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Healthcare Reform 2009 and Its Implications for Pharmacists (December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The US healthcare system has been widely criticized by many and praised by others for many reasons that are not mutually exclusive. There is no doubt that, compared with our peer industrialized countries, the US ranks near the bottom in many of the benchmark criteria such as life expectancy, infant mortality, and mortality of the population that is amenable to health care. Despite these shortcomings, the US has been a major innovator in healthcare technology including the development of biological and pharmacological drugs. The shortcomings of our system are often focused on the fact that a significant portion of the p...
Source: The Annals of Pharmacotherapy - November 17, 2009 Category: Drugs & Pharmacology Authors: Matzke GR Tags: Ann Pharmacother Source Type: journals

Seasonal, Avian, and Novel H1N1 Influenza: Prevention and Treatment Modalities (December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Influenza subtypes continue to change, causing disease in animals and humans. Utilization of immunization and antiviral treatment options are available to prevent, treat, and contain the spread of this infection. PMID: 19920156 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 17, 2009 Category: Drugs & Pharmacology Authors: Sym D, Patel PN, El-Chaar GM Tags: Ann Pharmacother Source Type: journals

Does Simvastatin Cause More Myotoxicity Compared with Other Statins? (December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Overall, the rates of severe myotoxicity with all statins are low, especially with low-to-moderate doses. However, recent trials for those using simvastatin 80 mg daily suggest a higher incidence of myotoxicity compared with maximum approved doses of other statins. Practitioners should be aware of these possible risks and individualize therapy to limit myotoxicity. PMID: 19920157 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 17, 2009 Category: Drugs & Pharmacology Authors: Backes JM, Howard PA, Ruisinger JF, Moriarty PM Tags: Ann Pharmacother Source Type: journals

Factors Associated with Multiple Medication Use in Different Age Groups(December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Multiple medicine use was associated with morbidity and poor self-rated health across all age groups. The vast majority of users of multiple drugs are taking a unique combination of medications. PMID: 19920158 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 17, 2009 Category: Drugs & Pharmacology Authors: Moen J, Antonov K, Larsson CA, Lindblad U, Nilsson JL, Råstam L, Ring L Tags: Ann Pharmacother Source Type: journals

Propylene Glycol Accumulation in Critically Ill Patients Receiving Continuous Intravenous Lorazepam Infusions(December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The continuous infusion rate and cumulative 24-hour lorazepam dose are strongly associated with and independently predict propylene glycol concentrations. Despite the absence of confirmed propylene glycol-associated adverse effects, clinicians should be aware that propylene glycol accumulation may occur with continuous-infusion lorazepam. PMID: 19920159 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 17, 2009 Category: Drugs & Pharmacology Authors: Horinek EL, Kiser TH, Fish DN, Maclaren R Tags: Ann Pharmacother Source Type: journals

Fesoterodine for the Treatment of Overactive Bladder (December) (CE).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Fesoterodine appears to be effective and generally safe for the treatment of overactive bladder. The efficacy and safety of fesoterodine in overactive bladder treatment seem to be at least similar to that of tolterodine. Although additional comparative trials are needed, based on available data, it does not appear that fesoterodine provides a substantial advantage over extended-release tolterodine in either efficacy or safety. PMID: 19920160 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 17, 2009 Category: Drugs & Pharmacology Authors: Tzefos M, Dolder C, Olin JL Tags: Ann Pharmacother Source Type: journals

The Impact of Ezetimibe on Endothelial Function and Other Markers of Cardiovascular Risk (December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Overall, the evidence to date suggests that administration of ezetimibe, either as monotherapy or in combination with a statin, exerts minimal beneficial effects on endothelial function and other ancillary measures of cardiovascular disease risk beyond those conferred by its cholesterol-lowering effects. Studies with larger sample sizes and follow-up beyond 12 weeks remain necessary to further define the impact of ezetimibe on the processes integral to the pathogenesis and progression of cardiovascular disease. PMID: 19920161 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 17, 2009 Category: Drugs & Pharmacology Authors: Bass A, Hinderliter AL, Lee CR Tags: Ann Pharmacother Source Type: journals

The Utility of Therapeutic Drug Monitoring for Ribavirin in Patients with Chronic Hepatitis C--A Critical Review (December) (CE).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: There is conflicting evidence about the existence of a correlation between ribavirin concentrations and virologic response or development of toxicity. This inconsistent evidence, coupled with the currently employed effective strategies that maximize sustained virologic response and minimize development of anemia, precludes the utility of TDM for ribavirin. PMID: 19920162 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 17, 2009 Category: Drugs & Pharmacology Authors: Chan AH, Partovi N, Ensom MH Tags: Ann Pharmacother Source Type: journals

Association Between Exposure to Topical Tacrolimus or Pimecrolimus and Cancers(December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Exposure to topical tacrolimus or pimecrolimus was not associated with an increase in the overall cancer rate. Use of topical tacrolimus may be associated with an increased risk of T-cell lymphoma. PMID: 19903860 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 10, 2009 Category: Drugs & Pharmacology Authors: Hui RL, Lide W, Chan J, Schottinger J, Yoshinaga M, Millares M Tags: Ann Pharmacother Source Type: journals

Colchicine for the Primary and Secondary Prevention of Pericarditis: An Update(December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Despite limitations in study designs, current evidence suggests a role for colchicine in the secondary prophylaxis for recurrent pericarditis. The evidence for use of colchicine as primary prophylaxis in PPS is indeterminate; therefore, colchicine cannot be recommended routinely. While colchicine should be recommended for the prevention of recurrent pericarditis, questions regarding the optimal regimen and long-term safety profile need to be further elucidated. PMID: 19903861 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 10, 2009 Category: Drugs & Pharmacology Authors: Kuo IF, Pearson GJ, Koshman SL Tags: Ann Pharmacother Source Type: journals

Multidrug-Resistant Enterococcus faecium Endocarditis Treated with Combination Tigecycline and High-Dose Daptomycin (December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Increasing doses of daptomycin may enhance efficacy without compromising safety, even in patients with some renal dysfunction. The combination of daptomycin and tigecycline may be useful for the treatment of multi-drug- resistant E. faecium. PMID: 19887592 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 3, 2009 Category: Drugs & Pharmacology Authors: Schutt AC, Bohm NM Tags: Ann Pharmacother Source Type: journals

Prevalence and Risk Factors for Acute Kidney Injury Associated with Parenteral Polymyxin B Use(December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Patients who developed AKI had a strikingly elevated mortality rate. Polymyxin B should be used with extreme caution in patients who have an abnormal baseline SCr; use vasoactive drugs; or have abdomen, blood, or catheter as the infection site. PMID: 19887593 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 3, 2009 Category: Drugs & Pharmacology Authors: Mendes CA, Cordeiro JA, Burdmann EA Tags: Ann Pharmacother Source Type: journals

Sorafenib-Induced Hepatic Encephalopathy (December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19861429 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 27, 2009 Category: Drugs & Pharmacology Authors: Marks AB, Gerard R, Fournier P, Coupe P, Gautier S Tags: Ann Pharmacother Source Type: journals

Successful Use of Topical Voriconazole 1% Alone as First-Line Antifungal Therapy Against Candida albicans Keratitis (December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Topical voriconazole 1% eye drops administered alone demonstrated success as first-line therapy against the most common fungal keratitis, C. albicans keratitis. PMID: 19861430 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 27, 2009 Category: Drugs & Pharmacology Authors: Al-Badriyeh D, Leung L, Davies GE, Stewart K, Kong D Tags: Ann Pharmacother Source Type: journals

Comment: Evaluation of the Modified Diet in Renal Disease Equation for Calculation of Carboplatin Dose(November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843829 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 19, 2009 Category: Drugs & Pharmacology Authors: de Lemos ML, Hamata L, Conklin J Tags: Ann Pharmacother Source Type: journals

Comment: Fatal Intracranial Bleed Potentially Due to a Warfarin and Influenza Vaccine Interaction(November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843830 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 19, 2009 Category: Drugs & Pharmacology Authors: Chock AW, Packard KA, Ohri LK Tags: Ann Pharmacother Source Type: journals

Authors' Reply: (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843831 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 19, 2009 Category: Drugs & Pharmacology Authors: Authors' Reply: (November). Tags: Ann Pharmacother Source Type: journals

Documentation Quality in Community Pharmacy: Completeness of Electronic Patient Records After Patients' First Visits(November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The EPR after a patient's first visit to the community pharmacy is often incomplete. For new patients, the pharmacist should more proactively and systematically gather patient information, and all relevant information should be recorded, preferably in coded form, in the pharmacy information system to allow more adequate clinical risk management. PMID: 19843832 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 19, 2009 Category: Drugs & Pharmacology Authors: Floor-Schreudering A, De Smet PA, Buurma H, Egberts AC, Bouvy ML Tags: Ann Pharmacother Source Type: journals

Evaluation of Pharmacist Use and Perception of Wikipedia as a Drug Information Resource (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843833 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 19, 2009 Category: Drugs & Pharmacology Authors: Brokowski L, Sheehan AH Tags: Ann Pharmacother Source Type: journals

Lacosamide: An Adjunctive Agent for Partial-Onset Seizures and Potential Therapy for Neuropathic Pain (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Lacosamide is an effective agent for adjunctive treatment of refractory partial-onset seizures. Its exact role in the treatment of neuropathic pain needs to be determined. PMID: 19843834 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 19, 2009 Category: Drugs & Pharmacology Authors: Harris JA, Murphy JA Tags: Ann Pharmacother Source Type: journals

Possible Interaction Between Topical Terbinafine and Acenocoumarol (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843835 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 19, 2009 Category: Drugs & Pharmacology Authors: Morales-Molina JA, Molina Arrebola MA, Robles PA, Mangana JC Tags: Ann Pharmacother Source Type: journals

Effect of Drug Information Request Templates on Pharmacy Student Compliance with the Modified Systematic Approach to Answering Drug Information Questions(November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Use of drug information request templates improves students' compliance with the modified systematic approach, most notably in obtaining background information and searching necessary references including primary literature. PMID: 19843836 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 19, 2009 Category: Drugs & Pharmacology Authors: Lavsa SM, Corman SL, Verrico MM, Pummer TL Tags: Ann Pharmacother Source Type: journals

Medication Use Across Transition Points from the Emergency Department: Identifying Factors Associated with Medication Discrepancies(November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Patient-, environment-, and drug-related factors contribute to the risk of medication discrepancies across transition points from the ED. PMID: 19843837 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 19, 2009 Category: Drugs & Pharmacology Authors: Manias E, Gerdtz MF, Weiland TJ, Collins M Tags: Ann Pharmacother Source Type: journals

A Comprehensive Review of the Loop Diuretics: Should Furosemide Be First Line? (November)(CE).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Growing evidence demonstrates more favorable pharmacokinetic profiles of torsemide and bumetanide compared with furosemide. Furthermore, torsemide may be more efficacious and safer than furosemide in patients with HF. A trial comparing all 3 drugs would be required to confirm torsemide as the primary loop diuretic in patients with HF, but based upon limited current evidence, we recommend torsemide over furosemide. Currently, little evidence exists to support either torsemide or bumetanide as first-line treatment over furosemide in patients with other edematous disease states. PMID: 19843838 [PubMed - as su...
Source: The Annals of Pharmacotherapy - October 19, 2009 Category: Drugs & Pharmacology Authors: Wargo KA, Banta WM Tags: Ann Pharmacother Source Type: journals

Safety of Concomitant Tamoxifen and Warfarin (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although concomitant use of warfarin and tamoxifen is deemed a contraindication, evidence regarding this potential interaction is limited. Therefore, safety of concomitant use of tamoxifen and warfarin may be similar to that of other drugs that interact with warfarin, requiring consistent and careful monitoring. However, more evidence is needed to warrant the routine use of this combination. PMID: 19843839 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 19, 2009 Category: Drugs & Pharmacology Authors: Givens CB, Bullock LN, Franks AS Tags: Ann Pharmacother Source Type: journals

Authors' Reply: (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
no JL PMID: 19843840 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 19, 2009 Category: Drugs & Pharmacology Authors: Authors' Reply: (November). Tags: Ann Pharmacother Source Type: journals

Does Advice from Pharmacy Staff Vary According to the Nonprescription Medicine Requested? (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Emerging patterns imply that pharmacy staff response may vary according to the medicine requested. It may be that pharmacists and their staff prioritize drugs or behaviors that they consider critically relevant as part of a risk management approach. This has possible implications for future scheduling policy. Further research using a range of scenarios would more fully explore the breadth of such behavior. This would aid identification of medicines that trigger professional intervention and inform development of targeted training programs. PMID: 19843841 [PubMed - as supplied by publisher] (Source: The Ann...
Source: The Annals of Pharmacotherapy - October 19, 2009 Category: Drugs & Pharmacology Authors: Kelly FS, Williams KA, Benrimoj SI Tags: Ann Pharmacother Source Type: journals

Neonatal Peritoneal Candidiasis Successfully Treated with Anidulafungin Add-On Therapy (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Peritoneal candidiasis is a common complication of bowel perforation in neonates. Anidulafungin's pharmacokinetic and antifungal properties make it a viable therapeutic option in the treatment of this disease in critically ill infants and children. PMID: 19826094 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 12, 2009 Category: Drugs & Pharmacology Authors: Varisco BM, Benner KW, Prabhakaran P Tags: Ann Pharmacother Source Type: journals

Meeting New Challenges in the Management of Anemia of Chronic Kidney Disease Through Collaborative Care with Pharmacists (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: An approach to CKD-associated anemia management that involves collaboration with pharmacists is essential to achieve patient-specific, cost-effective ESA therapy. PMID: 19826095 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 12, 2009 Category: Drugs & Pharmacology Authors: Bacchus S, O'Mara N, Manley H, Fishbane S Tags: Ann Pharmacother Source Type: journals

Evaluation of Compliance with Osteoporosis Treatment Guidelines After Initiation of a Pharmacist-Run Osteoporosis Service at a Family Medicine Clinic(November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: A pharmacist-run osteoporosis service significantly improved short-term compliance with guidelines, including appropriate DEXA scan frequency, pharmacotherapy, calcium and vitamin D supplementation, and nonpharmacologic education. PMID: 19826096 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 12, 2009 Category: Drugs & Pharmacology Authors: Hall LN, Shrader SP, Ragucci KR Tags: Ann Pharmacother Source Type: journals

Sliding Scale Versus Tight Glycemic Control in the Noncritically Ill at a Community Hospital(November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Patients treated with TC experienced more blood glucose measurements in the target range as compared with patients treated with SS with relatively low hypoglycemia rates. PMID: 19826097 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 12, 2009 Category: Drugs & Pharmacology Authors: Patel GW, Roderman N, Lee KA, Charles MM, Nguyen D, Beougher P, Kleja K, Casteneda E Tags: Ann Pharmacother Source Type: journals

Fospropofol: A New Sedative-Hypnotic Agent for Monitored Anesthesia Care (November) (CE).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Fospropofol is a viable addition to the class of sedative-hypnotic agents due to the minimization of unwanted adverse effects of propofol and maintenance of a favorable pharmacokinetic profile facilitating sedation, anxiolysis, and rapid recovery. However, there are limited safety data to justify its use without the presence of dedicated anesthesia personnel. PMID: 19826098 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 12, 2009 Category: Drugs & Pharmacology Authors: Moore GD, Walker AM, Maclaren R Tags: Ann Pharmacother Source Type: journals

Severe Apnea in an Infant Exposed to Lamotrigine in Breast Milk (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Infants can be exposed to clinically relevant doses of lamotrigine through breast-feeding. Individual risk/benefit assessment is important, and close monitoring of both mother and child is advisable, especially during the first 3 weeks postpartum. PMID: 19826099 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 12, 2009 Category: Drugs & Pharmacology Authors: Nordmo E, Aronsen L, Wasland K, Småbrekke L, Vorren S Tags: Ann Pharmacother Source Type: journals

Comparative Pharmacodynamics of Intermittent and Prolonged Infusions of Piperacillin/Tazobactam Using Monte Carlo Simulation and Steady-State Pharmacokinetic Data from Hospitalized Patients (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
With increasing antibiotic resistance in gram-negative pathogens, dosing strategies that optimize pharmacodynamic parameters of currently available antibiotics play an important role in treatment. The likelihood of success with piperacillin/tazobactam, a widely used broad-spectrum antibiotic, can be manipulated by increasing the amount of time that unbound drug concentrations remain above the pathogen's minimum inhibitory concentration (MIC). However, this success depends greatly on knowing the MIC value as well as accurately estimating the individual's pharmacokinetic parameters. Clinicians should carefully factor the...
Source: The Annals of Pharmacotherapy - October 5, 2009 Category: Drugs & Pharmacology Authors: Rotschafer JC, Ullman M Tags: Ann Pharmacother Source Type: journals

Bipolar Disorder Patient Care Opportunities: Let's Answer the Call (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bipolar disorder is a brain illness with complexities in its composition and treatment. Results from the National Comorbidity Survey Replication study estimate the lifetime prevalence of bipolar spectrum illnesses to be 4.5%. These patients were also reported to have their illnesses frequently treated suboptimally and to be at risk of suffering extensive disability. Pharmacists are in a key position to deliver important pharmacy care services to patients who have bipolar disorder and receive treatments in need of close monitoring. Described here are the results of this study and opportunities for pharmacists to support...
Source: The Annals of Pharmacotherapy - October 5, 2009 Category: Drugs & Pharmacology Authors: Caley CF Tags: Ann Pharmacother Source Type: journals

Bendamustine-Associated Hemolytic Anemia (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Continued monitoring of postmarketing data is necessary to correlate this occurrence of hemolytic anemia with bendamustine therapy. PMID: 19809007 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 5, 2009 Category: Drugs & Pharmacology Authors: Glance LE, Cumpston A, Kanate A, Remick SC Tags: Ann Pharmacother Source Type: journals

Use of Duloxetine in Pregnancy and Lactation (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: No developmental toxicity or other signs of toxicity were observed in an infant exposed to duloxetine during the second half of gestation and during breast-feeding in the first 32 days after birth. However, the possibility of functional/ neurobehavioral deficits appearing later in life cannot be excluded. PMID: 19809008 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 5, 2009 Category: Drugs & Pharmacology Authors: Briggs GG, Ambrose PJ, Ilett KF, Hackett LP, Nageotte MP, Padilla G Tags: Ann Pharmacother Source Type: journals

Comparative Pharmacodynamics of Intermittent and Prolonged Infusions of Piperacillin/Tazobactam Using Monte Carlo Simulations and Steady-State Pharmacokinetic Data from Hospitalized Patients(November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: At doses greater than or equal to 3.375 g every 8 hours, 4-hour infusions of piperacillin/tazobactam achieved excellent target attainment with lower daily doses compared with standard regimens at MICs less than or equal to 16 microg/mL. PMID: 19809009 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 5, 2009 Category: Drugs & Pharmacology Authors: Shea KM, Cheatham SC, Smith DW, Wack MF, Sowinski KM, Kays MB Tags: Ann Pharmacother Source Type: journals

Gastrointestinal Safety of Nonsteroidal Antiinflammatory Drugs and Selective Cyclooxygenase-2 Inhibitors in Patients on Warfarin(November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In general, nonselective NSAIDs and selective COX-2 inhibitors should be avoided in patients taking warfarin. In situations where patients require NSAIDs and cannot be managed using other therapies, our results suggest that selective COX-2 inhibitors are associated with fewer hospitalizations for GI bleeding. PMID: 19809010 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 5, 2009 Category: Drugs & Pharmacology Authors: Cheetham TC, Levy G, Niu F, Bixler F Tags: Ann Pharmacother Source Type: journals

Safety and Efficacy of Quetiapine in Bipolar Depression (November) (CE).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Based on the literature reviewed here, quetiapine appears to be a safe and efficacious short-term treatment option for bipolar depression. Patients with bipolar type I showed greater improvement on the MADRS than those with bipolar type II. Patients with a rapid-cycling disease course showed an improvement in depressive symptoms, regardless of bipolar type. PMID: 19809011 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 5, 2009 Category: Drugs & Pharmacology Authors: Bogart GT, Chavez B Tags: Ann Pharmacother Source Type: journals

Use of Combination Therapy with a {beta}-Blocker and Milrinone in Patients with Advanced Heart Failure (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Data are insufficient to make firm conclusions on the clinical benefit of combination therapy with a beta-blocker and milrinone in patients with advanced HF, although it appears that this regimen is well tolerated and may allow weaning of inotropic support. PMID: 19789358 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 28, 2009 Category: Drugs & Pharmacology Authors: Jennings DL, Thompson ML Tags: Ann Pharmacother Source Type: journals

Atenolol Hepatotoxicity: Report of a Complicated Case (October).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Despite the fact that beta-blocker-induced hepatotoxicity is probably extremely rare, it must be suspected and the drug therefore discontinued. PMID: 19776295 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 22, 2009 Category: Drugs & Pharmacology Authors: Dumortier J, Guillaud O, Gouraud A, Pittau G, Vial T, Boillot O, Scoazec JY Tags: Ann Pharmacother Source Type: journals

Analysis of Medications Returned to Community Pharmacies(October).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The majority of returned medications contained greater than 75% of the original amount issued. Identification of therapeutic groups having higher rates of returns due to medication changes or surplus to requirements may suggest areas to target to reduce medication waste. PMID: 19776296 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 22, 2009 Category: Drugs & Pharmacology Authors: James TH, Helms ML, Braund R Tags: Ann Pharmacother Source Type: journals

Impact of a Renal Drug Dosing Service on Dose Adjustment in Hospitalized Patients with Chronic Kidney Disease(October).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: A renal drug dosing service for patients hospitalized with CKD can increase the proportion of drug dosing that is adjusted to take into account renal function. This can save drug costs and may prevent ADEs. PMID: 19776297 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 22, 2009 Category: Drugs & Pharmacology Authors: Hassan Y, Al-Ramahi RJ, Aziz NA, Ghazali R Tags: Ann Pharmacother Source Type: journals

Derivation and Validation of the ASK-12 Adherence Barrier Survey(October).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The ASK-12 demonstrated adequate reliability and validity, and it may be a useful brief measure of adherence behavior and barriers to treatment adherence. PMID: 19776298 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 22, 2009 Category: Drugs & Pharmacology Authors: Matza LS, Park J, Coyne KS, Skinner EP, Malley KG, Wolever RQ Tags: Ann Pharmacother Source Type: journals

Efficacy of Fluconazole for the Treatment of Onychomycosis (October).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Fluconazole is less effective than terbinafine and itraconazole in the treatment of onychomycosis. However, fluconazole may be preferred in patients unable to tolerate other oral antifungal agents due to the dosing regimen, adverse effect profile, and drug interactions. PMID: 19776299 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 22, 2009 Category: Drugs & Pharmacology Authors: Brown SJ Tags: Ann Pharmacother Source Type: journals

Comparing Generic and Innovator Drugs: A Review of 12 Years of Bioequivalence Data from the United States Food and Drug Administration(October).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The criteria used to evaluate generic drug bioequivalence studies support the FDA's objective of approving generic drug formulations that are therapeutically equivalent to their innovator counterparts. PMID: 19776300 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 22, 2009 Category: Drugs & Pharmacology Authors: Davit BM, Nwakama PE, Buehler GJ, Conner DP, Haidar SH, Patel DT, Yang Y, Yu LX, Woodcock J Tags: Ann Pharmacother Source Type: journals

Efungumab: A Novel Agent in the Treatment of Invasive Candidiasis (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Efungumab is a new antifungal agent with a novel mechanism of action. Available clinical data and synergy studies support the use of efungumab in combination with other antifungal agents for the treatment of IC. Further safety data are needed before formulary recommendations can be made. PMID: 19773528 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 21, 2009 Category: Drugs & Pharmacology Authors: Karwa R, Wargo KA Tags: Ann Pharmacother Source Type: journals

Delivery of Antifungal Agents Using Bioactive and Nonbioactive Bone Cements(October).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Elution characteristics of most antifungals from bone cement spheres are probably not optimal for treatment of deep-seated fungal infections if a similar phenomenon of antifungal release manifests in vivo. Ceramic nonabsorbable impregnated devices must be removed after their lifespan expires and may necessitate another surgical procedure that can increase surgical risk and cost. Bioactive osteoconductive materials may provide a surgical alternative to nonabsorbable matrices. However, there have been no controlled trials demonstrating improved therapeutic outcomes with local therapy and assessing whether biodeg...
Source: The Annals of Pharmacotherapy - September 14, 2009 Category: Drugs & Pharmacology Authors: Sealy PI, Nguyen C, Tucci M, Benghuzzi H, Cleary JD Tags: Ann Pharmacother Source Type: journals

Successful Use of Dexmedetomidine for Sedation in a 24-Week Gestational Age Neonate (October).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Dexmedetomidine was an effective sedative and analgesic in a 24-week gestational age neonate treated for refractory agitation while on mechanical ventilation. Based on its documented efficacy for pain and sedation and its favorable adverse effect profile, dexmedetomidine warrants further study as first-line or adjunct therapy with narcotics for sedation in ventilated newborns. PMID: 19755621 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 14, 2009 Category: Drugs & Pharmacology Authors: O'Mara K, Gal P, Ransom JL, Wimmer Jr JE, Carlos RQ, Dimaguila MA, Davonzo C, Smith M Tags: Ann Pharmacother Source Type: journals