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Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach
Syst Biol Reprod Med. 2024 Dec;70(1):101-112. doi: 10.1080/19396368.2024.2325699. Epub 2024 Apr 17.ABSTRACTMDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and appropriate DDR regulation. There haven't been systematic investigations of MDC1 mutations that induce cancer and genomic instability. Variations in nsSNPs have the potential to modify the protein chemistry and their function. Describing functional SNPs in disease-associated genes ...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Vaishnavee Thote Susha Dinesh Sameer Sharma Source Type: research

Correlation between standard sperm parameters and sperm DNA fragmentation from 11,339 samples
Syst Biol Reprod Med. 2024 Dec;70(1):91-100. doi: 10.1080/19396368.2024.2333285. Epub 2024 Apr 17.ABSTRACTConventional semen parameters have long been considered fundamental in male fertility analyses. However, doubts have been raised regarding the clinical utility of the assessment of spermatozoa (sperm) DNA damage. In this retrospective study, we investigated the potential correlation between conventional semen parameters and semen DNA fragmentation (SDF) assessed as sperm DNA damage, in 11,339 semen samples collected between January 2019 and June 2022. We observed significant negative correlations between the DNA fragme...
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Reproduction Medicine Authors: Tingting Yang Lin Yu Jinyan Xu Lijuan Ying Yelin Jia Yan Zheng Bin Zhou Fuping Li Source Type: research

Correlation between standard sperm parameters and sperm DNA fragmentation from 11,339 samples
Volume 70, Issue 1, December 2024, Page 91-100 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Sexual Medicine Authors: Tingting YangLin YuJinyan XuLijuan YingYelin JiaYan ZhengBin ZhouFuping Lia Department of Andrology/Sichuan Human Sperm Bank, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. Chinab Key Laboratory of Birth Defects and Rela Source Type: research

Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach
Volume 70, Issue 1, December 2024, Page 101-112 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 17, 2024 Category: Sexual Medicine Authors: Vaishnavee ThoteSusha DineshSameer SharmaDepartment of Bioinformatics, BioNome, Bengaluru, India Source Type: research

Insight into the complexity of male infertility: a multi-omics review
Syst Biol Reprod Med. 2024 Dec;70(1):73-90. doi: 10.1080/19396368.2024.2317804. Epub 2024 Mar 22.ABSTRACTMale infertility is a reproductive disorder, accounting for 40-50% of infertility. Currently, in about 70% of infertile men, the cause remains unknown. With the introduction of novel omics and advancement in high-throughput technology, potential biomarkers are emerging. The main purpose of our work was to overview different aspects of omics approaches in association with idiopathic male infertility and highlight potential genes, transcripts, non-coding RNA, proteins, and metabolites worth further exploring. Using the Ge...
Source: Systems Biology in Reproductive Medicine - March 22, 2024 Category: Reproduction Medicine Authors: Rebeka Podgrajsek Alenka Hodzic Martin Stimpfel Tanja Kunej Borut Peterlin Source Type: research