The postoperative part of perioperative chemotherapy fails to provide a survival benefit in completely resected esophagogastric adenocarcinoma
Based on two benchmark studies perioperative chemotherapy (CTx) has become standard treatment for locally advanced esophagogastric adenocarcinoma (EGA) in Europe. However, only half of the patients in both studies actually received postoperative CTx (aCTx). Thus, we evaluated the prognostic impact of preoperative CTx (nCTx) and aCTx combined versus nCTx alone. Furthermore, we aimed to identify subgroups potentially beneficial of aCTx and factors associated with its non-administration. (Source: Surgical Oncology)
Source: Surgical Oncology - June 28, 2017 Category: Surgery Authors: Leila Sisic, Susanne Blank, Henrik Nienh üser, Georg Martin Haag, Dirk Jäger, Tom Bruckner, Katja Ott, Thomas Schmidt, Alexis Ulrich Source Type: research

Safety and efficacy for laparoscopic versus open hepatectomy: A meta-analysis
Laparoscopic hepatectomy (LH) is growing in popularity, but its efficacy and safety are still controversial. Few multicenter, large, population-based, prospective, randomized studies have compared LH with open hepatectomy (OH). We performed a meta-analysis to compare the treatment outcome of patients undergoing LH versus OH. (Source: Surgical Oncology)
Source: Surgical Oncology - June 28, 2017 Category: Surgery Authors: Bao Jin, Meiting Chen, Yutong Fei, Shunda Du, Yilei Mao Source Type: research

Minimally invasive gastrectomy for gastric cancer: A national perspective on oncologic outcomes and overall survival
Minimally invasive (MI) gastrectomy has become increasingly common as a resection technique for gastric cancer; however, data are limited regarding peri-operative morbidity, oncologic outcomes and long-term survival, particularly in the Western patient population. (Source: Surgical Oncology)
Source: Surgical Oncology - June 21, 2017 Category: Surgery Authors: Kenneth Leung, Zhifei Sun, Daniel P. Nussbaum, Mohamed A. Adam, Mathias Worni, Dan G. Blazer Source Type: research

How to conduct a high-quality original study on a diagnostic research topic
We present a concise and clear series of reviews to help Surgical Oncology's authors and readers to master the basic key components of how to conduct a high-quality original study or systematic review on a diagnostic or prognostic research topic from a methodological perspective. This is the first review of the series, which focuses on how to conduct a high-quality diagnostic study. (Source: Surgical Oncology)
Source: Surgical Oncology - June 21, 2017 Category: Surgery Authors: Xiaomei Yao, Emily Vella Source Type: research

A systemic review on radiofrequency assisted laparoscopic liver resection: Challenges and window to excel
Laparoscopic liver resection has progressively gained acceptance as a safe and effective procedure in the treatment of benign and malignant liver neoplasms. However, blood loss remains the major challenge in liver surgery. Several techniques and devices have been introduced in liver surgery in order to minimize intraoperative haemorrhage during parenchymal transection. Radiofrequency (RF)-assisted liver resection has been shown to be an effective method to minimise bleeding in open and laparoscopic liver resection. (Source: Surgical Oncology)
Source: Surgical Oncology - June 14, 2017 Category: Surgery Authors: Isabella Reccia, Jayant Kumar, Tomokazu Kusano, Artur Zanellato, Ahmed Draz, Duncan Spalding, Nagy Habib, Madhava Pai Source Type: research

Current trends in multimodality treatment of esophageal and gastroesophageal junction cancer – Review article
Multimodality treatment has now been widely introduced in the curatively intended treatment of esophageal and gastroesophageal junction cancer. We aim to give an overview of the scientific evidence for the available treatment strategies and to describe which trends that are currently developing. (Source: Surgical Oncology)
Source: Surgical Oncology - June 10, 2017 Category: Surgery Authors: Fredrik Klevebro, Simon Ekman, Magnus Nilsson Tags: Review Source Type: research

Editorial Board/Aims and Scope
(Source: Surgical Oncology)
Source: Surgical Oncology - June 1, 2017 Category: Surgery Source Type: research

Tumor model for surgical simulation to assess a minimally invasive endoscopic approach for midcheek mass removal
The midcheek is considered one of the most important facial area due to its involvement in mimic expression and communication. Pathology of this district is complex due to the variety of soft tissue belonging to the face. We propose a surgical simulation, to assess the feasibility of a new minimally invasive endoscopic approach for midcheek mass removal. (Source: Surgical Oncology)
Source: Surgical Oncology - May 27, 2017 Category: Surgery Authors: Giovanni Dell' Aversana Orabona, Antonio Romano, Paola Bonavolont à, Vincenzo Abbate, Alfonso Manfuso, Giorgio Iaconetta, Bernhard Hirt, Luigi Califano Source Type: research

Total pancreatoduodenectomy en bloc with superior mesenteric artery and vein resection after gemcitabine and nab-paclitaxel neoadjuvancy
Pancreatectomy for locally advanced adenocarcinoma affecting the superior mesenteric artery (SMA) and superior mesenteric vein (SMV) is still under discussion [1]. However, in selected cases, in light of the advancement of recent neoadjuvant treatments, it must be taken into account [2,3]. This video demonstrates some of the technical aspects of SMA and SMV resection as well as some tips of vascular reconstruction. (Source: Surgical Oncology)
Source: Surgical Oncology - May 22, 2017 Category: Surgery Authors: E. Vicente, Y. Quijano, B. Ielpo, H. Duran Source Type: research

Interleukins as new prognostic genetic biomarkers in non-small cell lung cancer
Surgery is the standard treatment for early-stage NSCLC, and platinum-based chemotherapy remains as the treatment of choice for advanced-stage NSCLC patients with na ïve EGFR status. However, overall 5-years relative survival rates are low. Interleukins (ILs) are crucial for processes associated with tumor development. In NSCLC, IL1B, IL6, IL12A, IL13 and IL16 gene polymorphisms may contribute to individual variation in terms of patient survival. The purpose of this study was to evaluate the association between IL gene polymorphisms and survival in NSCLC patients. (Source: Surgical Oncology)
Source: Surgical Oncology - May 22, 2017 Category: Surgery Authors: Cristina P érez-Ramírez, Marisa Cañadas-Garre, Ahmed Alnatsha, Miguel Ángel Molina, Ana I. Robles, Eduardo Villar, Juan Ramón Delgado, María José Faus-Dáder, Miguel Ángel Calleja-Hernández Source Type: research

Hepatic intra-arterial injection of irinotecan drug eluting beads (DEBIRI) for patients with unresectable colorectal liver metastases: A systematic review
To systematically review the safety and efficacy of transarterial drug-eluting beads, irinotecan (DEBIRI) for the treatment of pretreated patients with unresectable colorectal liver metastases (CRLM). (Source: Surgical Oncology)
Source: Surgical Oncology - May 22, 2017 Category: Surgery Authors: Olaguoke Akinwande, Meaghan Dendy, Johannes M. Ludwig, Hyun S. Kim Tags: Review Source Type: research

Portal vein ligation versus portal vein embolization for induction of hypertrophy of the future liver remnant: A systematic review and meta-analysis
An important risk of major hepatic resection is postoperative liver failure, which is directly related to insufficient future liver remnant (FLR). Portal vein embolization (PVE) and portal vein ligation (PVL) can minimize this risk by inducing hypertrophy of the FLR. The aim of this systematic review and meta-analysis was to investigate we have compared the efficacy and safety of PVE and PVL for FLR hypertrophy.A systematic search was conducted on the17th of January 2017. The methodological quality of the studies was assessed using the Oxford Critical Appraisal Skills Program for cohort studies. (Source: Surgical Oncology)
Source: Surgical Oncology - May 9, 2017 Category: Surgery Authors: C.J. Isfordink, M. Samim, M.N.G.J.A. Braat, A.M. Almaki, J. Hagendoorn, I.H.M. Borel Rinkes, I.Q. Molenaar Tags: Review Source Type: research

Efficacy and safety of combination therapy of chemoembolization and radiofrequency ablation with different time intervals for hepatocellular carcinoma patients
Combination of transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) has become an effective alternative therapy for hepatocellular carcinoma (HCC). In clinical practice, the choice of time interval between TACE and RFA is a key point for curative effect, but optimal time interval is uncertain in guidelines. We aim to explore the optimal time interval for HCC patients of Child-Pugh classification A or B. (Source: Surgical Oncology)
Source: Surgical Oncology - May 3, 2017 Category: Surgery Authors: Yue-min Feng, Xing Wang, Le Wang, Xiao-wen Ma, Hao Wu, Hao-ran Bu, Xiao-yu Xie, Jian-ni Qi, Qiang Zhu Source Type: research

Role of exosomes in treatment of hepatocellular carcinoma
Exosomes are nanovesicles that may play a role in intercellular communication by acting as carriers of functional contents such as proteins, lipids, RNA molecules and circulating DNA from donor to recipient cells. In addition, exosomes may play a potential role in immunosurveillance and tumor pathogenesis and progression. Recently, research has increasingly focused on the role of exosomes in hepatocellular carcinoma (HCC), the most common primary liver malignancy. We herein review data on emerging experimental and clinical studies focused on the role of exosomes in the pathogenesis, diagnosis, progression and chemotherapy ...
Source: Surgical Oncology - April 24, 2017 Category: Surgery Authors: Demetrios Moris, Eliza W. Beal, Jeffery Chakedis, Richard A. Burkhart, Carl Schmidt, Mary Dillhoff, Xufeng Zhang, Stamatios Theocharis, Timothy M. Pawlik Source Type: research

The impact of radiofrequency-assisted transection on local hepatic recurrence after resection of colorectal liver metastases
Resection is the gold standard in the treatment of liver metastases from colorectal cancer. An internal cooled radiofrequency electrode was described to achieve tissue coagulation to a greater margin width. The aim of this study is to determinate if a RF-assisted transection device (RFAT) has any effect on local hepatic recurrence (LHER) compared to conventional technologies.A study population of 103 patients who had undergone a hepatic surgical resection was retrospectively analysed. Patients were classified into two groups according to the device used: a RF-assisted device (RFAT group; n  = 45) and standard conventiona...
Source: Surgical Oncology - April 19, 2017 Category: Surgery Authors: R. Quesada, A. Moreno, I. Poves, E. Berjano, L. Grande, F. Burd ío Source Type: research