The Journal of Clinical Endocrinology and MetabolismThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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859 records returned

Isocitrate Dehydrogenase Mutations Are Rare in Pheochromocytomas and Paragangliomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: IDH mutations are very rare in paragangliomas and pheochromocytomas and do not appear to play an important role in oncogenic HIF activation known to be present in these tumors. PMID: 19915015 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 13, 2009 Category: Endocrinology Authors: Gaal J, Burnichon N, Korpershoek E, Roncelin I, Bertherat J, Plouin PF, de Krijger RR, Gimenez-Roqueplo AP, Dinjens WN Tags: J Clin Endocrinol Metab Source Type: journals

Insulin Resistance in Adolescents with Type 1 Diabetes and Its Relationship to Cardiovascular Function.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: T1D youth demonstrated IR, impaired functional exercise capacity and cardiovascular dysfunction. The phenotype of IR in T1D youth was unique, suggesting a pathophysiology that is different from T2D, yet may adversely affect long-term cardiovascular outcomes. PMID: 19915016 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 13, 2009 Category: Endocrinology Authors: Nadeau KJ, Regensteiner JG, Bauer TA, Brown MS, Dorosz JL, Hull A, Zeitler P, Draznin B, Reusch JE Tags: J Clin Endocrinol Metab Source Type: journals

Pioglitazone Compared with Metformin Increases Pericardial Fat Volume in Patients with Type 2 Diabetes Mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In T2DM patients, pioglitazone increases pericardial fat volume. This increase in pericardial fat volume did not negatively affect myocardial function after 24 wk. These observations question the notion of an inverse causal relationship between pericardial fat volume and myocardial function. PMID: 19915017 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 13, 2009 Category: Endocrinology Authors: Jonker JT, Lamb HJ, van der Meer RW, Rijzewijk LJ, Menting LJ, Diamant M, Bax JJ, de Roos A, Romijn JA, Smit JW Tags: J Clin Endocrinol Metab Source Type: journals

Limited Value of 18F-F-DOPA PET to Localize Pancreatic Insulin-Secreting Tumors in Adults with Hyperinsulinemic Hypoglycemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: 18F-FDOPA PET is of limited value in localizing pancreatic insulin secreting tumors in adult HH. Our results contrast with the referential study and require further analysis. PMID: 19915018 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 13, 2009 Category: Endocrinology Authors: Tessonnier L, Sebag F, Ghander C, De Micco C, Reynaud R, Palazzo FF, Conte-Devolx B, Henry JF, Mundler O, Taïeb D Tags: J Clin Endocrinol Metab Source Type: journals

Apoptotic Markers Indicate Nonalcoholic Steatohepatitis in Polycystic Ovary Syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data demonstrate elevation of apoptotic cell death, its correlation with IR, and a high prevalence of NASH in PCOS patients. Given this high prevalence, PCOS may be a risk factor for progressive hepatic sequelae. Incidence data are of strong interest. PMID: 19906783 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 11, 2009 Category: Endocrinology Authors: Tan S, Bechmann LP, Benson S, Dietz T, Eichner S, Hahn S, Janssen OE, Lahner H, Gerken G, Mann K, Canbay A Tags: J Clin Endocrinol Metab Source Type: journals

Pathogenicity of DNA Variants and Double Mutations in Multiple Endocrine Neoplasia Type 2 and Von Hippel-Lindau Syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: RET p.Tyr791Phe and p.Ser649Leu and VHL p.Pro81Ser are definitely not pathogenic mutations for VHL and MEN 2. Misinterpretation results in irreversible clinical consequences. PMID: 19906784 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 11, 2009 Category: Endocrinology Authors: Erlic Z, Hoffmann MM, Sullivan M, Franke G, Peczkowska M, Harsch I, Schott M, Gabbert HE, Valimäki M, Preuss SF, Hasse-Lazar K, Waligorski D, Robledo M, Januszewicz A, Eng C, Neumann HP Tags: J Clin Endocrinol Metab Source Type: journals

Serum Thyroid-Stimulating Hormone Concentration and Morbidity from Cardiovascular Disease and Fractures in Patients on Long-Term Thyroxine Therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Patients with a high or suppressed TSH had an increased risk of cardiovascular disease, dysrhythmias, and fractures, but patients with a low but unsuppressed TSH did not. It may be safe for patients treated with T4 to have a low but not suppressed serum TSH concentration. PMID: 19906785 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 11, 2009 Category: Endocrinology Authors: Flynn RW, Bonellie SR, Jung RT, Macdonald TM, Morris AD, Leese GP Tags: J Clin Endocrinol Metab Source Type: journals

Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Greater adiposity conferred by FTO and MC4R SNPs led to higher CRP levels, with no evidence for any reverse pathway. Future studies should extend our findings to other circulating inflammatory parameters. This study illustrates the potential power of Mendelian randomization to dissect directions of causality between intercorrelated metabolic factors. PMID: 19906786 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 11, 2009 Category: Endocrinology Authors: Welsh P, Polisecki E, Robertson M, Jahn S, Buckley BM, de Craen AJ, Ford I, Jukema JW, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Shepherd J, Hingorani AD, Smith GD, Schaefer E, Sattar N Tags: J Clin Endocrinol Metab Source Type: journals

Long-Term Safety of Recombinant Human Growth Hormone in Children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: After more than 20 yr, leukemia, a major safety issue initially believed associated with GH, has not been confirmed, but other signals, including risk of second malignancies in patients previously treated with irradiation, have been detected or confirmed through the NCGS. These data further clarify the events associated with rhGH and, although confirming a favorable overall safety profile, they also highlight specific populations at potential risk. PMID: 19906787 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 11, 2009 Category: Endocrinology Authors: Bell J, Parker KL, Swinford RD, Hoffman AR, Maneatis T, Lippe B Tags: J Clin Endocrinol Metab Source Type: journals

Effects of Olanzapine and Haloperidol on the Metabolic Status of Healthy Men.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Short-term treatment with olanzapine reduces fasting plasma free fatty acid concentrations and hampers insulin action on glucose disposal in healthy men, whereas haloperidol has less clear effects. Moreover, olanzapine, but not haloperidol, blunts the insulin-induced decline of plasma free fatty acids and triglyceride concentrations. Notably, these effects come about without a measurable change of body fat mass. PMID: 19906788 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 11, 2009 Category: Endocrinology Authors: Vidarsdottir S, de Leeuw van Weenen JE, Frölich M, Roelfsema F, Romijn JA, Pijl H Tags: J Clin Endocrinol Metab Source Type: journals

Impact of Lithium on Efficacy of Radioactive Iodine Therapy for Graves' Disease: A Cohort Study on Cure Rate, Time to Cure, and Frequency of Increased Serum Thyroxine After Antithyroid Drug Withdrawal.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: RAI combined with lithium is safe and more effective than RAI alone in the cure of hyperthyroidism due to Graves' disease. PMID: 19906789 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 11, 2009 Category: Endocrinology Authors: Bogazzi F, Giovannetti C, Fessehatsion R, Tanda ML, Campomori A, Compri E, Rossi G, Ceccarelli C, Vitti P, Pinchera A, Bartalena L, Martino E Tags: J Clin Endocrinol Metab Source Type: journals

Free Fatty Acid-Induced Hepatic Insulin Resistance is Attenuated Following Lifestyle Intervention in Obese Individuals with Impaired Glucose Tolerance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Both lifestyle interventions are effective in reducing hepatic insulin resistance under basal and hyperinsulinemic conditions. However, the reversal of FFA-induced hepatic insulin resistance is best achieved with a combined exercise/caloric-restriction intervention. PMID: 19906790 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 11, 2009 Category: Endocrinology Authors: Haus JM, Solomon TP, Marchetti CM, Edmison JM, González F, Kirwan JP Tags: J Clin Endocrinol Metab Source Type: journals

Thyroid Cancer in Systemic Lupus Erythematosus: A Case-Control Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggest that the prevalence of papillary thyroid cancer in SLE patients is higher than in age-matched controls, particularly in patients with thyroid autoimmunity. Consequently, careful thyroid surveillance is recommended during the follow-up of these patients. PMID: 19906791 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 11, 2009 Category: Endocrinology Authors: Antonelli A, Mosca M, Fallahi P, Neri R, Ferrari SM, D'Ascanio A, Ghiri E, Carli L, Miccoli P, Bombardieri S Tags: J Clin Endocrinol Metab Source Type: journals

Low Sensitivity of Glucagon Provocative Testing for Diagnosis of Pheochromocytoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The glucagon stimulation test offers insufficient diagnostic sensitivity for reliable exclusion or confirmation of pheochromocytoma. Because of this and the risk of hypertensive complications, the test should be abandoned in routine clinical practice. PMID: 19897672 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: Lenders JW, Pacak K, Huynh TT, Sharabi Y, Mannelli M, Bratslavsky G, Goldstein DS, Bornstein SR, Eisenhofer G Tags: J Clin Endocrinol Metab Source Type: journals

Acute Tissue Injury Caused by Subcutaneous Fat Biopsies Produces Endoplasmic Reticulum Stress.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Open, sc fat biopsies produced inflammation, hypoxia, ER stress, and decreased expression of adiponectin and leptin. These changes remained confined to the biopsy site for at least 4 h. PMID: 19897673 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: Boden G, Silviera M, Smith B, Cheung P, Homko C Tags: J Clin Endocrinol Metab Source Type: journals

Increased Urinary Excretion of 3-Methoxytyramine in Patients with Head and Neck Paragangliomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A substantial number of HNPGL patients have biochemically active tumors, reflected in increased excretion of 3-methoxytyramine, associated with increased dopamine excretion. Some patients only display increased excretion of 3-methoxytyramine, but not of other catecholamines or their metabolites. PMID: 19897674 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: van Duinen N, Steenvoorden D, Kema IP, Jansen JC, Vriends AH, Bayley JP, Smit JW, Romijn JA, Corssmit EP Tags: J Clin Endocrinol Metab Source Type: journals

Increased Generation of Fibrocytes in Thyroid-Associated Ophthalmopathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings suggest that fibrocytes may participate in the pathogenesis of TAO because they express relevant autoantigens such as IGF-I receptor and functional TSHR and differentially accumulate in orbital tissue in TAO. PMID: 19897675 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: Douglas RS, Afifiyan NF, Hwang CJ, Chong K, Haider U, Richards P, Gianoukakis AG, Smith TJ Tags: J Clin Endocrinol Metab Source Type: journals

Characterization of Two Constitutively Active Prolactin Receptor Variants in a Cohort of 95 Women with Multiple Breast Fibroadenomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We present the largest population with MFA ever described, 15% of which had a hPRLR exhibiting basal activity in vitro. This questions the involvement of the hPRLR in MFA etiology and the potential relevance of therapeutic inhibition of PRLR signaling in patients. PMID: 19897676 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: Courtillot C, Chakhtoura Z, Bogorad R, Genestie C, Bernichtein S, Badachi Y, Janaud G, Akakpo JP, Bachelot A, Kuttenn F, Goffin V, Touraine P, Tags: J Clin Endocrinol Metab Source Type: journals

Medullary Thyroid Carcinoma Cell Lines Contain a Self-Renewing CD133+ Population that Is Dependent on Ret Proto-Oncogene Activity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data support the existence of cancer stem-like cells in MTC, which exhibit the features of self-renewal and of multiple lineage differentiation that is dependent on ret proto-oncogene receptor activity. These findings may provide new insights to develop more promising therapy for MTC. PMID: 19897677 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: Zhu W, Hai T, Ye L, Cote GJ Tags: J Clin Endocrinol Metab Source Type: journals

Endothelial Progenitor Cells in Subclinical Hypothyroidism: The Effect of Thyroid Hormone Replacement Therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: SCH predicted lower EPC count, which improved with T4 treatment, independent of other CV risk factors, providing additional evidence that T4 replacement may improve CV risk in SCH. PMID: 19897678 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: Shakoor SK, Aldibbiat A, Ingoe LE, Campbell SC, Sibal L, Shaw J, Home PD, Razvi S, Weaver JU Tags: J Clin Endocrinol Metab Source Type: journals

Prevalence of Metabolic Syndrome in Adult Hypopituitary Growth Hormone (GH)-Deficient Patients Before and After GH Replacement.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: MetS prevalence in GHD patients was higher than in the general population in the United States and higher in the United States than Europe. Prevalence was unaffected by GH replacement, but baseline MetS status and obesity were strong predictors of MetS after GH treatment. PMID: 19897679 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: Attanasio AF, Mo D, Erfurth EM, Tan M, Ho KY, Kleinberg D, Zimmermann AG, Chanson P, Tags: J Clin Endocrinol Metab Source Type: journals

Increased Prevalance of the -211 T Allele of Follicle Stimulating Hormone (FSH) {beta} Subunit Promoter Polymorphism and Lower Serum FSH in Infertile Men.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In perspective, this genetic marker may have clinical significance in molecular diagnostics of male reproductive success and a potential to identify positive responders to FSH treatment. PMID: 19897680 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: Grigorova M, Punab M, Poolamets O, Kelgo P, Ausmees K, Korrovits P, Vihljajev V, Laan M Tags: J Clin Endocrinol Metab Source Type: journals

Bone Mineral Density and Serum Levels of Soluble Tumor Necrosis Factors, Estradiol, and Osteoprotegerin in Postmenopausal Women with Cirrhosis after Viral Hepatitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study shows that bone mass and bone resorption rates do not differ between postmenopausal women with viral cirrhosis and healthy postmenopausal controls and suggests that viral cirrhosis does not appear to increase the risk of osteoporosis in these women. High serum estradiol and OPG concentrations may contribute to preventing the bone loss associated with viral cirrhosis in postmenopausal women. PMID: 19897681 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: González-Calvin JL, Mundi JL, Casado-Caballero FJ, Abadia AC, Martin-Ibañez JJ Tags: J Clin Endocrinol Metab Source Type: journals

The Efficacy and Safety of Gonadotropin-Releasing Hormone Analog Treatment in Childhood and Adolescence: A Single Center, Long-Term Follow-Up Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Girls treated in childhood with GnRHa have normal BMI, BMD, body composition, and ovarian function in early adulthood. FH is not increased in girls with ICPP in whom GnRHa was initiated at about 8 yr. There is no evidence that GnRHa treatment predisposes to polycystic ovary syndrome or menstrual irregularities. PMID: 19897682 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: Magiakou MA, Manousaki D, Papadaki M, Hadjidakis D, Levidou G, Vakaki M, Papaefstathiou A, Lalioti N, Kanaka-Gantenbein C, Piaditis G, Chrousos GP, Dacou-Voutetakis C Tags: J Clin Endocrinol Metab Source Type: journals

Thyroid Hormone Induced Brown Adipose Tissue and Amelioration of Diabetes in a Patient with Extreme Insulin Resistance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This case demonstrates the TH effect on BAT activity and volume in this patient and an association between BAT activity and glucose levels in this patient. Because the contribution of TH on skeletal muscle energy expenditure and fuel metabolism was not assessed, an association between BAT activity and glucose homeostasis can only be suggested. PMID: 19897683 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: Skarulis MC, Celi FS, Mueller E, Zemskova M, Malek R, Hugendubler L, Cochran C, Solomon J, Chen C, Gorden P Tags: J Clin Endocrinol Metab Source Type: journals

Effects of a Mixed Meal on Hemodynamics and Autonomic Control of the Heart in Patients with Type 1 Diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hemodynamic, neurohormonal, and cardiac neural responses to eating are abnormal in type 1 diabetic patients, independently of insulin. PMID: 19892836 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 5, 2009 Category: Endocrinology Authors: Cozzolino D, Furlan R, Gruosso D, Di Maggio C, Miraglia Del Giudice E, Torella R, Giugliano D Tags: J Clin Endocrinol Metab Source Type: journals

Endogenous Glucagon-Like Peptide-1 Slows Gastric Emptying in Healthy Subjects, Attenuating Postprandial Glycemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: GLP-1 plays a physiological role to slow gastric emptying in health, which impacts on glucose absorption and, hence, postprandial glycemia. PMID: 19892837 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 5, 2009 Category: Endocrinology Authors: Deane AM, Nguyen NQ, Stevens JE, Fraser RJ, Holloway RH, Besanko LK, Burgstad C, Jones KL, Chapman MJ, Rayner CK, Horowitz M Tags: J Clin Endocrinol Metab Source Type: journals

Polymorphisms Identified through Genome-Wide Association Studies and Their Associations with Type 2 Diabetes in Chinese, Malays, and Asian-Indians in Singapore.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: SNPs at T2DM susceptibility loci identified through GWAS in populations of European ancestry show similar effects in Asian populations. Failure to detect these effects across different populations may be due to issues of power owing to limited sample size, lower minor allele frequency, or differences in genetic effect sizes. PMID: 19892838 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 5, 2009 Category: Endocrinology Authors: Tan JT, Ng DP, Nurbaya S, Ye S, Lim XL, Leong H, Seet LT, Siew WF, Kon W, Wong TY, Saw SM, Aung T, Chia KS, Lee J, Chew SK, Seielstad M, Tai ES Tags: J Clin Endocrinol Metab Source Type: journals

Sodium Glucose Cotransporter 2 Inhibitors as a New Treatment for Diabetes Mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: SGLT2 inhibitors are showing promise as a useful addition to the current therapeutic options in type 2 diabetes mellitus. Results of ongoing phase III clinical trials are awaited and will determine whether the risk-benefit ratio will allow approval of this new class of drug for the management of type 2 diabetes mellitus. PMID: 19892839 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 5, 2009 Category: Endocrinology Authors: Nair S, Wilding JP Tags: J Clin Endocrinol Metab Source Type: journals

The Common Genetic Variant of Luteinizing Hormone Has a Longer Serum Half-Life than the Wild Type in Heterozygous Women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Variant LH remains longer in circulation than wild type during GnRH receptor blockade in heterozygous women, in accord with its higher content of sialic acid. PMID: 19890021 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 4, 2009 Category: Endocrinology Authors: Wide L, Eriksson K, Sluss PM, Hall JE Tags: J Clin Endocrinol Metab Source Type: journals

Comparison of Simvastatin and Metformin in Treatment of Polycystic Ovary Syndrome: Prospective Randomized Trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Simvastatin treatment was superior to metformin alone, whereas a combination of simvastatin and metformin was not significantly superior to simvastatin alone. PMID: 19890022 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 4, 2009 Category: Endocrinology Authors: Banaszewska B, Pawelczyk L, Spaczynski RZ, Duleba AJ Tags: J Clin Endocrinol Metab Source Type: journals

Effect of Body Mass Index on Peak Growth Hormone Response to Provocative Testing in Children with Short Stature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In children with short stature, BMI affects peak stimulated GH and should be considered when interpreting GH testing. Higher BMI SDS, even within the normal range, may lead to overdiagnosis of GH deficiency. PMID: 19890023 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 4, 2009 Category: Endocrinology Authors: Stanley TL, Levitsky LL, Grinspoon SK, Misra M Tags: J Clin Endocrinol Metab Source Type: journals

Evolution of an Aggressive Prolactinoma into a Growth Hormone Secreting Pituitary Tumor Coincident with GNAS Gene Mutation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These observations suggest that 1)treatment of prolactinomas resistant to dopaminergic drugs is still a challenge, and 2) the appearance of gsp oncogene in a prolactinoma evolving into acromegaly might be the underlying mechanism of this rare transition, further confirming that this mutational change is associated with somatotroph growth and transformation. PMID: 19890024 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 4, 2009 Category: Endocrinology Authors: Lania AG, Ferrero S, Pivonello R, Mantovani G, Peverelli E, Di Sarno A, Beck Peccoz P, Spada A, Colao A Tags: J Clin Endocrinol Metab Source Type: journals

Body Fat Distribution, Adipocyte Size, and Metabolic Characteristics of Nondiabetic Adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our hypothesis that adipocyte size is the best predictor of metabolic characteristics was not supported in this population. The alternative explanation is that fat mass and body fat distribution have more influence on metabolic responses than adipocyte size. PMID: 19890025 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 4, 2009 Category: Endocrinology Authors: Mundi MS, Karpyak MV, Koutsari C, Votruba SB, O'Brien PC, Jensen MD Tags: J Clin Endocrinol Metab Source Type: journals

T Cell Responses to Steroid Cytochrome P450 21-Hydroxylase in Patients with Autoimmune Primary Adrenal Insufficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Patients with autoimmune Addison's disease have circulating 21OH-specific T cells, with amino acids 342-361 of 21OH possibly constituting a disease-specific epitope presented by HLA-DRB1*0404. PMID: 19890026 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 4, 2009 Category: Endocrinology Authors: Bratland E, Skinningsrud B, Undlien DE, Mozes E, Husebye ES Tags: J Clin Endocrinol Metab Source Type: journals

Association of Polymorphism in the Receptor for Advanced Glycation End Products (RAGE) Gene with Circulating RAGE Levels.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The CC genotype of SNP rs2070600 (Gly82Ser) was strongly associated with higher sRAGE levels in a Dutch population. The mechanism by which Gly82Ser polymorphism alters the sRAGE levels remains to be elucidated. PMID: 19890027 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 4, 2009 Category: Endocrinology Authors: Gaens KH, Ferreira I, van der Kallen CJ, van Greevenbroek MM, Blaak EE, Feskens EJ, Dekker JM, Nijpels G, Heine RJ, 't Hart LM, de Groot PG, Stehouwer CD, Schalkwijk CG Tags: J Clin Endocrinol Metab Source Type: journals

Associations between Common Genetic Polymorphisms in Angiopoietin-Like Proteins 3 and 4 and Lipid Metabolism and Adiposity in European Adolescents and Adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study underlines the role of ANGPTL3 in HDL-cholesterol metabolism as early as in adolescence. Our data also suggest possible associations between ANGPTL4 polymorphisms and body fat, but these findings require replication. PMID: 19890028 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 4, 2009 Category: Endocrinology Authors: Legry V, Bokor S, Cottel D, Beghin L, Catasta G, Nagy E, Gonzalez-Gross M, Spinneker A, Stehle P, Molnár D, Moreno LA, Amouyel P, Dallongeville J, Meirhaeghe A Tags: J Clin Endocrinol Metab Source Type: journals

For insulinomas, no place to hide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19890029 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 1, 2009 Category: Endocrinology Authors: Nauck MA, Meier JJ Tags: J Clin Endocrinol Metab Source Type: journals

Early Age at Menarche Associated with Cardiovascular Disease and Mortality.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Early age at menarche (before age 12 yr) was associated with increased risk of cardiovascular disease events, cardiovascular disease mortality, and overall mortality in women, and this association appeared to be only partly mediated by increased adiposity. PMID: 19880785 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 30, 2009 Category: Endocrinology Authors: Lakshman R, Forouhi NG, Sharp SJ, Luben R, Bingham SA, Khaw KT, Wareham NJ, Ong KK Tags: J Clin Endocrinol Metab Source Type: journals

Cognition Is Not Modified by Large but Temporary Changes in Sex Hormones in Men.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A significant change in sex hormone status, including complete hypogonadism, does not modify cognition in men. These findings, along with studies that show a risk for neurodegenerative disease in those with low testosterone, suggest that sex hormone status may be important for neuroprotection in aging but not modulation of normal day-to-day cognitive function. PMID: 19880786 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 30, 2009 Category: Endocrinology Authors: Young LA, Neiss MB, Samuels MH, Roselli CE, Janowsky JS Tags: J Clin Endocrinol Metab Source Type: journals

Recurrence of Hyperprolactinemia after Withdrawal of Dopamine Agonists: Systematic Review and Meta-Analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This meta-analysis showed that hyperprolactinemia will recur after dopamine agonist withdrawal in a considerable proportion of patients. The probability of treatment success was highest when cabergoline was used for at least 2 yr. PMID: 19880787 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 30, 2009 Category: Endocrinology Authors: Dekkers OM, Lagro J, Burman P, Jørgensen JO, Romijn JA, Pereira AM Tags: J Clin Endocrinol Metab Source Type: journals

Dynamics of Body Composition and Bone in Patients with Juvenile Idiopathic Arthritis Treated with Growth Hormone.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: During GH treatment, there was a significant increase and normalization of total bone and muscle CSA at final height. In accordance with an anabolic effect of GH, fat mass stabilized at the lower limit of healthy children. At final height, cortical and marrow CSA, relative to total bone CSA, were normalized in GH-treated patients. PMID: 19880788 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 30, 2009 Category: Endocrinology Authors: Bechtold S, Ripperger P, Pozza RD, Roth J, Häfner R, Michels H, Schwarz HP Tags: J Clin Endocrinol Metab Source Type: journals

The Role of 11ss-Hydroxysteroid Dehydrogenase 1 in Adipogenesis in Thyroid-Associated Ophthalmopathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Induction of 11beta-HSD1 activity and expression by inflammatory cytokines (TNF-alpha, IL-6) may enhance orbital adipocyte differentiation (adipogenesis) and limit proliferation in TAO. 11beta-HSD1 may also have a role in regulating the local orbital inflammatory response. PMID: 19880789 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 30, 2009 Category: Endocrinology Authors: Tomlinson JW, Durrani OM, Bujalska IJ, Gathercole LL, Tomlins PJ, Reuser TT, Rose GE, Curnow SJ, Stewart PM, Walker EA, Rauz S Tags: J Clin Endocrinol Metab Source Type: journals

Recombinant Insulin-Like Growth Factor (IGF)-I Treatment in Short Children with Low IGF-I Levels: First-Year Results from a Randomized Clinical Trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: rhIGF-I treatment was associated with age- and dose-dependent increases in first-year height velocity. Adverse events during treatment were less common than in previous studies and were generally transient, easily managed, and without known sequelae. PMID: 19880790 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 30, 2009 Category: Endocrinology Authors: Midyett LK, Rogol AD, Van Meter QL, Frane J, Bright GM, Tags: J Clin Endocrinol Metab Source Type: journals

Associations between Body Composition, Circulating Interleukin-1 Receptor Antagonist, Osteocalcin, and Insulin Metabolism in Active Acromegaly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data confirm and establish novel and complex interactions between bone, energy metabolism, and adipose tissue and suggest an unfavorable effect of OCN and GH/IGF-I in combination on insulin metabolism in active acromegaly. PMID: 19880791 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 30, 2009 Category: Endocrinology Authors: Ueland T, Fougner SL, Godang K, Lekva T, Schurgers LJ, Scholz H, Halvorsen B, Schreiner T, Aukrust P, Bollerslev J Tags: J Clin Endocrinol Metab Source Type: journals

Cytostatic Activity of Adenosine Triphosphate-Competitive Kinase Inhibitors in BRAF Mutant Thyroid Carcinoma Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study provides additional evidence of the promising nature of mutant BRAF as a molecular target for thyroid carcinoma cells. PMID: 19880792 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 30, 2009 Category: Endocrinology Authors: Salerno P, De Falco V, Tamburrino A, Nappi TC, Vecchio G, Schweppe RE, Bollag G, Santoro M, Salvatore G Tags: J Clin Endocrinol Metab Source Type: journals

Effect of Rosiglitazone, Metformin, and Glyburide on Bone Biomarkers in Patients with Type 2 Diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Commonly measured bone biomarkers suggest that changes in bone resorption may be partly responsible for the increased risk of fracture in women taking thiazolidinediones. PMID: 19875477 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 29, 2009 Category: Endocrinology Authors: Zinman B, Haffner SM, Herman WH, Holman RR, Lachin JM, Kravitz BG, Paul G, Jones NP, Aftring RP, Viberti G, Kahn SE, Tags: J Clin Endocrinol Metab Source Type: journals

Atypical Progeroid Syndrome due to Heterozygous Missense LMNA Mutations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: APS patients have a few overlapping but some distinct clinical features as compared with HGPS and mandibuloacral dysplasia. The pathogenesis of clinical manifestations in APS patients seems not to be related to accumulation of mutant farnesylated prelamin A. PMID: 19875478 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 29, 2009 Category: Endocrinology Authors: Garg A, Subramanyam L, Agarwal AK, Simha V, Levine B, D'Apice MR, Novelli G, Crow Y Tags: J Clin Endocrinol Metab Source Type: journals

Tumor Infiltrating Lymphocytes But Not Serum Pituitary Antibodies Are Associated with Poor Clinical Outcome after Surgery in Patients with Pituitary Adenoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: TILs and Pit Abs are present in a significant number of pituitary adenoma patients. Cell-mediated immunity appears to be predictive of a less favorable clinical outcome. PMID: 19875479 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 29, 2009 Category: Endocrinology Authors: Lupi I, Manetti L, Caturegli P, Menicagli M, Cosottini M, Iannelli A, Acerbi G, Bevilacqua G, Bogazzi F, Martino E Tags: J Clin Endocrinol Metab Source Type: journals

Clinical Applications of Diabetes Antibody Testing.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Islet autoantibody testing allows prediction of type 1 diabetes and definition of the latent autoimmune diabetes in adults subgroup of non-insulin-treated patients. Although useful for research, until therapies modulating the disease process become available, the benefit to individual patients is generally questionable. With a few exceptions, diabetes antibody testing does not yet have a role in routine clinical care. PMID: 19875480 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 29, 2009 Category: Endocrinology Authors: Bingley PJ Tags: J Clin Endocrinol Metab Source Type: journals