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Multimodality bronchoscopic imaging of recurrent respiratory papillomatosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recurrent respiratory papillomatosis (RRP) of the central airways requires removal to potentially reduce recurrence and risk for malignant transformation. Analogous to the principles of treatment for early lung cancer, a precise determination of the extent of cartilage invasion could help guide therapeutic decisions and monitor response to treatment. The purpose of this study was to determine whether a bronchoscopy platform comprised of white light bronchoscopy (WLB), endobronchial ultrasound (EBUS), and optical coherence tomography (OCT) could identify layered microstructure of RRP and underlying cartilage.Case study.A br...
Source: The Laryngoscope - November 19, 2009 Category: ENT & OMF Authors: Henri G. Colt, Septimiu D. Murgu, Bockhyun Jung, Yeh-Chan Ahn, Matt Brenner Source Type: journals

Clinical spectrum of patients with erosion of the inner ear by jugular bulb abnormalitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anatomic variants of the jugular bulb (JB) are common; however, abnormalities such as large high riding JB and JB diverticulum (JBD) are uncommon. Rarely, the abnormal JB may erode into the inner ear. The goal of our study is to report a large series of patients with symptomatic JB erosion into the inner ear.Retrospective review in an academic medical center.Eleven patients with JB abnormality eroding into the inner ear were identified on computed tomography (CT) scan of the temporal bone.Age at presentation was from 5 years to 82 years with six males and five females. The large JB or JBD eroded into the vestibular aqueduc...
Source: The Laryngoscope - November 18, 2009 Category: ENT & OMF Authors: David R. Friedmann, B. Thuy Le, Bidyut K. Pramanik, Anil K. Lalwani Source Type: journals

In reference to effect of the tympanostomy tube on postoperative retraction of the soft posterior meatal wall caused by habitual sniffingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: The Laryngoscope)
Source: The Laryngoscope - November 17, 2009 Category: ENT & OMF Authors: Dong-Hee Lee Source Type: journals

In response to transcricothyroid electromyographic monitoring of the recurrent laryngeal nerve (Laryngoscope 2009;119:1918-1921)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: The Laryngoscope)
Source: The Laryngoscope - November 11, 2009 Category: ENT & OMF Authors: Michael Hinni Source Type: journals

Diabetes-related changes in auditory brainstem responsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Determine effects on auditory brainstem response (ABR) of diabetes mellitus (DM) severity.A cross-sectional study investigating DM severity and ABR in military Veteran subjects with (166) and without (138) DM and with no more than moderate hearing loss.Subjects were classified by three age tertiles ( (Source: The Laryngoscope)
Source: The Laryngoscope - November 10, 2009 Category: ENT & OMF Authors: Dawn Konrad-Martin, Donald F. Austin, Susan Griest, Garnett P. McMillan, Daniel McDermott, Stephen Fausti Source Type: journals

In reference to transcricothyroid electromyographic monitoring of the recurrent laryngeal nerve (Laryngoscope 2009;119:1918-1921)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: The Laryngoscope)
Source: The Laryngoscope - November 10, 2009 Category: ENT & OMF Authors: Gianlorenzo Dionigi Source Type: journals

Bilateral cochlear implantation: Current concepts, indications, and resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The optimal treatment for bilateral hearing loss continues to evolve as cochlear implant (CI) and hearing aid technologies advance, as does our understanding of the central auditory system. Ongoing discussions continue on the validity and feasibility of bilateral CI in terms of performance, justification of need, medical/surgical safety concerns, and economics. The purpose of this review article is to provide an update on the advantages and disadvantages of bilateral CI and to provide a discussion on timing (simultaneous vs. sequential), technology (bimodal vs. binaural) and feasibility. Binaural advantages are found in bo...
Source: The Laryngoscope - November 6, 2009 Category: ENT & OMF Authors: Gregory J. Basura, Rose Eapen, Craig A. Buchman Source Type: journals

Supraglottic swelling may not correlate with tongue swelling in angiotensin converting enzyme inhibitor-induced angioedemaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a representative case. This observation suggests that all patients with ACEI-induced angioedema should undergo laryngeal fiberoptic examination and appropriate airway management. Laryngoscope, 2009 (Source: The Laryngoscope)
Source: The Laryngoscope - November 5, 2009 Category: ENT & OMF Authors: Shashank Saxena, Brian Gierl, David E. Eibling Source Type: journals

In reference to Lemierre's Syndrome: A Systematic Review (Laryngoscope 2009;119:1552-1559)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: The Laryngoscope)
Source: The Laryngoscope - November 4, 2009 Category: ENT & OMF Authors: Mohammed Iqbal Syed, David Baring, Craig Murray Source Type: journals

Pilot testing of an assessment tool for competency in mastoidectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study tests the hypothesis that residents of dissimilar training levels differ in their technical performance as measured by this tool.Cross-sectional validation study.Two or more faculty otolaryngologists evaluated each resident performing a cortical mastoidectomy on a cadaveric temporal bone. Performance was rated using global and checklist components of a mastoidectomy assessment tool.Fifteen internal and external faculty members evaluated 23 residents over 3 years resulting in 118 evaluations. Construct validity was observed as scores increased with clinical training year. These differences were greater for more c...
Source: The Laryngoscope - November 3, 2009 Category: ENT & OMF Authors: Kulsoom Laeeq, Nasir I. Bhatti, John P. Carey, Charles C. Della Santina, Charles J. Limb, John K. Niparko, Lloyd B. Minor, Howard W. Francis Source Type: journals

Additional heterozygous 2507A>C mutation of WFS1 in progressive hearing loss at lower frequenciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To describe the audiological profiles in a Japanese family with autosomal dominant hereditary sensorineural hearing loss (SNHL) and to identify the causative gene.A family study at an academic tertiary referral center.A family with autosomal dominant hereditary SNHL was enrolled. Hearing loss (HL) of affected members showed mid-frequency SNHL in childhood and progressed at lower frequencies with age, resulting in low-frequency SNHL. To understand the pathology of HL of this family, we performed a genetic analysis of WFS1, TECTA, and GJB2 by direct sequencing, and further audiovestibular examinations, including speech audio...
Source: The Laryngoscope - October 30, 2009 Category: ENT & OMF Authors: Taro Fujikawa, Yoshihiro Noguchi, Taku Ito, Masatoki Takahashi, Ken Kitamura Source Type: journals

Eco-conservation and healthcare ethics: A call to actionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: The Laryngoscope)
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Robin T. Cotton, Aliza P. Cohen Source Type: journals

Management of the N0 neck in recurrent laryngeal squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate the utility of neck dissections in patients undergoing salvage laryngectomy with a clinically negative neck.Retrospective cohort study.This retrospective review identified 71 patients with N0 necks who underwent salvage laryngectomy from 2001 to 2007. The standard practice of surgeons within our institution was different, thus neck dissections were performed on approximately one half of the patients, creating two groups for comparison. The number of neck dissections with positive metastasis were examined. Postoperative complications, overall survival, and site of recurrence were compared between patients with n...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Isaac A. Bohannon, Renee A. Desmond, Lisa Clemons, J. Scott Magnuson, William R. Carroll, Eben L. Rosenthal Source Type: journals

Outcomes of minimally invasive endoscopic resection of anterior skull base neoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study validated technical feasibility of MIER for diversity of benign and malignant ASB histopathology. Majority of patients were able to avoid adjunct craniotomy, whereas lumbar drainage was utilized in selective cases. This surgical strategy resulted in low complication rate and acceptable disease-free survival in patients with advanced T3 and T4 malignant lesions. Future studies should focus on multicenter trials to facilitate more robust survival analysis and comparison to open surgical approaches. Laryngoscope, 2009 (Source: The Laryngoscope)
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Pete S. Batra, Amber Luong, Seth J. Kanowitz, Burak Sade, Joung Lee, Donald C. Lanza, Martin J. Citardi Source Type: journals

Multifactorial dysphagia: Diffuse idiopathic skeletal hyperostosis and eosinophilic esophagitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Swallowing is a complex, multistage event with oral, pharyngeal, and esophageal phases. A thorough clinical examination for swallowing complaints begins to differentiate whether the problem is due to anatomic, mechanical, or neurologic etiologies. Based on the clinical suspicion, additional tests may be beneficial, including fluoroscopic and direct imaging methods, and electrophysiologic measurements. A multidisciplinary approach may also be advantageous, as in this case of dysphagia from diffuse idiopathic skeletal hyperostosis and eosinophilic esophagitis, which incorporated care from otolaryngology, speech pathology, or...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Grace Nimmons, Douglas J. Van Daele, Henry T. Hoffman, Satish S. Rao, Charles R. Clark Source Type: journals

Patterns of recurrence and survival of head and neck adenoid cystic carcinoma after definitive resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To determine factors impacting recurrence and long-term survival of adenoid cystic carcinoma (ACC) of the head and neck after definitive resection.Retrospective cohort study at an academic tertiary care hospital.Patients with ACC of the head and neck treated at our institution were reviewed. Those not receiving surgery, or with metastatic disease were excluded. Clinicopathological data on each patient was collected.Of 113 patients identified with ACC, 99 were studied. The overall median survival for the cohort was 71 months (mean ± standard deviation, 94 ± 79 months). American Joint Committee on Cancer (AJCC) tumor stage...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Agnes Oplatek, Enver Ozer, Amit Agrawal, Sumit Bapna, David E. Schuller Source Type: journals

Primary middle ear Epstein-Barr virus-related lymphoepithelial carcinoma: Case reports and systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To report two cases of primary lymphoepithelial carcinoma in the middle ear and to determine the optimal treatment for such lesions.Case reports and a systematic review of the literature.Primary lymphoepithelial carcinoma in the middle ear is an exceptionally rare condition with only two other cases reported in the literature. There appears to be an association with Epstein-Barr virus infection and in those patients originating from the Guangdong province of China, much as is the case for similar lesions found in the nasopharynx. Piecemeal rather than en bloc excision, in combination with adjuvant radiotherapy, appears to ...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Matthew P. A. Clark, Brian D. Westerberg, Kenneth W. Berean Source Type: journals

Is severe epistaxis associated with acetylsalicylic acid intake?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epistaxis represents a very common emergency in any ear, nose, and throat (ENT) department around the world. Despite other risk factors, acetylsalicylic acid (ASA) contributes to nosebleeds by its intrinsic ability to impair thrombocyte aggregation. The aim of this study was to investigate the influence of ASA on the severity of epistaxis and to compare it with other potential risk factors.A prospective cohort study was performed at the ENT department of University Hospital Zurich.A total of 591 events were evaluated concerning surgical interventions and the length of in-hospital stay. Further analyses regarding recurrence...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Michael B. Soyka, Kaspar Rufibach, Alex Huber, David Holzmann Source Type: journals

Management of patients treated with chemoradiotherapy for head and neck cancer without prophylactic feeding tubes: The University of Pittsburgh experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mucositis and dysphagia are common complications of chemoradiotherapy (CRT) for head and neck cancer that may necessitate nutritional support with a gastrostomy tube (G-tube).We reviewed records of patients who underwent and completed CRT, which included at least one traditional chemotherapeutic, for previously untreated head and neck cancer. G-tubes were placed as needed. The timing and duration of G-tube placement and treatment-related complications and risk factors for long-term G-tube use were analyzed.A total of 91 consecutive patients who received CRT, 68 as primary and 23 as postoperative treatment, were studied. Ra...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Brian T. McLaughlin, Abhay S. Gokhale, Yongli Shuai, Joyce Diacopoulos, Ricardo Carrau, Dwight E. Heron, Ryan P. Smith, Michael K. Gibson, Robert L. Ferris, Jennifer R. Grandis, Jonas T. Johnson, Athanassios Argiris Source Type: journals

Improvement of respiratory compromise through abductor reinnervation and pacing in a patient with bilateral vocal fold impairmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To determine whether respiratory compromise from bilateral vocal fold impairment (paralysis) can be objectively alleviated by reinnervation and pacing.A patient with paramedian vocal folds and synkinesis had a tracheotomy for stridor after bilateral laryngeal nerve injury and Miller Fisher syndrome. One posterior cricoarytenoideus (PCA) received a nerve-muscle pedicle fitted with a perineural electrode for pacemaker stimulation. The airway was evaluated endoscopically and by spirometry for up to 1 year.Bilateral vocal fold patency during quiet breathing was reversed to active vocal fold adduction during tracheal occlusion....
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Michael Broniatowski, Sharon Grundfest-Broniatowski, Aaron J. Hadley, Nemath S. Shah, Anca M. Barbu, Sue Ann Phillipbar, Kingman P. Strohl, Harvey M. Tucker, Dustin J. Tyler Source Type: journals

Chronic vocal fold scar restoration with hepatocyte growth factor hydrogelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Therapeutic challenges exist in the management of vocal fold scarring. We have previously demonstrated the therapeutic potential of hepatocyte growth factor (HGF) in the management of acute phase vocal fold scarring using a novel hydrogel-based HGF drug delivery system (DDS). However, the effect of HGF on matured vocal fold scarring remains unclear. The current study aims to investigate the effect of HGF-DDS on chronic vocal fold scarring using a canine model.Animal model.Vocal folds from eight beagles were unilaterally scarred by stripping the entire layer of the lamina propria; contralateral vocal folds were kept intact ...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Yo Kishimoto, Shigeru Hirano, Yoshiharu Kitani, Atsushi Suehiro, Hiroo Umeda, Ichiro Tateya, Shin-ichi Kanemaru, Yasuhiko Tabata, Juichi Ito Source Type: journals

Pediatric cholesteatoma and variants in the gene encoding connexin 26Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Connexin 26 is a gap junction protein encoded by the GJB2 gene. It is expressed in cholesteatoma, and mutations cause proliferative skin disorders and sensorineural hearing loss (SNHL). Deletions of GJB6, which encodes connexin 30, cause SNHL in a digenic manner with a heterozygous GJB2 mutation. We hypothesize that GJB2 and GJB6 mutations might influence the development of cholesteatoma.Prospective observational study to identify GJB mutations in pediatric cholesteatoma.Peripheral blood samples from 98 children with cholesteatoma were screened for mutations in the GJB2 gene by direct sequencing of the coding region (exon ...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Adrian L. James, Neil K. Chadha, Blake C. Papsin, Tracy L. Stockley Source Type: journals

Vocal process granuloma and glottal insufficiency: An overlooked etiology?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vocal process granuloma has been attributed to intubation, laryngopharyngeal reflux, and phonotraumatic/hyperfunctional vocal behaviors. Vocal process granuloma has recurrence rates following surgical excision approaching 92%. We hypothesize that a portion of persistent or idiopathic cases of vocal process granuloma result from underlying glottal insufficiency (GI) caused by paresis, scar, or atrophy. Our goal was to examine our vocal process granuloma population and determine the incidence of GI, treatment interventions, and outcomes.Retrospective chart review.Thirty-four patients with vocal process granuloma were divided...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Thomas L. Carroll, Jackie Gartner-Schmidt, Melissa M. Statham, Clark A. Rosen Source Type: journals

Transoral resection of short segment Zenker's diverticulum and cricopharyngeal myotomy: An alternative minimally invasive approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transoral treatment of cricopharyngeal bar and small Zenker's diverticulum remains a challenge. We propose a new transoral approach for transoral cricopharyngeal myotomy (TOCPM) for patients with cricopharyngeal spasm and pharyngeal bar, and for transoral resection of diverticula (TORD) with cricopharyngeal myotomy in the patient with small ( (Source: The Laryngoscope)
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Melissa Mortensen, Madeleine R. Schaberg, Eric M. Genden, Peak Woo Source Type: journals

A new mouse laryngeal transplantation rejection grading systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Development of a rat laryngeal transplantation model allowed for the first total human laryngeal transplantation by the senior author in 1998. In an effort to further our knowledge of the immune system's role in laryngeal rejection, a change to the mouse model was required. Prior to initiating immunosuppressive research protocols, a reliable mouse larynx rejection classification had to be established.Animal study.Thirty-one mouse laryngeal transplants (C57 BL/6 donors to C3H recipients) were performed and allowed to reject. Six time points were evaluated histologically: 1, 3, 5, 7, 9, and 15 days post-transplant. Eight ana...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: David G. Lott, Taha Z. Shipchandler, Olivia Dan, Robert R. Lorenz, Marshall Strome Source Type: journals

Patient reported voice outcome in recurrent respiratory papillomatosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study cohort, 68% scored above the VHI cutoff point, and 18% had an increased risk for depression or anxiety disorders (HADS). VHI scores were related to age, time between consecutive surgeries, time since last surgery, and passive coping. They were not related to gender, onset of RRP, or location. VHI scores were related to the SF-36 subscales social functioning (r = -0.43) and mental health (r = -0.43).Patients with RRP often report voice problems in daily life, and this is related to (a passive) coping style, social functioning, and mental health. Psychosocial intervention targeting an adaptive coping style may ...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Annette J. van Nieuwenhuizen, Rico N. P. M. Rinkel, Remco de Bree, C. René Leemans, Irma M. Verdonck-de Leeuw Source Type: journals

Decoy NF-[kappa]B fortified immature dendritic cells maintain laryngeal allograft integrity and provide enhancement of regulatory T cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The increased risk of malignancy associated with post-transplant immunosuppression limits the potential of laryngeal transplantation as a reconstructive option. This risk may be mitigated by utilizing decoy nuclear factor kappa B (NF-[kappa]B) immature dendritic cells (iDC) to provide donor-specific tolerance. The purpose of this study was to explore whether tolerogenic properties of iDC can be applied to composite tissue transplantation.Animal study.Five iDC-injected mice were euthanized at 15, 30, and 60 days post-laryngeal transplant. Control groups included five transplanted mice without immunosuppression, one iDC-inje...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: David G. Lott, Olivia Dan, Lina Lu, Marshall Strome Source Type: journals

Clarithromycin inhibits rhinovirus-induced bacterial adhesions to nasal epithelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We investigated the inhibitory effects of clarithromycin (CM) on the rhinovirus (RV)-induced expression of fibronectin (Fn) and carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which act as major receptors for Staphylococcus aureus and Haemophilus influenzae, respectively. We further investigated the effects of CM on secondary S. aureus and H. influenzae adhesions to RV-infected primary human nasal epithelial cells (HNECs).Cells were pretreated with 10 [mu]M CM 24 hours before RV-16 infection and for 48 hours thereafter. The expression levels of Fn and CEACAMs were assayed by reverse transcriptase-polyme...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Jong Hwan Wang, Si Hyeong Lee, Hyun Ja Kwon, Yong Ju Jang Source Type: journals

Bone chip-induced rhinosinusitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This case report describes both the pathophysiology and management of chronic rhinosinusitis (CRS). Specifically, we report a case of chronic maxillary rhinosinusitis with a free-floating maxillary sinus calcification (bone chip). After obtaining the computed tomography scan, the patient underwent endoscopic sinus surgery, with removal of the uncinate, enlargement of the diseased natural ostium of the maxillary sinus, and removal of the diseased bone chip. This eliminated the nidus for infection, ultimately restoring mucociliary flow. Laryngoscope, 2009 (Source: The Laryngoscope)
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Brian K. Reilly, David B. Conley Source Type: journals

Trends in the management of vestibular schwannomas at Johns Hopkins 1997-2007Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To assess trends in the management of unilateral vestibular schwannomas over an 11-year period and to identify disease- and provider-related influences.Retrospective chart review.Subjects presented to the Department of Otolaryngology-Head and Neck Surgery and the Department of Neurosurgery for management of unilateral vestibular schwannoma from 1997 through 2007, with at least two visits within the first year of presentation. The proportion of patients for whom initial management consisted of observation, surgical resection, or radiation therapy was determined, and the relative influence of study year, patient age, hearing...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Marietta Tan, Oluwaseun A. Myrie, Frank R. Lin, John K. Niparko, Lloyd B. Minor, Rafael J. Tamargo, Howard W. Francis Source Type: journals

Spiral ganglion loss outpaces inner hair cell loss in endolymphatic hydropsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study quantifies the relationship between neuronal degeneration and hair cell degeneration in ELH to evaluate the hypothesis that a primary neural insult would yield greater loss in the spiral ganglion than at the inner hair cell level.Following induction and histopathologic confirmation of endolymphatic hydrops in guinea pigs, the degree of hydrops, spiral ganglion loss, and hair cell degeneration were quantified and compared.Guinea pigs with surgically induced unilateral hydrops were sacrificed and their cochleas preserved. Hydrops severity and spiral ganglion density were quantified using automated methods. Hair ce...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Suhael R. Momin, Sami J. Melki, Kumar N. Alagramam, Cliff A. Megerian Source Type: journals

Transoral approach for plunging ranula - 10-Year experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we demonstrated our experience managing PRs via transoral excision of the SLG with marsupialization.Retrospective study.We retrospectively reviewed 20 patients at Chang Gung Memorial Hospital, Linkou, between January 1999 and April 2009. All patients received preoperative computed tomography or magnetic resonance imaging and were clinically diagnosed with PR. At surgery, the SLG was excised transorally with preservation of Wharton's duct and lingual nerve. The mucus contents of the PRs were drained through the posterior edge of the mylohyoid muscle.Two patients were found to have final diagnosis of lymphangi...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Shiang-Fu Huang, Chun-Ta Liao, Shy-Chyi Chin, I-How Chen Source Type: journals

Tissue-engineered allograft tracheal cartilage using fibrin/hyaluronan composite gel and its in vivo implantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Treatment and management of tracheal defects remain challenging in head and neck surgery. Various reconstruction techniques have been used, with no consensus on the best approach. The purpose of this study was to explore a novel strategy to fabricate tissue-engineered trachea by using fibrin/hyaluronic acid (HA) composite gel and evaluate the feasibility of creating tracheal cartilage.A preliminary animal experiment.Chondrocytes from rabbit cartilage were expanded and seeded into a culture dish at high density to form mechanically stable allograft tracheal cartilage using fibrin/HA composite gel. After a longitudinal cervi...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Dong Young Kim, JungHee Pyun, Jae Won Choi, Jang-Hee Kim, Jin Seok Lee, Hyang Ae Shin, Hyun-Jun Kim, Ha-Neul Lee, Byoung-Hyun Min, Heung Eok Cha, Chul-Ho Kim Source Type: journals

Epithelial differentiation of adipose-derived stem cells for laryngeal tissue engineeringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One potential treatment option for severe vocal fold scarring is to replace the vocal fold cover layer with a tissue-engineered structure containing autologous cells. As a first step toward that goal, we sought to develop a three-dimensional cell-populated matrix resembling the vocal fold layers of lamina propria and epithelium.Basic science investigation.Adipose-derived stem cells were cultured in fibrin hydrogels with various growth factors. At the end of the culture period, matrices were sectioned and labeled with immunomarkers to identify cell phenotype.Adipose-derived stem cells survived, attached, and populated three...
Source: The Laryngoscope - October 23, 2009 Category: ENT & OMF Authors: Jennifer L. Long, Patricia Zuk, Gerald S. Berke, Dinesh K. Chhetri Source Type: journals

Chemoradiation for patients with advanced oral cavity cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with advanced oral cavity cancer (OCC) typically have not been enrolled in clinical trials utilizing contemporary multimodality strategies. There exist dogmatic expectations of inferior outcome in OCC patients secondary to ineffectiveness of treatment and unacceptable toxicity. The purpose of this study was to analyze survival, swallowing function, and incidence of osteoradionecrosis (ORN) of patients with stage III/IV OCC who have undergone primary concomitant chemoradiotherapy (CRT).All advanced OCC patients who were enrolled in University of Chicago concomitant CRT protocols from 1994 to 2008 were reviewed. One...
Source: The Laryngoscope - October 22, 2009 Category: ENT & OMF Authors: Kerstin M. Stenson, Rangesh Kunnavakkam, Ezra E. W. Cohen, Louis D. Portugal, Elizabeth Blair, Daniel J. Haraf, Joseph Salama, Everett E. Vokes Source Type: journals

Transoral robotic surgery for oropharyngeal squamous cell carcinoma: A prospective study of feasibility and functional outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To investigate the feasibility of transoral robotic surgery as a method of surgical treatment of oropharyngeal squamous cell carcinoma.Prospective case study.Forty-five patients with previously untreated oropharyngeal squamous cell carcinoma underwent transoral robotic surgical removal of the tumor with or without neck dissection and with or without adjuvant therapy. Patients were observed and data were recorded on surgical time, blood loss, surgical complications, tracheostomy tube course, enteral feeding, and resumption of oral diet, speech outcomes, swallowing outcomes, and tumor recurrence.All 45 patients underwent com...
Source: The Laryngoscope - October 12, 2009 Category: ENT & OMF Authors: Eric J. Moore, Kerry D. Olsen, Jan L. Kasperbauer Source Type: journals

11.7 Tesla magnetic resonance microimaging of laryngeal tissue architectureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
High-resolution imaging of vocal folds that distinguishes vocal fold (VF) layered microstructure and VF implants would provide a key experimental tool for translational research investigating biomaterial-based interventions to treat vocal fold scar. To establish proof of concept, we studied whether 11.7 Tesla (T) magnetic resonance (MR) microimaging provides the needed resolution to resolve vocal fold tissue architecture.We performed ex vivo MR microimaging of fixed ferret and canine larynges to determine whether changes in the layered architecture can be detected in the presence of scar and subsequent to biomaterial injec...
Source: The Laryngoscope - October 11, 2009 Category: ENT & OMF Authors: Victoria L. M. Herrera, Jason C. Viereck, Gerardo Lopez-Guerra, Yoshihiko Kumai, James Kobler, Sandeep Karajanagi, Hyoungshin Park, Robert Hillman, Steven M. Zeitels Source Type: journals

Hearing aids: A contemporary reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A contemporary review of hearing aids is provided with a focus on current styles of amplification devices, the goals of a hearing aid fitting and the signal processing schemes that allow the clinician to meet these goals, and the need to couple outside devices to hearing aids. A variety of new features available on hearing aids that improve the listener's experience with amplification are described. Some future challenges in hearing aid design and hearing evaluation are presented. (Source: The Laryngoscope)
Source: The Laryngoscope - October 11, 2009 Category: ENT & OMF Authors: Catherine V. Palmer Source Type: journals

Parapharyngeal space pleomorphic adenoma: A 30-year reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was performed by examining the records and reviewing the pathology of 44 patients with PA of the parapharyngeal space treated at a single medical center from January 1975 to November 2005.Of the 44 patients with PA, 35 patients underwent 38 excisions. Eleven men and 27 women were treated surgically. Follow-up varied from 24 months to 180 months. There were three recurrences in two patients. Recurrence rates at 5 and 10 years were equal at 7.9%. Gender, age, tumor volume, surgical approach, pathologic surgical margin status, and prior resections were evaluated for significant prognostic factors. Advanced age prov...
Source: The Laryngoscope - October 11, 2009 Category: ENT & OMF Authors: Abie H. Mendelsohn, Sunita Bhuta, Thomas C. Calcaterra, Hubert B. Shih, Elliot Abemayor, Maie A. St. John Source Type: journals

AM-111 prevents hearing loss from semicircular canal injury in otitis mediaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Iatrogenic semicircular canal (SC) transection during mastoidectomy for chronic otitis media often leads to profound hearing loss. AM-111, an apoptosis inhibitor, has been shown to mitigate hearing loss resulting from a variety of inner ear injuries. The goal of this study was to determine if round window application of AM-111 following SC transection in the presence of Pseudomonas aeruginosa otitis media (PA-OM) may reduce the associated hearing loss.Prospective, randomized, controlled study in an animal model.PA-OM was induced bilaterally in 34 guinea pigs. After 3 days, both bullae were opened and the lateral SC of one ...
Source: The Laryngoscope - October 10, 2009 Category: ENT & OMF Authors: Tyler C. Grindal, Edith M. Sampson, Patrick J. Antonelli Source Type: journals

Thymic cyst: A fourth branchial cleft anomalyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a unique case of a fourth branchial cleft cyst found within the thymus of an adult patient. In the literature to date, there have been no reports of such a finding in the adult population. These anomalies can often cause recurrent acute suppurative thyroiditis or recurrent deep neck abscesses. Delay in recognizing the underlying etiology can lead to significant complications. Laryngoscope, 2009 (Source: The Laryngoscope)
Source: The Laryngoscope - October 7, 2009 Category: ENT & OMF Authors: Smriti Nayan, Jonathan MacLean, Doron Sommer Source Type: journals

Membranous labyrinth volumes in normal ears and Ménière disease: A three-dimensional reconstruction studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to determine the normal volume ranges of cochlear duct, saccule, and utricle, and to assess endolymphatic hydrops in Ménière disease.Retrospective temporal bone study.Three-dimensional (3-D) images of membranous labyrinth were reconstructed from 31 normal temporal bones, six temporal bones from three patients with bilateral Ménière disease, and 16 temporal bones from eight patients with unilateral Ménière disease. Volumes of each part of membranous labyrinth were measured in each temporal bone group after 3-D reconstruction.The mean volumes and upper normal volume limits (over the 95% co...
Source: The Laryngoscope - October 5, 2009 Category: ENT & OMF Authors: Norimasa Morita, Shin Kariya, Armin Farajzadeh Deroee, Sebahattin Cureoglu, Shigenobu Nomiya, Rie Nomiya, Tamotsu Harada, Michael M. Paparella Source Type: journals

Solitary fibrous tumor of the thyroid glandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of solitary fibrous tumor of the thyroid gland in a 51-year-old man with pre-existing right recurrent laryngeal nerve paralysis from a congenital tracheoesophageal fistula repair as an infant. The left thyroid lobe was enlarged and soft. Fine needle aspiration biopsy via ultrasound guidance demonstrated a hypercellular aspirate composed of spindle cells with bland nuclear morphology. Given this histomorphology and immunohistochemical profile, the diagnosis of solitary fibrous tumor was considered and confirmed following left thyroid lobectomy. Laryngoscope, 2009 (Source: The Laryngoscope)
Source: The Laryngoscope - October 4, 2009 Category: ENT & OMF Authors: Tarik Y. Farrag, Shien Micchelli, Ralph P. Tufano Source Type: journals

Effects of smoking on quality of life following sinus surgery: 4-year follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study is to report on long-term outcomes in a prospective study comparing the quality-of-life outcomes in smokers and nonsmokers undergoing functional endoscopic sinus surgery.Prospective clinical trial.A total of 235 patients were prospectively enrolled at a single tertiary academic center. Preoperative Sino-Nasal Outcomes Test (SNOT)-20 scores and comprehensive demographic and smoking data were obtained. Preoperative SNOT-20 scores were compared to postoperative SNOT-20 scores.Long-term follow-up results were available in 111/185 nonsmokers (60%) and 26/50 smokers (52%). Nonsmokers had a mean preopera...
Source: The Laryngoscope - October 4, 2009 Category: ENT & OMF Authors: Subinoy Das, Sunny S. Khichi, Helen Perakis, Troy Woodard, Stilianos E. Kountakis Source Type: journals

A contemporary review of balance dysfunction following vestibular schwannoma surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review aims to evaluate the literature pertaining to subjective balance dysfunction following vestibular schwannoma surgery; the effect of postoperative imbalance on disability, handicap and quality of life; and to determine factors that influence vestibular compensation.Ovid MEDLINE, Cochrane databases, and relevant contemporary texts were searched for papers relating to subjective balance dysfunction following vestibular schwannoma surgery. The quality of this clinical evidence was evaluated.The search yielded 26 studies assessing subjective balance dysfunction following vestibular schwannoma surgery. Analysis revea...
Source: The Laryngoscope - October 4, 2009 Category: ENT & OMF Authors: Yougan Saman, Doris-Eva Bamiou, Michael Gleeson Source Type: journals

Segmental hemangiomas of the upper airwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To characterize the anatomic distribution of segmental hemangiomas of the larynx and to describe indications for treatment modalities.Retrospective chart review.We performed a retrospective chart review of patients with cutaneous hemangiomas at a tertiary care center over a 4-year period. Only patients with upper airway hemangiomas were studied. We reviewed the anatomic distribution of hemangiomas within the upper airway and the treatment course of each patient.Of 1,226 patients with cutaneous hemangiomas, 108 (9%) were segmental in distribution. There were 56 patients (52%) who had a V3 distribution pattern, and 16 patien...
Source: The Laryngoscope - October 4, 2009 Category: ENT & OMF Authors: Teresa M. O, Ronda E. Alexander, Tali Lando, Nazaneen N. Grant, Jonathan A. Perkins, Andrew Blitzer, Milton Waner Source Type: journals

A contemporary review of sublingual immunotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The sublingual route has become an interesting and novel therapeutic option for the immunotherapeutic management of patients with allergies. Immunotherapy modifies the immune response by decreasing the specific IgE levels and Th2-type inflammation in the mucosa when allergen exposure occurs, shifting this toward a Th1-type response. Credible evidence exists of both effectiveness and safety of sublingual immunotherapy (SLIT) from several placebo-controlled double-blind studies. SLIT has been shown to be an effective treatment of allergic rhinitis and asthma in both children and adults. The therapy is well tolerated with mai...
Source: The Laryngoscope - October 4, 2009 Category: ENT & OMF Authors: Elina Toskala Source Type: journals

The mandibulotomy: Friend or foe? Safety outcomes and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To determine the safety outcomes of a unique mandibulotomy technique and to compare results to the world literature.Retrospective review of a tertiary care head and neck cancer practice.A total of 220 consecutive lip-splitting mandibulotomy access cases from 1998 to 2006 were identified in the University of Alberta's prospective head and neck surgery database and reviewed with follow-up to June 2009. Uniform surgical technique consisting of a lower lip-splitting incision, incisor extraction, a paramedian stair-step osteotomy, and combination fixation with direct interosseous wires and a compression miniplate was utilized f...
Source: The Laryngoscope - October 4, 2009 Category: ENT & OMF Authors: Peter T. Dziegielewski, Alex M. Mlynarek, John Dimitry, Jeffrey R. Harris, Hadi Seikaly Source Type: journals

Tissue-engineered trachea for airway reconstructionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scaffold-free cartilage has been used to engineer biocompatible and mechanically stable neotracheas in vivo. The purpose of this animal study was to determine if neotracheal constructs, implanted paratracheally, could successfully be used for segmental tracheal reconstruction.Animal study.Culture-expanded auricular rabbit chondrocytes were used to engineer scaffold-free cartilage sheets. Cartilage and a strap muscle flap were wrapped around a tube and implanted paratracheally. At 12 to 14 weeks postimplantation neotracheas were used to reconstruct 20 mm tracheal defects. Surgical technique was modified several times in an ...
Source: The Laryngoscope - October 4, 2009 Category: ENT & OMF Authors: Mark Weidenbecher, Harvey M. Tucker, David A. Gilpin, James E. Dennis Source Type: journals

Sudden bilateral sensorineural hearing loss after intravenous cocaine injection: A case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a 26-year-old man who presented to our outpatient department with a sudden severe hearing loss after intravenous injection of cocaine. The audiogram on admission showed symmetric air conduction levels up to 80 dB at 4 kHz. After treatment with intravenous sodium chloride, prednisolone, and pentoxifylline, the audiogram 2 days later showed a bilateral normacusis. A review of the literature on the topic is given and possible reasons for inner ear damages caused by cocaine are discussed. Laryngoscope, 2009 (Source: The Laryngoscope)
Source: The Laryngoscope - October 4, 2009 Category: ENT & OMF Authors: Markus Stenner, Konrad Stürmer, Dirk Beutner, Jens Peter Klussmann Source Type: journals