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Advances in Diagnostic, Staging, and Restaging Evaluation of Esophageal and Gastric Cancer
The initial endoscopic and staging evaluation of esophagogastric cancers must be accurate and comprehensive in order to select the optimal therapeutic plan for the patient. Esophageal and gastric cancers (and treatment paradigms) are delineated by their proximity to the cardia (within 2  cm). The most frequent and important symptom that informs the initial staging evaluation is dysphagia, which is associated with at least cT3 or locally advanced disease. Endoscopic ultrasound is often needed if earlier stage disease is suspected, preferably in combination with endoscopic mucosal o r submucosal resection or fine-needle asp...
Source: Surgical Oncology Clinics of North America - March 21, 2024 Category: Surgery Authors: Tamar Nobel, Smita Sihag Source Type: research

Precision Oncology and Cancer Surgery
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - February 23, 2024 Category: Surgery Authors: JASON K. SICKLICK Source Type: research

Copyright
ELSEVIER (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - February 23, 2024 Category: Surgery Source Type: research

Contributors
TIMOTHY M. PAWLIK, MD, MPH, PhD, FACS, FRACS (Hon) (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - February 23, 2024 Category: Surgery Source Type: research

Contents
Timothy M. Pawlik (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - February 23, 2024 Category: Surgery Source Type: research

Forthcoming Issues
Contemporary Management of Esophageal and Gastric Cancer (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - February 23, 2024 Category: Surgery Source Type: research

Conduit Selection for Reconstruction After Esophagectomy for Esophageal Cancer
The reconstruction of the esophagus after esophagectomy presents many technical and management challenges to surgeons. An effective gastrointestinal conduit that replaces the resected esophagus must have adequate length to reach the upper thoracic space or the neck, have robust vascular perfusion, and provide sufficient function for an adequate swallowing mechanism. The stomach is currently the preferred conduit for esophageal reconstruction after esophagectomy. However, there are circumstances, where the stomach cannot be utilized as a conduit. In these cases, an alternative conduit must be considered. The current alterna...
Source: Surgical Oncology Clinics of North America - February 19, 2024 Category: Surgery Authors: Robert E. Merritt Source Type: research

The Contemporary Management of Esophageal and Gastric Cancer
This issue of the Surgical Oncology Clinics of North America focuses on contemporary management of esophageal and gastric cancer. While relatively rare in the United States, esophageal and gastric cancers are diagnosed in roughly 22,000 to 25,000 individuals each year accounting for 10,000 to 16,000 cancer-related deaths annually.1 –3 Unlike in Asia where the incidence is high enough to justify routine screening, screening in the United States is generally not performed except among patients with high-risk features, such as Barrett esophagus. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - February 10, 2024 Category: Surgery Authors: Timothy M. Pawlik Tags: Foreword Source Type: research

The Contemporary Management of Esophageal and Gastric Cancer
On behalf of Dr Smita Sihag and myself, Dr Robert E Merritt, we are very excited about this special issue of the Surgical Oncology Clinics of North America. The ecosystem surrounding the management of esophageal and gastric cancer is rapidly changing with the addition of new therapeutic options and innovative surgical techniques. This special issue focuses on many important diagnostic, therapeutic, and operative components within the esophageal and gastric cancer ecosystem. The article in this issue entitled, “Advances in the Diagnostic, Staging, and Restaging Evaluation for Esophageal and Gastric Cancer,” by Sihag and...
Source: Surgical Oncology Clinics of North America - February 5, 2024 Category: Surgery Authors: Robert E. Merritt, Smita Sihag Tags: Preface Source Type: research

Endoscopic Therapies for Early Stage Esophageal and Gastric Cancers
Early detection of esophageal and gastric cancers offers the possibility of curative treatments with less-invasive interventions than traditional surgical approaches. This review highlights the main endoscopic therapeutic modalities used for early esophageal and gastric malignancies. Endoscopic resection techniques include endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD). EMR is beneficial for smaller, well-defined lesions and involves resecting the superficial layer of the mucosa. In contrast, ESD permits en bloc resection of larger lesions, including those involving the superficial submucosa,...
Source: Surgical Oncology Clinics of North America - February 3, 2024 Category: Surgery Authors: Tarek Nammour, Pari M. Shah Source Type: research

Minimally Invasive Techniques for Gastrectomy
Gastric adenocarcinoma is an aggressive disease and a leading cause of cancer-related deaths worldwide. Surgery entails either a total or a subtotal gastrectomy. These complex operations carry elevated morbidity and mortality with an extended recovery time. As such, research has focused on minimizing these risks and enhancing postoperative care. Robotic surgery is a newer platform that helps overcome some of the limitations of laparoscopy through three-dimensional vision, better mobility, and improved surgeon dexterity. As such, many surgeons have embraced robotics and advocated for their implementation in cancer surgery. ...
Source: Surgical Oncology Clinics of North America - January 30, 2024 Category: Surgery Authors: Samantha M. Ruff, Mary E. Dillhoff Source Type: research

Understanding the Landscape of Clinically Available Molecular Testing
Over the past three decades, the landscape of clinically available molecular tests has evolved due to advancements in basic science cancer research and the subsequent utilization of this knowledge to develop DNA, RNA, and protein-based molecular assays for oncology that can be employed for routine clinical use in diagnostics laboratories. Molecular testing of tumors is revealing gaps in previous histopathologic classification systems and opportunities for new, personalized treatment paradigms. Awareness of validated molecular assay options and their general advantages and limitations is crucial for oncology care providers ...
Source: Surgical Oncology Clinics of North America - January 29, 2024 Category: Surgery Authors: Julia A. Elvin Source Type: research

Current Multidisciplinary Lymphoma and Myeloma Management for Surgeons
Although there are more than 100 clinically distinct lymphoid neoplasms with varied prognoses and treatment approaches, they generally share high sensitivity to glucocorticoids, cytotoxic chemotherapy, and radiation. The disease control rates for lymphoid malignancies are higher than many solid tumors, and many are curable even when presenting with extensive involvement. Novel targeted therapies have improved disease control and cure rates for nearly all subtypes of lymphoid neoplasms. Surgical oncologists will primarily be involved in obtaining biopsies of sufficient quality to allow accurate diagnosis. However, there are...
Source: Surgical Oncology Clinics of North America - January 27, 2024 Category: Surgery Authors: William B. Pearse, Erin G. Reid Source Type: research

Cost-Effectiveness and the Economics of Genomic Testing and Molecularly Matched Therapies
Cost-effectiveness analysis of precision oncology can help guide value-driven care. Next-generation sequencing is increasingly cost-efficient over single gene testing because diagnostic algorithms require multiple individual gene tests to determine biomarker status. Matched targeted therapy is often not cost-effective due to the high cost associated with drug treatment. However, genomic profiling can promote cost-effective care by identifying patients who are unlikely to benefit from therapy. Additional applications of genomic profiling such as universal testing for hereditary cancer syndromes and germline testing in patie...
Source: Surgical Oncology Clinics of North America - January 27, 2024 Category: Surgery Authors: Sudeep Banerjee Source Type: research

Minimally Invasive Modified McKeown Esophagectomy
McKeown esophagectomy is a transthoracic esophagectomy with a cervical anastomosis that is an established mainstay for the management of benign and malignant esophageal pathology. It has gone through multiple modifications. The most current version utilizes robotic or minimally invasive ports through both the right chest and abdominal portions. There is decreased pain and hospital length of stay compared to the open technique. However, anastomotic leak and recurrent laryngeal nerve injury continue to occur. Advancements in management of complications has decreased mortality, making this surgical approach a relevant option ...
Source: Surgical Oncology Clinics of North America - January 25, 2024 Category: Surgery Authors: Ealaf Shemmeri, Jon O. Wee Source Type: research