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NDUFA9 and its crotonylation modification promote browning of white adipocytes by activating mitochondrial function in mice
This study establishes a theoretical foundation for the management and intervention of obesity, which is crucial in addressing obesity and related medical conditions in the future.PMID:38657899 | DOI:10.1016/j.biocel.2024.106583 (Source: The International Journal of Biochemistry and Cell Biology)
Source: The International Journal of Biochemistry and Cell Biology - April 24, 2024 Category: Biochemistry Authors: Yuexia Liu Zunhai Liu Zeyu Ren Qiannan Han Xinhao Chen Jialu Han Guiping Qiu Chao Sun Source Type: research

UHRF1 poly-auto-ubiquitination induced by the anti-cancer drug, thymoquinone, is involved in the DNA repair machinery recruitment
Int J Biochem Cell Biol. 2024 Apr 20:106582. doi: 10.1016/j.biocel.2024.106582. Online ahead of print.ABSTRACTDNA methylation is one of the most important epigenetic mark involved in many physiologic cellular processes and pathologies. During mitosis, the transmission of DNA methylation patterns from a mother to the daughter cells is ensured through the action of the Ubiquitin-like, containing PHD and RING domains, 1/DNA methyltransferase 1 (UHRF1/DNMT1) tandem. UHRF1 is involved in the silencing of many tumor suppressor genes (TSGs) via mechanisms that remain largely to be deciphered. The present study investigated the ro...
Source: The International Journal of Biochemistry and Cell Biology - April 22, 2024 Category: Biochemistry Authors: Naif A R Almalki Jamal S M Sabir Abdulkhaleg Ibrahim Mahmoud Alhosin Amer H Asseri Raed S Albiheyri Ali T Zari Ahmed Bahieldin Aqib Javed Yves M ély Ali Hamiche Marc Mousli Christian Bronner Source Type: research

UHRF1 poly-auto-ubiquitination induced by the anti-cancer drug, thymoquinone, is involved in the DNA repair machinery recruitment
Int J Biochem Cell Biol. 2024 Apr 20:106582. doi: 10.1016/j.biocel.2024.106582. Online ahead of print.ABSTRACTDNA methylation is one of the most important epigenetic mark involved in many physiologic cellular processes and pathologies. During mitosis, the transmission of DNA methylation patterns from a mother to the daughter cells is ensured through the action of the Ubiquitin-like, containing PHD and RING domains, 1/DNA methyltransferase 1 (UHRF1/DNMT1) tandem. UHRF1 is involved in the silencing of many tumor suppressor genes (TSGs) via mechanisms that remain largely to be deciphered. The present study investigated the ro...
Source: The International Journal of Biochemistry and Cell Biology - April 22, 2024 Category: Biochemistry Authors: Naif A R Almalki Jamal S M Sabir Abdulkhaleg Ibrahim Mahmoud Alhosin Amer H Asseri Raed S Albiheyri Ali T Zari Ahmed Bahieldin Aqib Javed Yves M ély Ali Hamiche Marc Mousli Christian Bronner Source Type: research

PYCR3 Modulates mtDNA Copy Number to Drive Proliferation and Doxorubicin Resistance in Triple-Negative Breast Cancer
Int J Biochem Cell Biol. 2024 Apr 18:106581. doi: 10.1016/j.biocel.2024.106581. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC) poses significant challenges in treatment due to its aggressive nature and limited therapeutic targets. Understanding the underlying molecular mechanisms driving TNBC progression and chemotherapy resistance is imperative for developing effective therapeutic strategies. Thus, in this study, we aimed to elucidate the role of pyrroline-5-carboxylate reductase 3 (PYCR3) in TNBC pathogenesis and therapeutic response. We observed that PYCR3 is significantly upregulated in TNBC specime...
Source: The International Journal of Biochemistry and Cell Biology - April 20, 2024 Category: Biochemistry Authors: Feifei Zhuang Shaoyan Huang Lei Liu Source Type: research

The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU
Int J Biochem Cell Biol. 2024 Apr 11;171:106571. doi: 10.1016/j.biocel.2024.106571. Online ahead of print.ABSTRACTCurrent treatment options for triple-negative breast cancer (TNBC) are limited to toxic drug combinations of low efficacy. We recently identified an aryl-substituted fatty acid analogue, termed CTU, that effectively killed TNBC cells in vitro and in mouse xenograft models in vivo without producing toxicity. However, there was a residual cell population that survived treatment. The present study evaluated the mechanisms that underlie survival and renewal in CTU-treated MDA-MB-231 TNBC cells. RNA-seq profiling id...
Source: The International Journal of Biochemistry and Cell Biology - April 12, 2024 Category: Biochemistry Authors: Md Khalilur Rahman Balasubrahmanyam Umashankar Hassan Choucair Kirsi Bourget Tristan Rawling Michael Murray Source Type: research

The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU
Int J Biochem Cell Biol. 2024 Apr 11;171:106571. doi: 10.1016/j.biocel.2024.106571. Online ahead of print.ABSTRACTCurrent treatment options for triple-negative breast cancer (TNBC) are limited to toxic drug combinations of low efficacy. We recently identified an aryl-substituted fatty acid analogue, termed CTU, that effectively killed TNBC cells in vitro and in mouse xenograft models in vivo without producing toxicity. However, there was a residual cell population that survived treatment. The present study evaluated the mechanisms that underlie survival and renewal in CTU-treated MDA-MB-231 TNBC cells. RNA-seq profiling id...
Source: The International Journal of Biochemistry and Cell Biology - April 12, 2024 Category: Biochemistry Authors: Md Khalilur Rahman Balasubrahmanyam Umashankar Hassan Choucair Kirsi Bourget Tristan Rawling Michael Murray Source Type: research

The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU
Int J Biochem Cell Biol. 2024 Apr 11;171:106571. doi: 10.1016/j.biocel.2024.106571. Online ahead of print.ABSTRACTCurrent treatment options for triple-negative breast cancer (TNBC) are limited to toxic drug combinations of low efficacy. We recently identified an aryl-substituted fatty acid analogue, termed CTU, that effectively killed TNBC cells in vitro and in mouse xenograft models in vivo without producing toxicity. However, there was a residual cell population that survived treatment. The present study evaluated the mechanisms that underlie survival and renewal in CTU-treated MDA-MB-231 TNBC cells. RNA-seq profiling id...
Source: The International Journal of Biochemistry and Cell Biology - April 12, 2024 Category: Biochemistry Authors: Md Khalilur Rahman Balasubrahmanyam Umashankar Hassan Choucair Kirsi Bourget Tristan Rawling Michael Murray Source Type: research

The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU
Int J Biochem Cell Biol. 2024 Apr 10:106571. doi: 10.1016/j.biocel.2024.106571. Online ahead of print.ABSTRACTCurrent treatment options for triple-negative breast cancer (TNBC) are limited to toxic drug combinations of low efficacy. We recently identified an aryl-substituted fatty acid analogue, termed CTU, that effectively killed TNBC cells in vitro and in mouse xenograft models in vivo without producing toxicity. However, there was a residual cell population that survived treatment. The present study evaluated the mechanisms that underlie survival and renewal in CTU-treated MDA-MB-231 TNBC cells. RNA-seq profiling identi...
Source: The International Journal of Biochemistry and Cell Biology - April 12, 2024 Category: Biochemistry Authors: Md Khalilur Rahman Balasubrahmanyam Umashankar Hassan Choucair Kirsi Bourget Tristan Rawling Michael Murray Source Type: research

The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU
Int J Biochem Cell Biol. 2024 Apr 10:106571. doi: 10.1016/j.biocel.2024.106571. Online ahead of print.ABSTRACTCurrent treatment options for triple-negative breast cancer (TNBC) are limited to toxic drug combinations of low efficacy. We recently identified an aryl-substituted fatty acid analogue, termed CTU, that effectively killed TNBC cells in vitro and in mouse xenograft models in vivo without producing toxicity. However, there was a residual cell population that survived treatment. The present study evaluated the mechanisms that underlie survival and renewal in CTU-treated MDA-MB-231 TNBC cells. RNA-seq profiling identi...
Source: The International Journal of Biochemistry and Cell Biology - April 12, 2024 Category: Biochemistry Authors: Md Khalilur Rahman Balasubrahmanyam Umashankar Hassan Choucair Kirsi Bourget Tristan Rawling Michael Murray Source Type: research

The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU
Int J Biochem Cell Biol. 2024 Apr 10:106571. doi: 10.1016/j.biocel.2024.106571. Online ahead of print.ABSTRACTCurrent treatment options for triple-negative breast cancer (TNBC) are limited to toxic drug combinations of low efficacy. We recently identified an aryl-substituted fatty acid analogue, termed CTU, that effectively killed TNBC cells in vitro and in mouse xenograft models in vivo without producing toxicity. However, there was a residual cell population that survived treatment. The present study evaluated the mechanisms that underlie survival and renewal in CTU-treated MDA-MB-231 TNBC cells. RNA-seq profiling identi...
Source: The International Journal of Biochemistry and Cell Biology - April 12, 2024 Category: Biochemistry Authors: Md Khalilur Rahman Balasubrahmanyam Umashankar Hassan Choucair Kirsi Bourget Tristan Rawling Michael Murray Source Type: research

INHBA regulates Hippo signaling to confer 5-FU chemoresistance mediated by cellular senescence in colon cancer cells
This study intended to investigate mechanisms of INHBA (inhibin A) in 5-FU resistance mediated by cellular senescence in colon cancer. Bioinformatics analysis of INHBA expression in colon cancer tissues, survival analysis, and correlation analysis of cellular senescence markers were performed. The effects of INHBA on the biological characteristics and 5-FU resistance of colon cancer cells were examined through loss/gain-of-function and molecular assays. Finally, a xenograft mouse model was built to validate the mechanism of INHBA in vivo. INHBA was upregulated in colon cancer and was significantly positively correlated wit...
Source: The International Journal of Biochemistry and Cell Biology - April 8, 2024 Category: Biochemistry Authors: Zhan Zhang Lili Chen Qiao Yang Xiaowan Tang Jianhua Li Guangwen Zhang Youqun Wang Hui Huang Source Type: research

INHBA regulates Hippo signaling to confer 5-FU chemoresistance mediated by cellular senescence in colon cancer cells
This study intended to investigate mechanisms of INHBA (inhibin A) in 5-FU resistance mediated by cellular senescence in colon cancer. Bioinformatics analysis of INHBA expression in colon cancer tissues, survival analysis, and correlation analysis of cellular senescence markers were performed. The effects of INHBA on the biological characteristics and 5-FU resistance of colon cancer cells were examined through loss/gain-of-function and molecular assays. Finally, a xenograft mouse model was built to validate the mechanism of INHBA in vivo. INHBA was upregulated in colon cancer and was significantly positively correlated wit...
Source: The International Journal of Biochemistry and Cell Biology - April 8, 2024 Category: Biochemistry Authors: Zhan Zhang Lili Chen Qiao Yang Xiaowan Tang Jianhua Li Guangwen Zhang Youqun Wang Hui Huang Source Type: research

INHBA regulates Hippo signaling to confer 5-FU chemoresistance mediated by cellular senescence in colon cancer cells
This study intended to investigate mechanisms of INHBA (inhibin A) in 5-FU resistance mediated by cellular senescence in colon cancer. Bioinformatics analysis of INHBA expression in colon cancer tissues, survival analysis, and correlation analysis of cellular senescence markers were performed. The effects of INHBA on the biological characteristics and 5-FU resistance of colon cancer cells were examined through loss/gain-of-function and molecular assays. Finally, a xenograft mouse model was built to validate the mechanism of INHBA in vivo. INHBA was upregulated in colon cancer and was significantly positively correlated wit...
Source: The International Journal of Biochemistry and Cell Biology - April 8, 2024 Category: Biochemistry Authors: Zhan Zhang Lili Chen Qiao Yang Xiaowan Tang Jianhua Li Guangwen Zhang Youqun Wang Hui Huang Source Type: research

INHBA regulates Hippo signaling to confer 5-FU chemoresistance mediated by cellular senescence in colon cancer cells
This study intended to investigate mechanisms of INHBA (inhibin A) in 5-FU resistance mediated by cellular senescence in colon cancer. Bioinformatics analysis of INHBA expression in colon cancer tissues, survival analysis, and correlation analysis of cellular senescence markers were performed. The effects of INHBA on the biological characteristics and 5-FU resistance of colon cancer cells were examined through loss/gain-of-function and molecular assays. Finally, a xenograft mouse model was built to validate the mechanism of INHBA in vivo. INHBA was upregulated in colon cancer and was significantly positively correlated wit...
Source: The International Journal of Biochemistry and Cell Biology - April 8, 2024 Category: Biochemistry Authors: Zhan Zhang Lili Chen Qiao Yang Xiaowan Tang Jianhua Li Guangwen Zhang Youqun Wang Hui Huang Source Type: research

Mitochondrial regulation of diabetic endothelial dysfunction: Pathophysiological links
Int J Biochem Cell Biol. 2024 Mar 30;170:106569. doi: 10.1016/j.biocel.2024.106569. Online ahead of print.ABSTRACTMicro- and macrovascular complications frequently occur in patients with diabetes, with endothelial dysfunction playing a key role in the development and progression of the complications. For the early diagnosis and optimal treatment of vascular complications associated with diabetes, it is imperative to comprehend the cellular and molecular mechanisms governing the function of diabetic endothelial cells. Mitochondria function as crucial sensors of environmental and cellular stress regulating endothelial cell v...
Source: The International Journal of Biochemistry and Cell Biology - March 31, 2024 Category: Biochemistry Authors: Xinyi Fang Yanjiao Zhang Haoran Wu Han Wang Runyu Miao Jiahua Wei Yuxin Zhang Jiaxing Tian Xiaolin Tong Source Type: research