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Geriatric pharmacotherapy updates.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19766955 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - August 1, 2009 Category: Geriatrics Authors: Guay DR Tags: Am J Geriatr Pharmacother Source Type: journals

Chorea associated with gabapentin use in an elderly man.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This article reports a case of chorea in an elderly patient who was receiving gabapentin for the treatment of anxiety. After gabapentin discontinuation, the chorea resolved completely, indicating a probable adverse drug reaction. PMID: 19766954 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - August 1, 2009 Category: Geriatrics Authors: Attupurath R, Aziz R, Wollman D, Muralee S, Tampi RR Tags: Am J Geriatr Pharmacother Source Type: journals

Determinants of antidepressant medication prescribing in elderly residents of aged care homes in Australia: A retrospective study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: There was preferential prescribing of SSRI antidepressants among these older aged care home residents with depression. Cognitive impairment alone was not significantly associated with antidepressant prescribing; however, these aged care home residents with dementia and mood disorders had an increased likelihood of being treated with antidepressants. The prescribing of TCAs was significantly associated with concurrent benzodiazepine use. PMID: 19766953 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - August 1, 2009 Category: Geriatrics Authors: Nishtala PS, McLachlan AJ, Bell JS, Chen TF Tags: Am J Geriatr Pharmacother Source Type: journals

Treatment of hypertension in an elderly outpatient population in the Netherlands.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Based on the findings of this study, the benefits of treating elderly patients with hypertension in clinical practice may be lower than those reported by HYVET. The study results support the current recommendation that all patients with hypertension should be treated with >1 antihypertensive medication if adequate control is not achieved at low doses of a single medication. PMID: 19766952 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - August 1, 2009 Category: Geriatrics Authors: Tulner LR, Kuper IM, van Campen JP, Koks CH, Mac Gillavry MR, Beijnen JH, Brandjes DP Tags: Am J Geriatr Pharmacother Source Type: journals

Cost-effectiveness of genotype-guided warfarin therapy for anticoagulation in elderly patients with atrial fibrillation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this decision analysis, genotype-guided warfarin therapy for anticoagulation in elderly patients with AF was potentially cost-effective, and its benefits were closely related to efficacy in preventing bleeding events. Clinical trials testing the efficacy of genotype-guided warfarin therapy are warranted. PMID: 19766951 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - August 1, 2009 Category: Geriatrics Authors: Leey JA, McCabe S, Koch JA, Miles TP Tags: Am J Geriatr Pharmacother Source Type: journals

Drug development for Alzheimer's disease: Where are we now and where are we headed?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Despite disappointing results from recently completed Phase III trials of several novel compounds, the extent and breadth of activity at all phases of clinical development suggest that new pharmacotherapeutic options for the treatment of AD will become available within the next decade. PMID: 19616185 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - June 1, 2009 Category: Geriatrics Authors: Sabbagh MN Tags: Am J Geriatr Pharmacother Source Type: journals

Anticoagulation for stroke prevention in elderly patients with atrial fibrillation, including those with falls and/or early-stage dementia: A single-center, retrospective, observational study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this well-monitored geriatric population with chronic AF, including patients with falls and/or dementia, a high percentage were prescribed warfarin (85%), with low rates of stroke, hemorrhage, and death at 12 months despite a low TTR. Patients with falls and/or dementia had a high mortality rate (~45%). PMID: 19616184 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - June 1, 2009 Category: Geriatrics Authors: Jacobs LG, Billett HH, Freeman K, Dinglas C, Jumaquio L Tags: Am J Geriatr Pharmacother Source Type: journals

Polypharmacy in hospitalized older adult cancer patients: Experience from a prospective, observational study of an Oncology-Acute care for elders unit.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We found that polypharmacy was common in older cancer patients and increased during hospitali-zation. We also found that most OACE team recommendations communicated to physicians were implemented even though the primary physicians were not members of the OACE team. Future randomized trials are needed to assess the impact of the OACE team model of care on adverse events, survival, and cost in hospitalized older adult cancer patients. PMID: 19616183 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - June 1, 2009 Category: Geriatrics Authors: Flood KL, Carroll MB, Le CV, Brown CJ Tags: Am J Geriatr Pharmacother Source Type: journals

Results of a longitudinal analysis of national data to examine relationships between organizational and market characteristics and changes in antipsychotic prescribing in US nursing homes from 1996 through 2006.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Antipsychotic use increased in US nursing homes from 1996 through 2006 and was associated with certain organizational characteristics and market characteristics. Future interventions to reduce antipsychotic use in nursing homes will have to focus on these factors. PMID: 19616182 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - June 1, 2009 Category: Geriatrics Authors: Castle NG, Hanlon JT, Handler SM Tags: Am J Geriatr Pharmacother Source Type: journals

Awareness of pharmaceutical cost-assistance programs among inner-city seniors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Viewing of live health insurance presentations and adequate health literacy were associated with greater awareness of important pharmaceutical cost-assistance programs in this study in low-income, elderly individuals. The findings suggest that use of live presentations, in addition to health literacy materials and messages, may be important strategies in promoting knowledge of and enrollment in state and federal pharmaceutical cost-assistance programs for low-income seniors. PMID: 19447364 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - April 1, 2009 Category: Geriatrics Authors: Federman AD, Safran DG, Keyhani S, Cole H, Halm EA, Siu AL Tags: Am J Geriatr Pharmacother Source Type: journals

Whom do older adults trust most to provide information about prescription drugs?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In this survey, older adults trusted physicians and pharmacists more than the other sources studied to provide information on prescription drugs. Trust in physicians to provide price information was an important moderator of the effect of high drug spending on cost-related nonadhcrence. Efforts to provide patients and their providers with comparative data on drug prices and effectiveness may reduce cost-related nonadhcrence. PMID: 19447363 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - April 1, 2009 Category: Geriatrics Authors: Donohue JM, Huskamp HA, Wilson IB, Weissman J Tags: Am J Geriatr Pharmacother Source Type: journals

Discrepancies in reported drug use in geriatric outpatients: relevance to adverse events and drug-drug interactions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Geriatricians should assume that the medication lists supplied by GPs are incomplete or incorrect, and be aware that in approximately 25% of patients, symptoms may be caused by medication use inaccurately described in the referral. Reports by the community pharmacy may supply valuable additional information. Because there are also discrepancies between patients and pharmacies, medication use from a database-with data from prescribing physicians and pharmacy systems-will still have to be confirmed by the patient. PMID: 19447362 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - April 1, 2009 Category: Geriatrics Authors: Tulner LR, Kuper IM, Frankfort SV, van Campen JP, Koks CH, Brandjes DP, Beijnen JH Tags: Am J Geriatr Pharmacother Source Type: journals

Potentially inappropriate medication prescribing in outpatient practices: prevalence and patient characteristics based on electronic health records.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In this analysis of data from elderly patients at 2 outpatient centers, a small set of 8 medications accounted for the majority of PIMs at both centers, irrespective of geographic and demographic variations. Female sex, polypharmacy, and number of primary care visits were significantly associated with PIM prescribing. In this analysis of data from elderly patients at 2 outpatient centers, a small set of 8 medications accounted for the majority of PIMs at both centers, irrespective of geographic and demographic variations. PMID: 19447361 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - April 1, 2009 Category: Geriatrics Authors: Buck MD, Atreja A, Brunker CP, Jain A, Suh TT, Palmer RM, Dorr DA, Harris CM, Wilcox AB Tags: Am J Geriatr Pharmacother Source Type: journals

Effect of discontinuing cholinesterase inhibitor therapy on behavioral and mood symptoms in nursing home patients with dementia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Results of this retrospective analysis suggest that, compared with longer duration of CHEI therapy, discontinuation of CHEIs in these nursing home residents with dementia was associated with some adverse behavioral changes and decreased time spent engaging in leisure-related activities. PMID: 19447360 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - April 1, 2009 Category: Geriatrics Authors: Daiello LA, Ott BR, Lapane KL, Reinert SE, Machan JT, Dore DD Tags: Am J Geriatr Pharmacother Source Type: journals

Self-reported prevalence and factors associated with nonadherence with glaucoma medications in veteran outpatients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In this small sample of VA patients with glaucoma, adherence to glaucoma medications could be improved, especially among those who reported difficulties using their medications and those who were nonwhite. PMID: 19447359 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - April 1, 2009 Category: Geriatrics Authors: Sleath B, Ballinger R, Covert D, Robin AL, Byrd JE, Tudor G Tags: Am J Geriatr Pharmacother Source Type: journals

Geriatric pharmacotherapy updates.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19281941 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - February 1, 2009 Category: Geriatrics Authors: Guay DR Tags: Am J Geriatr Pharmacother Source Type: journals

Update on medication-related problems in the elderly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19281940 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Pharmacotherapy - February 1, 2009 Category: Geriatrics Authors: Hanlon JT Tags: Am J Geriatr Pharmacother Source Type: journals

Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In the absence of definitive evidence of effectiveness, trials of low-dose methylphenidate in medically ill adults with depression, fatigue, or apathy, with monitoring for response and adverse effects, are appropriate. PMID: 19281939 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - February 1, 2009 Category: Geriatrics Authors: Hardy SE Tags: Am J Geriatr Pharmacother Source Type: journals

Effect of concomitant administration of meropenem and valproic acid in an elderly chinese patient.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Various factors make the effect of concomitant administration of meropenem and valproic acid unpredictable, even in the same patient. Caution should be used when administering meropenem and valproic acid concomitantly, especially in elderly patients with central nervous system disorders, even if the patient has had a successful prior experience with these 2 drugs. If concomitant administration is essential, very close serum concentration monitoring and clinical observation are necessary. PMID: 19281938 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - February 1, 2009 Category: Geriatrics Authors: Gu J, Huang Y Tags: Am J Geriatr Pharmacother Source Type: journals

Impact of a geriatric nursing home palliative care service on unnecessary medication prescribing.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The geriatric palliative care team was associated with a reduction in the number of unnecessary medications prescribed for older veterans in this nursing home. Future studies should evaluate the impact of decreasing unnecessary prescribing on clinical outcomes such as adverse drug reactions. PMID: 19281937 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - February 1, 2009 Category: Geriatrics Authors: Suhrie EM, Hanlon JT, Jaffe EJ, Sevick MA, Ruby CM, Aspinall SL Tags: Am J Geriatr Pharmacother Source Type: journals

Effect of a retrospective drug utilization review on potentially inappropriate prescribing in the elderly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The DAE RetroDUR was associated with a possible reduction in the use of potentially inappropriate prescription medications in these older adults. Further research, using a control population, is needed to show the impact on health care utilization and costs, adverse drug events, and health care and quality-of-life outcomes. PMID: 19281936 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - February 1, 2009 Category: Geriatrics Authors: Starner CI, Norman SA, Reynolds RG, Gleason PP Tags: Am J Geriatr Pharmacother Source Type: journals

Efficacy and safety profile of a single dose of hydromorphone compared with morphine in older adults with acute, severe pain: A prospective, randomized, double-blind clinical trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A single dose of IV hydromorphone at 0.0075 mg/kg was neither clinically nor statistically different from IV morphine at 0.05 mg/kg for the treatment of acute, severe pain at 30 minutes postbaseline in these older adults in the ED. The incidence of adverse effects was not statistically different. Our data suggest that hydromorphone and morphine in the doses given had similar efficacy and safety profiles in these older adults. Neither regimen provided >/=50% pain relief for the majority of patients. Future investigations of acute pain management in older adults should examine the efficacy and safety of highe...
Source: The American Journal of Geriatric Pharmacotherapy - February 1, 2009 Category: Geriatrics Authors: Chang AK, Bijur PE, Baccelieri A, Gallagher EJ Tags: Am J Geriatr Pharmacother Source Type: journals

Geriatric pharmacotherapy updates.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19161931 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Pharmacotherapy - December 1, 2008 Category: Geriatrics Authors: Guay DR Tags: Am J Geriatr Pharmacother Source Type: journals

Inappropriate sexual behaviors in cognitively impaired older individuals.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In general, unless the patient is engaging in or threatening dangerous acts involving physical contact, serotoninergics (first choice, SSRIs; second choice, TCAs) are first-line agents followed by antiandrogens (cyproterone acetate or medroxyprogesterone acetate) as second-line agents. LHRH agonists (first choice) and estrogens (second choice) are considered third-line agents. Combination therapy is reasonable if the patient fails to respond to monotherapy. PMID: 19161930 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Pharmacotherapy - December 1, 2008 Category: Geriatrics Authors: Guay DR Tags: Am J Geriatr Pharmacother Source Type: journals

An elderly patient with fluoroquinolone-associated achilles tendinitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Based on this outcome in this patient with UTI, fluoroquinolones should be used with caution, particularly in patients with risk factors predisposing to tendinitis, including advanced age and renal dysfunction. PMID: 19161929 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Pharmacotherapy - December 1, 2008 Category: Geriatrics Authors: Damuth E, Heidelbaugh J, Malani PN, Cinti SK Tags: Am J Geriatr Pharmacother Source Type: journals

Factors associated with adherence to medication regimens in older primary care patients: The steel valley seniors survey.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this sample of older patients assessed for medication management, independent cognitive processes were associated with the ability to set up a medication schedule and overall adherence to prescriptions. Better verbal memory functioning was strongly and independently associated with setting up a medication schedule, while better executive functioning was strongly and independently associated with being fully adherent to prescription instructions. Deficits in either cognitive ability could result in medication errors due to nonadherence. PMID: 19161928 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Pharmacotherapy - December 1, 2008 Category: Geriatrics Authors: Stoehr GP, Lu SY, Lavery L, Bilt JV, Saxton JA, Chang CC, Ganguli M Tags: Am J Geriatr Pharmacother Source Type: journals

Appropriate proton pump inhibitor use among older adults: A retrospective chart review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Almost 30% of patients receiving a PPI in this academic geriatric practice had no documented indication for PPI use. PMID: 19161927 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Pharmacotherapy - December 1, 2008 Category: Geriatrics Authors: George CJ, Korc B, Ross JS Tags: Am J Geriatr Pharmacother Source Type: journals

Osteoporosis pharmacotherapy and counseling services in US ambulatory care clinics: Opportunities for multidisciplinary interventions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Based on the prevalence of medication and nonmedication therapies, levels of osteoporosis care did not differ by ambulatory care setting. However, patterns of care varied by certain visit characteristics, including insurance type, age, and sex. PMID: 19161926 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Pharmacotherapy - December 1, 2008 Category: Geriatrics Authors: Teschemaker A, Lee E, Xue Z, Wutoh AK Tags: Am J Geriatr Pharmacother Source Type: journals

The quality of medication use in older adults: Methods of a longitudinal study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This longitudinal study is an initial step toward developing more comprehensive, patient-centered measures and interventions to address the quality of medication use in older adults. PMID: 19028378 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - October 1, 2008 Category: Geriatrics Authors: Roth MT, Moore CG, Ivey JL, Esserman DA, Campbell WH, Weinberger M Tags: Am J Geriatr Pharmacother Source Type: journals

Quantification and classification of errors associated with hand-repackaging of medications in long-term care facilities in Germany.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Among 48,512 medications inspected over 8 weeks in 3 German long-term care facilities, the rate of repackaging errors was 1.3%, involving 7.3% of daily pill organizers and the medications of 53.00% of residents. The largest proportion of errors involved incorrect halving of tablets. PMID: 19028377 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - October 1, 2008 Category: Geriatrics Authors: Gerber A, Kohaupt I, Lauterbach KW, Buescher G, Stock S, Lungen M Tags: Am J Geriatr Pharmacother Source Type: journals

Addressing delays in medication administration for patients transferred from the hospital to the nursing home: A pilot quality improvement project.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The intervention to improve patient safety by reducing medication delays for patients making the transition from the hospital to the NH was not successfully implemented, as medication orders were not transmitted to the NH-contracted pharmacies before patients' arrival at the NH. All patients making the transition from hospital to NH experienced a >12-hour delay in medication administration, and the mean number of missed doses of medications was >3. There is a need for further exploration of the reasons for and possible solutions to delays in medication administration during the transition to the NH, as w...
Source: The American Journal of Geriatric Pharmacotherapy - October 1, 2008 Category: Geriatrics Authors: Ward KT, Bates-Jensen B, Eslami MS, Whiteman E, Dattoma L, Friedman JL, Decastro Mariano J, Moore AA Tags: Am J Geriatr Pharmacother Source Type: journals

Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this population of community-dwelling elderly, use of typical agents was associated with an increased risk for hospitalization compared with atypical agents. PMID: 19028375 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - October 1, 2008 Category: Geriatrics Authors: Aparasu RR, Jano E, Johnson ML, Chen H Tags: Am J Geriatr Pharmacother Source Type: journals

Antipsychotic drug use among elderly nursing home residents in the United States.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Nearly 1 in 4 elderly nursing home residents in the United States received antipsychotic agents. Predisposing and need factors played a vital role in determining the use of antipsychotic agents in these elderly patients. Overall, the study findings suggest that there is a need to monitor antipsychotic drug use by elderly patients in US nursing homes in light of recent efficacy and safety data on atypical agents. PMID: 19028374 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - October 1, 2008 Category: Geriatrics Authors: Kamble P, Chen H, Sherer J, Aparasu RR Tags: Am J Geriatr Pharmacother Source Type: journals

Geriatric pharmacotherapy updates.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18775394 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - September 1, 2008 Category: Geriatrics Authors: Guay DR Tags: Am J Geriatr Pharmacother Source Type: journals

Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This report describes a case of a probable interaction between topical econazole lotion 1% and acenocoumarol that resulted in overanticoagulation and a life-threatening laryngeal hematoma in this elderly patient. PMID: 18775393 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - September 1, 2008 Category: Geriatrics Authors: Wey PF, Petitjeans F, Lions C, Ould-Ahmed M, Escarment J Tags: Am J Geriatr Pharmacother Source Type: journals

Megestrol acetate-associated adrenal insufficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This case of adrenal insufficiency in an elderly woman was probably related to MA use. Clinicians should be alert to the possibility of this adverse effect when considering use of MA therapy. PMID: 18775392 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - September 1, 2008 Category: Geriatrics Authors: Bulchandani D, Nachnani J, Amin A, May J Tags: Am J Geriatr Pharmacother Source Type: journals

Discrepancies between home medications listed at hospital admission and reported medical conditions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Nearly 70% of patients admitted to a medical ward had >/=1 unspecified medication listed in the admission note. Based on these results, health care professionals must bc careful to obtain and document complete medication histories with matching indications. PMID: 18775391 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - September 1, 2008 Category: Geriatrics Authors: Slain D, Kincaid SE, Dunsworth TS Tags: Am J Geriatr Pharmacother Source Type: journals

Comparison of estimated glomerular filtration rate with estimated creatinine clearance in the dosing of drugs requiring adjustments in elderly patients with declining renal function.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although an MDRD equation may be useful for estimating GFR, the CG(CrCl)-Eq should still be used for drug dosage adjustments. The CG(CrCl)-Eq may require a slight "adjustment factor" to be applied using serum creatinine values measured by newly established assay procedures. PMID: 18775390 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - September 1, 2008 Category: Geriatrics Authors: Spruill WJ, Wade WE, Cobb HH Tags: Am J Geriatr Pharmacother Source Type: journals

Contraindicated medication use among patients in a memory disorders clinic.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Despite research evidence and recommendations to avoid these CNS-active medications because of their adverse effects, they continue to be prescribed in elderly patients with cognitive impairments. Further research is needed to determine strategies that will help reduce their administration in this population. PMID: 18775389 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - September 1, 2008 Category: Geriatrics Authors: Barton C, Sklenicka J, Sayegh P, Yaffe K Tags: Am J Geriatr Pharmacother Source Type: journals

Risk of hospitalizations/emergency department visits and treatment costs associated with initial maintenance therapy using fluticasone propionate 500 microg/salmeterol 50 microg compared with ipratropium for chronic obstructive pulmonary disease in older adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Compared with the IPR cohort, the FSC 500/50 cohort was 45% less likely to have a COPD-related exacerbation event and had similar medical costs. FSC 500/50 was a more effective initial maintenance therapy than IPR for this Medicare population, and, despite the $260 increase in COPD-related pharmacy costs, there was no significant difference in COPD-related medical costs. PMID: 18775388 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - September 1, 2008 Category: Geriatrics Authors: Blanchette CM, Akazawa M, Dalal A, Simoni-Wastila L Tags: Am J Geriatr Pharmacother Source Type: journals

Publisher's Announcement.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18775387 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - September 1, 2008 Category: Geriatrics Authors: Donoso VS Tags: Am J Geriatr Pharmacother Source Type: journals

Geriatric pharmacotherapy updates.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18675771 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - June 1, 2008 Category: Geriatrics Authors: Guay DR Tags: Am J Geriatr Pharmacother Source Type: journals

Use of computer decision support interventions to improve medication prescribing in older adults: A systematic review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Various types of CDS interventions may be effective in improving medication prescribing in older adults, but few studies reported clinical outcomes related to changes in medication prescribing. Data from this study should help to guide refinement and testing of future CDS interventions that specifically target older adult populations that are taking multiple medications. PMID: 18675770 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - June 1, 2008 Category: Geriatrics Authors: Yourman L, Concato J, Agostini JV Tags: Am J Geriatr Pharmacother Source Type: journals

Cardiovascular risk factors and dementia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: From a clinical perspective, these data further support the rationale for physicians to provide effective management of CVD risk factors and for patients to be compliant with such recommendations to possibly prevent cognitive decline/dementia.118). PMID: 18675769 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - June 1, 2008 Category: Geriatrics Authors: Fillit H, Nash DT, Rundek T, Zuckerman A Tags: Am J Geriatr Pharmacother Source Type: journals

Adverse effects of propafenone after long-term therapy with the addition of citalopram.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease. PMID: 18675768 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - June 1, 2008 Category: Geriatrics Authors: Garcia A Tags: Am J Geriatr Pharmacother Source Type: journals

Mirtazapine associated with profound hyponatremia: Two case reports.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The likelihood of mirtazapine use causing hyponatremia in these 2 cases was "probable" according to criteria of the Naranjo Adverse Drug Reaction Probability Scale (score, 6). A review of published cases found that mirtazapine-associated hyponatremia occurred in patients aged >60 years, after a mean of 6.5 days and with doses as low as 7.5 mg daily. The mean sodium nadir was 117.2 mEq/L, but after stopping mirtazapine, the mean time to recovery was 11 days. Clinicians should be aware of the possibility of this reaction in elderly patients and should monitor sodium levels in high-risk patients if symptoms su...
Source: The American Journal of Geriatric Pharmacotherapy - June 1, 2008 Category: Geriatrics Authors: Cheah CY, Ladhams B, Fegan PG Tags: Am J Geriatr Pharmacother Source Type: journals

A before and after study of medical students' and house staff members' knowledge of ACOVE quality of pharmacologic care standards on an acute care for elders unit.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A pharmacotherapist-led educational intervention improved the scores of medical students and house staff on a test evaluating knowledge of evidence-based recommendations for pharmacotherapy in the elderly. PMID: 18675766 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - June 1, 2008 Category: Geriatrics Authors: Jellinek SP, Cohen V, Nelson M, Likourezos A, Goldman W, Paris B Tags: Am J Geriatr Pharmacother Source Type: journals

Methodology of an ongoing, randomized controlled trial to prevent falls through enhanced pharmaceutical care.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The study is using a rigorous randomized controlled research design, which will enhance the internal validity of its findings. Results of the study, which will be reported after the completion of follow-up data collection activities, will enable us to assess the effects of the intervention on both medication use and the incidence of falls. If the intervention is found to be effective, it will provide a resource for community pharmacists working with older adults at high risk of medication-related falls. PMID: 18675765 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - June 1, 2008 Category: Geriatrics Authors: Ferreri S, Roth MT, Casteel C, Demby KB, Blalock SJ Tags: Am J Geriatr Pharmacother Source Type: journals

Effect of darbepoetin alfa administered once monthly on maintaining hemoglobin levels in older patients with chronic kidney disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Darbepoetin alfa administered QM maintained Hb levels >/=11 g/dL in patients with CKD (not on dialysis) aged <65, 65 to 74, and >/=75 years. This treatment regimen may help optimize anemia management for older community-dwelling and long-term care patients. PMID: 18675764 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - June 1, 2008 Category: Geriatrics Authors: Silver MR, Agarwal A, Krause M, Lei L, Stehman-Breen C Tags: Am J Geriatr Pharmacother Source Type: journals

Geriatric pharmacotherapy updates.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18396248 [PubMed - in process]
Source: The American Journal of Geriatric Pharmacotherapy - March 1, 2008 Category: Geriatrics Authors: Guay DR Tags: Am J Geriatr Pharmacother Source Type: journals