Marr's three levels of analysis are useful as a framework for neuroscience
J Physiol. 2024 Apr 16. doi: 10.1113/JP279549. Online ahead of print.NO ABSTRACTPMID:38628044 | DOI:10.1113/JP279549 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: M áté Lengyel Source Type: research
Cross Talk opposing view: Marr's three levels of analysis are not useful as a framework for neuroscience
J Physiol. 2024 Apr 16. doi: 10.1113/JP279550. Online ahead of print.NO ABSTRACTPMID:38628062 | DOI:10.1113/JP279550 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: Jonathan W Pillow Source Type: research
Crosstalk rebuttal: Marr's three levels of analysis are not useful as a framework for neuroscience
J Physiol. 2024 Apr 16. doi: 10.1113/JP286426. Online ahead of print.NO ABSTRACTPMID:38628068 | DOI:10.1113/JP286426 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: M áté Lengyel Source Type: research
CrossTalk rebuttal
J Physiol. 2024 Apr 16. doi: 10.1113/JP286427. Online ahead of print.NO ABSTRACTPMID:38628075 | DOI:10.1113/JP286427 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: Jonathan W Pillow Source Type: research
Optical recordings of organellar membrane potentials and the components of membrane conductance in lysosomes
J Physiol. 2024 Apr 16. doi: 10.1113/JP283825. Online ahead of print.ABSTRACTThe eukaryotic cell is highly compartmentalized with organelles. Owing to their function in transporting metabolites, metabolic intermediates and byproducts of metabolic activity, organelles are important players in the orchestration of cellular function. Recent advances in optical methods for interrogating the different aspects of organellar activity promise to revolutionize our ability to dissect cellular processes with unprecedented detail. The transport activity of organelles is usually coupled to the transport of charged species; therefore, i...
Source: The Journal of Physiology - April 16, 2024 Category: Physiology Authors: Cristian Castillo-Velasquez Ella Matamala Diego Becerra Patricio Orio Sebastian E Brauchi Source Type: research
Motor unit discharge rate modulation during isometric contractions to failure is intensity- and modality-dependent
This study examined MUDR adjustments during different submaximal isometric knee extension tasks to failure. Participants performed a sustained and an intermittent task at 20% and 50% of maximal voluntary torque (MVT), respectively (Experiment 1). High-density surface EMG signals were recorded from vastus lateralis (VL) and medialis (VM) and decomposed into individual MU discharge timings, with the identified MUs tracked from recruitment to task failure. MUDR was quantified and normalised to intervals of 10% of contraction time (CT). MUDR of both muscles exhibited distinct modulation patterns in each task. During the 20% MV...
Source: The Journal of Physiology - April 15, 2024 Category: Physiology Authors: Tamara Valen čič Paul Ansdell Callum G Brownstein Padraig M Spillane Ale š Holobar Jakob Škarabot Source Type: research
On the role of dysferlin in striated muscle: membrane repair, t-tubules and Ca < sup > 2+ < /sup > handling
J Physiol. 2024 Apr 14. doi: 10.1113/JP285103. Online ahead of print.ABSTRACTDysferlin is a 237 kDa membrane-associated protein characterised by multiple C2 domains with a diverse role in skeletal and cardiac muscle physiology. Mutations in DYSF are known to cause various types of human muscular dystrophies, known collectively as dysferlinopathies, with some patients developing cardiomyopathy. A myriad of in vitro membrane repair studies suggest that dysferlin plays an integral role in the membrane repair complex in skeletal muscle. In comparison, less is known about dysferlin in the heart, but mounting evidence suggests t...
Source: The Journal of Physiology - April 14, 2024 Category: Physiology Authors: C J Quinn E J Cartwright A W Trafford K M Dibb Source Type: research
On the role of dysferlin in striated muscle: membrane repair, t-tubules and Ca < sup > 2+ < /sup > handling
J Physiol. 2024 Apr 14. doi: 10.1113/JP285103. Online ahead of print.ABSTRACTDysferlin is a 237 kDa membrane-associated protein characterised by multiple C2 domains with a diverse role in skeletal and cardiac muscle physiology. Mutations in DYSF are known to cause various types of human muscular dystrophies, known collectively as dysferlinopathies, with some patients developing cardiomyopathy. A myriad of in vitro membrane repair studies suggest that dysferlin plays an integral role in the membrane repair complex in skeletal muscle. In comparison, less is known about dysferlin in the heart, but mounting evidence suggests t...
Source: The Journal of Physiology - April 14, 2024 Category: Physiology Authors: C J Quinn E J Cartwright A W Trafford K M Dibb Source Type: research
Recombinant human proteoglycan 4 lowers inflammation and atherosclerosis susceptibility in female low-density lipoprotein receptor knockout mice
In conclusion, we have shown that peritoneal administration and subsequent systemic exposure to rhPRG4 beneficially impacts the inflammatory state and reduces atherosclerosis susceptibility in mice. Our findings highlight that PRG4 is not only a lubricant but also acts as an anti-inflammatory agent. KEY POINTS: Endogenously produced proteoglycan 4 is found in atherosclerotic lesions and its genetic deficiency in mice is associated with enhanced atherosclerosis susceptibility. In this study we investigated the anti-atherogenic potential of chronic treatment with recombinant human PRG4 in hypercholesterolaemic female low-den...
Source: The Journal of Physiology - April 12, 2024 Category: Physiology Authors: Menno Hoekstra Olga S C Snip Philip Janusz Mireia N A Bernab é Kleijn Edward R Truitt Benjamin D Sullivan Tannin A Schmidt Gregory D Jay Miranda Van Eck Source Type: research
Considerations for assessing sex differences in performance fatiguability
J Physiol. 2024 Apr 12. doi: 10.1113/JP285951. Online ahead of print.NO ABSTRACTPMID:38606983 | DOI:10.1113/JP285951 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 12, 2024 Category: Physiology Authors: Brooke Alvar Steven J O'Bryan Dale M Harris Source Type: research
Commonality and heterogeneity of pacemaker mechanisms in the male reproductive organs
J Physiol. 2024 Apr 12. doi: 10.1113/JP284756. Online ahead of print.ABSTRACTDuring emission, the first phase of ejaculation, smooth muscle in organs of the male reproductive tract (MRT) vigorously contract upon sympathetic nerve excitation to expel semen consisting of sperm and seminal plasma. During inter-ejaculation phases, the epididymis, seminal vesicles and prostate undergo spontaneous phasic contractions (SPCs), this transporting and maintaining the quality of sperm and seminal plasma. Recent studies have revealed platelet-derived growth factor receptor α-expressing (PDGFRα+) subepithelial interstitial cells in se...
Source: The Journal of Physiology - April 12, 2024 Category: Physiology Authors: Hikaru Hashitani Mitsue Takeya Dirk F van Helden Source Type: research
Comment on: 'Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart' by Saint-Martin Willer et al
J Physiol. 2024 Apr 12. doi: 10.1113/JP286611. Online ahead of print.NO ABSTRACTPMID:38607230 | DOI:10.1113/JP286611 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 12, 2024 Category: Physiology Authors: Merten Pr üser Felix Wiedmann Constanze Schmidt Source Type: research
Recombinant human proteoglycan 4 lowers inflammation and atherosclerosis susceptibility in female low-density lipoprotein receptor knockout mice
In conclusion, we have shown that peritoneal administration and subsequent systemic exposure to rhPRG4 beneficially impacts the inflammatory state and reduces atherosclerosis susceptibility in mice. Our findings highlight that PRG4 is not only a lubricant but also acts as an anti-inflammatory agent. KEY POINTS: Endogenously produced proteoglycan 4 is found in atherosclerotic lesions and its genetic deficiency in mice is associated with enhanced atherosclerosis susceptibility. In this study we investigated the anti-atherogenic potential of chronic treatment with recombinant human PRG4 in hypercholesterolaemic female low-den...
Source: The Journal of Physiology - April 12, 2024 Category: Physiology Authors: Menno Hoekstra Olga S C Snip Philip Janusz Mireia N A Bernab é Kleijn Edward R Truitt Benjamin D Sullivan Tannin A Schmidt Gregory D Jay Miranda Van Eck Source Type: research
Considerations for assessing sex differences in performance fatiguability
J Physiol. 2024 Apr 12. doi: 10.1113/JP285951. Online ahead of print.NO ABSTRACTPMID:38606983 | DOI:10.1113/JP285951 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 12, 2024 Category: Physiology Authors: Brooke Alvar Steven J O'Bryan Dale M Harris Source Type: research
Commonality and heterogeneity of pacemaker mechanisms in the male reproductive organs
J Physiol. 2024 Apr 12. doi: 10.1113/JP284756. Online ahead of print.ABSTRACTDuring emission, the first phase of ejaculation, smooth muscle in organs of the male reproductive tract (MRT) vigorously contract upon sympathetic nerve excitation to expel semen consisting of sperm and seminal plasma. During inter-ejaculation phases, the epididymis, seminal vesicles and prostate undergo spontaneous phasic contractions (SPCs), this transporting and maintaining the quality of sperm and seminal plasma. Recent studies have revealed platelet-derived growth factor receptor α-expressing (PDGFRα+) subepithelial interstitial cells in se...
Source: The Journal of Physiology - April 12, 2024 Category: Physiology Authors: Hikaru Hashitani Mitsue Takeya Dirk F van Helden Source Type: research
