The Effects of Mucopolysaccharide Polysulfate on Steroid-Induced Tight Junction Barrier Dysfunction in Human Epidermal Keratinocytes and a 3D Skin Model
Conclusion: The present study demonstrated that MPS improved TJ barrier impairment induced by CP. The improvement of TJ barrier function may partially be responsible for the delayed relapse of AD induced by the combination of MPS and TCS. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 25, 2023 Category: Dermatology Source Type: research
Skin physiology, mucosal functions and symptoms are modulated by grass pollen and ozone double exposure in allergic patients
Conclusion: Skin physiology and nasal mucosal symptoms and are negativ ely affected by ozone and grass pollen DE in allergic patients. The negative effects showed, in some parameters, a dose(time)-response relationship. The surface pH can be regarded as a possible modulatory mechanism. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 16, 2023 Category: Dermatology Source Type: research
The Epidermal Environment ’s Influence on the Dermal Environment in Response to External Stress
Conclusion: Epidermal changes in epidermal environment and conditions in response to external stress affect dermal conditions, and these negative effects of external stress on various skin layers can be pharmacologically mitigated. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 16, 2023 Category: Dermatology Source Type: research
The epidermal environment ’s influence on the dermal environment
in response to external stress
Conclusion: Epidermal Changes in epidermal environment and conditions in response to external stress, affect dermal conditions, and these negative effects of external stress on various skin layers can be pharmacologically mitigated. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 16, 2023 Category: Dermatology Source Type: research
Alterations in Epidermal Biophysical Properties in Autistic Children
Autism is a neurodevelopmental disorder. Individuals with autism can exhibit multiple neurological symptoms such as deficit in social communication, restricted interests, and repetitive behaviors. Recent study showed that murine model of autism displays an increased transepidermal water loss (TEWL) and dry skin. But whether epidermal functions are also altered in children with autism is unknown. In the present study, TEWL, stratum corneum hydration, and skin surface pH were compared between children with autism (N = 56) and normal controls (N = 48). Our results showed that children with autism exhibited lower stratum corne...
Source: Skin Pharmacology and Physiology - March 14, 2023 Category: Dermatology Source Type: research
Alterations in Epidermal Biophysical Properties in Autistic Children
Autism is a neurodevelopmental disorder. Individuals with autism can exhibit multiple neurological symptoms such as deficit in social communication, restricted interests and repetitive behaviors. Recent study showed that murine model of autism displays an increased transepidermal water loss (TEWL) and dry skin. But whether epidermal functions are also altered in children with autism is unknown. In the present study, TEWL, stratum corneum hydration and skin surface pH were compared between children with autism (N=56) and normal controls (N=48). Our results showed that children with autism exhibited lower stratum corneum hyd...
Source: Skin Pharmacology and Physiology - March 14, 2023 Category: Dermatology Source Type: research
Development of an In Vitro Functional Assay to Evaluate the Occlusive Properties of Moisturizers on Dry Skin
Conclusion: This newly developed experimental method may be helpful to develop new and improved occlusive moisturizers for the treatment of dry skin conditions. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 2, 2023 Category: Dermatology Source Type: research
Evaluation of a Novel Skin Emollient Cream on Skin Lipidome and Lipid Organization
Conclusion: G/P-emollient cream may be beneficial for skin pathologies by modifying SC lipids, balancing CER levels and ratios, and improving the barrier function. Importantly, the cream structure mimics that of the SC and penetrated the lower SC layers without compromising its lamellar structure.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 8, 2023 Category: Dermatology Source Type: research
Evaluation of a Novel Skin Emollient Cream on Skin Lipidome and Lipid Organization
Conclusion: G/P-emollient cream may be beneficial for skin pathologies by modifying SC lipids, balancing CER levels and ratios, and improving the barrier function. Importantly, the cream structure mimics that of the SC and penetrated the lower SC layers without compromising its lamellar structure. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 8, 2023 Category: Dermatology Source Type: research
Evaluation of a novel skin emollient cream on skin lipidome and lipids organization
Introduction: The stratum corneum (SC) matrix is composed of free fatty acids, cholesterol and ceramides (CERs), which play a key role in the skin barrier function. Changes in the composition and content of skin lipids will affect the function of the skin barrier. The effect of a glycerol/petrolatum-based emollient (G/P-emollient) cream on the lipid profiles of isolated ex vivo human SC and the SC of a reconstructed human epithelial (RHE) model were measured.
Methods: The spatial organization of the cream and the isolated SC intercellular matrix was studied using X-ray diffraction. The inter-bilayer distance in the multi-...
Source: Skin Pharmacology and Physiology - February 8, 2023 Category: Dermatology Source Type: research
Skin Care in Neonates and Infants: A Scoping Review
The objective of this scoping review was to obtain an overview about the evidence of skin care activities in neonates and infants. Studies from 2010 were eligible if the population was (skin) healthy neonates and infants; if the concept was skin care interventions; and if the context was at home, in a community setting, in a pediatric outpatient service, or in a hospital. We searched for the literature via OVID in MEDLINE and Embase, in the Cochrane Library, in trial registries and for gray literature.Summary: We identified 42 studies since 2010, which examined four main skin care interventions: bathing, wiping, washing, a...
Source: Skin Pharmacology and Physiology - February 7, 2023 Category: Dermatology Source Type: research
