The British Journal of Nutrition
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Consumption of caffeinated coffee and a high carbohydrate meal affects postprandial metabolism of a subsequent oral glucose tolerance test in young, healthy males.
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Caffeine and caffeinated coffee (CC) elicit acute insulin insensitivity when ingested before a carbohydrate load. The effects of CC on glucose tolerance and insulin sensitivity when co-ingested with a high carbohydrate meal and on postprandial metabolism of a subsequent (second) carbohydrate load have not been studied. In a randomised, crossover design, ten healthy males ingested either CC (5 mg caffeine/kg body weight), decaffeinated coffee (DC) or water (W; equal volume) co-ingested with a high glycaemic index cereal followed 3 h later by a 75 g oral glucose tolerance test. After the initial meal, insulin area under ...
Source: The British Journal of Nutrition - November 5, 2009 Category: Nutrition Authors: Moisey LL, Robinson LE, Graham TE Tags: Br J Nutr Source Type: journals
Administration of loperamide and addition of wheat bran to the diets of weaner pigs decrease the incidence of diarrhoea and enhance their gut maturation.
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The influence of fibre inclusion and transit time regulation on the performance, health status, microbial activity and population, physico-chemical characteristics of the hindgut digesta and intestinal morphology in early weaned pigs were examined. For these experiments, wheat bran (WB) was used as fibre source and loperamide as a drug (LOP) to increase the digesta transit time. In Expt 1, a total of 128 early weaned pigs were randomly distributed in a 2 x 2 factorial combination of WB inclusion (0 v. 40 g/kg) and LOP administration (0 v. 0.07 mg/kg body weight) during 13 d. For Expt 2, a total of twenty-four piglets w...
Source: The British Journal of Nutrition - November 5, 2009 Category: Nutrition Authors: Molist Gasa F, Ywazaki M, Gómez de Segura Ugalde A, Hermes RG, Gasa Gasó J, Pérez Hernández JF Tags: Br J Nutr Source Type: journals
Changing the zinc:iron ratio in a cereal-based nutritional supplement has no effect on percent absorption of iron and zinc in Sri Lankan children.
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The Thriposha programme is a community-level nutrition intervention in Sri Lanka that provides a combination of energy, protein and micronutrients as a 'ready-to-eat' cereal-based food. We measured the bioavailability of Fe and Zn from Thriposha formula at two different molar ratios of Zn:Fe in order to determine the effect on Fe and Zn absorption. Children 4-7 years (n 53) were given a meal prepared with 50 g Thriposha containing 1.5 mg Zn as zinc sulphate and either 9 mg (high Fe concentration (HiFe)) or 4.5 mg (low Fe concentration (LoFe)) Fe as ferrous fumarate. Zn and Fe percent absorption were measured using stab...
Source: The British Journal of Nutrition - November 5, 2009 Category: Nutrition Authors: Hettiarachchi M, Liyanage C, Hilmers D, Griffin I, Abrams SA Tags: Br J Nutr Source Type: journals
Effect of dark chocolate on plasma epicatechin levels, DNA resistance to oxidative stress and total antioxidant activity in healthy subjects.
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Dark chocolate (DC) may be cardioprotective by antioxidant properties of flavonoids. We investigated the effect of DC (860 mg polyphenols, of which 58 mg epicatechin) compared with white chocolate (WC; 5 mg polyphenols, undetectable epicatechin) on plasma epicatechin levels, mononuclear blood cells (MNBC) DNA damage and plasma total antioxidant activity (TAA). Twenty healthy subjects followed a balanced diet (55 % of energy from carbohydrates, 30 % from fat and 1 g protein/kg body weight) for 4 weeks. Since the 14th day until the 27th day, they introduced daily 45 g of either WC (n 10) or DC (n 10). Whole experimental ...
Source: The British Journal of Nutrition - November 5, 2009 Category: Nutrition Authors: Spadafranca A, Martinez Conesa C, Sirini S, Testolin G Tags: Br J Nutr Source Type: journals
Variegate porphyria induces plasma and neutrophil oxidative stress: effects of dietary supplementation with vitamins E and C.
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In conclusion, women affected by VP present a situation of inflammation, plasma oxidative damage and neutrophils more primed to the oxidative burst, with decreased antioxidant activities and increased ROS production capabilities and protein oxidative damage. Dietary supplementation with vitamin E (50 mg/d) and vitamin C (150 mg/d) for 6 months decreased plasma oxidative damage and enhanced the erythrocyte activities of CAT and GR.
PMID: 19883519 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - November 3, 2009 Category: Nutrition Authors: Ferrer MD, Tauler P, Sureda A, Palacín C, Tur JA, Pons A Tags: Br J Nutr Source Type: journals
Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease.
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Inflammatory bowel disease (IBD) is a major source of morbidity in children and adults. Its incidence is rising, particularly in young people. IBD carries a lifelong risk of cancer, which is proportional to disease duration. Drug and surgical treatments rarely offer cure and often carry a high side effect burden. Dietary therapy is highly effective in Crohn's disease. For these reasons, there is much interest in developing novel dietary treatments in IBD. Curcumin, a component of the spice turmeric, and an anti-inflammatory and anti-cancer agent, shows preclinical and clinical potential in IBD. Its mechanisms of action...
Source: The British Journal of Nutrition - November 2, 2009 Category: Nutrition Authors: Epstein J, Docena G, Macdonald TT, Sanderson IR Tags: Br J Nutr Source Type: journals
The protective role of amla ( Emblica officinalis Gaertn.) against fructose-induced metabolic syndrome in a rat model.
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We investigated the effects of amla (Emblica officinalis Gaertn.) on fructose-induced metabolic syndrome using a rat model. Male Wistar rats were fed a high-fructose (65 %) diet or standard chow for 1 week, and treated with an ethyl acetate (EtOAc) extract of amla, a polyphenol-rich fraction, at 10 or 20 mg/kg body weight per d, or vehicle, for 2 weeks. Serum glucose, TAG, total cholesterol and blood pressure levels of the high-fructose diet-fed rats were increased compared with those of the normal rats (P < 0.001). However, the EtOAc extract of amla ameliorated the high fructose-induced metabolic syndrome, includin...
Source: The British Journal of Nutrition - November 2, 2009 Category: Nutrition Authors: Kim HY, Okubo T, Juneja LR, Yokozawa T Tags: Br J Nutr Source Type: journals
Modulation of nucleotide excision repair in human lymphocytes by genetic and dietary factors.
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In conclusion, improved NER capacity upon dietary intervention was detected in individuals carrying multiple low-activity alleles. The XPA G23A polymorphism might be a predictor for NER capacity.
PMID: 19878615 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - November 2, 2009 Category: Nutrition Authors: Langie SA, Wilms LC, Hämäläinen S, Kleinjans JC, Godschalk RW, van Schooten FJ Tags: Br J Nutr Source Type: journals
A low-protein diet supplemented with ketoacids plays a more protective role against oxidative stress of rat kidney tissue with 5/6 nephrectomy than a low-protein diet alone.
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The objective of the present study was to compare the efficacy of a low-protein diet supplemented with ketoacids (LPD+KA) and a low-protein diet alone (LPD) in halting the development of renal lesions in CKD. 5/6 Nephrectomy Sprague-Dawley rats were randomly divided into three groups, and fed with either 22 % protein (normal-protein diet; NPD), 6 % protein (LPD) or 5 % protein plus 1 % ketoacids (LPD+KA) for 24 weeks. Sham-operated rats were used as controls. Each 5/6 nephrectomy group included fifteen rats and the control group included twelve rats. Proteinuria, decreased renal function, glomerular sclerosis and tubuloint...
Source: The British Journal of Nutrition - November 2, 2009 Category: Nutrition Authors: Gao X, Wu J, Dong Z, Hua C, Hu H, Mei C Tags: Br J Nutr Source Type: journals
Comparison of body fatness measurements by near-infrared reactance and dual-energy X-ray absorptiometry in normal-weight and obese black and white women.
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In conclusion, although there was a significant relationship between NIR- and DXA-derived BF %, NIR under-predicted BF % in normal-weight and obese black South African women compared to DXA, but to a greater extent in subjects with very high levels of adiposity (>45 %). The results of single-site NIR as a measure of BF % should therefore be interpreted with caution, particularly in women of African descent and in those with very high levels of adiposity.
PMID: 19878617 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - November 2, 2009 Category: Nutrition Authors: Jennings CL, Micklesfield LK, Lambert MI, Lambert EV, Collins M, Goedecke JH Tags: Br J Nutr Source Type: journals
Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats.
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Conjugated linoleic acid (CLA) has been reported as having body fat lowering properties and the ability to modulate the inflammatory system in several models. In the present study, the effects of CLA added to saturated fat diets, from vegetable and animal origins, on the serum adipokine profile of obese Zucker rats were assessed. In addition, the fatty acid composition of epididymal and retroperitoneal adipose tissues was determined and a principal component analysis (PCA) was used to assess possible relationships between fatty acids and serum metabolites. Atherogenic diets (2 % cholesterol) were formulated with palm o...
Source: The British Journal of Nutrition - November 2, 2009 Category: Nutrition Authors: Martins SV, Lopes PA, Alfaia CM, Rodrigues PO, Alves SP, Pinto RM, Castro MF, Bessa RJ, Prates JA Tags: Br J Nutr Source Type: journals
Changes in white muscle transcriptome induced by dietary energy levels in two lines of rainbow trout ( Oncorhynchus mykiss) selected for muscle fat content.
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Energy intake and genetic background are major determinants of muscle fat content in most animals, including man. We combined genetic selection and dietary energy supply to study the metabolic pathways involved in genetic and nutritional control of fat deposition in the muscle of rainbow trout (Oncorhynchus mykiss). Two experimental lines of rainbow trout, selected for lean (L) or fat (F) muscle, were fed with diets containing either 10 or 23 % lipids from the first feeding, up to 6 months. At the end of the trial, trout exhibited very different values of muscle fat content (from 4.2 to 10.1 % wet weight). Using microa...
Source: The British Journal of Nutrition - October 30, 2009 Category: Nutrition Authors: Kolditz CI, Plagnes-Juan E, Quillet E, Lefèvre F, Médale F Tags: Br J Nutr Source Type: journals
Comparison of the effects of a liquid yogurt and chocolate bars on satiety: a multidimensional approach.
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In conclusion, this approach of satiety revealed that a liquid yogurt induced a lower subjective motivation to eat than chocolate bars during the hour preceding the spontaneous onset of a meal, without affecting subsequent food intake.
PMID: 19874632 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - October 29, 2009 Category: Nutrition Authors: Chapelot D, Payen F Tags: Br J Nutr Source Type: journals
Plasma alkylresorcinol metabolites as potential biomarkers of whole-grain wheat and rye cereal fibre intakes in women.
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It has been demonstrated that intact plasma alkylresorcinols (AR) and urinary AR metabolites could be used as biomarkers of whole-grain intake. Thereafter, we developed the method for the plasma AR metabolites, which is more convenient and requires less sample pretreatment than the analysis of intact plasma AR. The aim of the present study is to evaluate whether AR metabolites measured in plasma, in the same population, could also be considered as useful biomarkers of cereal fibre. Fifty-six women were recruited in a cross-sectional and observational study. Dietary intake (5-d record) and plasma AR metabolites (3,5-dih...
Source: The British Journal of Nutrition - October 29, 2009 Category: Nutrition Authors: Aubertin-Leheudre M, Koskela A, Samaletdin A, Adlercreutz H Tags: Br J Nutr Source Type: journals
Effects of a breakfast yoghurt, with additional total whey protein or caseinomacropeptide-depleted alpha-lactalbumin-enriched whey protein, on diet-induced thermogenesis and appetite suppression.
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In conclusion, consumption of a breakfast yoghurt drink with added whey or alpha-lac increased energy expenditure, protein balance and decreased fat balance compared with a NP breakfast. The alpha-lac-enriched yoghurt drink suppressed hunger and the desire to eat more than the whey-enriched yoghurt drink.
PMID: 19874634 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - October 29, 2009 Category: Nutrition Authors: Hursel R, van der Zee L, Westerterp-Plantenga MS Tags: Br J Nutr Source Type: journals
Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma.
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Dietary antioxidants are important in protecting against oxidative stress. We have previously demonstrated that circulating dietary antioxidant levels are reduced in asthma. The present study examined the variation in dietary antioxidant levels in asthma, according to airway responsiveness, asthma control and clinical asthma pattern. Peripheral blood was collected from forty-one subjects with stable, persistent asthma. Airway responsiveness was assessed by hypertonic saline challenge. Asthma control was assessed using the Asthma Control Questionnaire. Clinical asthma pattern was determined using Global Initiative for A...
Source: The British Journal of Nutrition - October 29, 2009 Category: Nutrition Authors: Wood LG, Gibson PG Tags: Br J Nutr Source Type: journals
Effect of almond-enriched high-monounsaturated fat diet on selected markers of inflammation: a randomised, controlled, crossover study.
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In conclusion, consumption of almonds influenced a few but not all of the markers of inflammation and haemostasis. A clear dose response was not observed for any of the markers studied.
PMID: 19874636 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - October 29, 2009 Category: Nutrition Authors: Rajaram S, Connell KM, Sabaté J Tags: Br J Nutr Source Type: journals
Effects of organically and conventionally produced feed on biomarkers of health in a chicken model.
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Consumers expect organic products to be healthier. However, limited research has been performed to study the effect of organic food on health. The present study aimed to identify biomarkers of health to enable future studies in human subjects. A feeding experiment was performed in two generations of three groups of chickens differing in immune responsiveness, which were fed identically composed feeds from either organic or conventional produce. The animals of the second generation were exposed to an immune challenge and sacrificed at 13 weeks of age. Feed and ingredients were analysed on macro- and micronutrients, i.e....
Source: The British Journal of Nutrition - October 28, 2009 Category: Nutrition Authors: Huber M, van de Vijver LP, Parmentier H, Savelkoul H, Coulier L, Wopereis S, Verheij E, van der Greef J, Nierop D, Hoogenboom RA Tags: Br J Nutr Source Type: journals
Effect of calcium on iron absorption in women with marginal iron status.
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We measured non-haem Fe absorption with and without added Ca in a short-term feeding study, in thirteen women with marginal Fe status, by the use of a double stable isotope technique. Supplementing 500 mg Ca as calcium carbonate significantly (P = 0.0009) reduced Fe absorption from a single meal from 10.2 % (range 2.2-40.6) to 4.8 % (range 0.7-18.9). A significant inverse correlation in the absence ( - 0.67, P = 0.010) and presence ( - 0.58, P = 0.037) of Ca, respectively, was found between Fe absorption and Fe stores measured by serum ferritin (SF). Wide variation in Fe absorption was observed between individuals in t...
Source: The British Journal of Nutrition - October 28, 2009 Category: Nutrition Authors: Benkhedda K, L'abbé MR, Cockell KA Tags: Br J Nutr Source Type: journals
Total parenteral nutrition in children and adolescents treated with high-dose chemotherapy followed by autologous haematopoietic transplants.
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Total parenteral nutrition (TPN) is still of great importance for haematopoietic stem cell transplantation (HSCT) patients because one of the major adverse effects of the high-dose therapy followed by HSCT is an inadequate oral nutrition intake. The aim of the study was analysis of TPN of young patients in the HSCT period. Twenty-two patients 1.8-20.8 year-old, median 5.4, treated with high-dose therapy and autologous HSCT because of malignancy were included into the study. Grafts contained 1.35-7.9 x 106, median 3.75 x 106 CD34+ cells/kg. Engraftment occurred as follows: granulocytes >0.5 x 109/l on +11 d (8-25); p...
Source: The British Journal of Nutrition - October 28, 2009 Category: Nutrition Authors: Wędrychowicz A, Spodaryk M, Krasowska-Kwiecień A, Goździk J Tags: Br J Nutr Source Type: journals
Can Iberian red deer ( Cervus elaphus hispanicus) discriminate among essential minerals in their diet?
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Optimal foraging predicts that animals should be able to assess the content of important nutrients in food. Ungulates discriminate salt and P, but discrimination of other minerals is controversial even though they are also essential and often limiting. Animal scientists have explained this taste through palatability, which predicts the same pattern of discrimination for calves and hinds and greater consumption by the latter. Social learning may also be involved, predicting a correlation between mother and calf and less consumption by the latter. The present study examines the consumption behaviour of free-choice supple...
Source: The British Journal of Nutrition - October 28, 2009 Category: Nutrition Authors: Ceacero F, Landete-Castillejos T, García AJ, Estévez JA, Gallego L Tags: Br J Nutr Source Type: journals
Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta.
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Some dietary fats are a risk factor for Alzheimer's disease (AD) but the mechanisms for this association are presently unknown. In the present study we showed in wild-type mice that chronic ingestion of SFA results in blood-brain barrier (BBB) dysfunction and significant delivery into the brain of plasma proteins, including apo B lipoproteins that are endogenously enriched in amyloid-beta (Abeta). Conversely, the plasma concentration of S100B was used as a marker of brain-to-blood leakage and was found to be increased two-fold because of SFA feeding. Consistent with a deterioration in BBB integrity in SFA-fed mice was ...
Source: The British Journal of Nutrition - October 28, 2009 Category: Nutrition Authors: Takechi R, Galloway S, Pallebage-Gamarallage MM, Wellington CL, Johnsen RD, Dhaliwal SS, Mamo JC Tags: Br J Nutr Source Type: journals
Maternal consumption of fructo-oligosaccharide diminishes the severity of skin inflammation in offspring of NC/Nga mice.
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Strategies to manipulate the gut microbiota in infancy have been considered to prevent the development of allergic diseases later in life. We aimed to elucidate the effects of maternal dietary supplementation with a prebiotic oligosaccharide on gut microbiota and spontaneously developing atopic dermatitis-like skin lesions in the offspring of NC/Nga mice. Female NC/Nga mice were fed diets either with or without fructo-oligosaccharide supplementation during pregnancy and lactation. After weaning, offspring were fed the diets supplemented with or without fructo-oligosaccharide for 11 weeks in an air-uncontrolled conventi...
Source: The British Journal of Nutrition - October 27, 2009 Category: Nutrition Authors: Fujiwara R, Takemura N, Watanabe J, Sonoyama K Tags: Br J Nutr Source Type: journals
Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury.
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Recently, broccoli, a vegetable of the Brassica family, has been found to protect the myocardium from ischaemic reperfusion injury through the redox signalling of sulphoraphane, which is being formed from glucosinolate present in this vegetable. Since cooked broccoli loses most of its glucosinolate, we assumed that fresh broccoli could be a superior cardioprotective agent compared to cooked broccoli. To test this, two groups of rats were fed with fresh (steamed) broccoli or cooked broccoli for 30 d, while a third group was given vehicle only for the same period of time. After 30 d, all the rats were sacrificed, and the...
Source: The British Journal of Nutrition - October 27, 2009 Category: Nutrition Authors: Mukherjee S, Lekli I, Ray D, Gangopadhyay H, Raychaudhuri U, Das DK Tags: Br J Nutr Source Type: journals
Acute ingestion of resistant starch reduces food intake in healthy adults.
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Resistant starch (RS), a non-viscous dietary fibre, may have postprandial effects on appetite regulation and metabolism, although the exact effects and mechanisms are unknown. An acute randomised, single-blind crossover study, aimed to determine the effects of consumption of 48 g RS on appetite compared to energy and available carbohydrate-matched placebo. Twenty young healthy adult males consumed either 48 g RS or the placebo divided equally between two mixed meals on two separate occasions. Effects on appetite were assessed, using an ad libitum test meal and 24-h diet diaries for energy intake, and using visual analo...
Source: The British Journal of Nutrition - October 27, 2009 Category: Nutrition Authors: Bodinham CL, Frost GS, Robertson MD Tags: Br J Nutr Source Type: journals
Comparison of (6 S)-5-methyltetrahydrofolic acid v. folic acid as the reference folate in longer-term human dietary intervention studies assessing the relative bioavailability of natural food folates: comparative changes in folate status following a 16-week placebo-controlled study in healthy adults.
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Folic acid (pteroylmonoglutamic acid) has historically been used as the reference folate in human intervention studies assessing the relative bioavailability of dietary folate. Recent studies using labelled folates indicated different plasma response kinetics to folic acid than to natural (food) folates, thus obviously precluding its use in single-dose experiments. Since differences in tissue distribution and site of biotransformation were hypothesised, the question is whether folic acid remains suitable as a reference folate for longer-term intervention studies, where the relative bioavailability of natural (food) fol...
Source: The British Journal of Nutrition - October 26, 2009 Category: Nutrition Authors: Wright AJ, King MJ, Wolfe CA, Powers HJ, Finglas PM Tags: Br J Nutr Source Type: journals
Calcium requirements for bone growth in Canadian boys and girls during adolescence.
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Adequate dietary intake during the growth period is critical for bone mineral accretion. In 1997, an adequate intake (AI) of 1300 mg/d Ca was set for North American adolescents aged 9-18 years based on best available data. We determined bone Ca accrual values from age 9 to 18 years taking into account sex and maturity. Furthermore, we used the accrual data to estimate adolescents' Ca requirements. Total body bone mineral content (TBBMC) of eighty-five boys and sixty-seven girls participating in the Saskatchewan Paediatric Bone Mineral Accrual Study were used to determine annual TBBMC accumulation over the pubertal grow...
Source: The British Journal of Nutrition - October 26, 2009 Category: Nutrition Authors: Vatanparast H, Bailey DA, Baxter-Jones AD, Whiting SJ Tags: Br J Nutr Source Type: journals
Building skeletons during adolescence: what is the target?
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PMID: 19852874 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - October 26, 2009 Category: Nutrition Authors: Abrams SA Tags: Br J Nutr Source Type: journals
Quantitative differences in intestinal Faecalibacterium prausnitzii in obese Indian children.
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Gut bacteria contribute to energy conservation in man through their ability to ferment unabsorbed carbohydrate. The present study examined the composition of predominant faecal microbiota in obese and non-obese children. The participants (n 28) aged 11-14 years provided fresh faecal samples and completed a dietary survey consisting of 24 h diet recall and a FFQ of commonly used foods taken over the previous 3 months. Faecal bacteria were quantitated by real-time PCR using primers targeted at 16S rDNA. Of the participants, fifteen (seven female) were obese, with median BMI-for-age at the 99th percentile (range 97 to>...
Source: The British Journal of Nutrition - October 22, 2009 Category: Nutrition Authors: Balamurugan R, George G, Kabeerdoss J, Hepsiba J, Chandragunasekaran AM, Ramakrishna BS Tags: Br J Nutr Source Type: journals
Wanted: specific nutritional biomarkers for food consumption for the study of its protective role in health.
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PMID: 19849870 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - October 22, 2009 Category: Nutrition Authors: Andres-Lacueva C, Zamora-Ros R Tags: Br J Nutr Source Type: journals
Role of zinc along with ascorbic acid and folic acid during long-term in vitro albumin glycation.
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The present study aimed to investigate the role of Zn alone and in the presence of ascorbic acid (AA) and folic acid (FA) in albumin glycation. Glycation was performed by incubations of bovine serum albumin with glucose at 37 degrees C along with Zn, AA or FA separately and Zn+AA or Zn+FA for 150 d. Glycation-mediated modifications were monitored as fluorescence of advanced glycation endproducts, carbonyl formation, beta aggregation (thioflavin T and Congo red dyes), albumin-bound Zn, thiol groups and glycated aggregate's toxicity in HepG2 cells. Zn inhibited glycation and beta aggregation, probably due to observed hig...
Source: The British Journal of Nutrition - October 22, 2009 Category: Nutrition Authors: Tupe RS, Agte VV Tags: Br J Nutr Source Type: journals
Effects of oats on plasma cholesterol and lipoproteins in C57BL/6 mice are substrain specific.
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Cholesterol-lowering effects of oats have been demonstrated in both animals and human subjects. However, the crucial properties of oat-containing diets that determine their health effects need to be further investigated to optimise their use. A mouse model would be a valuable tool, but few such studies have been published to date. We investigated the effects of oat bran on plasma cholesterol and lipoproteins in two substrains of C57BL/6 mice. Western diet was made atherogenic by the addition of 0.8 % cholesterol and 0.1 % cholic acid. After 4 weeks on atherogenic diet, total plasma cholesterol had increased from 1.86-2...
Source: The British Journal of Nutrition - October 19, 2009 Category: Nutrition Authors: Andersson KE, Immerstrand T, Swärd K, Bergenståhl B, Lindholm MW, Oste R, Hellstrand P Tags: Br J Nutr Source Type: journals
Assessing dietary intake in a population undergoing a rapid transition in diet and lifestyle: the Arctic Inuit in Nunavut, Canada.
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The aims of the present study were to (1) characterise the diets of adult Inuit; (2) highlight foods for a nutritional and lifestyle intervention programme; (3) develop a quantitative FFQ (QFFQ) to evaluate the programme and monitor changes in dietary intake in this population over time. A dietary survey using single 24-h dietary recalls was conducted among Inuit aged between 19 and 87 years in two communities in Nunavut, Canada. Eighty-seven subjects completed the recalls (response rate was approximately 73 %). The mean energy intake for men and women was 9530 and 6939 kJ, respectively. The intakes of dietary fibre an...
Source: The British Journal of Nutrition - October 19, 2009 Category: Nutrition Authors: Sharma S, Cao X, Roache C, Buchan A, Reid R, Gittelsohn J Tags: Br J Nutr Source Type: journals
Dietary patterns of school-age children in Scotland: association with socio-economic indicators, physical activity and obesity.
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The Survey of Sugar Intake among Children in Scotland was carried out in May to September 2006. The present study aimed to identify dietary patterns in school-aged children from the survey and investigate associations with socio-economic factors, obesity and physical activity. Habitual diet was assessed using the Scottish Collaborative Group FFQ. Height and weight were measured by trained fieldworkers. A total of 1233 FFQ were available for analysis. Dietary patterns were identified by age (5-11 and 12-17 years) and sex using principal components analysis. Associations between factor scores and socio-economic status, e...
Source: The British Journal of Nutrition - October 15, 2009 Category: Nutrition Authors: Craig LC, McNeill G, Macdiarmid JI, Masson LF, Holmes BA Tags: Br J Nutr Source Type: journals
n-3 and n-6 Polyunsaturated fatty acids suppress sterol regulatory element binding protein activity and increase flow of non-esterified cholesterol in HepG2 cells.
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The plasma lipid-lowering effect of PUFA, one of their main beneficial effects, is considered to be related to the regulation of lipid biosynthesis through transcription factors including sterol regulatory element binding proteins (SREBP). In the present study, we compared the effect of different PUFA on SREBP activity in HepG2 cells, using a sterol regulatory element-luciferase reporter construct as a probe. Supplementation with different fatty acids reduced SREBP activity in the order 20 : 5n-3 = 18 : 2n-6 = 20 : 4n-618 : 3n-3 = 22 : 6n-3 = 22 : 5n-618 : 1n-9. The suppression of SREBP activity greatly depended on the...
Source: The British Journal of Nutrition - October 13, 2009 Category: Nutrition Authors: Di Nunzio M, van Deursen D, Verhoeven AJ, Bordoni A Tags: Br J Nutr Source Type: journals
Folate status of Ghanaian populations in London and Accra.
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Migration to the UK is associated with higher incidence of stroke in African populations. A low folate status has been associated with increased risk of stroke, likely to be mediated through raised plasma homocysteine concentrations. We conducted a cross-sectional study to compare blood folate and homocysteine concentrations in eighty healthy Ghanaian migrants living in London matched by sex, age and occupation to 160 individuals from an urban population in Accra, Ghana. Folate intake was determined using three 24 h recalls. Fasting blood samples were collected for the determination of serum and erythrocyte folate and ...
Source: The British Journal of Nutrition - October 13, 2009 Category: Nutrition Authors: Owusu M, Thomas J, Wiredu E, Pufulete M Tags: Br J Nutr Source Type: journals
The potential health benefits of legumes as a good source of dietary fibre.
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The objective of the present study was to determine the potential health benefits of legumes as a good source of dietary fibre. Six to ten local legumes were studied as follows: cowpeas, mung beans, pole sitao, chickpeas, green peas, groundnuts, pigeon peas, kidney beans, lima beans and soyabeans. The following studies were conducted: (a) mineral availability, in vitro; (b) glycaemic index (GI) in non-diabetic and diabetic human subjects; (c) the cholesterol-lowering effect in human subjects with moderately raised serum cholesterol levels. The highest Fe availability among legumes was for lima beans (9.5 (sem 0.1)) while f...
Source: The British Journal of Nutrition - October 13, 2009 Category: Nutrition Authors: Trinidad TP, Mallillin AC, Loyola AS, Sagum RS, Encabo RR Tags: Br J Nutr Source Type: journals
Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study.
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In conclusion, we found borderline significant negative associations between the intake of marine n-3 PUFA and ACS among healthy men.
PMID: 19825219 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - October 13, 2009 Category: Nutrition Authors: Joensen AM, Schmidt EB, Dethlefsen C, Johnsen SP, Tjønneland A, Rasmussen LH, Overvad K Tags: Br J Nutr Source Type: journals
Lipid content and fatty acids composition of mature human milk in rural North China.
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To determine the lipid content and fatty acid (FA) composition of breast milk from fifty-two lactating women between ninth and twelfth lactation weeks in rural North China. The mothers were questioned on their dietary habits. Total milk lipids extracts were transmethylated and analysed using GLC to determine FA contents. The mean lipid content was 40.21 (sd 1.43) g/l. SFA constituted 35.92 % of the total FA. Medium-chain and long-chain SFA presented levels of 10.91 and 25.01 %, respectively. MUFA and PUFA constituted 32.59 and 19.97 % of the total FA, respectively. Oleic, linoleic and alpha-linolenic acid (ALA) present...
Source: The British Journal of Nutrition - October 13, 2009 Category: Nutrition Authors: Wan ZX, Wang XL, Xu L, Geng Q, Zhang Y Tags: Br J Nutr Source Type: journals
Red wine metabolites modulate NF-kappaB, activator protein-1 and cAMP response element-binding proteins in human endothelial cells.
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We have studied the effect of human serum, collected after red wine consumption (RWS), on TNF-alpha-dependent activation of transcription factors (NF-kappaB, activator protein-1 (AP-1) and cAMP response element-binding proteins) and on the expression of selected genes involved in cell adhesion or fibrinolysis processes in human primary endothelial cells (human umbilical vein endothelial cells (HUVEC)). Our data indicate that RWS containing RW metabolites, isolated after 40 min from an acute consume of wine (5 ml/kg body weight), induces nuclear translocation of NF-kappaB and AP-1 in the absence of any further stimulus....
Source: The British Journal of Nutrition - October 13, 2009 Category: Nutrition Authors: Canali R, Comitato R, Ambra R, Virgili F Tags: Br J Nutr Source Type: journals
Glutamine attenuates acute lung injury by inhibition of high mobility group box protein-1 expression during sepsis.
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In conclusion, GLN attenuated ALI and improved survival by the inhibition of HMGB-1 expression during sepsis in rats. These benefits were associated with the enhancement of HSP70 expression by GLN.
PMID: 19825222 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - October 13, 2009 Category: Nutrition Authors: Kwon WY, Suh GJ, Kim KS, Jo YH, Lee JH, Kim K, Jung SK Tags: Br J Nutr Source Type: journals
Modulatory effects of black v. green tea aqueous extract on hyperglycaemia, hyperlipidaemia and liver dysfunction in diabetic and obese rat models.
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Cardiovascular complications are a major cause of morbidity and mortality in patients with diabetes, obesity and the metabolic syndrome. Recently, there has been an increasing interest in tea as a protective agent against CVD. Here, we compared the modulatory effects of two different doses (50 and 100 mg/kg body weight given orally for 28 consecutive days) of black tea aqueous extract (BTE, rich in theaflavins and thearubigins) and green tea aqueous extract (GTE, rich in catechins) on experimentally induced hyperglycaemia, hyperlipidaemia and liver dysfunction by alloxan (which destroys pancreatic beta-cells and induce...
Source: The British Journal of Nutrition - October 12, 2009 Category: Nutrition Authors: Ramadan G, El-Beih NM, Abd El-Ghffar EA Tags: Br J Nutr Source Type: journals
Dietary fibre and phytate - a balancing act: results from three time points in a British Birth Cohort.
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An investigation was carried out to determine whether there were significant changes in the intake of dietary fibre (NSP) and phytate of adult men and women in the UK from 1982 (aged 36 years) to 1999 (aged 53 years). The 1253 subjects studied were members of the Medical Research Council National Survey of Health and Development; a longitudinal study of a nationally representative cohort of births in 1946. Food intake was recorded in a 5 d diary at age 36 years in 1982, 43 years in 1989 and 53 years in 1999. The food composition database was amended with revised values for phytate. Outcome measures were mean intakes of...
Source: The British Journal of Nutrition - October 12, 2009 Category: Nutrition Authors: Prynne CJ, McCarron A, Wadsworth ME, Stephen AM Tags: Br J Nutr Source Type: journals
The effect of polyphenol-rich dark chocolate on fasting capillary whole blood glucose, total cholesterol, blood pressure and glucocorticoids in healthy overweight and obese subjects.
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Numerous studies indicate that polyphenol-rich chocolate reduces fasting blood glucose, blood pressure (BP) and total cholesterol in healthy individuals and hypertensives with or without glucose intolerance. The aim of the present study was to investigate the effect of two doses of polyphenol-rich dark chocolate (DC) on fasting capillary whole blood glucose, total cholesterol and BP and to examine whether improvements in these parameters are associated with changes in adrenocorticoid excretion in overweight and obese individuals. The study used a randomised, single-blind, cross-over design where fourteen overweight and...
Source: The British Journal of Nutrition - October 12, 2009 Category: Nutrition Authors: Almoosawi S, Fyfe L, Ho C, Al-Dujaili E Tags: Br J Nutr Source Type: journals
Membrane fatty acid composition of rat skeletal muscle is most responsive to the balance of dietary n-3 and n-6 PUFA.
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The present study quantifies the relationships between diet fatty acid profile and fatty acid composition of rat skeletal muscle phospholipids. Young adult male Sprague-Dawley rats were fed, for 8 weeks, on one of twelve moderate-fat diets (25 % of total energy) differing only in fatty acid profile. SFA content ranged from 8-88 % of total fatty acids, MUFA 6-65 %, total PUFA 4-81 %, n-6 PUFA 3-70 % and n-3 PUFA 1-70 %. Diet PUFA included only essential fatty acids 18 : 2n-6 and 18 : 3n-3. The balance between n-3 and n-6 PUFA (PUFA balance) in the diet ranged from 1 : 99 to 86 : 14 % n-3 PUFA:n-6 PUFA. The slope of musc...
Source: The British Journal of Nutrition - October 12, 2009 Category: Nutrition Authors: Abbott SK, Else PL, Hulbert AJ Tags: Br J Nutr Source Type: journals
Anti-diabetic and hypoglycaemic effects of Momordica charantia (bitter melon): a mini review.
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It has been estimated that up to one-third of patients with diabetes mellitus use some form of complementary and alternative medicine. Momordica charantia (bitter melon) is a popular fruit used for the treatment of diabetes and related conditions amongst the indigenous populations of Asia, South America, India and East Africa. Abundant pre-clinical studies have documented the anti-diabetic and hypoglycaemic effects of M. charantia through various postulated mechanisms. However, clinical trial data with human subjects are limited and flawed by poor study design and low statistical power. The present article reviews the ...
Source: The British Journal of Nutrition - October 12, 2009 Category: Nutrition Authors: Leung L, Birtwhistle R, Kotecha J, Hannah S, Cuthbertson S Tags: Br J Nutr Source Type: journals
Protective effect of apricot ( Prunus armeniaca L.) on hepatic steatosis and damage induced by carbon tetrachloride in Wistar rats.
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The present study was planned to investigate the protective effect of 10 % and 20 % apricot-containing feed on carbon tetrachloride (CCl4)-induced hepatic steatosis and damage. Adult male Wistar rats (n 42) were divided into six groups of seven each, as follows: control group; CCl4 group; CCl4+10 % apricot group; CCl4+20 % apricot group; 10 % apricot group; 20 % apricot group. All apricot groups were fed with 10 % or 20 % apricot-containing feed for 5 months. CCl4 injections were applied to the CCl4 groups at the dose of 1 mg/kg for 3 d at the end of 5 months. In the CCl4 group, vacuolated hepatocytes and hepatic necro...
Source: The British Journal of Nutrition - October 12, 2009 Category: Nutrition Authors: Ozturk F, Gul M, Ates B, Ozturk IC, Cetin A, Vardi N, Otlu A, Yilmaz I Tags: Br J Nutr Source Type: journals
Oligomeric proanthocyanidins improve memory and enhance phosphorylation of vascular endothelial growth factor receptor-2 in senescence-accelerated mouse prone/8.
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Senescence-accelerated mouse prone/8 (SAMP8), a murine model of accelerated senescence, shows age-related deficits in learning and memory. We investigated the effect of oligomeric proanthocyanidins (oligomers) on memory impairment using the SAMP8 model involving the oral administration of oligomers for 5 weeks. To analyse memory improvement in SAMP8, we performed Morris water maze, object location and object recognition tests. The oral administration of oligomers improved spatial and object recognition impairment in SAMP8. Expressions of phosphorylated neurofilament-H (P-NF-H, axon marker), microtubule-associated prote...
Source: The British Journal of Nutrition - October 12, 2009 Category: Nutrition Authors: Lee YA, Cho EJ, Yokozawa T Tags: Br J Nutr Source Type: journals
Disodium ascorbyl phytostanol phosphate (FM-VP4), a modified phytostanol, is a highly active hypocholesterolaemic agent that affects the enterohepatic circulation of both cholesterol and bile acids in mice.
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In conclusion, FM-VP4 reduced intestinal cholesterol absorption, plasma and liver cholesterol and affected bile acid homeostasis by inducing bile acid intestinal reabsorption and changed the liver expression of genes that play an essential role in cholesterol homeostasis. This is the first phytosterol or stanol that affects bile acid metabolism and lowers plasma cholesterol levels in normocholesterolaemic mice.
PMID: 19822032 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - October 12, 2009 Category: Nutrition Authors: Méndez-González J, Süren-Castillo S, Calpe-Berdiel L, Rotllan N, Vázquez-Carrera M, Escolà-Gil JC, Blanco-Vaca F Tags: Br J Nutr Source Type: journals
n-3 Fatty acids prevent whereas trans-fatty acids induce vascular inflammation and sudden cardiac death.
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n-3 PUFA have well-recognised cardio-beneficial effects. In contrast, premature coronary deaths are associated with consumption of high levels of trans-fatty acids (TFA). The present study determined the effects of n-3 PUFA and TFA on sudden cardiac death and vascular inflammation. A rat coronary ligation model was used to study the effect of fatty acids on sudden cardiac death, whereas a mouse femoral artery ligation model was used to study compensatory vascular remodelling. Human aortic endothelial cells (HAEC) were utilised for the in vitro studies to investigate expression of inflammatory molecules. Feeding animals...
Source: The British Journal of Nutrition - October 12, 2009 Category: Nutrition Authors: Siddiqui RA, Harvey KA, Ruzmetov N, Miller SJ, Zaloga GP Tags: Br J Nutr Source Type: journals
