A Multi-dimensional Classifier to Support Lung Transplant Referral in Patients with Pulmonary Fibrosis
Lung transplantation remains the sole curative option for patients with idiopathic pulmonary fibrosis (IPF), but donor organs remain scarce, and many eligible patients die prior to transplant. Tools to optimize the timing of transplant referral are urgently needed. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 28, 2024 Category: Transplant Surgery Authors: Janelle Vu Pugashetti, John S. Kim, Michael P. Combs, Shwu-Fan Ma, Ayodeji Adegunsoye, Angela L. Linderholm, Mary E. Strek, Ching-Hsien Chen, Daniel F. Dilling, Timothy P.M. Whelan, Kevin R. Flaherty, Fernando J. Martinez, Imre Noth, Justin M. Oldham Tags: Original Clinical Science Source Type: research

Outcomes Following Concomitant Multi-Organ Heart Transplantation from Circulatory Death Donors: The United States Experience
Donation after circulatory death (DCD) has reemerged as a method of expanding the donor heart pool. Given the high waitlist mortality of multiorgan heart candidates, we evaluated waitlist outcomes associated with willingness to consider DCD offers and post-transplant outcomes following DCD transplant for these candidates. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 26, 2024 Category: Transplant Surgery Authors: Alice L. Zhou, Alexandra A. Rizaldi, Armaan F. Akbar, Jessica M. Ruck, Elizabeth A. King, Ahmet Kilic Tags: Original Clinical Science Source Type: research

Differences in excess mortality by recipient sex after heart transplant: An Individual Patient Data Meta-Analysis
Identification of differences in mortality risk between female and male heart transplant recipients may prompt sex-specific management strategies. Because worldwide, males of all ages have higher absolute mortality rates than females, we aimed to compare the excess risk of mortality (risk above the general population) in female versus male heart transplant recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 22, 2024 Category: Transplant Surgery Authors: Amanda J. Vinson, Xun Zhang, Mourad Dahhou, Caner S üsal, Bernd Döhler, Anette Melk, Ruth Sapir-Pichhadze, Heloise Cardinal, Germaine Wong, Anna Francis, Helen Pilmore, Lauren T. Grinspan, Bethany J. Foster Tags: Original Clinical Science Source Type: research

Sixth monovalent XBB.1.5 vaccine elicits robust immune response against emerging SARS-CoV-2 variants in heart transplant recipients
Continued circulation of SARS-CoV-2 has driven the selection of variants with improved ability to escape pre-existing vaccine-induced responses, posing a persistent threat to heart transplant recipients (HTRs). The immunogenicity and safety of the updated XBB.1.5-containing monovalent vaccines are unknown. We prospectively enrolled 52 HTRs who had previously received a 5-dose ancestral-derived monovalent and bivalent mRNA vaccination schedule to receive the monovalent XBB.1.5 vaccine. Immunogenicity was evaluated using live virus micro-neutralization assays. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 22, 2024 Category: Transplant Surgery Authors: Yael Peled, Arnon Afek, Jignesh K. Patel, Ehud Raanani, Amit Segev, Eilon Ram, Alexander Fardman, Roy Beigel, Menucha Jurkowicz, Nofar Atari, Limor Kliker, Ital Nemet, Michal Mandelboim Tags: Brief Communication Source Type: research

Untangling severe pulmonary hypertension in copd
Pulmonary hypertension (PH) is a pathophysiological disorder characterized by an abnormal increase in pulmonary arterial pressure (PAP) that may be due to or associated with a variety of clinical conditions.1 Pulmonary hypertension is a major health problem with an estimated prevalence of 1% of the global population, mainly because it is a frequent complication of prevalent chronic heart or lung diseases.2 Pulmonary hypertension is common in patients with chronic obstructive pulmonary disease (COPD). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 22, 2024 Category: Transplant Surgery Authors: Joan Albert Barber à, Víctor Ivo Peinado, Isabel Blanco Source Type: research

Normothermic Regional Perfusion in the United States: A Call for Improved Data Collection
“I have but one lamp by which my feet are guided, and that is the lamp of experience.” (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 21, 2024 Category: Transplant Surgery Authors: Alice L. Zhou, Armaan F. Akbar, Ahmet Kilic Source Type: research

Hemodynamic Management of Cardiogenic Shock in the Intensive Care Unit
Hemodynamic derangements are defining features of cardiogenic shock. Randomized clinical trials have examined the efficacy of various therapeutic interventions, from percutaneous coronary intervention to inotropes and mechanical circulatory support (MCS). However, hemodynamic management in cardiogenic shock has not been well-studied. This State-of-the-Art review will provide a framework for hemodynamic management in cardiogenic shock, including a description of the four therapeutic phases from initial ‘Rescue’ to ‘Optimization’, ‘Stabilization’ and ‘de-Escalation or Exit therapy’ (R-O-S-E), phenotyping and ...
Source: The Journal of Heart and Lung Transplantation - March 20, 2024 Category: Transplant Surgery Authors: Hoong Sern Lim, Jos é González-Costello, Jan Belohlavek, Elric Zweck, Vanessa Blumer, Benedikt Schrage, Thomas C. Hanff Tags: State of the art Source Type: research

Noninvasive Assessment of Liver Stiffness in Right Heart Failure: A New Phenotype Requiring Further Exploration
Right heart failure (RHF) remains the leading cause of mortality in pulmonary hypertension, and currently there are no effective therapeutics to enhance RV function1. RHF is lethal because it ultimately leads to multi-organ dysfunction with studies demonstrating derangements in the brain, kidney, liver, gastrointestinal tract, and skeletal muscle function function2. Recently, the deleterious effects of RHF on hepatic function, or cardiohepatic syndrome (CHS), have garnered attention due its important prognostic implications. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 20, 2024 Category: Transplant Surgery Authors: Michael T Patterson, Kurt W. Prins Source Type: research

Applications of transcriptomics in ischemia reperfusion research in lung transplantation
Ischemia-reperfusion (IR) injury contributes to primary graft dysfunction, a major cause of early mortality after lung transplantation. Transcriptomics uses high-throughput techniques to profile the RNA transcripts within a sample and provides a unique view of the mechanisms underlying various biological processes. This review aims to highlight the applications of transcriptomics in lung IR injury studies, which have thus far revealed inflammatory responses to be the major event activated by IR, identified potential biomarkers and therapeutic targets, and investigated the mechanisms of therapeutic interventions. (Source: T...
Source: The Journal of Heart and Lung Transplantation - March 19, 2024 Category: Transplant Surgery Authors: Jamie E. Jeon, Yasal Rajapaksa, Shaf Keshavjee, Mingyao Liu Tags: State of the art Source Type: research

Incidental Finding and Treatment of An Anomalous Aortic Origin of the Right Coronary Artery in a Pediatric Donor ’s Heart prior to Implantation
Coronary artery anomalies in donor hearts are an infrequent incidental finding during intraoperative coronary artery inspection. Herein, we report a pediatric case of restrictive cardiomyopathy with secondary pulmonary hypertension, who underwent a heart transplant, and the procured heart was discovered to have a right coronary artery (RCA) anomaly with anomalous origin from the ascending aorta and with an intramural course. This necessitated RCA unroofing during the transplant. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 18, 2024 Category: Transplant Surgery Authors: Fumiya Yoneyama, Iki Adachi, William J Dreyer, Silvana Molossi, Jeffery S. Heinle, Ziyad Binsalamah Tags: Case Anecdotes, Comments and Opinions Source Type: research

Right ventricular pressure-strain relationship-derived myocardial work reflects contractility: validation with invasive pressure-volume analysis
Three-dimensional (3D) echocardiography-derived right ventricular (RV) ejection fraction (EF) and global longitudinal strain (GLS) are valuable RV functional markers; nevertheless, they are substantially load-dependent. Global myocardial work index (GMWI) is a novel parameter calculated by the area of the RV pressure-strain loop. By adjusting myocardial deformation to instantaneous pressure, it may reflect contractility.To test this hypothesis, we enrolled 60 patients who underwent RV pressure-conductance catheterization to determine load-independent markers of RV contractility and ventriculo-arterial coupling. (Source: Th...
Source: The Journal of Heart and Lung Transplantation - March 18, 2024 Category: Transplant Surgery Authors: B álint Károly Lakatos, Zvonimir Rako, Ádám Szijártó, Bruno R. Brito da Rocha, Manuel J. Richter, Alexandra Fábián, Henning Gall, Hossein A. Ghofrani, Nils Kremer, Werner Seeger, Daniel Zedler, Selin Yildiz, Athiththan Yogeswaran, Béla Merkely, K Tags: Brief Communication Source Type: research

Impact of Controlled Hypothermic Preservation on Outcomes Following Heart Transplantation
Severe primary graft dysfunction (PGD) is a major cause of early mortality after heart transplant. but the impact of donor organ preservation conditions on severity of PGD and survival have not been well characterized. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 17, 2024 Category: Transplant Surgery Authors: David D ’Alessandro, Jacob Schroder, Dan M. Meyer, Andrija Vidic, Yasuhiro Shudo, Scott Silvestry, Marzia Leacche, Christopher M. Sciortino, Maria Rodrigo, Si M. Pham, Hannah Copeland, Jeffrey P. Jacobs, Masashi Kawabori, Koji Takeda, Andreas Zuckermann Source Type: research

Editorial Board
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 15, 2024 Category: Transplant Surgery Source Type: research

Information for Readers
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 15, 2024 Category: Transplant Surgery Source Type: research

Table of Contents
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 15, 2024 Category: Transplant Surgery Source Type: research