Wu et al (J Infect Dis 2016; 214[suppl 3]:S326-32)
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Tags: ERRATUM Source Type: research
Reply to Lagier et al
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Khanna, S., Button, J. E., Lombardo, M.-J., Vulic, M., Henn, M. R., Cook, D. N., Pomerantz, R. J., Hohmann, E. L. Tags: CORRESPONDENCE Source Type: research
Critical Microbiological View of SER-109
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Lagier, J.-C., Cadoret, F., Raoult, D. Tags: CORRESPONDENCE Source Type: research
Reply to Mori
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Siegers, J. Y., van Riel, D. Tags: CORRESPONDENCE Source Type: research
Vaccination Effectively Prevents Central Nervous System Invasion by Influenza A(H5N1) Virus Through the Olfactory Pathway: A Proposed Mechanism of Neuroprotection
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Mori, I. Tags: CORRESPONDENCE Source Type: research
The Early Adaptive Immune Response in the Pathophysiological Process of Pneumococcal Meningitis
Conclusions. B and T cells are important effector cells delaying the spread of pneumococci from the brain to the systemic circulation and shaping the immune response, thereby prolonging the survival of the host in the absence of antibiotic treatment. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Ribes, S., Nessler, S., Heide, E.-C., Malzahn, D., Perske, C., Brück, W., Nau, R. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
The Third Signal Cytokine Interleukin 12 Rather Than Immune Checkpoint Inhibitors Contributes to the Functional Restoration of Hepatitis D Virus-Specific T Cells
Conclusions. This investigation of virus-specific T-cell immunity in patients with HDV infection, the largest to date, revealed premature aging of immune cells and impaired T-cell functionality. This could be restored by blocking inhibitory pathways and, in particular, by supplementing with IL-12. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Schirdewahn, T., Grabowski, J., Owusu Sekyere, S., Bremer, B., Wranke, A., Lunemann, S., Schlaphoff, V., Kirschner, J., Hardtke, S., Manns, M. P., Cornberg, M., Wedemeyer, H., Suneetha, P. V. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
Molecular Epidemiology of Ascaris Infection Among Pigs in Iowa
Ascaris is a large roundworm parasite that infects humans and pigs throughout the world. Molecular markers have been used to study parasite transmission in Ascaris-endemic and -nonendemic regions of the world. In the United States, ascariasis still persists in commercial swine and has been designated a neglected disease of poverty in humans. However, relatively few data are available for evaluation of zoonotic transmission. In the present study, we obtained adult worms from abattoirs and characterized each worm on the basis of the gene encoding nuclear internal transcribed sequence (ITS) and mitochondrial cox1. Restriction...
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Jesudoss Chelladurai, J., Murphy, K., Snobl, T., Bader, C., West, C., Thompson, K., Brewer, M. T. Tags: PARASITES Source Type: research
Trimethoprim-Sulfamethoxazole Prophylaxis During Live Malaria Sporozoite Immunization Induces Long-Lived, Homologous, and Heterologous Protective Immunity Against Sporozoite Challenge
Trimethoprim-sulfamethoxazole (TMP-SMX) is widely used in malaria-endemic areas in human immunodeficiency virus (HIV)–infected children and HIV-uninfected, HIV-exposed children as opportunistic infection prophylaxis. Despite the known effects that TMP-SMX has in reducing clinical malaria, its impact on development of malaria-specific immunity in these children remains poorly understood. Using rodent malaria models, we previously showed that TMP-SMX, at prophylactic doses, can arrest liver stage development of malaria parasites and speculated that TMP-SMX prophylaxis during repeated malaria exposures would induce prot...
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Hobbs, C. V., Anderson, C., Neal, J., Sahu, T., Conteh, S., Voza, T., Langhorne, J., Borkowsky, W., Duffy, P. E. Tags: PARASITES Source Type: research
Monocyte Activation Is Associated With Worse Cognitive Performance in HIV-Infected Women With Virologic Suppression
Conclusions. Monocyte activation was associated with worse cognitive performance, and associations persisted despite viral suppression. Persistent inflammatory mechanisms related to monocytes correlate to clinically pertinent brain outcomes. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Imp, B. M., Rubin, L. H., Tien, P. C., Plankey, M. W., Golub, E. T., French, A. L., Valcour, V. G. Tags: HIV/AIDS Source Type: research
Malaria Parasitemia and Parasite Density in Antiretroviral-Treated HIV-Infected Adults Following Discontinuation of Cotrimoxazole Prophylaxis
Conclusion. Discontinuation of CTX by HIV-infected adults receiving ART resulted in progressive increases in malaria parasitemia prevalence and burden.
Clinical Trials Registration. NCT01425073. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Ottichilo, R. K., Polyak, C. S., Guyah, B., Singa, B., Nyataya, J., Yuhas, K., John-Stewart, G., Waitumbi, J. N. Tags: HIV/AIDS Source Type: research
Redeploying {beta}-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections
We report a new approach to the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections by demonstrating that oxacillin can be used to significantly attenuate the virulence of MRSA despite the pathogen being resistant to this drug. Using mechanistic in vitro assays and in vivo models of invasive pneumonia and sepsis, we show that oxacillin-treated MRSA strains are significantly attenuated in virulence. This effect is based primarily on the oxacillin-dependent repression of the accessory gene regulator quorum-sensing system and altered cell wall architecture, which in turn lead to increased susceptibility...
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Waters, E. M., Rudkin, J. K., Coughlan, S., Clair, G. C., Adkins, J. N., Gore, S., Xia, G., Black, N. S., Downing, T., O'Neill, E., Kadioglu, A., O'Gara, J. P. Tags: BACTERIA Source Type: research
Humanized Mice Reproduce Acute and Persistent Human Adenovirus Infection
Severe human adenovirus (HAdV) infections are an increasing threat for immunosuppressed individuals, particularly those who have received stem cell transplants. It has been previously hypothesized that severe infections might be due to reactivation of a persistent infection, but this hypothesis has been difficult to test owing to the lack of a permissive in vivo model of HAdV infection. Here we established a humanized mouse model that reproduces features of acute and persistent HAdV infection. In this model, acute infection correlated with high mortality, weight loss, liver pathology, and expression of viral proteins in se...
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Rodriguez, E., Ip, W. H., Kolbe, V., Hartmann, K., Pilnitz-Stolze, G., Tekin, N., Gomez-Medina, S., Munoz-Fontela, C., Krasemann, S., Dobner, T. Tags: VIRUSES Source Type: research
2-Year Efficacy, Immunogenicity, and Safety of Vigoo Enterovirus 71 Vaccine in Healthy Chinese Children: A Randomized Open-Label Study
Conclusions. Two doses of Vigoo EV71 vaccine could provide sustained protection against EV71-associated HFMD in healthy Chinese children.
Clinical Trials Registration. NCT01508247. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Wei, M., Meng, F., Wang, S., Li, J., Zhang, Y., Mao, Q., Hu, Y., Liu, P., Shi, N., Tao, H., Chu, K., Wang, Y., Liang, Z., Li, X., Zhu, F. Tags: VIRUSES Source Type: research
A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4{Delta}30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers
This study evaluated rWN/DEN430 in flavivirus-naive adults aged 50–65 years and found it to be safe and immunogenic. Outbreaks of WNV infection tend to be unpredictable, and a safe and effective vaccine will be an important public health tool. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Pierce, K. K., Whitehead, S. S., Kirkpatrick, B. D., Grier, P. L., Jarvis, A., Kenney, H., Carmolli, M. P., Reynolds, C., Tibery, C. M., Lovchik, J., Janiak, A., Luke, C. J., Durbin, A. P., Pletnev, A. G. Tags: VIRUSES Source Type: research
