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Autosomal dominant polycystic kidney disease: 2009 update for internists.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Because autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic abnormalities seen in today's medical practice, many internists will likely treat patients affected by this condition. Genetic abnormalities have been increasingly recognized, and the pathophysiology of the disease is beginning to be unraveled. Because of advances in imaging technology, surrogate markers for disease progression have allowed clinical studies of newer therapeutic agents to proceed. In the near future, therapies for this common genetic disease may be available to either prevent or stabilize the disease course fo...
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Bennett WM Tags: Korean J Intern Med Source Type: journals

Update on endoscopic treatment of chronic pancreatitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endoscopic therapy has been increasingly recognized as the effective therapy in selected patients with chronic pancreatitis. Utility of endotherapy in various conditions occurring in chronic pancreatitis is discussed. Its efficacy, limitations, and alternatives are addressed. For the best management of these complex entities, a multidisciplinary approach involving expertise in all pancreatic specialties is essential to achieve the goal. PMID: 19721851 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Yoo BM, Lehman GA Tags: Korean J Intern Med Source Type: journals

Early detection of asymptomatic coronary artery disease in patients with type 2 diabetes mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19721852 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Youn HJ Tags: Korean J Intern Med Source Type: journals

Early detection of asymptomatic coronary artery disease in patients with type 2 diabetes mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We recommend a routine screening for CAD in type 2 diabetic patients who have a longer (>/=10 years) diabetic duration or a family history of CAD, even if they are asymptomatic for CAD. PMID: 19721853 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Yoo WS, Kim HJ, Kim D, Lee MY, Chung HK Tags: Korean J Intern Med Source Type: journals

Endoscopic pancreatic sphincterotomy: indications and complications.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: EPST showed a low incidence of complications and a high rate of treatment success; thus, EPST is a relatively safe procedure that can be used to treat pancreatic diseases. Pancreatic drainage procedures and additional EST following EPST did not reduce the incidence of procedure-related complications. PMID: 19721854 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Joo YW, Yoon JH, Cho SC, Lee KN, Ha NR, Lee HL, Lee OY, Yoon BC, Choi HS, Hahm JS, Lee DH, Lee MH Tags: Korean J Intern Med Source Type: journals

Endoscopic and histopathologic predictors of recurrence of colorectal adenoma on lowering the miss rate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The recurrence rate of colorectal adenoma corrected by lowering the miss rate was lower than reported rates. The presence of multiple adenomas on initial colonoscopy was an important predictor of recurrence. PMID: 19721855 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Ji JS, Choi KY, Lee WC, Lee BI, Park SH, Choi H, Kim BW, Chae HS, Park YM, Park YJ Tags: Korean J Intern Med Source Type: journals

Assessment of the efficacy of reducing peginterferon alfa-2a and ribavirin dose on virologic response in koreans with chronic hepatitis C.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We suggest that using at least 80% of the peginterferon alpha-2a dose in Koreans not only maintains SVR but also reduces drug side effects during the entire treatment period. A lower dose of ribavirin may be as efficacious as a standard dose. PMID: 19721856 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Kwon JH, Bae SH, Choi JY, Yoon SK, Byun KS, Paik SW, Lim YS, Lee HC, Han KH, Lee KS Tags: Korean J Intern Med Source Type: journals

Significance of inflammatory markers in diabetic patients with stable coronary artery disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In diabetic patients, age, hsCRP, and HbA1c were associated with stable CAD. Among these factors, hsCRP levels were significantly correlated with multivessel involvement in diabetic CAD. Therefore, high hsCRP levels may be a strong predictor for atherosclerotic progression of the coronary arteries in diabetic patients, suggesting that regular screening tests should be performed. PMID: 19721857 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Lee HJ, Her SH, Im YS, Won KY, Yoo SH, Kim DB, Shin DI, Kim PJ, Seung KB, Kim JH, Kim KY Tags: Korean J Intern Med Source Type: journals

Selectively decreased expression of peroxiredoxins induced by silica in pulmonary epithelial cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Silica treatment induces a decrease of Prx I expression in lung epithelial cell lines regardless of the presence of ROS. The silica-induced degradation of Prx does not involve the ubiquitin-proteasomal pathway. PMID: 19721858 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Lee HL, Kim YS, Park JH, Chung WY, Lee KS, Oh YJ, Sheen SS, Park KJ, Hwang SC Tags: Korean J Intern Med Source Type: journals

Long-term effects of rosiglitazone on the progressive decline in renal function in patients with type 2 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study suggests that rosiglitazone theatment slows the progressive deterioration of renal function in patients with type 2 diabetes. PMID: 19721859 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Kim MK, Ko SH, Baek KH, Ahn YB, Yoon KH, Kang MI, Lee KW, Song KH Tags: Korean J Intern Med Source Type: journals

The efficacy and safety of ezetimibe and low-dose simvastatin as a primary treatment for dyslipidemia in renal transplant recipients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Ezetimibe and low-dose statin treatment is safe and effective as a primary treatment for dyslipidemia in renal transplant patients. PMID: 19721860 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Yoon HE, Song JC, Hyoung BJ, Hwang HS, Lee SY, Jeon YJ, Choi BS, Kim YS, Yang CW Tags: Korean J Intern Med Source Type: journals

Pretreatment with darbepoetin attenuates renal injury in a rat model of Cisplatin-induced nephrotoxicity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: DPO exhibits a renoprotective effect in experimental cisplatin-induced renal injury, the mechanism of which may involve DPO antiinflammatory and antiapoptotic effects. PMID: 19721861 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Choi DE, Jeong JY, Lim BJ, Lee KW, Shin YT, Na KR Tags: Korean J Intern Med Source Type: journals

Paraquat intoxication in subjects who attempt suicide: why they chose paraquat.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Only 38% of patients who attempted suicide with PQ intentionally selected PQ. Thus, greater control of PQ availability is needed, especially in patients at risk. PMID: 19721862 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Seok SJ, Gil HW, Jeong DS, Yang JO, Lee EY, Hong SY Tags: Korean J Intern Med Source Type: journals

Bone Marrow T Cells are Superior to Splenic T Cells to Induce Chimeric Conversion After Non-Myeloablative Bone Marrow Transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results suggest that DLI using BM-T cells, even in small numbers, is more potent at inducing chimeric conversion in mixed chimerism than DLI using SP-T cells. Further study is needed to determine whether cryopreserved BM-T cells are an effective cell source for DLI to consolidate donor-dominant chimerism in clinical practice without concerns about GVHD. PMID: 19721863 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Park HS, Cho SG, Park MJ, Min SY, Chang HS, Kim HJ, Lee S, Min CK, Lee JW, Min WS, Kim CC, Kim HY Tags: Korean J Intern Med Source Type: journals

Blood Stream Infections by Candida glabrata and Candida krusei: A Single-Center Experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Renal insufficiency and prior fluconazole prophylaxis were associated with the development of C. glabrata or C. krusei fungemia. Fungemia-related mortality of C. glabrata or C. krusei was higher than that of C. albicans. Outcomes appeared to be related to catheter removal, APACHE II scores, and shock. PMID: 19721864 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Choi HK, Jeong SJ, Lee HS, Chin BS, Choi SH, Han SH, Kim MS, Kim CO, Choi JY, Song YG, Kim JM Tags: Korean J Intern Med Source Type: journals

A case of idiopathic adulthood ductopenia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease of unknown etiology characterized by adult onset, an absence of autoantibodies, inflammatory bowel disease, and a loss of interlobular bile ducts. In the present report, a case fulfilling the IAD criteria is described. A 19-year-old man was admitted to the hospital for persistent elevation of transaminases and alkaline phosphatase without clinical symptoms. Viral hepatitis markers and autoantibodies were absent. The patient had a normal extrahepatic biliary tree and had no evidence of inflammatory bowel disease. A liver biopsy specimen showed ...
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Park BC, Park SM, Choi EY, Chae HB, Yoon SJ, Sung R, Lee SK Tags: Korean J Intern Med Source Type: journals

A Synonymous Genetic Alteration of LMX1B in a Family with Nail-Patella Syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The gene responsible for nail-patella syndrome, LMX1B, has recently been identified on chromosome 9q. Here we present a patient with nail-patella syndrome and an autosomal dominant pattern of inheritance. A 17-year-old girl visited our clinic for the evaluation and treatment of proteinuria. She had dystrophic nails, palpable iliac horns, and hypoplastic patellae. Electron microscopy of a renal biopsy showed irregular thickening of the glomerular basement membrane. A family history over three generations revealed five affected family members. Genetic analysis found a change of TCG to TCC, resulting in a synonymous alter...
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Ham JH, Shin SJ, Joo KR, Park SM, Sung HY, Kim JS, Choi JS, Choi YJ, Song HC, Choi EJ Tags: Korean J Intern Med Source Type: journals

Chinese Bellflower Root Anaphylaxis: IgE-Binding Components and Cross-Reactivity With Mugwort and Birch.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 56-year-old man who had suffered from seasonal rhinitis in spring and autumn experienced recurrent generalized urticaria and an oral burning sensation after eating several cooked herbs for 3 months. A skin-prick test showed positive responses to various pollens, celery, Chinese bellflower, and arrowroot. The Chinese bellflower-specific IgE ELISA OD value was 1.547. Oral challenge with unprocessed raw Chinese bellflower root provoked oral burning sensation, eyelid swelling, generalized urticaria, and hypotension. In an ELISA inhibition test, IgE binding to Chinese bellflower was significantly inhibited by Chinese bell...
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Kim SH, Lee SM, Park HW, Cho SH, Min KU, Kim YY, Chang YS Tags: Korean J Intern Med Source Type: journals

A new onset of systemic lupus erythematosus developed after bee venom therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present here a case of a 49-year-old female who experienced a new onset lupus after undergoing bee venom therapy, and this looked like a case of angioedema. The patient was successfully treated with high dose steroids and antimalarial drugs. We discuss the possibility of bee venom contributing to the development of SLE, and we suggest that such treatment should be avoided in patients with lupus. PMID: 19721868 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 31, 2009 Category: Internal Medicine Authors: Rho YH, Woo JH, Choi SJ, Lee YH, Ji JD, Song GG Tags: Korean J Intern Med Source Type: journals

Established and newly proposed mechanisms of chronic cyclosporine nephropathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cyclosporine (CsA) has improved patient and graft survival rates following solid-organ transplantation and has shown significant clinical benefits in the management of autoimmune diseases. However, the clinical use of CsA is often limited by acute or chronic nephropathy, which remains a major problem. Acute nephropathy depends on the dosage of CsA and appears to be caused by a reduction in renal blood flow related to afferent arteriolar vasoconstriction. However, the mechanisms underlying chronic CsA nephropathy are not completely understood. Activation of the intrarenal renin-angiotensin system (RAS), increased releas...
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Yoon HE, Yang CW Tags: Korean J Intern Med Source Type: journals

Clinical outcome of paraquat poisoning.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19543485 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Yoon SC Tags: Korean J Intern Med Source Type: journals

Marked recovery from paraquat-induced lung injury during long-term follow-up.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Recovery of nearly normal pulmonary structure and function may occur over several years following paraquat poisoning. Pulmonary function (both forced vital capacity and forced expiratory volume in 1 sec) evolved toward normal in the long-term survivors of paraquat poisoning with initial prominent lung injuries. PMID: 19543486 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Lee KH, Gil HW, Kim YT, Yang JO, Lee EY, Hong SY Tags: Korean J Intern Med Source Type: journals

Diagnostic yield of tissue sampling using a bite-on-bite technique for incidental subepithelial lesions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The bite-on-bite technique for subepithelial lesions is an effective and safe method in selected cases. This technique may be useful for incidental subepithelial lesions, especially those of the esophagus, except for ones with a high risk of bleeding or thick overlying epithelium. PMID: 19543487 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Ji JS, Lee BI, Choi KY, Kim BW, Choi H, Huh M, Chung WC, Chae HS, Chung IS Tags: Korean J Intern Med Source Type: journals

The association between the serum sodium level and the severity of complications in liver cirrhosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Hyponatremia, especially serum levels <or=130 mmol/L, may indicate the existence of severe complications associated with liver cirrhosis. PMID: 19543488 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Kim JH, Lee JS, Lee SH, Bae WK, Kim NH, Kim KA, Moon YS Tags: Korean J Intern Med Source Type: journals

Cilostazol protects endothelial cells against lipopolysaccharide-induced apoptosis through ERK1/2- and P38 MAPK-dependent pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Cilostazol protects HUVECs against LPS-induced apoptosis by suppressing mitochondria-dependent apoptotic signaling. Activation of ERK1/2 and p38 MAPKs, and subsequent stimulation of CREB phosphorylation and Bcl-2 expression, may be responsible for the cellular signaling mechanism of cilostazol-mediated protection. PMID: 19543489 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Lim JH, Woo JS, Shin YW Tags: Korean J Intern Med Source Type: journals

The pulmonary embolism severity index in predicting the prognosis of patients with pulmonary embolism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The PESI class was found to be significantly correlated with the 30-day mortality rate, hospital mortality, and overall mortality. Our data indicate that the PESI can be used to predict the prognosis of patients with pulmonary embolism and in making medical decisions regarding the treatment of patients with pulmonary embolism. PMID: 19543490 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Choi WH, Kwon SU, Jwa YJ, Kim JA, Choi YH, Chang JH, Jung H, Doh JH, Namgung J, Lee SY, Lee WR Tags: Korean J Intern Med Source Type: journals

Clinicopathologic characteristics of T-cell non-Hodgkin's lymphoma: a single institution experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The relative frequency of T-cell NHL seems to be decreasing in Korea, although NASAL remains frequent. Korean patients with ALCL appear to have an unfavorable prognosis. Large-scale studies are warranted for Korean patients with T-cell NHL. PMID: 19543491 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Ko OB, Lee DH, Kim SW, Lee JS, Kim S, Huh J, Suh C Tags: Korean J Intern Med Source Type: journals

Diagnosis and species identification of mycobacterial infections by polymerase chain reaction-restriction fragment length polymorphism analysis of sterile body fluids.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: PCR-RFLP analysis of sterile body fluids may be a useful method for the diagnosis of mycobacterial infections and for the differentiation of mycobacterial species. PMID: 19543492 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Cho CH, Han SH, Chin BS, Choi SH, Lee HS, Kim CO, Kim MS, Choi JY, Song YG, Kim JM Tags: Korean J Intern Med Source Type: journals

Effect of the combined use of tramadol and milnacipran on pain threshold in an animal model of fibromyalgia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We observed potentiation of the antihyperalgesic effect when milnacipran and tramadol were administered in combination in an animal model of fibromyalgia. Further research is required to determine the efficacy of various combination treatments in fibromyalgia in humans. PMID: 19543493 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Kim SH, Song J, Mun H, Park KU Tags: Korean J Intern Med Source Type: journals

Gastric yolk sac tumor: a case report and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gastric yolk sac tumors are extremely rare and their prognosis is poor; most patients have widespread metastases at the time of diagnosis. The treatment of gastric yolk sac tumors consists of aggressive chemotherapy combined with radiotherapy and surgery. Here, we first report a case of gastric yolk sac tumor presenting as an early gastric cancer that was cured after a gastrectomy with lymphadenectomy. PMID: 19543494 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Kim YS, Kim SH, Seong JK, Lee BS, Jeong HY, Song KS Tags: Korean J Intern Med Source Type: journals

A case of hepatocellular carcinoma within hepatocellular adenoma in a non-cirrhotic male.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here on this case along with a brief review of the relevant literature. PMID: 19543495 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Kim DH, Kim SU, Nam DH, Choi YJ, Park SM, Lee CK, Kim do Y Tags: Korean J Intern Med Source Type: journals

Acute embolic occlusion of the left common iliac artery treated with intra-arterial thrombolysis and percutaneous thrombectomy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of acute embolic occlusion of the left common iliac artery in a patient with atrial fibrillation who was treated successfully using mechanical thrombectomy following intra-arterial thrombolysis. PMID: 19543496 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Lee WS, Lee KJ, Ryu WS Tags: Korean J Intern Med Source Type: journals

Acute fibrinous and organizing pneumonia following hematopoietic stem cell transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the first case of AFOP following allogeneic hematopoietic stem cell transplantation. PMID: 19543497 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Lee SM, Park JJ, Sung SH, Kim Y, Lee KE, Mun YC, Lee SN, Seong CM Tags: Korean J Intern Med Source Type: journals

The clinical characteristics of Anisakis allergy in Korea.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anisakidae larvae can cause anisakiasis when ingested by humans. Although several groups have reported a gastrointestinal Anisakis allergy among people in Spain and Japan, our report is the first to summarize the clinical features of 10 Anisakis allergy cases in Korea. We enrolled 10 Korean patients (6 men and 4 women) who complained of aggravated allergic symptoms after ingesting raw fish or seafood. Sensitization to Anisakis was confirmed by detecting serum specific IgE to Anisakis simplex. The most common manifestation of anisakiasis was urticaria (100%), followed by abdominal pain (30%) and anaphylaxis (30%). All p...
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Choi SJ, Lee JC, Kim MJ, Hur GY, Shin SY, Park HS Tags: Korean J Intern Med Source Type: journals

Overview of therapeutic drug monitoring.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Therapeutic drug monitoring (TDM) is the clinical practice of measuring specific drugs at designated intervals to maintain a constant concentration in a patient's bloodstream, thereby optimizing individual dosage regimens. It is unnecessary to employ TDM for the majority of medications, and it is used mainly for monitoring drugs with narrow therapeutic ranges, drugs with marked pharmacokinetic variability, medications for which target concentrations are difficult to monitor, and drugs known to cause therapeutic and adverse effects. The process of TDM is predicated on the assumption that there is a definable relationshi...
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Kang JS, Lee MH Tags: Korean J Intern Med Source Type: journals

Clinical significance of anaerobic infections.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19270475 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Lee DG Tags: Korean J Intern Med Source Type: journals

Clinical features and prognostic factors of anaerobic infections: a 7-year retrospective study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Anaerobic infection is polymicrobial and has a significant role in morbidity and mortality. Underlying liver disease was associated with poor prognosis in anaerobic infection. PMID: 19270476 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Park Y, Choi JY, Yong D, Lee K, Kim JM Tags: Korean J Intern Med Source Type: journals

Reproducibility of regional pulse wave velocity in healthy subjects.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The PWV measurement system used in this study provides accurate analysis results with high reproducibility. It is necessary to provide an accurate algorithm for the detection of additional features such as flow wave, reflection wave, and dicrotic notch from a pulse waveform. PMID: 19270477 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Lee NB, Park CG Tags: Korean J Intern Med Source Type: journals

Relationship between left atrial size and stroke in patients with sinus rhythm and preserved systolic function.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The LA dimension is significantly related to the incidence of stroke. Therefore, strategies for prevention of stroke in patients with preserved LVSF and SR should be considered in cases of LA enlargement. PMID: 19270478 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Kim BS, Lee HJ, Kim JH, Jang HS, Bae BS, Kang HJ, Lee BR, Jung BC Tags: Korean J Intern Med Source Type: journals

Cost analysis of iron-related complications in a single institute.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The medical costs of IRCs are considerable, and more effective iron-chelating therapy is necessary to save medical resources and improve patient care. More in the way of comprehensive health and economic studies of IRCs are needed to allow both clinicians and health-policy makers to make better decisions. PMID: 19270479 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Kim KH, Kim JW, Rhee JY, Kim MK, Kim BS, Kim I, Bang SM, Yoon SS, Lee JS, Han KS, Park S, Kim BK Tags: Korean J Intern Med Source Type: journals

Gemcitabine, Etoposide, Cisplatin, and Dexamethasone in Patients With Refractory or Relapsed Non-Hodgkin's Lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: GEPD chemotherapy in patients with refractory or relapsed NHL was effective as a salvage therapy and helpful for stem cell harvest followed by autologous transplantation. PMID: 19270480 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Kim KH, Joo YD, Sohn CH, Shin HJ, Chung JS, Cho GJ, Shin SH, Kim YS, Lee WS Tags: Korean J Intern Med Source Type: journals

A Comparison of Patient Acceptance and Preferences Between CT Colonography and Conventional Colonoscopy in Colorectal Cancer Screening.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although CT colonography is a safe and noninvasive screening test for colorectal cancer, further study is required to increase patient acceptance. PMID: 19270481 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Jung HS, Park DK, Kim MJ, Yu SK, Kwon KA, Ku YS, Kim YK, Kim JH Tags: Korean J Intern Med Source Type: journals

EGFR and KRAS Mutations in Patients With Adenocarcinoma of the Lung.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Mutations of KRAS were present in 9.6% (9 of 94) of the samples: eight in codon 12 and one in codon 13. EGFR mutations were never found in tumors with KRAS mutations, suggesting a mutually exclusive relationship. PMID: 19270482 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Jang TW, Oak CH, Chang HK, Suo SJ, Jung MH Tags: Korean J Intern Med Source Type: journals

The effect of residual renal function at the initiation of dialysis on patient survival.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although there was no difference in the mortality rate based on residual renal function, hemodialysis patients with a lower estimated glomerular filtration rate showed a higher mortality rate than those with a higher estimated glomerular filtration rate. PMID: 19270483 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Kim SG, Kim NH Tags: Korean J Intern Med Source Type: journals

Long-term survival in a patient with ruptured hepatocellular carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 57-yr-old woman previously diagnosed with chronic hepatitis B was admitted via the emergency room because she suddenly developed epigastric pain with abdominal distension. On computed tomography (CT), a round enhancing mass was found on the left hepatic lobe with ascites in the peritoneal space. Bloody ascites were found upon tapping the ascites, and this led to the diagnosis of ruptured hepatocellular carcinoma (HCC). The patient was immediately treated with transcatheter arterial chemoembolization (TACE) including 50 mg of adriamycin and 10 mL of lipiodol, and then we performed left lateral segmentectomy 20 days la...
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Kim JS, Yoon SK, Kim JA, Kim CW, Bae SH, Choi JY, Jung CK Tags: Korean J Intern Med Source Type: journals

Novel LMNA Gene Mutation in a Patient With Atypical Werner's Syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here the first case of atypical Werner's syndrome with frameshift mutation that was caused by T506del. PMID: 19270485 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Doh YJ, Kim HK, Jung ED, Choi SH, Kim JG, Kim BW, Lee IK Tags: Korean J Intern Med Source Type: journals

Successful treatment of small-cell lung cancer with irinotecan in a hemodialysis patient with end-stage renal disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The prognosis of patients with end-stage renal disease has improved with advances in hemodialysis techniques. However, many patients who undergo hemodialysis suffer from various types of cancer. Limited data is available to guide clinical management of these patients who may have impaired renal function. Here, we report our experience with the use of irinotecan for the treatment of a hemodialysis patient with small-cell lung cancer and end-stage renal disease. PMID: 19270486 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Kim DM, Kim HL, Chung CH, Park CY Tags: Korean J Intern Med Source Type: journals

An antinuclear antibody-negative patient with lupus nephritis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Systemic lupus erythematosus (SLE) is a typical autoimmune disease that's characterized by various autoantibodies to nuclear and cytoplasmic antigens. The presence of antinuclear antibodies (ANA) in serum is generally considered a decisive diagnostic sign of SLE. However, a small subset of SLE patients who had the typical clinical features of SLE was reported to show persistently negative ANA tests. Our report describes a 16-yr-old female who presented with the clinical manifestations of SLE such as malar rash, photosensitivity, arthritis, lymphopenia, pericarditis and proteinuria. The serum autoantibodies were all neg...
Source: The Korean Journal of Internal Medicine - March 1, 2009 Category: Internal Medicine Authors: Kim HA, Chung JW, Park HJ, Joe DY, Yim HE, Park HS, Suh CH Tags: Korean J Intern Med Source Type: journals

Hepatocyte nuclear factor 1-alpha mutation in normal glucose-tolerant subjects and early-onset type 2 diabetic patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results indicate that MODY3 mutations are not rare in Korean early-onset type 2 diabetes patients in Korea and suggest that MODY3 mutations in patients with early-onset type 2 diabetes need to be further evaluated. PMID: 19119252 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 1, 2008 Category: Internal Medicine Authors: Lim DM, Huh N, Park KY Tags: Korean J Intern Med Source Type: journals

Factors for poor prognosis of near-fatal asthma after recovery from a life-threatening asthma attack.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These prognostic factors may induce irreversible obstruction of the airways with subsequent acute exacerbation of asthma or the need for continual oral corticosteroids after being discharged from the hospital. Patients with these factors should be treated appropriately, under close surveillance. PMID: 19119253 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 1, 2008 Category: Internal Medicine Authors: Kim MS, Cho YJ, Moon HB, Cho SH Tags: Korean J Intern Med Source Type: journals