The Journal of Nutritional Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Ferulic acid, a bioactive component of rice bran, improves oxidative stress and mitochondrial biogenesis and dynamics in mice and in human mononuclear cells
The aim of the study was to characterize the molecular effects of rice bran enzymatic extract (RBEE) and its components on vascular oxidative stress and mitochondrial dysfunction during atherogenesis in ApoE −/− mice and in humans. Mice were fed a high-fat, high-cholesterol diet (HFD) or HFD supplemented with 5% rice bran RBEE for 21 weeks. RBEE prevented development of atherosclerotic plaques and oxidative stress in mouse aorta, as exemplified by increased GSH/GSSG ratio, reduced peroxiredoxin-SO3 and reduced lipid peroxidation. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - June 26, 2017 Category: Biochemistry Authors: Cristina Perez-Ternero, Christian M. Werner, Alexander G. Nickel, Maria Dolores Herrera, Maria-Jos é Motilva, Michael Böhm, Maria Alvarez de Sotomayor, Ulrich Laufs Source Type: research

A-type ECG and EGCG dimers inhibit 3 T3-L1 differentiation by binding to cholesterol in lipid rafts
The present study aimed to explore the underlying mechanisms of epicatechin-3-gallate-(4 β→8, 2β→O→7)-epicatechin-3-gallate (A-type ECG dimer) and epigallocatechin-3-gallate-(4β→8, 2β→O→7)-epigallocatechin-3-gallate (A-type EGCG dimer) involved in their strong inhibitory effects on 3 T3-L1 preadipocytes differentiation. In the synthetic “lipid raft-like” liposome, A- type ECG and EGCG dimers incorporated into the liposome with high affinity and decreased the fluidity of the liposome. In 3 T3-L1 preadipocytes, A-type ECG and EGCG dimers possibly bonded to lipid rafts cholesterol and disrupted the integri...
Source: The Journal of Nutritional Biochemistry - June 26, 2017 Category: Biochemistry Authors: Wei Zhu, Xiangyi Deng, Jinming Peng, Bo Zou, Chunmei Li Source Type: research

High purity tocotrienols attenuate atherosclerotic lesion formation in apoE-KO mice
This study investigated the effect of high-purity T3 on atherosclerotic lesion formation and the underlying mechanisms. Male apolipoprotein E knockout (apoE-KO) mice were fed a cholesterol-containing diet either alone or supplemented with T3 concentrate (Toc-free T3) or with α-Toc for 12 weeks. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - June 26, 2017 Category: Biochemistry Authors: Akira Shibata, Teiko Kobayashi, Akira Asai, Takahiro Eitsuka, Shinichi Oikawa, Teruo Miyazawa, Kiyotaka Nakagawa Source Type: research

Obesity and malnutrition similarly alters the renin-angiotensin system and inflammation in mice and human adipose
The main goal of the present study was to evaluate the metabolic profile, inflammatory markers and the gene expression of components of the renin-angiotensin system (RAS) in the visceral adipose tissue of eutrophic, obese and malnourished individuals and mice models of obesity and food restriction. Male Swiss mice were divided into eight groups and fed different levels of food restriction (20%, 40% or 60%) using standard or high-fat diet. Metabolic profile and adipose tissues were assessed. The expression of AGT, ACE, ACE2, IL-6 and TNF- α in the mice epididymal adipose tissue and the human visceral adipose tissue were as...
Source: The Journal of Nutritional Biochemistry - June 26, 2017 Category: Biochemistry Authors: Thales de Almeida Pinheiro, Ant ônio Sérgio Barcala-Jorge, João Marcus Oliveira Andrade, Thaisa de Almeida Pinheiro, Emíllio César Neves Ferreira, Thaisa Soares Crespo, Gislaine Candida Batista-Jorge, Cássio André Vieira, Deborah de Farias de Lelis Source Type: research

Resveratrol prevents the combined maternal plus post-weaning high-fat diets induced hypertension in male offspring
Maternal high-fat (HF) diet is believed to induce oxidative stress and activate nutrient-sensing signals, which increases the risk of adult offspring to develop hypertension. We investigated whether resveratrol prevents the combined maternal plus post-weaning HF diets-induced hypertension in adult male offspring, with a focus on the kidney. Female Sprague –Dawley rats received either a normal diet (ND) or HF diet (D12331, Research Diets) for 5 weeks before mating and during gestation and lactation. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - June 26, 2017 Category: Biochemistry Authors: You-Lin Tain, Yu-Ju Lin, Jiunn-Ming Sheen, I-Chun Lin, Hong-Ren Yu, Li-Tung Huang, Chien-Ning Hsu Source Type: research

Fructose intake exacerbates the contractile response elicited by norepinephrine in mesenteric vascular bed of rats via increased endothelial prostanoids
Chronic fructose intake induces major cardiovascular and metabolic disturbances and is associated with the development of hypertension due to changes in vascular function. We hypothesized that high fructose intake for 6 weeks would cause metabolic syndrome and lead to initial vascular dysfunction. Male Wistar rats were assigned to receive fructose (FRU, 10%) or drinking water (CON) for 6 weeks. Systolic blood pressure was evaluated by tail plethysmography. Fasting glucose, insulin and glucose tolerance were measured at the end of the follow-up. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - June 20, 2017 Category: Biochemistry Authors: Glauciene J. Sousa, Phablo Wendell C. Oliveira, Breno V. Nogueira, Ant ônio F. Melo Junior, Thaís de Oliveira Faria, Eduardo Frizera Meira, José G. Mill, Nazaré S. Bissoli, Marcelo P. Baldo Source Type: research

ω-3 polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice
Many studies have shown that dietary intake of ω-3 polyunsaturated fatty acids (PUFAs) reduces the risks of colorectal cancer, however the underlying mechanisms are not well understood. Here we used a LC-MS/MS-based lipidomics to explore the roles of eicosanoid signaling in the anti-colorectal cancer effects of ω-3 PUFAs. Our results showed th at dietary feeding of ω-3 PUFAs-rich diets suppressed growth of MC38 colorectal tumor, and modulated profiles of fatty acids and eicosanoid metabolites in C57BL/6 mice. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - June 20, 2017 Category: Biochemistry Authors: Weicang Wang, Jun Yang, Yoshiki Nimiya, Kin Sing Stephen Lee, Katherine Sanidad, Weipeng Qi, Elvira Sukamtoh, Yeonhwa Park, Zhenhua Liu, Guodong Zhang Source Type: research

The antioxidant and anti-inflammatory properties of lycopene in mice lungs exposed to cigarette smoke
Lycopene is a carotenoid with known antioxidant and anti-inflammatory properties. We aimed to evaluate the in vitro and in vivo effects of lycopene on reducing the redox imbalance and inflammation induced by cigarette smoke (CS). For the in vitro study, J774A.1 (Macrophages) cells were incubated in the presence of 0.5, 1.0, 2.0, 4.0, 8.0, 10.0 and 25 μM of lycopene for 3, 6 and 24 h or in the presence of 0.1%, 0,25%, 0.5%, 0.625%, 1.25%, 2.25%, 5% and 10% cigarette smoke extract (CSE) for 3, 6 and 24 h to assess cell viability and measurement of intracellular ROS. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - June 19, 2017 Category: Biochemistry Authors: K.K.D. Campos, G.R. Ara újo, T.L. Martins, A.C.B. Bandeira, G.P. Costa, A. Talvani, C.C.M. Garcia, L.A. Oliveira, D.C. Costa, F.S. Bezerra Source Type: research

Table of Contents
(Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - June 8, 2017 Category: Biochemistry Source Type: research

Non-alcoholic fatty liver disease impairs the cytochrome P-450 dependent metabolism of alpha-tocopherol (vitamin E)
This study aims at investigate in in vivo and in vitro models of non-alcoholic fatty liver disease (NAFLD) the enzymatic metabolism of α-tocopherol (vitamin E) and its relationship with vitamin E-responsive genes with key role in the lipid metabolism and detoxification of the liver. The experimental models included mice feed a high-fat diet combined or not with fructose (HFD+F) and HepG2 human hepatocarcinoma cells treated with th e lipogenic factors palmitate, oleate or fructose. CYP4F2 protein, a cytochrome P-450 isoform with proposed α-tocopherol ω-hydroxylase activity, decreased in HFD and even more in HFD+F mice li...
Source: The Journal of Nutritional Biochemistry - June 7, 2017 Category: Biochemistry Authors: D. Bartolini, P. Torquato, C. Barola, A. Russo, C. Rychlicki, D. Giusepponi, G. Bellezza, A. Sidoni, R. Galarini, G. Svegliati-Baroni, Francesco Galli Source Type: research

Microbial metabolites are associated with a high adherence to a Mediterranean dietary pattern using a 1H –NMR-based untargeted metabolomics approach
The study of biomarkers of dietary patterns including the Mediterranean diet (MedDiet) is scarce and could improve the assessment of these patterns. Moreover, it could provide a better understanding of health benefits of dietary patterns in nutritional epidemiology.We aimed to determine a robust and accurate biomarker associated with a high adherence to a MedDiet pattern that included dietary assessment and its biological effect.In this cross-sectional study, we included 56 and 63 individuals with high (H-MDA) and low (L-MDA) MedDiet adherence categories, respectively, all from the PREDIMED (Prevenci ón con Dieta Mediterr...
Source: The Journal of Nutritional Biochemistry - June 7, 2017 Category: Biochemistry Authors: Enrique Almanza-Aguilera, Mireia Urpi-Sarda, Rafael Llorach, Rosa V ázquez-Fresno, Mar Garcia-Aloy, Francesc Carmona, Alex Sanchez, Francisco Madrid-Gambin, Ramon Estruch, Dolores Corella, Cristina Andres-Lacueva Source Type: research

Role of polyphenols and polyphenol-rich foods in the modulation of PON1 activity and expression
The objective of the present review is to provide the main evidence about the role and the potential mechaninsm of action of polyphenols and polyphenol-rich foods in the modulation of PON1 gene expression and activity.A total of 76 in vitro and in vivo studies were included in the review. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - June 5, 2017 Category: Biochemistry Authors: Daniela Martini, Cristian Del Bo ’, Marisa Porrini, Salvatore Ciappellano, Patrizia Riso Source Type: research

Tomato (Lycopersicon esculentum) or Lycopene Supplementation Attenuates Ventricular Remodeling After Myocardial Infarction Through Different Mechanistic Pathways
The objective of this study was to evaluate the influence of tomato or lycopene supplementation on cardiac remodeling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: the sham group (animals that underwent simulated surgery) that received a standard chow (S;n=18); the infarcted group that received a standard chow (MI;n=13); the infarcted group supplemented with lycopene (1 mg of lycopene/kg body weight/day), (MIL;n=16); and the infarcted group supplemented with tomato, (MIT;n=16). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - June 1, 2017 Category: Biochemistry Authors: Bruna LB Pereira, Patr ícia P Reis, Fábio E Severino, Tainara P Felix, Mariana G Braz, Flávia R Nogueira, Renata A C Silva, Ana C Cardoso, Maria AM Lourenço, Amanda M Figueiredo, Fernanda Chiuso-Minicucci, Paula S Azevedo, Bertha F Polegato, Katashi O Source Type: research

Maternal liver docosahexaenoic acid (DHA) stores are increased via higher serum unesterified DHA uptake in pregnant Long Evans rats
Maternal docosahexaenoic acid (DHA, 22:6n-3) supplies the developing fetus during pregnancy; however, the mechanisms are unclear. We utilized pregnant rats to determine rates of DHA accretion, tissue unesterified DHA uptake and whole-body DHA synthesis-secretion. Female rats maintained on a DHA-free, 2% α-linolenic acid diet were either:1) sacrificed at 56 days for baseline measures, 2) mated and sacrificed at 14–18 days of pregnancy or 3) or sacrificed at 14–18 days as age-matched virgin controls. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - June 1, 2017 Category: Biochemistry Authors: Adam H. Metherel, Alex P. Kitson, Anthony F. Domenichiello, R.J. Scott Lacombe, Kathryn E. Hopperton, Marc-Olivier Tr épanier, Shoug M. Alashmali, Lin Lin, Richard P. Bazinet Source Type: research

Soy compared with milk protein in a Western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats
Soy protein is effective at preventing hepatic steatosis; however, the mechanisms are poorly understood. We tested the hypothesis that soy versus dairy protein-based diet would alter microbiota and attenuate hepatic steatosis in hyperphagic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Male OLETF rats were randomized to “Western” diets containing milk protein isolate (MPI), soy protein isolate (SPI), or 50:50 MPI/SPI (MS) (n=9–10/group; 21% kcal protein) for 16 weeks. SPI attenuated (P (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - May 31, 2017 Category: Biochemistry Authors: Matthew R. Panasevich, Colin M. Schuster, Kathryn E. Phillips, Grace M. Meers, Sree V. Chintapalli, Umesh D. Wankhade, Kartik Shankar, Dustie N. Butteiger, Elaine S. Krul, John P. Thyfault, R. Scott Rector Source Type: research