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Growth and Adult Height Attainment in Danish Transgender Adolescents Treated with GnRH Analog and Sex Hormones
CONCLUSION: The minor reduction in adult height of trans girls after hormone treatment may be beneficial to some, whereas trans boys did not experience height gain.PMID:38627922 | DOI:10.1210/clinem/dgae263 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2024 Category: Endocrinology Authors: Pernille Badsberg Norup Mette Ewers Haahr Peter Christiansen Lise Aksglaede Line Cleemann Trine Holm Johannsen Anders Juul Katharina M Main Source Type: research

Letter to the Editor from A.H. Jan Danser and Ingrid M. Garrelds: The clinical impact of sample storage at -20 °C on renin reference intervals and aldosterone-renin ratio calculations
J Clin Endocrinol Metab. 2024 Apr 17:dgae243. doi: 10.1210/clinem/dgae243. Online ahead of print.NO ABSTRACTPMID:38629832 | DOI:10.1210/clinem/dgae243 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2024 Category: Endocrinology Authors: A H Jan Danser Ingrid M Garrelds Source Type: research

Approach to the Neonate with Hypoglycemia
J Clin Endocrinol Metab. 2024 Apr 17:dgae267. doi: 10.1210/clinem/dgae267. Online ahead of print.ABSTRACTAfter birth, healthy neonates undergo a period of altered glucose metabolism, known as "transitional hypoglycemia". During the first 0-4 hours of life, the mean plasma glucose concentration decreases to 57 mg/dL, then by 72-96 hours of life increases to 82 mg/dL, well within the normal adult range. Recent data suggests that transitional hypoglycemia is due to persistence of the fetal beta cell's lower threshold for insulin release, resulting in a transient hyperinsulinemic state. While hypoglycemia is an expected part o...
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2024 Category: Endocrinology Authors: Katherine Lord Diva D De Le ón Source Type: research

Reply to: Letter to the Editor from A.H. Jan Danser and Ingrid M. Garrelds: The clinical impact of sample storage at -20 °C on renin reference intervals and aldosterone-renin ratio calculations
J Clin Endocrinol Metab. 2024 Apr 17:dgae245. doi: 10.1210/clinem/dgae245. Online ahead of print.NO ABSTRACTPMID:38629857 | DOI:10.1210/clinem/dgae245 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2024 Category: Endocrinology Authors: Ömer Özcan Jacquelien J Hillebrand Wendy P J den Elzen Annemieke C Heijboer Source Type: research

Genital Surgery Outcomes Using an Individualized Algorithm for Hormone Management in Transfeminine Individuals
CONCLUSION: An individualized algorithm for preoperative hormone management for TF GS resulted in perioperative continuation of GAHT for the majority of individuals without significantly increasing the risk for post-operative surgical complications while maintaining stable behavioral health measures perioperatively.PMID:38629916 | DOI:10.1210/clinem/dgae269 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2024 Category: Endocrinology Authors: Justine Herndon Nidhi Gupta Caroline Davidge-Pitts Nicole Imhof Cesar Gonzalez Sara Carlson Marissa Will Jorys Martinez-Jorge Vahe Fahradyan Lily Tamire Anna Lin Todd B Nippoldt Alice Y Chang Source Type: research

Genomic landscape and clinical features of advanced thyroid carcinoma: a national database study in Japan
CONCLUSION: Genetic abnormalities with treatment options were found in 62.7% of advanced thyroid carcinomas. TP53 abnormality was an independent poor prognostic factor for overall survival in differentiated thyroid carcinoma. The time to treatment failure for lenvatinib was not different based on genetic profile.PMID:38630010 | DOI:10.1210/clinem/dgae271 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2024 Category: Endocrinology Authors: Soji Toda Yukihiko Hiroshima Hiroyuki Iwasaki Katsuhiko Masudo Source Type: research

Impact of oral bisphosphonate drug holiday on mortality following hip fracture: a population-based cohort study
CONCLUSIONS: Post-fracture mortality is higher in people who discontinue risedronate, but not alendronate, for 1 or 2 years after being adherent to treatment for at least 5 years. The type of bisphosphonate may be a factor to consider when planning drug holidays.PMID:38630464 | DOI:10.1210/clinem/dgae272 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2024 Category: Endocrinology Authors: Miriam T Y Leung Justin P Turner Clara Marquina Jenni Ilomaki Tim Tran J Simon Bell Source Type: research

Correction to: "Differential Diagnosis of Post Pancreatitis Diabetes Mellitus Based on Pancreatic and Gut Hormone Characteristics"
J Clin Endocrinol Metab. 2024 Apr 17:dgae232. doi: 10.1210/clinem/dgae232. Online ahead of print.NO ABSTRACTPMID:38630627 | DOI:10.1210/clinem/dgae232 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2024 Category: Endocrinology Source Type: research

Characterization of 35 novel NR5A1/SF-1 variants identified in individuals with atypical sexual development: The SF1next study
CONCLUSIONS: Genetic analyses and functional assays do not explain the observed wide phenotype of individuals with these novel NR5A1/SF-1 variants. In nine individuals, additional likely disease-causing variants in other genes were found, strengthening the hypothesis that the broad phenotype of DSD associated with NR5A1/SF-1 variants may be caused by an oligogenic mechanism.PMID:38623954 | DOI:10.1210/clinem/dgae251 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Rawda Naamneh Elzenaty Idoia Martinez de Lapiscina Chrysanthi Kouri Kay-Sara Sauter Grit Sommer Luis Casta ño Christa E Fl ück SF1next study group Source Type: research

Regulation of the Function of T Follicular Helper Cells and B Cells in Type 1 Diabetes Mellitus by the OX40/OX40L Axis
CONCLUSIONS: The peripheral Tfh cells proportion increased and the OX40 expression in peripheral Tfh cells was upregulated in patients with T1DM versus patients with T2DM. OX40/OX40L signaling enhanced the Tfh-cell function to assist B-cell differentiation, which may contribute to the pathogenesis of T1DM.PMID:38625053 | DOI:10.1210/clinem/dgae248 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Xuan Du Yan Zhu Wen Lu Nannan Fu Qin Wang Bimin Shi Source Type: research

Association between maternal fasting glucose levels throughout pregnancy and preschoolers' refractive errors
CONCLUSIONS: High level of fasting plasma glucose trajectories during pregnancy has been observed to be associated with 6-year-old children's refractive error, hypermetropia and astigmatism. The first and the second trimesters may be critical periods for the effects of maternal blood glucose on children's vision. The long-term effect of maternal glucose metabolism on children's visual development deserves further study.PMID:38625056 | DOI:10.1210/clinem/dgae247 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Yufan Guo Jixing Zhou Jingru Lu Linlin Zhu Xuemei Hao Shuangqin Yan Juan Tong Shuman Tao Shaojun Xu Fangbiao Tao Kun Huang Source Type: research

GH and prolactin co-secreting adenomas: it is time for a definition
J Clin Endocrinol Metab. 2024 Apr 16:dgae262. doi: 10.1210/clinem/dgae262. Online ahead of print.NO ABSTRACTPMID:38625822 | DOI:10.1210/clinem/dgae262 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Luiz Eduardo Wildemberg M ônica R Gadelha Source Type: research

Genetic Susceptibility, Mendelian randomization and Nomogram Model Construction of Gestational Diabetes Mellitus
CONCLUSION: Functional polymorphisms can change women's susceptibility to GDM and the predictive nomogram model based on genetic and environmental factors can effectively distinguish individuals with different GDM risks in early stages of pregnancy.PMID:38625888 | DOI:10.1210/clinem/dgae200 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Qiulian Liang Ming Li Gongchen Huang Ruiqi Li Linyuan Qin Ping Zhong Xuekun Xing Xiangyuan Yu Source Type: research

Dietary n-3 fatty acids intake and all-cause and cardiovascular mortality in patients with pre-diabetes and diabetes
CONCLUSIONS: Increased dietary intake of n-3 PUFA, particularly ALA and DPA, was associated with a reduced risk of all-cause and cardiovascular mortality among Americans with prediabetes and diabetes.PMID:38625900 | DOI:10.1210/clinem/dgae265 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Jinhang Che Na He Xue Kuang Caiyin Zheng Ruoyu Zhou Xiaodan Zhan Zengzhang Liu Source Type: research

Association of acylcarnitines with maternal cardiometabolic risk factors is defined by chain length: the S-PRESTO study
CONCLUSIONS: This study provides the metabolic and physiological basis of maternal carnitine homeostasis, which can be used in assessment of maternal cardiometabolic health at preconception to improve pregnancy outcomes.PMID:38625914 | DOI:10.1210/clinem/dgae255 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Li Chen Xue Ping Goh Anne K Bendt Karen Mei-Ling Tan Melvin Khee-Shing Leow Kok Hian Tan Jerry K Y Chan Shiao-Yng Chan Yap Seng Chong Peter D Gluckman Johan G Eriksson Markus R Wenk Sartaj Ahmad Mir Source Type: research