced liver injury and a rapidly evolving field, as our understanding of both the basic immunopathology of CPI hepatitis (CPI-H) ...
Source: Seminars in Liver Disease - December 15, 2023 Category: Gastroenterology Authors: Gudd, Cathrin L.C. Sheth, Roosey Thursz, Mark R. Triantafyllou, Evangelos Possamai, Lucia A. Tags: Review Article Source Type: research
The Hepatic Porphyrias: Revealing the Complexities of a Rare Disease
Semin Liver Dis DOI: 10.1055/s-0043-1776760 The porphyrias are a group of metabolic disorders that are caused by defects in heme biosynthesis pathway enzymes. The result is accumulation of heme precursors, which can cause neurovisceral and/or cutaneous photosensitivity. Liver is commonly either a source or target of excess porphyrins, and porphyria-associated hepatic dysfunction ranges from minor abnormalities to liver failure. In this review, the first of a three-part series, we describe the defects commonly found in each of the eight enzymes involved in heme biosynthesis. We also discuss the pathophysiology of the hepati...
Source: Seminars in Liver Disease - November 16, 2023 Category: Gastroenterology Authors: Balogun, Oluwashanu Nejak-Bowen, Kari Tags: Review Article Source Type: research
Hedgehog Signaling: Implications in Liver Pathophysiology
In conclusion, Hedgehog signaling must be precisely controlled in adult liver cells to maintain liver health. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - November 10, 2023 Category: Gastroenterology Authors: Dutta, Rajesh Kumar Jun, JiHye Du, Kuo Diehl, Anna Mae Tags: Review Article Source Type: research
