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Mortality and drug exposure in a 5-year cohort of patients with chronic liver disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Drug exposure in general was not associated with higher mortality except for a few categories. Mortality in patients with chronic liver disease was high and is associated with simple laboratory values. PMID: 19924579 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 19, 2009 Category: Journals (General) Authors: Hug BL, Lipsitz SR, Seger DL, Karson AS, Wright SC, Bates DW Tags: Swiss Med Wkly Source Type: journals

Estimation of cost-of-illness in patients with psoriasis in Switzerland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Moderate-to-severe psoriasis is associated with a significant impact on the quality of life and at least 4-fold higher costs than mild psoriasis, indicating the need for efficient control of the disease. This cost-of-illness study provides specific health economic data for future healthcare decision making, particularly with the advent of new therapeutic agents for effective psoriasis control. PMID: 19924580 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 19, 2009 Category: Journals (General) Authors: Navarini AA, Laffitte E, Conrad C, Piffaretti P, Brock E, Ruckdaeschel S, Trüeb RM Tags: Swiss Med Wkly Source Type: journals

Female adolescents' views on a youth-friendly clinic.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The main point for female adolescent patient satisfaction lies in a long term, trustworthy relationship with their caregiver. Confidentiality and accessibility were secondary for our patients. PMID: 19924581 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 19, 2009 Category: Journals (General) Authors: Suris JC, Mauerhofer A, Berchtold A, Akré C, Michaud PA Tags: Swiss Med Wkly Source Type: journals

Surveillance of extended-spectrum-beta-lactamase-producing enterobacteriaceae in a Swiss tertiary care hospital.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The prevalence of ESBL-E carriage among patients coming from regions with endemic rates or those previously identified as carriers is high; on-admission screening should be considered for these high risk populations. Documented nosocomial ESBL-E transmission was low. PMID: 19924582 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 19, 2009 Category: Journals (General) Authors: Fankhauser C, Zingg W, Francois P, Dharan S, Schrenzel J, Pittet D, Harbarth S Tags: Swiss Med Wkly Source Type: journals

Psychogenic aphonia: No fixation even after a lengthy period of aphonia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Even after a lengthy period of aphonia a complete recovery of the voice function is possible in nearly all cases. Countertransference phenomena in therapists are discussed as the possible reason why they usually decide on treatment aimed primarily at dealing with the symptoms. PMID: 19924583 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 19, 2009 Category: Journals (General) Authors: Kolbrunner J, Menet AD, Seifert E Tags: Swiss Med Wkly Source Type: journals

Management and prognosis of status epilepticus according to hospital setting: a prospective study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Although not statistically significant, we observed a slightly worse SE prognosis in a large academic centre as compared to smaller hospitals. Since SE severity was similar in the two settings but adherence to national treatment guidelines was higher in the academic centre, further investigation on the prognostic role of SE treatment and outcome determinants is required. PMID: 19924584 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 19, 2009 Category: Journals (General) Authors: Rossetti AO, Novy J, Ruffieux C, Olivier P, Foletti GB, Hayoz D, Burnand B, Logroscino G Tags: Swiss Med Wkly Source Type: journals

First wave of the influenza A/H1N1v pandemic in Switzerland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Suspected A/H1N1v-infection contributed to considerable health-care burden in Switzerland. However, the rate of true positivity was low (5%), hospitalisations rare (5%), and mortality did not occur. Therefore, the first wave of the A/H1N1v-pandemic in Switzerland was rather media "hype" than real threat. PMID: 19918702 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 16, 2009 Category: Journals (General) Authors: Nickel CH, Stephan FP, Dangel M, Blume K, Gehrisch R, Dumoulin A, Tschudin S, Keller DI, Hirsch HH, Widmer AF, Bingisser R Tags: Swiss Med Wkly Source Type: journals

Medtech: a new window for SMW.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19918695 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - October 17, 2009 Category: Journals (General) Authors: Perruchoud AP Tags: Swiss Med Wkly Source Type: journals

Medtech: Potential for innovation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19918696 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - October 17, 2009 Category: Journals (General) Authors: Bestetti G Tags: Swiss Med Wkly Source Type: journals

The challenges in artificial muscle research to treat incontinence.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sphincters to guarantee continence are in pricipal the simplest muscles, because only two states (closed and open) seem to be important. The healthy urinary sphincter, however, provides dynamic components. During the filling phase the increase in tonus prevents urinary loss. The sphincter rapidly responds to pressure pulses caused, for example, by coughing. Contemporary artificial sphincters, however, merely generate two states and often induce atrophy and erosion. Hence the success of commercially available, continually improved implants is still limited. This communication reviews two physical principles, shape memor...
Source: Swiss Medical Weekly - October 17, 2009 Category: Journals (General) Authors: Müller B, Deyhle H, Mushkolaj S, Wieland M Tags: Swiss Med Wkly Source Type: journals

Remote monitoring of cardiovascular implantable electronic devices. Prerequisite or luxury?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The number of patients implanted with cardiovascular electronic devices (CIED) like implantable defibrillators (ICD), cardiac resynchronisation (CRT) devices, and pacemakers continues to grow. These devices require regular follow-up interrogation in dedicated device clinics. Contemporary CIED are capable of wireless remote interrogation and monitoring. This technology has been proven to be technically reliable and helpful in certain conditions. It is of particular benefit in monitoring devices that are under a safety alert since it allows early identification of device malfunction and minimises the risk of under-report...
Source: Swiss Medical Weekly - October 17, 2009 Category: Journals (General) Authors: Sticherling C, Kühne M, Schaer B, Altmann D, Osswald S Tags: Swiss Med Wkly Source Type: journals

Do we really need cartilage tissue engineering?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The in vitro engineering of functionally developed biological cartilage substitutes, based on cells and appropriate structural and soluble factors, is an attractive concept for the clinical treatment of cartilage injuries and degeneration. The field of cartilage tissue engineering has developed strongly in the last few years, bringing together the scientific, clinical and commercial interests of highly interdisciplinary communities. However, engineered grafts are still far from being the standard of care for cartilage repair. In this review we present some of the issues challenging the reproducible engineering of funct...
Source: Swiss Medical Weekly - October 17, 2009 Category: Journals (General) Authors: Pelttari K, Wixmerten A, Martin I Tags: Swiss Med Wkly Source Type: journals

Symptom assessment in lumbar stenosis/spondylolysis - patient questionnaire versus physician chart.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The agreement of main symptoms between the charts and the patient questionnaires seems to be low and may be ameliorated with more time and more structured interviews to ensure that the physician's patient chart more closely reflects the patient's self-rating, than was the case in this study. PMID: 19918700 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - October 17, 2009 Category: Journals (General) Authors: Huber JF, Dabis E, Huesler J, Ruflin GB Tags: Swiss Med Wkly Source Type: journals

Barriers to influenza vaccination of frail elders receiving home care: their primary care physician's perspective.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19918701 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - October 17, 2009 Category: Journals (General) Authors: Kherad O, Spada A, Zumwald C, Rutschmann OT Tags: Swiss Med Wkly Source Type: journals

TGF-beta signaling in COPD: deciphering genetic and cellular susceptibilities for future therapeutic regimen.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the developed world and associated with a high individual and socioeconomic burden. Despite emerging preventive efforts and ongoing clinical trials, the frequency and mortality of COPD are expected to continue to rise over the next decades. COPD is defined as an irreversible expiratory airflow limitation, which is caused by various degrees of the following two main features: First, small airway disease (SAD), which includes airway inflammation and remodelling, and second, emphysema, which is characterised by airspace enlargement. The ...
Source: Swiss Medical Weekly - October 2, 2009 Category: Journals (General) Authors: Königshoff M, Kneidinger N, Eickelberg O Tags: Swiss Med Wkly Source Type: journals

Morbidity and mortality in HIV-infected individuals - a shift towards comorbidities.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Combination antiretroviral therapy (cART) has dramatically improved the prognosis of HIV-infected persons to a level close to a normal life expectancy in a significant proportion of treated individuals. On starting cART HIV-induced immune deficiency can be prevented or, if already present, reconstituted. Remaining morbidity and mortality is partly due to late presentation of patients, when CD4-T-cells have already fallen below 200 cells/muL often accompanied by symptomatic disease. However, at present morbidity and mortality are mainly related to comorbidities such as hepatitis and tumours at least partly associated wi...
Source: Swiss Medical Weekly - October 2, 2009 Category: Journals (General) Authors: Battegay M, Elzi L Tags: Swiss Med Wkly Source Type: journals

Asthma data from the Swiss Sentinel Surveillance Network, 1989-2005 - from monitoring to research.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These findings are similar to those from other studies for the same time-period and show that the SSSN can generate valid scientific data. PMID: 19838875 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - October 2, 2009 Category: Journals (General) Authors: Bollag U Tags: Swiss Med Wkly Source Type: journals

Long-term cardiovascular and non-cardiovascular mortality in women and men with type 1 and type 2 diabetes mellitus: A 30-year follow-up in Switzerland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Patients with type 1 and type 2 diabetes had an increased long-term mortality compared with the general Swiss population. Excess mortality was higher in type 1 compared with type 2 diabetes and in women compared with men for both types of diabetes, but steadily decreased over the last two decades. PMID: 19838876 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - October 2, 2009 Category: Journals (General) Authors: Allemann S, Saner C, Zwahlen M, Christ ER, Diem P, Stettler C Tags: Swiss Med Wkly Source Type: journals

New insights into the pathogenesis of Crohn's disease: are they relevant for therapeutic options?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During the last few years significant advances have been achieved in the understanding of the pathogenesis of inflammatory bowel disease (IBD). A genetic susceptibility to Crohn's disease has been proven by identification of variations as risk factor NOD2/CARD15. Functional data on NOD2/CARD15 and NF-kappaB activation indicate that an inflammatory reaction of the intestinal mucosa, as an immediate response of the innate immune system, may be necessary for the maintenance of gut homeostasis. Crohn's disease is now also discussed as an impaired and inadequate immune reaction and no longer only as a hyper-responsiveness o...
Source: Swiss Medical Weekly - September 18, 2009 Category: Journals (General) Authors: Vavricka SR, Rogler G Tags: Swiss Med Wkly Source Type: journals

Targeting burn prevention in the paediatric population : a prospective study of childrens' burns in the Lausanne area.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: If we were to describe the highest "at risk" candidate for a burn in our region, it would be a boy aged 15 months to 5 years who is burned by a cup of hot liquid on his hand, at home, around mealtime, in the presence of one or both parents. Reduced attention in the safe domestic setting is probably responsible. PMID: 19838870 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - September 18, 2009 Category: Journals (General) Authors: Natterer J, de Buys Roessingh A, Reinberg O, Hohlfeld J Tags: Swiss Med Wkly Source Type: journals

Swiss national MD-PhD-program: an outcome analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The MD-PhD students and graduates surveyed were satisfied with their education and most of them continued a research-orientated career. Regarding the overall positive evaluation, this study supports the view that MD-PhD graduates are well qualified for a successful career in academic medicine. PMID: 19838871 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - September 18, 2009 Category: Journals (General) Authors: Kuehnle K, Winkler DT, Meier-Abt PJ Tags: Swiss Med Wkly Source Type: journals

Glycaemic control in hospitalised diabetic patients at the University Hospital Basel in 2002 and in 2005.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
INTRODUCTION: Hyperglycaemia has been shown to be detrimental in severely ill patients. Prospective randomized controlled trials in ICU patients demonstrated the benefit of near-normoglycaemia in reducing morbidity and mortality. Recommendations of professional societies (e.g., the American Diabetes Association) on glycaemic control in hospitalised patients have recently been published. It was therefore of interest to assess whether glycaemic control of diabetic subjects in our hospital adhered to these guidelines. No recent data are available on the glycaemic control of hospitalised diabetic patients in Switzerland. M...
Source: Swiss Medical Weekly - September 18, 2009 Category: Journals (General) Authors: Thomann R, Lenherr C, Keller U Tags: Swiss Med Wkly Source Type: journals

Abstracts of the Annual Meeting of the Swiss Society of Gastroenterology, Swiss Society for Visceral Surgery, and the Swiss Association for the Study of the Liver. September 17-18, 2009. Zurich, Switzerland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19810187 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - September 4, 2009 Category: Journals (General) Tags: Swiss Med Wkly Source Type: journals

Body mass index, blood pressure, and serum cholesterol in young Swiss men: an analysis on 56784 army conscripts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Prevalence rates of excess bodyweight and of elevated blood pressure are high in young Swiss men, and these entities are strongly interrelated. Excess body weight and high blood pressure are independently associated with high serum cholesterol in this population. Excess bodyweight and associated risk factors should receive increased attention in young Swiss men. PMID: 19795526 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - September 4, 2009 Category: Journals (General) Authors: Saely CH, Risch L, Frey F, Lupi GA, Leuppi JD, Drexel H, Huber AR Tags: Swiss Med Wkly Source Type: journals

External radiotherapy with or without hormonal ablation therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19736588 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - September 4, 2009 Category: Journals (General) Authors: Zimmermann F Tags: Swiss Med Wkly Source Type: journals

Mapping of atrial fibrillation - basic research and clinical applications.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite five decades of intensive research, mechanisms initiating and stabilising atrial fibrillation (AF) are still not fully understood. Nevertheless, mapping studies, next to clinical trials and research on cellular electrophysiology, have provided key information that has led to a much more profound understanding of the arrhythmia. Contact mapping using multi-electrode arrays (MEAs) is the gold standard for high-resolution mapping in basic research and clinical trials, and continuously contributes to a better description of mechanisms perpetuating AF. It thereby provides information needed to target and test new ph...
Source: Swiss Medical Weekly - September 4, 2009 Category: Journals (General) Authors: Eckstein J, Kühne M, Osswald S, Schotten U Tags: Swiss Med Wkly Source Type: journals

External radiotherapy for prostate cancer with or without androgen deprivation: Geneva, 1991 to 2004.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: AD+RT significantly improved both 10-year OS and bDFS, especially in patients with high-risk disease at diagnosis. Patients treated with RT alone presented with continuous failures during the 10-year interval of observation, thus questioning the wisdom of proposing RT alone at doses below 74 Gy, especially for patients with long life expectancies. PMID: 19736590 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - September 4, 2009 Category: Journals (General) Authors: Miralbell R, Pampallona S, Rouzaud M, Pugliesi A, Weber D, Ares C Tags: Swiss Med Wkly Source Type: journals

MicroRNAs: critical mediators of differentiation, development and disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MicroRNAs (miRNAs) are small non-coding RNAs that are expressed in higher eukaryoates and have even been found in viral genomes. They usually act as endogenous repressors of target genes by either inhibiting translation, causing mRNA degradation, or by a combination of both mechanisms. More than 850 mature miRNA sequences have been identified in humans, and although this accounts for less than 2% of human genes, it is predicted that 30% of mRNAs are targeted by miRNAs. miRNAs play critical roles in most cellular processes including development, differentiation, and the homeostasis of both a cell and an organism. Moreov...
Source: Swiss Medical Weekly - August 21, 2009 Category: Journals (General) Authors: Friedman JM, Jones PA Tags: Swiss Med Wkly Source Type: journals

Prevalence of microalbuminuria and its associated cardiovascular risk: German and Swiss results of the recent global i-SEARCH survey.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Patients with MAU are common in clinical cardiology and its presence is associated with a wide variety of cardiovascular risk factors and co-morbid cardiovascular conditions. A more aggressive multi-factorial treatment might help to reduce this risk constellation. PMID: 19705307 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 21, 2009 Category: Journals (General) Authors: Tebbe U, Bramlage P, Thoenes M, Paar WD, Danchin N, Volpe M, Schrader J, Noll G, Burnier M, Böhm M Tags: Swiss Med Wkly Source Type: journals

Detection of intake of nonsteroidal anti-inflammatory drugs in elderly patients with heart failure. How to ask the patient?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: NSAID use in heart failure patients is relatively common. Specific questioning may help to increase detection of NSAID intake and information on its hazardous effects to decrease NSAID use. PMID: 19705308 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 21, 2009 Category: Journals (General) Authors: Muzzarelli S, Tobler D, Leibundgut G, Schindler R, Buser P, Pfisterer ME, Brunner-La Rocca HP Tags: Swiss Med Wkly Source Type: journals

Impact of job insecurity on sexual desire: an exploratory analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: An increasing fear of job loss is associated with a deterioration in sexual desire. These first preliminary findings should promote further epidemiological and clinical prospective studies on the impact of job insecurity on intimate relationships and sexual dysfunction. PMID: 19705309 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 21, 2009 Category: Journals (General) Authors: Domenighetti G, Tomada A, Marazzi A, Abazi O, Quaglia J Tags: Swiss Med Wkly Source Type: journals

Abstracts of the 15th Wonca Europe Conference, 16-19 September 2009, Basel, Switzerland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19693713 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 18, 2009 Category: Journals (General) Tags: Swiss Med Wkly Source Type: journals

Abstracts of the Joint annual congress of the Swiss Society for Allergology and Immunology and the Swiss Society for Infectious Diseases, March 19/20, 2009, Geneva, Switzerland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19693714 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 18, 2009 Category: Journals (General) Tags: Swiss Med Wkly Source Type: journals

Abstracts Reha Schweiz Kongress 2009: Musculosceletal rehabilitation - evidence and competence, March 12/13, 2009, Interlaken, Switzerland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19693715 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 18, 2009 Category: Journals (General) Tags: Swiss Med Wkly Source Type: journals

Effects of interventions on the demand for hospital services in an influenza pandemic: a sensitivity analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The range of outcomes, resulting from parameter uncertainty, reaches from outpatient and hospitalization values which are half as high as the median to values which double the median. A combination of antiviral treatment and social distancing can considerably mitigate a severe pandemic, but will only bring it under control for the most optimistic parameter constellation combining (mild outbreaks with a high compliance of interventions). PMID: 19675954 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 11, 2009 Category: Journals (General) Authors: Vidondo B, Oberreich J, Brockmann SO, Duerr HP, Schwehm M, Eichner M Tags: Swiss Med Wkly Source Type: journals

What makes a good lung?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The functional capacity of the human lung as gas exchanger is to a large extent determined by structural design. Quantitative structure-function correlations can be established by morphometry. A very large surface of air-blood contact, together with a very thin tissue barrier, are required to permit adequate oxygen uptake under work conditions. However, these design features also pose problems, such as how to ventilate and perfuse this large surface evenly and efficiently, or how to ensure mechanical stability against surface forces with a minimum of supporting tissue. The discussion focuses on the extent to which nove...
Source: Swiss Medical Weekly - July 10, 2009 Category: Journals (General) Authors: Weibel ER Tags: Swiss Med Wkly Source Type: journals

Appropriateness of respiratory care: evidence-based guidelines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Despite a marked heterogeneity of scientific evidence, the method used allowed us to develop commonly agreed local guidelines for respiratory care. In addition, this work fostered a closer relationship between physiotherapists and physicians in our institution. PMID: 19629766 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - July 10, 2009 Category: Journals (General) Authors: Rosière J, Vader JP, Sokol Cavin M, Grant K, Larcinese A, Voellinger R, Burnand B, Revelly JP, Fitting JW Tags: Swiss Med Wkly Source Type: journals

Factors influencing emergency delays in acute stroke management.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Transportation by ambulance and referral by the patient or family significantly improved admission delays and early in-hospital management. Correct recognition of stroke symptoms further contributed to significant shortening of admission time. Educational programmes should take these findings into account. PMID: 19629767 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - July 10, 2009 Category: Journals (General) Authors: Sekoranja L, Griesser AC, Wagner G, Njamnshi AK, Temperli P, Herrmann FR, Grandjean R, Niquille M, Vermeulen B, Rutschmann OT, Sarasin F, Sztajzel R Tags: Swiss Med Wkly Source Type: journals

Age and gender distribution of primary hyperparathyroidism and incidence of surgical treatment in a European country with a particularly high life expectancy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In a European population with high life expectancy, the hospitalisation rate of PHPT is higher in women and increases continuously with age. Incidence of PTX is highest in patients aged 70-74 years. These findings underscore the need for further research on the impact of population aging on the treatment patterns of PHPT. PMID: 19629768 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - July 10, 2009 Category: Journals (General) Authors: Richert L, Trombetti A, Herrmann FR, Triponez F, Meier C, Robert JH, Rizzoli R Tags: Swiss Med Wkly Source Type: journals

Epidemiology of atrial fibrillation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atrial fibrillation is the most common sustained cardiac arrhythmia in the general population. Unfortunately, current treatment strategies aiming at the elimination of atrial fibrillation have limited long term success rates and significant risks. In this context, recent publications have provided many insights on potentially treatable risk factors for the occurrence of atrial fibrillation, such as alcohol, blood pressure, obesity, inflammation and nutritional factors. In this review, we summarise the current evidence on these risk factors and indicate areas in need of further investigation. The current evidence shows ...
Source: Swiss Medical Weekly - June 26, 2009 Category: Journals (General) Authors: Conen D, Osswald S, Albert CM Tags: Swiss Med Wkly Source Type: journals

Management of transitional-cell carcinoma of the renal pelvis and ureter.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transitional-cell carcinoma of the renal pelvis or ureter is a relatively rare disease. Several risk factors are smoking, occupational carcinogens, analgesic abuse or Balkan nephropathy. The grade and stage of the disease have the most significant impact on the outcome. The treatment of renal pelvis and ureter tumours is open or laparoscopic surgery varying from conservative to more extensive surgical procedures, i.e. radical nephroureterectomy including removal of the contents of Gerota's fascia with ipsilateral ureter and a cuff of bladder at its distal extent. Most available data are from retrospective studies and s...
Source: Swiss Medical Weekly - June 26, 2009 Category: Journals (General) Authors: Ozsahin M, Ugurluer G, Zounair A Tags: Swiss Med Wkly Source Type: journals

Oscillometric measurement of ankle-brachial index in patients with suspected peripheral disease: comparison with Doppler method.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Results of automated oscillometric ABI determination correlated well with Doppler-assisted measurements and could be obtained in shorter time. Agreement was particularly high. PMID: 19562530 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - June 26, 2009 Category: Journals (General) Authors: Diehm N, Dick F, Czuprin C, Lawall H, Baumgartner I, Diehm C Tags: Swiss Med Wkly Source Type: journals

Sperm mediated human coagulation factor VIII gene transfer and expression in transgenic mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Human FVIII gene transgenic mice can be produced by the SMGT technique and express human FVIII protein in their bodies. PMID: 19562531 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - June 26, 2009 Category: Journals (General) Authors: Yin J, Zhang JJ, Shi GG, Xie SF, Wang XF, Wang HL Tags: Swiss Med Wkly Source Type: journals

Procalcitonin and other biomarkers to improve assessment and antibiotic stewardship in infections - hope for hype?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review aims to provide physicians with an overview of the potential of procalcitonin to guide antibiotic therapy in respiratory tract infections and in sepsis. Knowledge of the strengths and weaknesses of procalcitonin are prerequisites for a rational and safe use in clinical routine. In most infections a true gold standard for diagnosis does not exist, therefore physicians must remain sceptical towards observational studies evaluating procalcitonin. Interpretation of procalcitonin levels must always include the clinical setting and knowledge of assay characteristics, particularly the setting of specific cut-off r...
Source: Swiss Medical Weekly - June 12, 2009 Category: Journals (General) Authors: Schuetz P, Christ-Crain M, Müller B Tags: Swiss Med Wkly Source Type: journals

Diagnosis of mild bleeding disorders.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The precise diagnosis of a severe haemorrhagic disorder is usually not too problematic. However, physicians are most often faced with individuals consulting for mild haemorrhagic symptoms, particularly occurring after a surgical intervention. The problem here is to evaluate whether this person really has a bleeding disorder requiring special investigations and treatments, particularly if another invasive procedure is planned. The key point is to ask the appropriate questions to discriminate bleeding occurring in normal subjects from that occurring in patients with haemostatic disorders. Recently, bleeding questionnaire...
Source: Swiss Medical Weekly - June 12, 2009 Category: Journals (General) Authors: de Moerloose P, Levrat E, Fontana P, Boehlen F Tags: Swiss Med Wkly Source Type: journals

Reasons why people in Switzerland seek assisted suicide: the view of patients and physicians.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Both prescribing physicians and;patients provided with assistance to die quite often mentioned pain and other concerns, many of which were objectively assessable and related to unbearable suffering or unreasonable disability. Concerns referable to autonomy and individual judgement were more often noted by people seeking help than by the prescribing physicians. PMID: 19529991 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - June 12, 2009 Category: Journals (General) Authors: Fischer S, Huber CA, Furter M, Imhof L, Mahrer Imhof R, Schwarzenegger C, Ziegler SJ, Bosshard G Tags: Swiss Med Wkly Source Type: journals

Effects of thyroxine replacement on serum creatinine and cystatin C in patients with primary and central hypothyroidism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: CysC was low at diagnosis of hypothyroidism and significantly increased following T4 replacement in patients with primary as well as central hypothyroidism. T4 replacement decreased Cr levels in patients with primary hypothyroidism whereas Cr remained unchanged in;patients with central hypothyroidism. CysC may not accurately reflect kidney function in patients with primary and central thyroid dysfunction. PMID: 19529992 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - June 12, 2009 Category: Journals (General) Authors: Goede DL, Wiesli P, Brändle M, Bestmann L, Bernays RL, Zwimpfer C, Schmid C Tags: Swiss Med Wkly Source Type: journals

An influenza smiley.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19449215 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 29, 2009 Category: Journals (General) Authors: Kaiser L Tags: Swiss Med Wkly Source Type: journals

An overview of cow's milk allergy in children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Food allergies have increased over the past decade and are an important problem in daily clinical practice. They affect 6% of children and 3 to 4% of adults. Furthermore, around 20% of the population falsely believe that they are allergic to some foods and follow unnecessarily restrictive diets. For infants, the problem is even more acute as they need appropriate feeding in order to achieve normal growth and avoid bone and metabolic problems. Although any food can cause a reaction, few foods are responsible for the large majority of the symptoms: i.e., milk, eggs, wheat, peanuts, nuts, fish, shellfish. Of these, cow's ...
Source: Swiss Medical Weekly - May 29, 2009 Category: Journals (General) Authors: Benhamou AH, Schäppi Tempia MG, Belli DC, Eigenmann PA Tags: Swiss Med Wkly Source Type: journals

Heart rate response determines long term exercise capacity after heart transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Heart rate response is one of the most important predictors of exercise capacity in HTx recipients with complete chronotropic competence and without relevant transplant vasculopathy or acute allograft rejection. PMID: 19492196 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 29, 2009 Category: Journals (General) Authors: Käser A, Martinelli M, Feller M, Carrel T, Mohacsi P, Hullin R Tags: Swiss Med Wkly Source Type: journals