The Journal of Infectious Diseases Latest Issue
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RtxA1‐Induced Expression of the Small GTPase Rac2 Plays a Key Role in the Pathogenicity of Vibrio vulnificus
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
Infection with the human pathogen Vibrio vulnificus leads to the generation of reactive oxygen species (ROS) via NAD(P)H oxidase (Nox) in host cells. In the present study, we employed mutant V. vulnificus strains to identify an essential virulence factor responsible for this ROS generation. We found that repeats‐in‐toxin A1 (RtxA1) expressed by V. vulnificus acts via Nox1 to induce significant ROS generation in the intestine epithelial cells, which ultimately results in cell death. Furthermore, RtxA1 modulates the small GTPase Rac2,...
Source: The Journal of Infectious Diseases Latest Issue - November 17, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Erratum: Kohut et al (J Infect Dis 2009; 200:1434–42)Email this article to a colleague.
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The Journal of Infectious Diseases, Volume 200, Issue 12, Page 1949, 15 December 2009. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 17, 2009 Category: Infectious Diseases Tags: article Erratum Source Type: journals
Reviewers of Volume 200Email this article to a colleague.
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The Journal of Infectious Diseases, Volume 200, Issue 12, Page 1950-1953, 15 December 2009.
The Journal of Infectious Diseases thanks its many reviewers for their valuable advice and criticism. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 17, 2009 Category: Infectious Diseases Tags: article Source Type: journals
Cryptosporidium parvum Induces B7‐H1 Expression in Cholangiocytes by Down‐Regulating MicroRNA‐513Email this article to a colleague.
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We report here that the protozoan parasite Cryptosporidium parvum induced B7‐H1 expression in cultured human cholangiocytes. Induced expression of B7‐H1 was identified in cells after exposure to infective C. parvum parasite or parasite lysate. Interestingly, the level of microRNA‐513 (miR‐513) was reduced in cells after exposure to C. parvum, which resulted in a relief of 3′ untranslated region–mediated translational suppression of B7‐H1. Overexpression of miR‐513 through transfection of miR‐513 precursor inhibited C. parvum–induced B7‐H1 protein expression. Moreover, enhanced apoptotic cell death was...
Source: The Journal of Infectious Diseases Latest Issue - November 16, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Identification of a Parasitic Immunomodulatory Protein Triggering the Development of Suppressive M1 Macrophages during African TrypanosomiasisEmail this article to a colleague.
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We report the identification of a novel putative Trypanosoma brucei M1 cell–triggering protein. The recombinant trypanosome‐suppressive immunomodulating factor (rTSIF) induced TNF and NO secretion by macrophages. Moreover, M1 cells triggered by rTSIF block T cell proliferation in a manner dependent on NO, interferon γ, and cell contact. Furthermore, rTSIF could down‐regulate type 2–oriented immune responses. Therefore, trypanosome‐suppressive immunomodulating factor (TSIF) may represent a new parasite molecule with the potential to modulate the host immune network, whereby it could contribute to the inflammatory...
Source: The Journal of Infectious Diseases Latest Issue - November 13, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Circumcision and Risk of Sexually Transmissible Infections in a Community‐Based Cohort of HIV‐Negative Homosexual Men in Sydney, AustraliaEmail this article to a colleague.
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Conclusions. These are the first prospective data obtained from homosexual men to assess circumcision status as a risk factor for STIs. Circumcised men were at reduced risk of incident syphilis but no other prevalent or incident STIs. Circumcision is unlikely to have a substantial public health impact in reducing acquisition of most STIs in homosexual men. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 13, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Pre‐ and Postexposure Use of Human Monoclonal Antibody against H5N1 and H1N1 Influenza Virus in Mice: Viable Alternative to OseltamivirEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
New strategies to prevent and treat influenza virus infections are urgently needed. A recently discovered class of monoclonal antibodies (mAbs) neutralizing an unprecedented spectrum of influenza virus subtypes may have the potential for future use in humans. Here, we assess the efficacies of CR6261, which is representative of this novel class of mAbs, and oseltamivir in mice. We show that a single injection with 15 mg/kg CR6261 outperforms a 5‐day course of treatment with oseltamivir (10 mg/kg/day) with respect to both prophylaxis an...
Source: The Journal of Infectious Diseases Latest Issue - November 13, 2009 Category: Infectious Diseases Tags: article BRIEF REPORT Source Type: journals
The Lambaréné Organ Dysfunction Score (LODS) Is a Simple Clinical Predictor of Fatal Malaria in African ChildrenEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
Background. Plasmodium falciparum malaria accounts for >1 million deaths annually, mostly among young children in sub‐Saharan Africa. Identifying those individuals who are likely to die is crucial. Several factors have been independently associated with death. Because malaria is a systemic disease, a quantitative score combining such risk factors may be superior. Methods. We used both forward and backward stepwise logistic regression to select the best predictors of death, as evaluated for 23,890 African children with severe P. ...
Source: The Journal of Infectious Diseases Latest Issue - November 13, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Dengue Virus Infections and Maternal Antibody Decay in a Prospective Birth Cohort Study of Vietnamese InfantsEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of maternally derived DENV immunoglobulin (Ig) G and the incidence of DENV infection were determined in a prospectively studied cohort of 1244 Vietnamese infants. Higher concentrations of total IgG and DENV‐reactive IgG were found in cord plasma relative to maternal plasma. Maternally derived DENV‐neutralizing and E protein–reactive IgG titers declined to below measurable levels in >90% of infants by 6 months of age. In contrast, IgG ...
Source: The Journal of Infectious Diseases Latest Issue - November 13, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Age‐Related Increase in the Frequency of CD4+ T Cells That Produce Interferon‐γ in Response to Staphylococcal Enterotoxin B during ChildhoodEmail this article to a colleague.
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Conclusions. These observations indicate that the IFN‐γ response of CD4+ T cells to SEB remains limited for a much longer interval than was reported elsewhere, extending to the second decade of life. Observed differences in CD45RO+CD4+ T cell function indicate that CD4+ T cells with the same phenotypes do not possess equivalent functional capabilities. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 12, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
HIV‐1 Evolution Following Transmission to an HLA‐B*5801‐Positive PatientEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
The human immunodeficiency virus type 1 (HIV‐1)–specific immune responses of patients with the HLA‐B*57/5801 alleles who spontaneously control viral replication serve as an important model for T cell–based HIV‐1 vaccines. Determining the breadth of this response and the extent of virologic escape in primary infection in these patients is therefore critical. Here we document the development of mutations in 3 HLA‐B*5801‐restricted epitopes in gag, nef, and pol in an HLA‐B*5801‐positive patient who had a viral load of onl...
Source: The Journal of Infectious Diseases Latest Issue - November 12, 2009 Category: Infectious Diseases Tags: article BRIEF REPORT Source Type: journals
Cost‐Effectiveness of Adult Circumcision in a Resource‐Rich Setting for HIV Prevention among Men Who Have Sex with MenEmail this article to a colleague.
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Conclusions. Circumcision of adult MSM may be cost‐effective in this resource‐rich setting. However, the intervention costs are high relative to the costs spent on other HIV prevention programs. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 12, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
A Live Attenuated H1N1 M1 Mutant Provides Broad Cross‐Protection against Influenza A Viruses, Including Highly Pathogenic A/Vietnam/1203/2004, in MiceEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
The emergence of novel influenza A H1N1 and highly pathogenic avian influenza (HPAI) H5N1 viruses underscores the urgency of developing efficient vaccines against an imminent pandemic. M(NLS‐88R) (H1N1), an A/WSN/33 mutant with modifications in the multibasic motif 101RKLKR105 of the matrix (M1) protein and its adjacent region, was generated by reverse genetics. The M(NLS‐88R) mutant had in vitro growth characteristics similar to those of wild‐type A/WSN/33 (wt‐WSN), but it was attenuated in mice. Vaccination with M(NLS‐88R) n...
Source: The Journal of Infectious Diseases Latest Issue - November 12, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Efficacy of Inactivated Split‐Virus Influenza Vaccine against Culture‐Confirmed Influenza in Healthy Adults: A Prospective, Randomized, Placebo‐Controlled TrialEmail this article to a colleague.
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Conclusion. TIV is efficacious against culture‐confirmed influenza in healthy adults. Trial Registration. ClinicalTrials.gov identifier: NCT00363870. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 12, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Borrelia burgdorferi Stimulates Macrophages to Secrete Higher Levels of Cytokines and Chemokines than Borrelia afzelii or Borrelia gariniiEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
To delineate the inflammatory potential of the 3 pathogenic species of Borrelia burgdorferi sensu lato, we stimulated monocyte‐derived macrophages from healthy human donors with 10 isolates each of B. burgdorferi, Borrelia afzelii, or Borrelia garinii recovered from erythema migrans skin lesions of patients with Lyme borreliosis from the United States or Slovenia. B. burgdorferi isolates from the United States induced macrophages to secrete significantly higher levels of interleukin (IL)‐8, CCL3, CCL4, IL‐6, IL‐10, and tumor nec...
Source: The Journal of Infectious Diseases Latest Issue - November 12, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Reply to Menzo et alEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 200, Issue 11, Page 1799-1800, 1 December 2009. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 12, 2009 Category: Infectious Diseases Tags: article CORRESPONDENCE Source Type: journals
Low‐Abundance Drug Resistance Mutations: Extending the HIV Paradigm to Hepatitis B VirusEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 200, Issue 11, Page 1798-1799, 1 December 2009. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 12, 2009 Category: Infectious Diseases Tags: article CORRESPONDENCE Source Type: journals
Selection of Parasites with Diminished Drug Susceptibility by Amodiaquine‐Containing Antimalarial Regimens in UgandaEmail this article to a colleague.
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Conclusions. Prior therapy selected for diminished response to MDAQ, which suggests that AQ‐containing regimens may rapidly lose efficacy in Africa. The mechanism of diminished MDAQ response is not fully explained by known mutations in pfmdr1. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 12, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Erratum: Szymczakiewicz‐Multanowska et al (J Infect Dis 2009; 200:841–8)Email this article to a colleague.
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The Journal of Infectious Diseases, Volume 200, Issue 11, Page 1801-1802, 1 December 2009. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 11, 2009 Category: Infectious Diseases Tags: article Erratum Source Type: journals
Endoglin in African Children with Plasmodium falciparum Malaria: A Novel Player in Severe Malaria Pathogenesis?Email this article to a colleague.
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Conclusions. High sEng levels may attenuate anti‐inflammatory response resulting in clinical deterioration of patients with P. falciparum malaria. Our results further corroborate the role of the vascular compartment, especially the endothelium, in severe malaria pathogenesis. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 10, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Enhanced Expression of dltABCD Is Associated with the Development of Daptomycin Nonsusceptibility in a Clinical Endocarditis Isolate of Staphylococcus aureusEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
Using isogenic clinical bloodstream Staphylococcus aureus strains from a patient with relapsing endocarditis, we investigated the transcriptional profiles of the mprF and dlt genes in the context of cell‐surface charge and daptomycin nonsusceptibility. As in prior studies, a point mutation within mprF was observed in the daptomycin‐nonsusceptible strain. However, neither the transcriptional profile of mprF nor the membrane phospholipid analyses were compatible with the anticipated mprF gain‐in‐function phenotype. In contrast, we...
Source: The Journal of Infectious Diseases Latest Issue - November 9, 2009 Category: Infectious Diseases Tags: article BRIEF REPORT Source Type: journals
Pseudomonas aeruginosa Population Biology in Chronic Obstructive Pulmonary DiseaseEmail this article to a colleague.
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Conclusions. Intraclonal microevolution and the frequent turnover or loss of clones are typical for infections with P. aeruginosa in COPD. This epidemiological signature differs from that of the chronic carriage of the same P. aeruginosa clone in patients with cystic fibrosis. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 6, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Efficient Transmission of Swine‐Adapted but Not Wholly Avian Influenza Viruses among Pigs and from Pigs to FerretsEmail this article to a colleague.
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Conclusions. Our data indicate that swine‐adapted influenza viruses spread readily among pigs and from pigs to other susceptible mammalians and support the notion that AIVs undergo genetic adaptation to efficiently cross the species barrier. Our transmission models hold potential to study the factors that lead to the generation of pandemic influenza viruses. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 6, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Constitutive Expression of the Antimicrobial Peptide RNase 7 Is Associated with Staphylococcus aureus Infection of the SkinEmail this article to a colleague.
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Conclusions. In conjunction with the existing evidence from in vitro studies, these findings suggest that antimicrobial peptides found at high baseline levels in healthy skin, such as RNase 7, confer protection against S. aureus infection of the skin. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 6, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
A Listeria monocytogenes Strain Is Still Virulent despite Nonfunctional Major Virulence GenesEmail this article to a colleague.
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This study aimed to characterize the A23 strain, which exhibits a pulsed‐field gel electrophoresis profile specific to low‐virulence strains. This strain has the same causal mutations as the group III strains and a supplementary mutation in the mpl gene, leading to the absence of internalin A expression and the presence of inactive internalin B, phosphatidyl‐inositol phospholipase C, and phosphatidylcholine phospholipase C. Despite these mutations in major virulence genes, the A23 strain formed plaques in cell monolayers and contaminated 100% of inoculated mice, suggesting that it evolved from group III strains by ac...
Source: The Journal of Infectious Diseases Latest Issue - November 6, 2009 Category: Infectious Diseases Tags: article BRIEF REPORT Source Type: journals
Malaria Control, Elimination, and Eradication: The Role of the Evolving Biomedical Research AgendaEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 30, 2009 Category: Infectious Diseases Tags: article PERSPECTIVE Source Type: journals
The Potential Role of Vaccines in the Elimination of Falciparum Malaria and the Eventual Eradication of MalariaEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 30, 2009 Category: Infectious Diseases Tags: article PERSPECTIVE Source Type: journals
Perspective on Malaria Eradication: Is Eradication Possible without Modifying the Mosquito?Email this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 30, 2009 Category: Infectious Diseases Tags: article PERSPECTIVE Source Type: journals
Reassortment between Amantadine‐Resistant and ‐Sensitive H1N1 Influenza A Viruses Generated an Amantadine‐Sensitive Virus during the 2007–2008 SeasonEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
The frequency of the amantadine‐resistant H1N1 influenza A virus has been increasing since the 2005–2006 season. It is unclear whether reassortment was involved in this trend. Here, we show that cocirculation of amantadine‐resistant and ‐sensitive strains led to the genesis of amantadine‐sensitive reassortant virus during the 2007–2008 season. Thereafter, the reassortant virus predominated. This contrasts with the trend for the H3N2 virus, in which the amantadine‐resistant reassortant virus became predominant. The results ...
Source: The Journal of Infectious Diseases Latest Issue - October 29, 2009 Category: Infectious Diseases Tags: article BRIEF REPORT Source Type: journals
Immunopathogenesis and Diagnosis of Tuberculosis and Tuberculosis‐Associated Immune Reconstitution Inflammatory Syndrome during Early Antiretroviral TherapyEmail this article to a colleague.
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Conclusions. Type 1 effector T cell responses are prominent in ART‐associated tuberculosis, but additional immune defects may be more important in paradoxical TB‐IRIS. IFN‐γ release assays may contribute to the prediction and diagnosis of tuberculosis during early ART. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 29, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Low Bone Mineral Density, Renal Dysfunction, and Fracture Risk in HIV Infection: A Cross‐Sectional StudyEmail this article to a colleague.
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Conclusions. In this mostly male population, low BMD was significantly associated with PI therapy. Tenofovir recipients showed evidence of increased bone turnover. Measurement of BMD and estimation of fracture risk may be warranted in treated HIV‐infected adults. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 29, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Response to Vicriviroc in Treatment‐Experienced Subjects, as Determined by an Enhanced‐Sensitivity Coreceptor Tropism Assay: Reanalysis of AIDS Clinical Trials Group A5211Email this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
The enhanced‐sensitivity Trofile assay (Monogram Biosciences) was used to retest coreceptor use at both study screening and study entry for 118 treatment‐experienced subjects in AIDS Clinical Trials Group A5211 who had CCR5‐tropic (R5) virus detected by the original Trofile assay at study screening. Among 90 recipients of vicriviroc, a significantly ($P< .001$) greater mean reduction in HIV‐1 RNA was observed in 72 subjects with R5 virus versus 15 subjects reclassified as having dual/mixed‐tropic viruses at screening: −1.11 ...
Source: The Journal of Infectious Diseases Latest Issue - October 29, 2009 Category: Infectious Diseases Tags: article BRIEF REPORT Source Type: journals
Conserved HIV‐1 Epitopes Continuously Elicit Subdominant Cytotoxic T‐Lymphocyte ResponsesEmail this article to a colleague.
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Conclusions. Subdominant CTL recognition of conserved HIV‐1 epitopes commonly occurs from the primary through chronic stages of HIV‐1 infection. These findings underscore the challenge in designing T cell–based vaccines that can induce immunodominant CTL responses to conserved HIV‐1 regions. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 29, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Immunosuppressive Signature of Cutaneous Mycobacterium ulcerans Infection in the Peripheral Blood of Patients with Buruli Ulcer DiseaseEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
Buruli ulcer disease (BUD) is an emerging human disease caused by infection with Mycobacterium ulcerans, which leads to the development of necrotic skin lesions. The pathogenesis of the ulcer is closely associated with the production of mycolactone, a diffusible cytotoxin with immunomodulatory properties. To identify immunological correlates of BUD, we performed a broad screen of inflammatory mediators in serum samples and stimulated whole‐blood supernatants of patients. We found that patients with active ulcers displayed a distinctiv...
Source: The Journal of Infectious Diseases Latest Issue - October 28, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Tetraacylated Lipopolysaccharide of Yersinia pestis Can Inhibit Multiple Toll‐Like Receptor–Mediated Signaling Pathways in Human Dendritic CellsEmail this article to a colleague.
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Conclusions. LPS‐37°C can inhibit stimulation of DCs not only via TLR4 signaling but also via TLR2 and TLR9. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 28, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Infection with Mycobacterium tuberculosis Beijing Genotype Strains Is Associated with Polymorphisms in SLC11A1/NRAMP1 in Indonesian Patients with TuberculosisEmail this article to a colleague.
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We examined this hypothesis in Indonesia by spoligotyping M. tuberculosis isolates recovered from 336 patients with pulmonary tuberculosis and typing the patients’ SLC11A1 gene (formerly known as “NRAMP1”), which is involved in susceptibility to tuberculosis. The M. tuberculosis Beijing genotype, which comprised 29.8% of all isolates, was strongly associated with 2 polymorphisms in SLC11A1: the D543N G allele (odds ratio [OR], 2.15; $P=.005$) and the 3′ untranslated region (3′UTR) insertion/insertion genotype (OR, 2.5; $P< .001$). This finding supports the hypothesis of coevolution of M. tuberculosis and the huma...
Source: The Journal of Infectious Diseases Latest Issue - October 28, 2009 Category: Infectious Diseases Tags: article BRIEF REPORT Source Type: journals
Early Sexual Experiences and Risk Factors for Bacterial VaginosisEmail this article to a colleague.
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Conclusions. This study shows a strong association between BV and penile‐vaginal sex with multiple partners but found no BV in sexually inexperienced women, once a history of noncoital sexual practices was elicited. Our findings indicate that BV is not present in truly sexually inexperienced women. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 28, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Bacterial Vaginosis: Are We Coming Full Circle?Email this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 28, 2009 Category: Infectious Diseases Tags: article EDITORIAL COMMENTARY Source Type: journals
Overproduction of Acyloxyacyl Hydrolase by Macrophages and Dendritic Cells Prevents Prolonged Reactions to Bacterial Lipopolysaccharide In VivoEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
Although recognition of lipopolysaccharide (LPS) by the myeloid differentiation factor 2–Toll‐like receptor 4 complex is important for triggering protective inflammatory responses in animals, terminating many of these responses requires LPS inactivation by a host lipase, acyloxyacyl hydrolase (AOAH). To test whether endogenously produced recombinant AOAH can modulate responses to LPS and gram‐negative bacteria, we engineered transgenic mice that overexpress AOAH in dendritic cells and macrophages, cell types that normally produce ...
Source: The Journal of Infectious Diseases Latest Issue - October 27, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
WU and KI Polyomaviruses in the Brains of HIV‐Positive Patients With and Without Progressive Multifocal LeukoencephalopathyEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
The polyomaviruses KI (KIPyV) and WU (WUPyV) were recently identified mainly in respiratory samples from children and immunosuppressed patients. Investigation of 54 autopsy brain tissue samples from 22 subjects demonstrated that WUPyV DNA and KIPyV DNA could be detected in 1 of 4 human immunodeficiency virus (HIV)–positive individuals with progressive multifocal leukoencephalopathy (PML) and in 3 of 10 HIV‐positive individuals without PML, but not in 8 HIV‐negative individuals. Viruses were localized in all regions of the central ...
Source: The Journal of Infectious Diseases Latest Issue - October 27, 2009 Category: Infectious Diseases Tags: article BRIEF REPORT Source Type: journals
Erratum: van Zoelen et al (J Infect Dis 2009; 200:765–73)Email this article to a colleague.
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The Journal of Infectious Diseases, Volume 200, Issue 10, Page 1629-1632, 15 November 2009. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 26, 2009 Category: Infectious Diseases Tags: article Erratum Source Type: journals
Erratum: Kawachi et al (J Infect Dis 2009; 200:510–15)Email this article to a colleague.
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The Journal of Infectious Diseases, Volume 200, Issue 10, Page 1629, 15 November 2009. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 26, 2009 Category: Infectious Diseases Tags: article ERRATUM Source Type: journals
Avoiding Guillan‐Barré Syndrome Following Swine Origin Pandemic H1N1 2009 Influenza VaccinationEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 200, Issue 10, Page 1627-1628, 15 November 2009. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 26, 2009 Category: Infectious Diseases Tags: article CORRESPONDENCE Source Type: journals
Distribution of Herpes Simplex Virus Type 1 and Varicella Zoster Virus in Ganglia of the Human Head and NeckEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
The distribution of the neurotropic alphaherpesviruses—herpes simplex virus type 1 (HSV‐1) and type 2 (HSV‐2) and varicella zoster virus (VZV)—was determined in autonomic and sensory ganglia of the head and neck obtained from formalin‐fixed human cadavers. HSV‐1 and VZV DNA were found in 18 of 58 and 16 of 58 trigeminal, 23 of 58 and 11 of 58 pterygopalatine, 25 of 60 and 14 of 60 ciliary, 25 of 48 and 11 of 48 geniculate, 15 of 50 and 8 of 50 otic, 14 of 47 and 4 of 47 submandibular, 18 of 58 and 10 of 58 superior cervical,...
Source: The Journal of Infectious Diseases Latest Issue - October 26, 2009 Category: Infectious Diseases Tags: article BRIEF REPORT Source Type: journals
Natural Control of HIV‐1 Replication and Long‐Term Nonprogression: Overlapping but Distinct PhenotypesEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 23, 2009 Category: Infectious Diseases Tags: article EDITORIAL COMMENTARY Source Type: journals
Domain 3 of Hepatitis C Virus Core Protein Is Sufficient for Intracellular Lipid AccumulationEmail this article to a colleague.
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In this study, we investigated the sufficiency of d3 to promote lipid accumulation, the role of HCV genotype in d3 lipid accumulation, and the subcellular distribution of d3. Methods. Stable cell lines expressing green fluorescent protein (GFP) fusions with isolates of HCV genotype 3 core steatosis‐associated d3 (d3S), non–steatosis‐associated d3 (d3NS), and genotype 1 d3 (d3G1) were analyzed by means of immunofluorescence, oil red O (ORO) staining, and triglyceride quantitation. Results. Cells that expressed d3S had statistically significantly more ORO than did cells expressing d3NS or d3G1 ($P=.02$ and (Sourc...
Source: The Journal of Infectious Diseases Latest Issue - October 23, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Clinical Outcomes of Elite Controllers, Viremic Controllers, and Long‐Term Nonprogressors in the US Department of Defense HIV Natural History StudyEmail this article to a colleague.
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We examined groups of elite controllers (ie, subjects with plasma HIV RNA levels of (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 23, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Salmonella Infection of Gallbladder Epithelial Cells Drives Local Inflammation and Injury in a Model of Acute Typhoid FeverEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
The gallbladder is often colonized by Salmonella during typhoid fever, yet little is known about bacterial pathogenesis in this organ. With use of a mouse model of acute typhoid fever, we demonstrate that Salmonella infect gallbladder epithelial cells in vivo. Bacteria in the gallbladder showed a unique behavior as they replicated within gallbladder epithelial cells and remained confined to those cells without translocating to the mucosa. Infected gallbladders showed histopathological damage characterized by destruction of the epitheliu...
Source: The Journal of Infectious Diseases Latest Issue - October 23, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Human Papillomavirus (HPV) Type 16 and Type 18 DNA Loads at Baseline and Persistence of Type‐Specific Infection during a 2‐Year Follow‐UpEmail this article to a colleague.
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Conclusion. Prevalent infection with a higher viral load of HPV‐16 or HPV‐18 was associated with short‐ but not long‐term persistence. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 22, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
No Rebound of Morbidity following Intermittent Preventive Sulfadoxine‐Pyrimethamine Treatment of Malaria in Infants in GabonEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
In the context of a trial studying intermittent preventive sulfadoxine‐pyrimethamine treatment of malaria in infants in Lambaréné, Gabon, children aged 18–30 months were followed up after having received their last dose at an age of 15 months. In the intention‐to‐treat population, the protective efficacy against all malaria episodes was −18.0 (95% confidence interval, −97.4 to 29.5; $P=.529$). The protective efficacy against first or only anemia episode was −45.3 (95% confidence interval, −234.5 to 36.3; $P=.375$). The...
Source: The Journal of Infectious Diseases Latest Issue - October 22, 2009 Category: Infectious Diseases Tags: article BRIEF REPORT Source Type: journals
