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368 records returned

Inhibition of NMDA receptors underlies the neuroprotective effect of ginsenoside Rb3.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In order to investigate the mechanisms underlying the neuroprotective effect of ginsenoside Rb3, rat hippocampal neurons were primarily cultured, and exposed to 1 mM N-methyl-D-aspartate (NMDA), cell viability and lactate dehydrogenase leakage were measured. Ca2+ influx was determined by calcium imaging with a laser confocal microscopy. The influences of ginsenoside Rb3 on these variables were examined. Patch-clamp technique was used to observe the effects of ginsenoside Rb3 on NMDA-evoked current. The results show that treatment of Rb3 raised the neuronal viability, reduced the leakage of lactate dehydrogenase, and in...
Source: The American Journal of Chinese Medicine - November 18, 2009 Category: Complementary Medicine Authors: Peng LL, Shen HM, Jiang ZL, Li X, Wang GH, Zhang YF, Ke KF Tags: Am J Chin Med Source Type: journals

A six-week acupoint stimulation intervention for quitting smoking.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study creates a six-week acupoint stimulation program for quitting smoking by conducting an experimental research design and then evaluating its effects. A total of 59 smokers, 28 +/- 7.6 years of mean age, volunteered to participate and were randomly assigned to the experimental or sham group. The current investigation administered anti-smoking acupoints to the experimental group for six weeks, whereas the sham group used sham acupoints for six weeks. Before and after the six-week intervention, the participants completed questionnaires and offered blood samples. This research collected data of demographic factors, se...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Yeh ML, Chang CY, Chu NF, Chen HH Tags: Am J Chin Med Source Type: journals

The Effect on Serotonin and MDA Levels in Depressed Patients with Insomnia when Far-Infrared Rays are Applied to Acupoints.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Little is known about the effect of far-infrared rays (FIR) on serotonin and malondialdehyde levels in depressed patients with insomnia. The purpose of this study is to assess the effect of far-infrared rays on depressed people with insomnia. A randomized design was used to determine this effect. A total of 70 inpatients were recruited with the clinical diagnosis of depression with sleep disturbance. In the experimental group, FIR was applied to three chosen acupuncture points by a patch-like sticker for a period of 15 minutes twice a week. The three acupuncture points are Nei-Kuan (PC6), Shenmen (HT7) and Sanyinjiao (...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Chang Y, Liu YP, Liu CF Tags: Am J Chin Med Source Type: journals

Anti-Obesity Effect of Blumea balsamifera Extract in 3T3-L1 Preadipocytes and Adipocytes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obesity, the leading metabolic disease in the world, is a serious health problem in industrialized countries. We investigated the anti-obesity effect of Blumea balsamifera extract on adipocyte differentiation of 3T3-L1 preadipocytes and anti-obesity effect of 3T3-L1 adipocytes. We found that treatment with an extract of Blumea balsamifera suppressed lipid accumulation and glycerol-3-phosphate dehydrogenase (GPDH) activity without affecting cell viability in 3T3-L1 preadipocytes and adipocytes. Furthermore, Blumea balsamifera extract brought significant attenuation of expressions of key adipogenic transcription factors,...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Kubota H, Kojima-Yuasa A, Morii R, Huang X, Norikura T, Rho SN, Matsui-Yuasa I Tags: Am J Chin Med Source Type: journals

Trigona laeviceps Propolis from Thailand: Antimicrobial, Antiproliferative and Cytotoxic Activities.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Propolis is one of the natural bee products which has long been used as a crude preventative and prophylactic medicine, and has been reported to possess antibacterial, antiviral, anti-inflammatory, antioxidative and anticancer properties. Propolis of the stingless bee, Trigona laeviceps, was extracted by water or methanol at 35% (w/v) yielding a crude water or a methanolic extract at 60 and 80 mg/ml, respectively, which is 17.1 and 22.9% (w/w) of the total propolis, respectively. The antimicrobial activity of both crude extracts was assayed on four selected pathogenic microbes by using the agar well diffusion method. T...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Umthong S, Puthong S, Chanchao C Tags: Am J Chin Med Source Type: journals

Gingko biloba Extract (EGb 761) Prevents Increase of Bad-Bcl-X(L) Interaction Following Cerebral Ischemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated whether EGb 761 modulates Bcl-2 family proteins in ischemic brain injury. Male adult rats were treated with EGb 761 (100 mg/kg) or vehicle prior to middle cerebral artery occlusion (MCAO), brain tissues were collected 24 hours after MCAO. EGb761 administration significantly decreased the number of TUNEL-positive cells in the cerebral cortex. Ischemic brain injury induced decrease of Bcl-2 and Bcl-X(L) levels. EGb 761 prevented not only the injury-induced decrease of Bcl-2 and Bcl-X(L) levels, but also the injury-induced increase of Bax. Moreover, in the presence of EGb 761, the interaction of Bad an...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Koh PO Tags: Am J Chin Med Source Type: journals

Protective Effects of Total Flavones of Rhododendra against Global Cerebral Ischemia Reperfusion Injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this research was to demonstrate the protective effects and possible mechanisms of total flavones of rhododendra (TFR) against global cerebral ischemia reperfusion injury in rats. Global cerebral ischemia/reperfusion injury was caused by four vessel occlusion (bilateral vertebral arteries and bilateral carotid arteries, 4-VO). The electroencephalographic (EEG) changes were recorded. The EEG, brain water content, levels of malondialdehyde (MDA) and lactate dehydrogenase (LDH) activity in plasma, aggregation of platelets induced by ADP, and the resting and CaCl(2)-induced increase of free intracellular cal...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Yu T, Chen QE, Chen ZW, Xiong Z, Ye M Tags: Am J Chin Med Source Type: journals

Yam (Dioscorea pseudojaponica Yamamoto) Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced by D-Galactose.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study attempted to access the neuroprotective effect of yam (Dioscorea pseudojaponica Yamamoto) on the senescent mice induced by D-gal. The mice in the experiments were administered orally with yam (20, 100 or 500 mg/kg for 4 weeks, from the sixth week). The learning and memory abilities of the mice in Morris water maze test and the mechanisms involved in the neuroprotective effect of yam on the mice brain tissue were investigated. The content of diosgenin in the yam was also detected by using HPLC. Mice treated with yam were found to significantly improve their learning and memory abilities in Morris water maze test ...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Chiu CS, Deng JS, Hsieh MT, Fan MJ, Lee MM, Chueh FS, Han CK, Lin YC, Peng WH Tags: Am J Chin Med Source Type: journals

A study of the comparative effects of hawthorn fruit compound and simvastatin on lowering blood lipid levels.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This project studied the lowering blood lipids effect in atherosclerotic ApoE-deficient mice. Group A mice (n = 6), fed with a normal diet, served as the negative control. The experimental groups used mice fed with a high cholesterol diet (HCD) for eight weeks, and then selected for inclusion in the study on the basis of high blood lipid levels and the formation of atherosclerotic lesion plaque, which was indicated by an ultrasound biomicroscopy test. Eighteen mice met the selection criteria (atherosclerotic mice with high blood lipid levels) and these were randomly assigned into three groups B, C and D (n = 6). Group ...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Xu H, Xu HE, Ryan D Tags: Am J Chin Med Source Type: journals

A Low Molecular Weight Polysaccharide Isolated from Agaricus blazei Murill (LMPAB) Exhibits Its Anti-Metastatic Effect by Down-Regulating Metalloproteinase-9 and Up-Regulating Nm23-H1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The components of Agaricus blazei Murill (AbM) have been shown to possess antitumor potentials. Herein, we attempted to explore the anti-metastatic effect and underlying mechanism of a low molecular weight polysaccharide isolated from AbM (LMPAB). Matrigel invasion assay was applied to evaluate the effect of LMPAB on migration of BEL-7402 hepatic cancer cells in vitro. In vivo, the anti-metastatic effect of LMPAB was investigated in mouse B16 melanoma and a double-grafted SW180 tumor models. mRNA and protein levels of metalloproteinase-9 (MMP-9) or nm23-H1 upon LMPAB treatment were detected by real-time PCR and immunoh...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Niu YC, Liu JC, Zhao XM, Cao J Tags: Am J Chin Med Source Type: journals

Rhein lysinate suppresses the growth of tumor cells and increases the anti-tumor activity of taxol in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, rhein lysinate offers an anti-tumor activity in vivo and is hopeful to be a chemotherapeutic drug. PMID: 19885952 [PubMed - in process] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Lin YJ, Zhen YZ, Shang BY, Zhen YS Tags: Am J Chin Med Source Type: journals

Anti-Tumor Activity of Polysaccharides Isolated from Patrinia scabra Bunge on U14 Cervical Carcinoma Bearing Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of our study was to investigate the effect of Patrinia scabra Bunge polysaccharide (PSB-P2) on cervical cancer cell (U14)-bearing mice. The tumor weight of mice treated with PSB-P2 (40, 80 mg/kg b.w.) was significantly lower than that of the control group and serum lactate dehydrogenase (LDH) activity was decreased, while serum alkaline phosphatase (AKP) level was only changed slightly. Meanwhile, the number of apoptotic tumor cells was significantly increased in the mice by the treatment of PSB-P2 (40, 80 mg/kg b.w.). At the same time, cell cycle analysis showed the accumulation of tumor cells in the G0/G1 pha...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Lu WZ, Geng GX, Li QW, Li J, Liu FZ, Han ZS, Gao DW, Yan X, Yang XL Tags: Am J Chin Med Source Type: journals

The Proliferation and Migration Effects of Huangqi on RSC96 Schwann Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluated the proliferation effects of huangqi on neuron regeneration. We investigated the molecular mechanisms, which include: (1) cyclin D1, A, E-cell cycle factors and MAPK signaling proliferation (2) FGF-2-UPA-MMPs migration signaling. After treatment with various Huanqi concentrations (1.25, 12.5, 125, 250 and 500 mug/ml,), we observed that Huanqi can increase Rsc 96 cell proliferation at 12.5 mug/ml (p < 0.01) concentration determined by the MTT and wound healing tests. Examination by RT-PCR and Western blotting assay showed that Huangqi is able to stimulate the mRNA and protein expressions of cyclin D1...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Fang WK, Ko FY, Wang HL, Kuo CH, Chen LM, Tsai FJ, Tsai CH, Chen YS, Kuo WW, Huang CY Tags: Am J Chin Med Source Type: journals

The anti-hyperglycemic effect of plants in genus gynura cass.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gynura divaricata (L.) DC and G. bicolor DC are used as secret recipes to treat diabetes mellitus in some parts of China. Pharmacological tests were performed to prove the anti-hyperglycemic effect of these two plants of genus Gynura Cass. in this study. Both water and 95% ethanol extracts of fresh G. divaricata had significant effects on lowering blood glucose level in normal mice, in which the dose of 0.4 g (crude drug)/kg of 95% ethanol extract was more effective than 50 mg/kg glyburide. The ethyl acetate and n-butanol extracts of dried G. divaricata had significant effects on lowering blood glucose level in normal ...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Li WL, Ren BR, Min-Zhuo , Hu Y, Lu CG, Wu JL, Chen J, Sun S Tags: Am J Chin Med Source Type: journals

A Study on the Antioxidant Activity and Tissues Selective Inhibition of Lipid Peroxidation by Saponins from the Roots of Platycodon grandiflorum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Platycodi Radix is the root of Platycodon grandiflorum (Jacq.) A. DC and has been used as a traditional medicine in China. According to the theory of traditional Chinese medicine, Platycodi Radix (PR) possesses the character of lung meridian tropism (Guijing) and has selective effects on the lung and respiratory system. The aim of this study was to confirm the antioxidant effects of saponins from Platycodi Radix (PRS), with emphasis on its selective inhibition of lipid peroxidation in different tissues. The hydroxyl radical scavenging activity was determined by a H(2)O(2)/Fe(2+) system; a modified thiobarbituric acid r...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Fu XJ, Liu HB, Wang P, Guan HS Tags: Am J Chin Med Source Type: journals

Structural Determination and Antioxidant Activity of a Polysaccharide from the Fruiting Bodies of Cultured Cordyceps sinensis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A water-soluble polysaccharide named CPS1 had been isolated from C. sinensis mycelium by hot water extraction, ethanol precipitation, anion-exchange, and gel-permeation chromatography. UV spectra, FTIR spectra, partial acid hydrolysis, PMP precolumn derivation, periodate oxidation and Smith degradation studies were conducted to elucidate its structure. The results indicated that CPS1 was a glucomannogalactan with the monosaccharide composition of glucose: mannose: galactose = 2.8: 2.9: 1. The total carbohydrate content of CPS1 was 99.0%. The weight-average molecular weight was 8.1 x 10(3) Da. The results predicted (1 -...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Wang Y, Wang M, Ling Y, Fan W, Wang Y, Yin H Tags: Am J Chin Med Source Type: journals

Characterization of the Possible Mechanisms Underlying the Hypotensive and Spasmogenic Effects of Loranthus ferrugineus Methanolic Extract.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the present study, L. ferrugineus methanol extract (LFME) was evaluated for its blood pressure lowering effect in anesthetized normotensive Sprague Dawley (SD) rats and its spasmogenic effect in isolated guinea pig ileum. The possible mechanism(s) of action were also investigated. LFME was obtained by Soxhlet extraction. The rats were fasted overnight and anesthetized with sodium pentobarbitone (60 mg/kg i.p.). LFME was administered in i.v. boluses in the concentrations of 25, 50, 100 and 200 mg/kg respectively, with concomitant monitoring of mean arterial pressure (MAP). It was found that LFME dose-dependently redu...
Source: The American Journal of Chinese Medicine - November 6, 2009 Category: Complementary Medicine Authors: Ameer OZ, Salman IM, Siddiqui MJ, Yam MF, Sriramaneni RN, Sadikun A, Ismail Z, Shah AM, Asmawi MZ Tags: Am J Chin Med Source Type: journals

Analysis of trace elements in chinese therapeutic foods and herbs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The bioactive elements in Chinese therapeutic foods and herbs that are frequently consumed by people in both the East and West are analyzed. These elements in their appropriate dosage range are considered to be beneficial to health. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and Atomic Absorption Spectrometry (AAS) were applied to determine the concentrations of various elements. Twenty-two Chinese therapeutic foods and herbs, resourced from the traditional high therapeutic quality areas or provinces were selected. Bioactive analysis focused on Lanthanum (La), Strontium (Sr), Zinc (Zn) and Selenium (Se), esp...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Xu H, Xu HE Tags: Am J Chin Med Source Type: journals

Electroacupuncture Induces Differential Effects between Yin and Yang: A Study using Cutaneous Blood Flow and Temperature Recordings of the Hand's Dorsum and Palm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the results of the present study were consistent with the underlying theory of TCM that considers the fundamental differences between Yin and Yang. PMID: 19655403 [PubMed - in process] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Lu CC, Jan YM, Li TC, Hsieh CL Tags: Am J Chin Med Source Type: journals

Disruption of glial function regulates the effects of electro-acupuncture at tsusanli on gastric activity in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we observed the effect of EA at Tsusanli (ST 36) on regulation of gastric activity. Propentofylline (PPF), a glial metabolic inhibitor, was used to inhibit the function of glial cells. EA at Tsusanli showed that the expressions of glial fibrillary acidic protein (GFAP) and OX42 increased significantly compared to that of the control group, and gastric electric change was obvious, with significantly higher frequency and wave amplitude compared to the control group. The expressions of GFAP and OX42 were decreased markedly when pretreated with PPF group than without PPF pretreatment group. Compared to the Tsusa...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Wang SZ, Liu XD, Huang YX, Ma QJ, Wang JJ Tags: Am J Chin Med Source Type: journals

Long-Term Effects of Panax Ginseng on Disposition of Fexofenadine in Rats in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to explore the pharmacokinetic interaction of Panax Ginseng with fexofenadine in rats. Sprague-Dawley (SD) male rats were divided randomly into four groups: control oral and treatment oral dose groups (n = 6, respectively); control intravenous and treatment intravenous dose groups (n = 5, respectively). A single dose of fexofenadine (10 mg/kg for intravenous group rats and 100 mg/kg for oral dose group rats) was administered after 14 consecutive days of gastric gavage feeding of panax ginseng suspension (150 mg/kg/day) to treatment groups while the same volume of vehicle (1.6% ethanol) was administe...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Zhang R, Jie J, Zhou Y, Cao Z, Li W Tags: Am J Chin Med Source Type: journals

Effects of Extracts from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on MSU Crystal-Induced Rats Gouty Arthritis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effects of extract of Paederia scandens (LOUR.) MERRILL (Rubiaceae) (EPS), a Chinese traditional herbal medicine, on inflammatory and immune responses and their mechanisms in MSU crystals-induced (GA) rats were studied. GA rats were established. Ankle joint volume of rats was measured by volume meter; the level of TNF-alpha and IL-1beta was determined by radioimmunoassay. mRNA expressions of TNF-alpha and IL-1beta in synovial tissue of GA rats were analyzed by RT-PCR, and the expression of NF-kappaB was detected by immunohistochemistry. The administration of EPS (2.25, 4.5 g/kg, ig 9 days) inhibited the inflammator...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Ma Y, Zhou LL, Yan HY, Liu M Tags: Am J Chin Med Source Type: journals

Efficacy of Different Fractions of Anethum graveolens Leaves on Serum Lipoproteins and Serum and Liver Oxidative Status in Experimentally Induced Hypercholesterolaemic Rat Models.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was to disclose the antioxidant and hypolipidaemic properties of different fractions of the Anethum graveolens extract (AGE), evaluated in hypercholesterolaemic rats. The animals were divided into five groups, Group I served as healthy control; groups II to V were made hypercholesterolaemic by feeding high-fat diet (HFD) for 3 weeks. After induction of hypercholesterolaemia, the rats in groups III to V received different fractions [diethyl ether (EEF), ethyl acetate (EAF) and water (WF) fractions, respectively] of the AGE at a dose of 50 mg/kg body weight per day for 2 weeks. Feeding HFD increased serum total ch...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Bahramikia S, Yazdanparast R Tags: Am J Chin Med Source Type: journals

Scorpion venom peptides accelerate hematopoietic recovery of myelosuppression in irradiated mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sublethally irradiated mice were administered with scorpion venom peptides (SVP) or with PBS in the saline control group, 3 days before and 7 consecutive days after irradiation. Hematopoietic recovery was assessed by bone marrow (BM) cell proliferation index (PI) and colony forming unit-granulocyte/macrophage (CFU-GM), spleen weight index (SI) and thymus weight index (TI), colony-forming unit-spleen (CFU-S) and peripheral leukocyte counts. In addition, IL-1alpha and SCF levels in BM, IL-6 and GM-CSF levels in serum were determined. In SVP treated groups, PI was improved dramatically versus control mice on day 22 after ...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Dong W, Wang L, Kong T, He Y Tags: Am J Chin Med Source Type: journals

In vitro Activity of Impatiens balsamina L. Against Multiple Antibiotic-Resistant Helicobacter pylori.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, anti-H. pylori activity of I. balsamina L. was investigated. The MICs, MBCs, time-kill assay, and effect of environmental pH for the plant extracts were determined. The test H. pylori strains have resistance to clarithromycin (CLR), metronidazole (MTZ), and levofloxacin (LVX). From our results, all part (root/stem/leaf, seed, and pod) extracts of I. balsamina L. exhibited bactericidal H. pylori activity. Specifically, the pod extract had significantly lower MICs and MBCs (1.25-2.5 and 1.25-5.0 mug/ml, respectively). Of the five pod-extraction solvents, both ethyl acetate and acetone were the most efficient f...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Wang YC, Wu DC, Liao JJ, Wu CH, Li WY, Weng BC Tags: Am J Chin Med Source Type: journals

(-)-Epigallocatechin-3-Gallate (EGCG) Increases the Viability of Serum-Starved A549 Cells Through Its Effect on Akt.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study has shown that EGCG protects A549 cells from apoptosis induced by serum deprivation via Akt activation and this protective effect may limit the clinical use of EGCG in treating and preventing NSCLC. PMID: 19655410 [PubMed - in process] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Kim MJ, Kim HI, Chung J, Jeong TS, Park HR Tags: Am J Chin Med Source Type: journals

Protective Effect of Ursolic Acid from Cornus officinalis on the Hydrogen Peroxide-Induced Damage of HEI-OC1 Auditory Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The fruits of Cornus officinalis have been used in traditional oriental medicine for treatment of inner ear diseases, such as tinnitus and hearing loss. In the present study, we investigated the protective effect of C. officinalis on hydrogen peroxide-induced cytotoxicity in HEI-OC1 auditory cells. The results from bioassay-guided fractionation of methanol extract of C. officinalis fruits showed that ursolic acid is a major active component. Ursolic acid (0.05-2 mug/ml) had protective effect against the HEI-OC1 cell damage and reduced lipid peroxidation in a dose-dependent manner. In addition, pre-treatment with ursoli...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Yu HH, Hur JM, Seo SJ, Moon HD, Kim HJ, Park RK, You YO Tags: Am J Chin Med Source Type: journals

Total saponins of panax ginseng induces k562 cell differentiation by promoting internalization of the erythropoietin receptor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was to examine the effect of TSPG or the combination of erythropoietin (EPO) and TSPG on the erythroid differentiation of K562 cells, and their corresponding mechanisms regarding erythropoietin receptor (EPOR) expression. Under light and electron microscopes, the TSPG- or TSPG + EPO-treated K562 cells showed a tendency to undergo erythroid differentiation; early and intermediate erythroblast-like cells were observed. Hemoglobin and HIR2 expressions were significantly increased. As determined by Western blotting analysis, the EPOR protein level in the K562 cytoplasmic membrane was significantly decreased after TS...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Zuo G, Guan T, Chen D, Li C, Jiang R, Luo C, Hu X, Wang Y, Wang J Tags: Am J Chin Med Source Type: journals

Inhibition of NMDA Receptors Underlies the Neuroprotective Effect of Ginsenoside Rb(3).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In order to investigate the mechanisms underlying the neuroprotective effect of ginsenoside Rb(3), rat hippocampal neurons were primarily cultured, and exposed to 1 mM N-methyl-D-aspartate (NMDA), cell viability and lactate dehydrogenase leakage were measured. Ca(2+) influx was determined by calcium imaging with a laser confocal microscopy. The influences of ginsenoside Rb(3) on these variables were examined. Patch-clamp technique was used to observe the effects of ginsenoside Rb(3) on NMDA-evoked current. The results show that treatment of Rb(3) raised the neuronal viability, reduced the leakage of lactate dehydrogena...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Peng LL, Shen HM, Jiang ZL, Li X, Wang GH, Zhang YF, Ke KF Tags: Am J Chin Med Source Type: journals

The Augmented Anti-Tumor Effects of Antrodia camphorata Co-Fermented with Chinese Medicinal Herb in Human Hepatoma Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, in this study, we have demonstrated a novel strategy of fermenting A. camphorata with Chinese medicinal herb (AC-CF), which augmented their anti-tumor effects in human hepatoma HepG2 cells as compared to the traditional ones (AC-FB or AC-SS). PMID: 19655414 [PubMed - in process] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Li SL, Huang ZN, Hsieh HH, Yu WC, Tzeng WY, Lee GY, Chen YP, Chang CY, Chuu JJ Tags: Am J Chin Med Source Type: journals

Protective effect of magnolol against hydrogen peroxide-induced oxidative stress in human lens epithelial cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, magnolol was observed to protect against H(2)O(2)-induced cytotoxicity in HLE B-3 cells. Magnolol inhibited the generation of reactive oxygen species (ROS), loss of mitochondrial membrane potential (Delta psi m) and release of cytochrome c from mitochondria caused by H(2)O(2) into cytosol in HLE B-3 cells. Magnolol also inhibited H(2)O(2)-induced expressions of caspase-9 and caspase-3 and reduction of Bcl-2/Bax ratio. Moreover, magnolol attenuated the deactivation of ERK/MAPK (extracellular signal-regulated kinase/mitogen activated protein kinase) and the enhanced activation of p38, JNK (c-Jun N-terminal kin...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Yao K, Zhang L, Ye PP, Tang XJ, Zhang YD Tags: Am J Chin Med Source Type: journals

Antioxidant and Antiproliferative Activities of Crossostephium chinensis (L.) Makino.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Crossostephium chinensis (L.) (CC) Makino is a common traditional Chinese medicinal plant used to dehumidify and cure rheumatism and arthralgia. The water and methanol extracts of C. chinensis (CCW and CCM) were evaluated for their antioxidant and antiproliferative activities. The antioxidant activities of CC were evaluated by using ABTS radical scavenging, DPPH radical scavenging, nitric oxide scavenging and superoxide scavenging methods. Iron chelating activity, lipid peroxidation, total polyphenol contents, total flavonoid contents and total flavonol contents were also detected. In all the tested models, both CCW an...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Chang TN, Huang GJ, Ho YL, Huang SS, Chang HY, Chang YS Tags: Am J Chin Med Source Type: journals

Antioxidant and antiradical activities of wu ling shen in a cell free system.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The present study aimed to investigate the antioxidant and antiradical activities of Wu Ling Shen, a popular medicinal fungus (Xylaria nigripes) used in traditional Chinese medicine preparations. Two different X. nigripes materials, the cultivated X. nigripes mycelia (XN) and a commercial X. nigripes product (XNP), were used to prepare the aqueous (XN-H vs. XNP-H) and ethanol (XN-E vs. XNP-E) extracts for this study. Polyphenol and total polysaccharide contents of these extracts were also examined. Results showed that extracts of XN possessed stronger antioxidant and antiradical activities than XNP in all tested model ...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Ko HJ, Song A, Lai MN, Ng LT Tags: Am J Chin Med Source Type: journals

New exploration and understanding of traditional chinese medicine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Traditional Chinese Medicine (TCM), originating from oriental philosophy and culture, has been developing through a series of special research and experiments with meditation, accumulation of experiences, and a complete comprehension of ancient theories and methods. However, compared with Conventional Western Medicine (CWM), the theory of TCM is complicated and not easily accepted by Westerners. It is important to explore TCM by using modern scientific techniques and theories. Utilizing his frontier experience and up-to-date scientific knowledge, Dr. Qian Xuesen has been trying to incorporate some key principles with t...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Xutian S, Zhang J, Louise W Tags: Am J Chin Med Source Type: journals

Identification of Linkage Disequilibrium SNPs from a Kidney-Yang Deficiency Syndrome Pedigree.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, KDS is involved in special SNP linkage disequilibrium in the intragenic level, and genes within the flanks of these SNPs suggest some essential symptoms of KDS. However, definitive evidence to confirm or exclude these loci and to establish their biological activities will be required. PMID: 19606505 [PubMed - in process] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Ding WJ, Zeng YZ, Li WH, Zhang TE, Liu WW, Teng XK, Ma YX, Yan SL, Wan JM, Wang MQ Tags: Am J Chin Med Source Type: journals

An analytical review of the chinese literature on qigong therapy for diabetes mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diabetes rates have doubled in China over the past decade. However, as conventional medicine offers neither a sound explanation nor an effective cure, patients with diabetes increasingly seek complementary and alternative therapies. It was reported that the traditional Chinese medical approach, Qigong, might produce therapeutic benefits with minimal side-effects in this condition. The Qigong Database, the China National Knowledge Infrastructure, and the library databases of Chinese institutions from 1978 to middle of 2008 on open trials, laboratory studies, and controlled clinical studies were reviewed. Over 35 studies...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Chen KW, Liu T, Zhang H, Lin Z Tags: Am J Chin Med Source Type: journals

The efficacy of kiko exercises on the prevention of migraine headaches: a pilot study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Migraine headaches, a common chronic medical problem, require prophylactic treatment when they are frequent and severe. This is the first study to investigate the efficacy of Kiko, a Japanese practice of Qigong that uses repetitive coordinated breathing and movement as a prophylactic treatment of migraine headaches. This pilot study, a single arm, non-randomized 4-month trial, investigated whether 3 months of Kiko training would reduce the severity and/or frequency of migraine and/or MIDAS scores. The baseline migraine data were collected from participants in the first month and then participants were taught Kiko exerc...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Elinoff V, Lynn SJ, Ochiai H, Hallquist M Tags: Am J Chin Med Source Type: journals

Effects of acupuncture stimulation on recovery ability of male elite basketball athletes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to investigate the effects of acupuncture stimulation on athletes' recovery abilities. Subjects were selected from 30 male elite university basketball players who were randomly assigned to 3 groups: acupuncture group, sham group, and normal (control) group, each containing 10 subjects. Acupuncture was carried out on each athlete in acupuncture group at the Neiguan (PC6) and Zusanli (ST36) acupoints, beginning at 15 min prior to exercise and continuing until exhaustion of the subject. Similar acupuncture was also carried out on each athlete in the sham group but the positions were 1 cm away from the PC6 and...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Lin ZP, Lan LW, He TY, Lin SP, Lin JG, Jang TR, Ho TJ Tags: Am J Chin Med Source Type: journals

Acupuncture stimulation improves balance function in stroke patients: a single-blinded controlled, randomized study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The disturbance of balance function is one of main etiology resulting in falling down in stroke patients. A number of studies report that acupuncture may improve the motor function of stroke patients. Therefore, the aim of the present study was to investigate the effect of acupuncture on balance function. We designed a single-blinded, controlled, randomized study. A total of 30 stroke patients were randomized into experimental and control groups. Experimental groups received acupuncture treatment accompanied by the manual twisting of needles and obtaining of qi (the subjects experienced sensations of soreness, numbness...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Liu SY, Hsieh CL, Wei TS, Liu PT, Chang YJ, Li TC Tags: Am J Chin Med Source Type: journals

Seven-star needle stimulation improves language and social interaction of children with autistic spectrum disorders.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This is a randomized controlled trial that aimed to evaluate the effect of the Seven-star Needle Stimulation treatment on children with Autistic Spectrum Disorders (ASD). Thirty-two children with ASD were assigned randomly into the treatment and control groups. Children in the treatment group underwent 30 sessions of stimulation over 6 weeks, while children in the control group were on a waiting list and did not receive treatment during this period of time. Intervention consisted of a treatment regime comprising of 30 sessions of Seven-star Needle Stimulation, delivered over 6 weeks. Each session lasted 5 to 10 min, ch...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Chan AS, Cheung MC, Sze SL, Leung WW Tags: Am J Chin Med Source Type: journals

A characteristic estimation of bio-signals for electro-acupuncture stimulations in human subjects.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This research evaluates the effect of physiological responses during electrical acupuncture (EA) stimulation on specific acupuncture points (APs: PC5 and PC6). A variety of special responses in the human body were determined by electroencephalogram (EEG), heart rate (HR) in an electrocardiogram (ECG), and skin impedance test for 2 groups, sham group as a control and a group under acupuncture stimulation. The total stimulation time in this study was set for 5 min since the effect of EA on all recorded parameters became stable within this period. According to the experiments, during EA stimulation of PC5 and PC6, the pow...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Kim MS, Cho YC, Moon JH, Pak SC Tags: Am J Chin Med Source Type: journals

A Astragalus Improved Cardiac Function of Adriamycin-Injured Rat Hearts by Upregulation of SERCA2a Expression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated the effect of Astragalus on hemodynamic changes in adriamycin (ADR)-injured rat hearts and its underlying molecular mechanism. Sprague-Dawley rats were divided into four groups: control, ADR only, ADR + low dose of Astragalus and ADR + high dose of Astragalus. Rats were injected intraperitoneally with 6 equal doses of ADR (cumulative dose, 12 mg/kg) over a period of 2 weeks. Treatment of Astragalus began 1 day before the onset of ADR injection and was given orally once a day for 50 days (3.3 or 10 g/kg/day). Five weeks after the final injection of ADR, rats treated with ADR only showed a significant...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Su D, Li HY, Yan HR, Liu PF, Zhang L, Cheng JH Tags: Am J Chin Med Source Type: journals

Protective Effect of Origanum majorana L. 'Marjoram' on Various Models of Gastric Mucosal Injury in Rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
'Marjoram,' Origanum majorana L., a culinary aromatic medicinal herb is known to possess various therapeutic properties. We evaluated the antiulcerogenic activity of the ethanol extract in hypothermic restraint stress-, indomethacin-, necrotizing agents- (80% ethanol, 25% NaCl and 0.2 M NaOH) induced ulcers and basal gastric acid secretion using pylorus ligated Shay rat-model. Marjoram at doses of 250 and 500 mg/kg of body weight, significantly decreased the incidence of ulcers, basal gastric secretion and acid output. Furthermore, the extract replenished the ethanol-induced depleted gastric wall mucus and nonprotein s...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Al-Howiriny T, Alsheikh A, Alqasoumi S, Al-Yahya M, Eltahir K, Rafatullah S Tags: Am J Chin Med Source Type: journals

Gingko biloba Extract (EGb 761) Prevents Ischemic Brain Injury by Activation of the Akt Signaling Pathway.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this study suggests that EGb 761 prevents cell death due to brain injury and that EGb 761 protection is affected by preventing the injury-induce decrease of Akt phosphorylation. PMID: 19606514 [PubMed - in process] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Cho JH, Sung JH, Cho EH, Won CK, Lee HJ, Kim MO, Koh PO Tags: Am J Chin Med Source Type: journals

Chronic Rhodiola rosea Extract Supplementation Enforces Exhaustive Swimming Tolerance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We explored the effects and mechanisms of Rhodiola rosea extract supplementation on swimming-induced fatigue in rats. The concentrations of active components in Rhodiola rosea have been determined by high performance liquid chromatography-mass spectrometer. The Rhodiola rosea extract supplementation in water for 2-4 weeks was evaluated in male Wistar rats with 90-min unloaded swimming exercise and 5% body weight loaded swimming up to fatigue. We measured the fatigue biomarkers, including blood urea nitrogen (BUN), glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT), lactate dehydrogenase (LD...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Lee FT, Kuo TY, Liou SY, Chien CT Tags: Am J Chin Med Source Type: journals

Analgesic and Anti-Inflammatory Activities of Methanol Extract from Desmodium triflorum DC in Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we evaluated the analgesic effect of methanol extract from Desmodium triflorum DC (MDT) by using animal models of acetic acid-induced writhing response and formalin test. The anti-inflammatory effect of MDT was investigated by lambda-carrageenan-induced paw edema in mice. In order to study the anti-inflammatory mechanism of MDT, we detected the activities of glutathione peroxidase (GPx) and glutathione reductase (GRd) in the liver, the levels of interleukin-1beta (IL-1beta), tumor necrosis factor (TNF-alpha), malondialdehyde (MDA) and nitric oxide (NO) in the edema paw tissue. In the analgesic test, MDT (0.5...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Lai SC, Peng WH, Huang SC, Ho YL, Huang TH, Lai ZR, Chang YS Tags: Am J Chin Med Source Type: journals

Potential Anti-Cancer Activities of Furanodiene, A Sesquiterpene from Curcuma wenyujin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Furanodiene is a sesquiterpene extracted from the essential oil of the rhizome of Curcuma wenyujin Y.H. Chen et C. Ling (Wen Ezhu). Furanodiene is the primary component in Wen Ezhu's essential oil, accounting for more than 20% by weight. In vitro, MTT assay was used to compare the inhibitory effects of furanodiene and Wen Ezhu's essential oil on 11 human cancer cell lines. Compared to the essential oil, furanodiene showed stronger growth inhibitions on Hela, Hep-2, HL-60, PC3, SGC-7901 and HT-1080 cells with IC(50) between 0.6-4.8 mug/ml. In vivo, furanodiene was also found to exhibit inhibitory effects on the growth o...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Sun XY, Zheng YP, Lin DH, Zhang H, Zhao F, Yuan CS Tags: Am J Chin Med Source Type: journals

Effect of Zizyphus jujuba Extract on the Inhibition of Adipogenesis in 3T3-L1 Preadipocytes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obesity, the leading metabolic disease in the world, is a serious health problem in industrialized countries. The Zizyphus jujuba fruit has been used as traditional Chinese medicinal herb and considered to affect various physiological functions in the body for thousands of years. We investigated the anti-obesity effect of Z. jujuba on adipocyte differentiation of 3T3-L1 preadipocytes and found that treatment with an extract of Z. jujuba suppressed lipid accumulation and glycerol-3-phosphate dehydrogenase (GPDH) activity without affecting cell viability. Further fractionation of the initial Z .jujuba extract with organi...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Kubota H, Morii R, Kojima-Yuasa A, Huang X, Yano Y, Matsui-Yuasa I Tags: Am J Chin Med Source Type: journals

Selective Cytotoxic Effects on Human Cancer Cell Lines of Phenolic-Rich Ethyl-Acetate Fraction from Rhus verniciflua Stokes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rhus verniciflua Stokes (RVS) is a plant with a long history of medicinal use in Eastern Asia. RVS has been widely used to treat gastritis, stomach cancer and atherosclerosis. The cytotoxic effects of different solvent fractions from an RVS ethanol extract were measured in 11 human cancer cell lines. The study showed that the ethyl-acetate (EtOAC) fraction was the most cytotoxic. This fraction contains a number of phenolic compounds, and this phenolic-rich EtOAC fraction was particularly effective against gastric and breast cancer cells. A purified phenolic-rich EtOAC fraction (PPEF) had a stronger apoptotic effect on ...
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Kim JH, Jung CH, Jang BH, Go HY, Park JH, Choi YK, Hong SI, Shin YC, Ko SG Tags: Am J Chin Med Source Type: journals

Letter to the Editor - Comparison of Antioxidant Effects of Various Scutellaria baicalensis Fractions and the Potential Role of Catalase Upregulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract received. PMID: 19606520 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - July 18, 2009 Category: Complementary Medicine Authors: Tong R, Mehendale SR, Wang CZ, Shao Z, Yuan CS Tags: Am J Chin Med Source Type: journals