Therapeutic Apheresis and DialysisThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Lessons From Single Cell Organisms: Insights Into the Antimicrobial and Toxic Effects of Peritoneal Dialysate BasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although it was first described over a quarter of a century ago, the mechanisms behind the antimicrobial activity of fresh peritoneal dialysate have been poorly understood. Recent insight into the biochemistry appears to suggest that at least part of the effect resides in the salts of the carboxylic acids. An understanding of the metabolic pathways of both sensitive and resistant organisms has not only led to an understanding of the mechanisms of the antimicrobial effect, but also may have provided the insight for future studies to reduce toxicity to the peritoneal membrane. While our knowledge base in this area is still e...
Source: Therapeutic Apheresis and Dialysis - October 30, 2009 Category: Hematology Authors: Charles J Diskin Source Type: journals

Apheresis Induces Oxidative Stress in Blood CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oxidative stress mediates damage to various cells and is thought to be involved in various pathologies, including hereditary and acquired hemolytic anemias. It is induced by a multitude of physiological and environmental factors, including extracorporeal manipulation of blood. As a result, hemodialysis induces oxidative damage to red blood cells, thereby increasing their susceptibility to hemolysis and shortening their life span. We studied the effect of apheresis on the oxidative status of blood components. Using flow cytometric measurements, we showed that red blood cells, lymphocytes, monocytes, and polymorphonuclear ce...
Source: Therapeutic Apheresis and Dialysis - October 30, 2009 Category: Hematology Authors: Johnny Amer, Shoshana Frankenburg, Eitan Fibach Source Type: journals

Retrospective Analysis of Long-term Lipid Apheresis at a Single CenterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We retrospectively analyzed 10 906 lipid apheresis sessions (heparin-induced lipoprotein precipitation, direct adsorption of lipoproteins, double filtration plasmapheresis, dextran sulfate adsorption, and immunoadsorption) in 38 patients who were consecutively treated in our department during the last 20 years. The incidences of major cardiovascular events (MACE) (death, cerebrovascular accident, myocardial infarction, limb amputation, and renal vascular involvement) were taken separately as primary end-points or as a combined end-point. The time-course of secondary end-points (coronary and extracranial status of arteries,...
Source: Therapeutic Apheresis and Dialysis - October 30, 2009 Category: Hematology Authors: Michael J Koziolek, Ulrich Hennig, Antonia Zapf, Carsten Bramlage, Clemens Grupp, Victor W Armstrong, Frank Strutz, Gerhard A Müller Source Type: journals

Does Concomitant Administration of Sevelamer and Calcium Carbonate Modify the Control of Phosphatemia?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is no guideline regarding the concomitant or distant administration of sevelamer and calcium carbonate. Our aim was to determine whether serum phosphate varied when sevelamer and calcium carbonate were administered concomitantly in comparison to administration at separate meals. Fourteen chronic hemodialysis patients were enrolled in this cross-over, randomized trial. Each subject underwent two four-week study periods. During the "concomitant" period, subjects were instructed to take both sevelamer and calcium carbonate together at each meal, whereas in the "separate" period, they were required to take them at separa...
Source: Therapeutic Apheresis and Dialysis - October 30, 2009 Category: Hematology Authors: Georges Ouellet, Héloïse Cardinal, Marjolaine Mailhot, Louis-Georges Ste-Marie, Louise Roy Source Type: journals

Physical Activity Is Necessary to Prevent Deterioration of the Walking Ability of Patients Undergoing Maintenance HemodialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Maintenance of the walking ability is very important for smooth continuation of maintenance hemodialysis (HD). The aim of the present study was to clarify the physical activity level in daily living that HD patients should maintain to prevent deterioration of their walking ability. Outpatients undergoing maintenance HD, consisting of 65 males and 88 females with a mean age of 64 ± 11 years, were recruited for the present study. Their physical activity level was recorded over a week with an accelerometer. The physical activity level in daily living was defined as the sum of the lengths of time for which the patients were e...
Source: Therapeutic Apheresis and Dialysis - October 30, 2009 Category: Hematology Authors: Toshiki Kutsuna, Atsuhiko Matsunaga, Takuya Matsumoto, Akira Ishii, Kazuya Yamamoto, Kazuki Hotta, Naoko Aiba, Yutaka Takagi, Atsushi Yoshida, Naonobu Takahira, Takashi Masuda Source Type: journals

Comparing the Autoantibody Levels and Clinical Efficacy of Double Filtration Plasmapheresis, Immunoadsorption, and Intravenous Immunoglobulin for the Treatment of Late-onset Myasthenia GravisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to investigate the effects of double-filtration plasmapheresis (DFPP), immunoadsorption (IA) and intravenous immunoglobulin (IVIg) in the treatment of late-onset myasthenia gravis (MG). A total of 40 late-onset MG patients were randomly divided into three groups: 15 patients were treated with DFPP; 10 patients were treated with IA; and 15 patients received IVIg. The titers of titin antibodies (Titin-ab), acetylcholine receptor antibodies (AChR-ab), presynaptic membrane antibody (Prsm-ab) were detected before and after the treatment, and the quantitative MG score (QMG score) was assessed by blinded...
Source: Therapeutic Apheresis and Dialysis - October 30, 2009 Category: Hematology Authors: Jun-Feng Liu, Wei-Xin Wang, Jun Xue, Chong-Bo Zhao, Huai-Zhou You, Jia-Hong Lu, Yong Gu Source Type: journals

Cell-free DNA in the Peritoneal Effluent of Peritoneal Dialysis SolutionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The beneficial effects of novel peritoneal dialysis solutions low in glucose degradation products regarding peritoneal cell apoptosis and necrosis are well established in vitro, however in vivo data is lacking. Cell-free DNA quantification is a possible method to determine cell damage through apoptosis and necrosis in vivo. We performed a prospective, cross-over study on 26 stable continuous ambulatory peritoneal dialysis (CAPD) patients, treating each patient for 3 months in a randomized order with a conventional, lactate-buffered, acidic solution (solution D) and a novel, bicarbonate/lactate-buffered neutral solution (so...
Source: Therapeutic Apheresis and Dialysis - August 11, 2009 Category: Hematology Authors: Jernej Pajek, Radoslav Kveder, Andrej Guček, Andrej [Scaron]koberne, Andrej Bren, Maja Bučar, Darko Černe, Jana Lukač-Bajalo Source Type: journals

Effects of Dialysis Purity on Uremic DyslipidemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dyslipidemia, a prominent feature of end-stage renal disease, is considered a risk factor for premature atherosclerosis in hemodialysis (HD) patients. Dyslipidemia is related to loss of kidney function as well as use of low-flux cellulosic dialyzer membranes, but the effects of dialysate purity are unknown. Forty-eight incident HD patients started high-flux polysulfone maintenance HD, either with conventional (potentially contaminated) or with on-line produced ultrapure dialysate. The quality of the dialysis fluid (CFU/mL, endotoxin concentration), markers of inflammation (C-reactive protein, Il-6), and parameters of the l...
Source: Therapeutic Apheresis and Dialysis - August 10, 2009 Category: Hematology Authors: Helmut Schiffl, Susanne M Lang Source Type: journals

Low-Density Lipoprotein Apheresis Decreases Ferritin, Transferrin and Vitamin B12, Which May Cause Anemia in Serially Treated PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical observations revealed an increased prevalence of iron deficiency anemia without chronic bleeding in patients treated with serial low-density lipoprotein (LDL) apheresis. Since several different proteins are adsorbed by LDL apheresis beside pro-atherogenic lipoproteins, we examined the modification of the full blood count, plasma iron, vitamin B12, folic acid, and hemolysis by LDL apheresis. Nineteen patients (55 (50[ndash]59) years, 4 female, 15 male) undergoing chronic LDL apheresis due to mixed dyslipidemia (N = 17), homozygous familiar hypercholesterolemia (N = 1) or isolated elevated lipoprotein(a) (N = 1) wer...
Source: Therapeutic Apheresis and Dialysis - August 10, 2009 Category: Hematology Authors: Carsten P Bramlage, Victor W Armstrong, Antonia Zapf, Peter Bramlage, Gerhard A Mueller, Michael J Koziolek Source Type: journals

Apheresis Technologies and Clinical Applications: The 2007 International Apheresis RegistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The developments in apheresis technologies and techniques and their clinical applications worldwide are technologically, sociologically, and economically motivated. As in the past apheresis surveys, the statistics have highlighted both the differences by geographic region in clinical practice and in the type of technologies utilized. While a national view of apheresis is very important, an international view may be more representative overall of this therapeutic modality than national results that are highly dependent on the local economics and the available technologies. These regional differences have provided a basis fo...
Source: Therapeutic Apheresis and Dialysis - August 10, 2009 Category: Hematology Authors: Paul S Malchesky, Anna P Koo, Christine I Skibinski, Angela T Hadsell, Lisa A Rybicki Source Type: journals

Connective Tissue Growth Factor Knockdown Attenuated Matrix Protein Production and Vascular Endothelial Growth Factor Expression Induced by Transforming Growth Factor-β1 in Cultured Human Peritoneal Mesothelial CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests that downregulation of CTGF may represent a potential therapeutic approach for peritoneal fibrosis through decreasing ECM accumulation and angiogenesis. (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - July 16, 2009 Category: Hematology Authors: Li Xiao, Fu-You Liu, You-Ming Peng, Shao-Bin Duan Source Type: journals

15-Deoxy-Δ12,14-prostaglandin J2 Inhibits Angiotensin II-induced Fibronectin Expression via Hepatocyte Growth Factor Induction in Human Peritoneal Mesothelial CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
15-Deoxy-[Delta]12,14-prostaglandin J2 (15d-PGJ2) is an endogenous peroxisome proliferator-activated receptor [gamma] (PPAR[gamma]) agonist that suppresses progressive matrix deposition; however, little is known about the effects of 15d-PGJ2 on human peritoneal mesothelial cells (HPMCs). We investigated the following: (i) the expression of PPAR[gamma]; (ii) the effect of 15d-PGJ2 on angiotensin II (Ang II)-induced fibronectin (FN) expression and secretion; (iii) the effect of 15d-PGJ2 (with or without Ang II and with or without the specific PPAR[gamma] antagonist GW9662) and pioglitazone, a synthetic PPAR[gamma] agonist, o...
Source: Therapeutic Apheresis and Dialysis - July 16, 2009 Category: Hematology Authors: Yukio Yokoyama, Takao Masaki, Kei Kiribayashi, Ayumu Nakashima, Keiko Kokoroishi, Takahiko Ogawa, Nobuoki Kohno, Noriaki Yorioka Source Type: journals

Impact of Renal Survival on the Course and Outcome of Systemic Lupus Erythematosus Patients Treated With Chronic Peritoneal DialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This longitudinal study investigated whether renal survival can affect the course and outcome of systemic lupus erythematosus (SLE) patients treated with chronic peritoneal dialysis (PD). Thirty-five SLE patients, out of 1115 end-stage renal disease (ESRD) patients treated with chronic PD, were seen between 1990 and 2007 at the Chang Gung Memorial Hospital. Patients were followed up for a mean of 38.8 ± 22.9 months. There were no significant differences between patients with short renal survival (3 years) for the various demographic variables such as age, sex, PD duration, immunosuppressive drug administration, or exchang...
Source: Therapeutic Apheresis and Dialysis - July 16, 2009 Category: Hematology Authors: Chih-Chia Liang, Chiu-Ching Huang, I-Kuan Wang, Chiz-Tzung Chang, Kuan-Hsing Chen, Cheng-Hao Weng, Ja-Liang Lin, Cheng-Chieh Hung, Chih-Wei Yang, Tzung-Hai Yen Source Type: journals

Italian Multicenter Study on Low-Density Lipoprotein Apheresis: Retrospective Analysis (2007)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A retrospective study[mdash]the Italian Multicenter Study on Low-density Lipoprotein Apheresis (IMS-LDLa)[mdash]was carried out, which involved 19 centers for LDLa in Italy, distributed all over the country[mdash]in the north, center, south, and the major islands. The survey was conducted through two consecutive questionnaires, which can be downloaded online from a dedicated site. The total number of procedures performed until 2007 was 31 012, and the number of patients undergoing treatment until 2007 were 229. The treated patients still surviving consisted of 136 (74 males and 62 females); those surviving but not treated ...
Source: Therapeutic Apheresis and Dialysis - July 16, 2009 Category: Hematology Authors: Claudia Stefanutti Source Type: journals

Acute and Subacute Effect of Rheopheresis on Microvascular Endothelial Function in Patients Suffering From Age-related Macular DegenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was performed on seven patients affected by the atrophic form of age-related macular degeneration (AF-ARMD). The patients under investigation belonged to a larger study aimed at evaluating the efficacy of rheopheresis treatment (RT) on the visual function of AF-ARMD patients. Following the protocol of the larger study, patients received RT twice a week, every two weeks, for a total of ten treatments, as well as high-dose supplementation with zinc and vitamins A, E and beta-carotene. Recruited patients underwent skin laser Doppler flowmetry coupled with skin iontophoresis of the endothelium-dependent vasodilator ...
Source: Therapeutic Apheresis and Dialysis - July 16, 2009 Category: Hematology Authors: Marco Rossi, Rodolfo Puccini, Maria Chiara Romagnoli, Cinzia Di Maria, Paola Mattei, Matteo Bernini, Claudio Marconcini, Gino Santoro Source Type: journals

Liver Transplantation Avoided in Patients With Fulminant Hepatic Failure Who Received Albumin Dialysis With the Molecular Adsorbent Recirculating System While on the Waiting List: Impact of the Duration of TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eighteen patients with fulminant hepatic failure due to various medical causes were listed for emergency liver transplantation and treated with extracorporeal albumin dialysis sessions using the molecular adsorbent recirculating system (MARS) at our center over a 74-month period. Due to improvement of liver function, transplantation could be avoided in 9 patients (50%, 95% confidence interval 29% to 71%) who fully recovered afterwards. This improvement rate was higher than the rate of improvement in the French cohort of fulminant hepatic failure patients with similar etiologies (19.3%, 95% confidence interval 14.9% to 24.6...
Source: Therapeutic Apheresis and Dialysis - July 16, 2009 Category: Hematology Authors: Christophe Camus, Sylvain Lavoué, Arnaud Gacouin, Philippe Compagnon, Karim Boudjéma, Christian Jacquelinet, Rémi Thomas, Yves Le Tulzo Source Type: journals

One Year Efficacy and Safety of Lanthanum Carbonate for Hyperphosphatemia in Japanese Chronic Kidney Disease Patients Undergoing HemodialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides further evidence that the administration of LaC over a period of one year is safe and effective for the reduction of serum phosphate levels in CKD patients undergoing hemodialysis. (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - June 16, 2009 Category: Hematology Authors: Takashi Shigematsu Source Type: journals

Comparison of Different Low Density Lipoprotein Apheresis Machines on Brain Natriuretic Peptide Levels in Patients With Familial HypercholesterolemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, LDL apheresis therapy, possibly through its immediate improvement of vascular flow and/or removal of the peptide from plasma, results in a significant reduction of BNP levels. The increased reduction of BNP by HELP may result from its superior acute alterations of rheological markers. (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - June 15, 2009 Category: Hematology Authors: Patrick Moriarty, Rachel Sosland, Cheryl Gibson, John Belmont Source Type: journals

Poor Glycemic Control is a Significant Predictor of Cardiovascular Events in Chronic Hemodialysis Patients With DiabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We investigated the impact of glycemic control on the emergence of cardiovascular disease (CVD) in diabetic patients who were on maintenance hemodialysis in a prospective observational study. One hundred and thirty-four diabetic hemodialysis patients (63 ± 10 years-old, hemodialysis duration of 4.5 ± 3.9 years) at a single dialysis center were enrolled. The cohort was observed prospectively for 5 years, and the emergence of fatal and non-fatal CVD was recorded. Patients were categorized into two groups; good (mean hemoglobin (Hb) A1C (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - May 27, 2009 Category: Hematology Authors: Yoshihiro Tsujimoto, Eiji Ishimura, Hideki Tahara, Ryuusuke Kakiya, Hidenori Koyama, Masanori Emoto, Tetsuo Shoji, Masaaki Inaba, Hiroshi Kishimoto, Tsutomu Tabata, Yoshiki Nishizawa Source Type: journals

Planning a Social Activity to Improve Psychological Well-being and Quality of Life of Hemodialysis Patients: A Pilot StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We aimed to investigate the impact of social activity on anxiety-depression, self-esteem and quality of life in hemodialysis patients. Ninety-one patients were recruited to the current study. Of these, 31 patients wanted to take part in a theater play, while 60 patients (group C) did not. Thirty-one patients were randomly assigned to two groups: Group A (N = 15) started activities immediately and group B (N = 16) was assigned to a waiting list to be included in the activity of theater acting four months later. Beck Depression Inventory, Beck Anxiety Inventory, Rosenberg Self-esteem Scale and World Health Organization Quali...
Source: Therapeutic Apheresis and Dialysis - May 26, 2009 Category: Hematology Authors: Ozen Onen Sertoz, Gulay Ascı, Fatma Toz, Soner Duman, Hayriye Elbi, Ercan Ok Source Type: journals

Periodic Therapeutic Plasma Exchange in Patients With Moderate to Severe Chronic Myasthenia Gravis Non-Responsive to Immunosuppressive Agents: An Eight Year Follow-UpEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present our experience with periodic therapeutic plasma exchange (TPE), in 11 patients with MG resistant to intravenous immunoglobulin (IVIg) therapy, who had frequent relapses even whilst on high doses of immunosuppressive drugs, over a period of 8 years. All patients underwent TPE until control of their symptoms was achieved, and afterwards TPE sessions were continued periodically in an attempt to achieve remission of the disease, without immunosuppressant therapy. Two of the patients were progressively weaned off immunosuppressive agents, as well as TPE, and they are now symptom free. The other nine patients are stil...
Source: Therapeutic Apheresis and Dialysis - April 21, 2009 Category: Hematology Authors: Nik I Triantafyllou, Eirini Ioannis Grapsa, Evangelia Kararizou, Erasmia Psimenou, Antonios Lagguranis, Athanasios Dimopoulos Source Type: journals

A Case Report of Efficiency of Double Filtration Plasmapheresis in Treatment of Goodpasture's SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Goodpasture's syndrome is characterized by pulmonary hemorrhage, rapid progressive glomerulonephritis and the presence of anti-glomerular basement membrane (anti-GBM) antibodies. Here, we report a case of Goodpasture's syndrome that we treated with double filtration plasmapheresis (DFPP) combined with immunosuppression therapy. The patient was a 32-year-old man with the main complaints of low-grade fever, general fatigue and dyspnea. The clinical diagnosis was renal-pulmonary syndrome based on pulmonary hemorrhage on chest X-ray, rapid progressive renal insufficiency, and elevated C-reactive protein (CRP). Goodpasture's sy...
Source: Therapeutic Apheresis and Dialysis - April 21, 2009 Category: Hematology Authors: Nagasu Hajime, Abe Michiko, Kuwabara Atsunori, Kawai Tatsuo, Nishi Yuko, Okuda Naoki, Sakaguchi Katsuhiko Source Type: journals

Hemodialysis Versus Peritoneal Dialysis: A Case Control Study of Survival in Patients With Chronic Kidney Disease Stage 5Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is still controversial whether the mode of dialysis or preexisting comorbidities may influence the prognosis of patients with chronic kidney disease stage 5. Therefore, we performed a prospective case control study to evaluate whether the mode of dialysis may influence outcome. We found 25 cases on peritoneal dialysis (PD) treatment and 75 age and sex-matched controls on hemodialysis (HD) treatment for more than 3 months. Analysis was by intention-to-treat. During the follow up of 58 months, 6 out of 25 patients (24%) died in the PD group, whereas in the HD group 26 out of 75 patients (35%) died (relative risk 0.69 [95%...
Source: Therapeutic Apheresis and Dialysis - April 18, 2009 Category: Hematology Authors: Alexandra Maier, Franziska Stocks, Wolfgang Pommer, Walter Zidek, Martin Tepel, Alexandra Scholze Source Type: journals

Zinc Deficiency Anemia and Effects of Zinc Therapy in Maintenance Hemodialysis PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Quantitative adjuvant zinc therapy using polaprezinc was performed to examine the correlation between zinc concentration and anemia in maintenance hemodialysis patients to propose appropriate treatment. Anemia and serum zinc concentration were measured in 117 patients with chronic renal failure receiving outpatient maintenance hemodialysis at Tsuyama Chuo Kinen Hospital. Two bags of polaprezinc (containing zinc 34 mg/day) were administered to 58 patients with lower than normal zinc levels (Zn < 80 mg/dl) as adjuvant zinc therapy to assess anemia improvement. Zinc concentration and all anemia parameters showed significant p...
Source: Therapeutic Apheresis and Dialysis - April 17, 2009 Category: Hematology Authors: Tatsuo Fukushima, Hideyuki Horike, Shigeatsu Fujiki, Shingo Kitada, Tamaki Sasaki, Naoki Kashihara Source Type: journals

Efficacy of High-Throughput Leukocytapheresis for Rheumatoid Arthritis With a Reduced Response to InfliximabEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Infliximab (INF), a tumor necrosis factor-alpha (TNF-[alpha]) inhibitor, is an effective drug for patients with rheumatoid arthritis (RA). However, some patients receive no clinical benefit, or the agents gradually lose their effect. Five sessions of high-throughput leukocytapheresis (LCAP) were given at a frequency of once a week using a Cellsorba CS-180S to four patients with a reduced response to INF. The clinical response to LCAP was evaluated using the 28-joint disease activity score with C-reactive protein (DAS28-CRP) and with the erythrocyte sedimentation rate (DAS28-ESR). DAS28-CRP decreased significantly from 5.8 ...
Source: Therapeutic Apheresis and Dialysis - April 17, 2009 Category: Hematology Authors: Yukinao Sakai, Saori Sakai, Tomoyuki Otsuka, Dai Ohno, Tsuneo Murasawa, Kazuo Munakata, Kyoichi Mizuno Source Type: journals

C-C Chemokine Receptor 2 Expression by Circulating Monocytes Influences Atherosclerosis in Patients on Chronic HemodialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mortality from cardiovascular or cerebrovascular disease due to atherosclerosis is increased in patients on chronic hemodialysis. Monocyte chemoattractant protein-1 and its receptor, C-C chemokine receptor 2, play an important role in recruiting monocytes to atherosclerotic lesions. The relationship between atherosclerosis in hemodialysis patients and C-C chemokine receptor 2 expression is unknown. Fifty-six patients on chronic hemodialysis and 27 age- and sex-matched controls were enrolled. Serum levels of monocyte chemoattractant protein-1 and expression of C-C chemokine receptor 2 by circulating monocytes were determine...
Source: Therapeutic Apheresis and Dialysis - April 17, 2009 Category: Hematology Authors: Satoshi Okumoto, Yoshihiko Taniguchi, Ayumu Nakashima, Takao Masaki, Takafumi Ito, Takahiko Ogawa, Norihisa Takasugi, Nobuoki Kohno, Noriaki Yorioka Source Type: journals

Ionized Alkaline Water: New Strategy for Management of Metabolic Acidosis in Experimental AnimalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Metabolic acidosis can occur as a result of either the accumulation of endogenous acids or loss of bicarbonate from the gastrointestinal tract or the kidney, which represent common causes of metabolic acidosis. The appropriate treatment of acute metabolic acidosis has been very controversial. Ionized alkaline water was not evaluated in such groups of patients in spite of its safety and reported benefits. So, we aimed to assess its efficacy in the management of metabolic acidosis in animal models. Two models of metabolic acidosis were created in dogs and rats. The first model of renal failure was induced by ligation of both...
Source: Therapeutic Apheresis and Dialysis - April 17, 2009 Category: Hematology Authors: Hassan Abol-Enein, Osama A Gheith, Nashwa Barakat, Eman Nour, Abd-Elhameed Sharaf Source Type: journals

Target for Glycemic Control in Type 2 Diabetic Patients on Hemodialysis: Effects of Anemia and Erythropoietin Injection on Hemoglobin A1cEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In hemodialysis (HD) patients the glycated hemoglobin (HbA1c) level may underestimate glycemic control. The aim of this study is to estimate accurate glycemic control in type 2 diabetic patients on HD. Type 2 diabetes patients (N = 87) who had been receiving maintenance HD for at least one year were enrolled. HbA1c and the percentage of glycated albumin relative to total the serum albumin (%GA) were measured in blood samples and the factors that affected the %GA/HbA1c ratio were examined. There were significant and positive correlations between the plasma glucose and either the HbA1c levels (r = 0.539, P < 0.01) or the %GA...
Source: Therapeutic Apheresis and Dialysis - April 1, 2009 Category: Hematology Authors: Takashi Uzu, Tsuguru Hatta, Naoko Deji, Tamani Izumiya, Hisami Ueda, Itsuko Miyazawa, Masami Kanasaki, Keiji Isshiki, Toshiji Nishio, Tetsuro Arimura Tags: Original Articles Source Type: journals

Corporate SponsorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The ISFA wishes to acknowledge the following 2009 Corporate Sponsors (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - March 26, 2009 Category: Hematology Tags: Corporate Sponsors Source Type: journals

Upcoming MeetingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Therapeutic Apheresis and Dialysis - March 26, 2009 Category: Hematology Tags: Communications Source Type: journals

Standard on Microbiological Management of Fluids for Hemodialysis and Related Therapies by the Japanese Society for Dialysis Therapy 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Committee of Scientific Academy of the Japanese Society for Dialysis Therapy (JSDT) proposes a new standard on microbiological management of fluids for hemodialysis and related therapies. This standard is within the scope of the International Organization for Standardization (ISO), which is currently under revision. This standard is to be applied to the central dialysis fluid delivery systems (CDDS), which are widely used in Japan. In this standard, microbiological qualities for dialysis water and dialysis fluids are clearly defined by endotoxin level and bacterial count. The qualities of dialysis fluids were classifie...
Source: Therapeutic Apheresis and Dialysis - March 26, 2009 Category: Hematology Authors: Hideki Kawanishi, Takashi Akiba, Ikuto Masakane, Tadashi Tomo, Michio Mineshima, Tadayuki Kawasaki, Hideki Hirakata, Tadao Akizawa Tags: Clinical Treatment Guidelines Source Type: journals

Case Reports of the Use of Immunoadsorption or Plasma Exchange in High-risk Pregnancies of Women With Antiphospholipid SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conventional treatment of antiphospholipid syndrome (APS) pregnancies with aspirin and/or heparin is sometimes unable to counteract maternal and/or fetal complications. In this article we report the cases of two patients who were unresponsive to conventional treatment for APS during their first pregnancy, and who were treated in the following pregnancy with plasma exchange and immunoadsorption respectively, in addition to conventional therapy. Both patients had a history of thrombotic events, a previous pregnancy loss at the 11th week of gestation and the same antiphospholipid antibody profile (lupus anticoagulant activity...
Source: Therapeutic Apheresis and Dialysis - March 26, 2009 Category: Hematology Authors: Maria Bortolati, Piero Marson, Silvia Chiarelli, Tiziana Tison, Myriam Facchinetti, Maria Teresa Gervasi, Giustina De Silvestro, Amelia Ruffatti Tags: Case Reports, Clinical Treatment Guidelines and Protocols Source Type: journals

A Case Report of Successful Long-term Relapse Control by Protein-A Immunoadsorption in an Immunosuppressive-treated Patient With End-stage Renal Disease Due to Wegener's GranulomatosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A long-term female hemodialysis patient with end-stage renal disease due to Wegener's granulomatosis (WG) experienced a severe relapse when immunosuppressive therapy was switched from prednisone and cyclophosphamide to azathioprine maintenance therapy. Ten courses of protein A immunoadsorption therapy and switching immunosuppressive therapy to mycophenolate mofetil have proved to be very successful and free of side effects. The patient has fully recovered from all clinical WG symptoms and is still in remission ten months after the treatment. (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - March 26, 2009 Category: Hematology Authors: Michael Koch, Matthias Kohnle, Rudolf Trapp Tags: Case Reports, Clinical Treatment Guidelines and Protocols Source Type: journals

A Case Report of Amitriptyline Poisoning Successfully Treated With the Application of Plasma ExchangeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Amitriptyline is a very frequently prescribed antidepressant agent and is very often involved in attempted suicides. Amitriptyline intoxication necessitates primary therapeutic approaches that include gastric irrigation and recurrent administration of activated charcoal. In the case of pronounced anticholinergic findings, physostigmine is of proven benefit and hypertonic sodium bicarbonate can be used to shorten the QRS duration and AV interval. In cases of a comatosed state, hemoperfusion and plasma exchange can be used. In this case report we present a case of severe amitriptyline poisoning that we successfully managed w...
Source: Therapeutic Apheresis and Dialysis - March 26, 2009 Category: Hematology Authors: Burcu Belen, Alkim Akman, Nurullah Yüksel, Günter Dilsiz, Idil Yenicesu, Rana Olguntürk Tags: Case Reports, Clinical Treatment Guidelines and Protocols Source Type: journals

Granulocyte and Monocyte Adsorption Apheresis Therapy Modulates Monocyte-Derived Dendritic Cell Function in Patients With Ulcerative ColitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to elucidate the molecular mechanisms responsible for the therapeutic effects of granulocyte and monocyte adsorption apheresis (GMA). We investigated the alterations in circulating monocyte subsets and monocyte-derived dendritic cell (moDC) function after GMA therapy in ulcerative colitis (UC) patients. Eighteen patients with UC were enrolled: 14 patients were responders, and 4 patients were non-responders. Peripheral venous blood was obtained within 5 min before and 5 min after GMA therapy. Flow cytometric analysis for monocyte markers (CD14/CD16) was then performed. Monocyte-derived dendritic ce...
Source: Therapeutic Apheresis and Dialysis - March 26, 2009 Category: Hematology Authors: Yuko Iwakami, Atsushi Sakuraba, Toshiro Sato, Yasuhiro Takada, Motoko Izumiya, Hitoshi Ichikawa, Toshifumi Hibi Tags: Original Articles Source Type: journals

Single Lipoprotein Apheresis Session Improves Cardiac Microvascular Function in Patients With Elevated Lipoprotein(a): Detection by Stress/Rest Perfusion Magnetic Resonance ImagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, cardiac magnetic resonance imaging detects subtle treatment-related changes in regional myocardial perfusion in patients with elevated Lp(a) and coronary artery disease undergoing lipoprotein apheresis. (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - March 26, 2009 Category: Hematology Authors: Steffen Bohl, Ursula Kassner, Rahel Eckardt, Wolfgang Utz, Jacqueline Mueller-Nordhorn, Andreas Busjahn, Hans-Peter Thomas, Hassan Abdel-Aty, Reinhard Klingel, Santica Marcovina, Rainer Dietz, Elisabeth Steinhagen-Thiessen, Jeanette Schulz-Menger, Anja Vo Tags: Original Articles Source Type: journals

Low Density Lipoprotein Apheresis in Pediatric Patients With Homozygous Familial HypercholesterolemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, LDL apheresis, started under the age of eight years, combined with lipid-lowering drugs, provides a safe and effective lowering of the mean LDL-C levels in pediatric homozygous FH; and there are more problems with compliance for pediatric LDL apheresis than in the adult population. (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - March 26, 2009 Category: Hematology Authors: Mahmut Coker, Sema Kalkan Ucar, Damla Goksen Simsek, Sukran Darcan, Mustafa Bak, Sule Can Tags: Original Articles Source Type: journals

Malnutrition–Inflammation Complex Syndrome and Hepatitis C in Maintenance Hemodialysis PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Protein-energy malnutrition and inflammation are among the leading causes of poor outcome in hemodialysis patients. Hepatitis C virus (HCV) infection is accompanied by elevated proinflammatory mediators, also found in dialysis patients with malnutrition[ndash]inflammation complex syndrome. We aimed to study the rate and characteristics of malnutrition[ndash]inflammation complex syndrome (MICS) in hemodialysis patients, especially those with hepatitis C. The study included 147 patients (mean age 55.1 ± 12.9 years), 24.5% of whom were HCV-positive, undergoing adequate hemodialysis three times a week for the last 52.7 ± 52....
Source: Therapeutic Apheresis and Dialysis - March 26, 2009 Category: Hematology Authors: Vlastimir Vlatkovic, Jasna Trbojevic-Stankovic, Biljana Stojimirovic Tags: Original Articles Source Type: journals

Plasmapheresis and Intravenous Immunoglobulin in Early Antibody-Mediated Rejection of the Renal Allograft: A Single-Center ExperienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this retrospective single center study was to evaluate two different approaches to AMR. We retrospectively evaluated data files from 936 patients who had undergone renal transplantation in 2002[ndash]2006. In 2002[ndash]2003, patients with AMR were treated with five plasmapheresis sessions (PP group, N = 13), and in 2004[ndash]2006 they received five plasmapheresis session along with intravenous immunoglobulin 0.5 g/kg (PP+IVIg group, N = 11). Twelve months of follow-up data was analyzed. First year graft survival was significantly higher in the PP+IVIg group than in the PP group (90.9% vs. 46.2%; P = 0.04...
Source: Therapeutic Apheresis and Dialysis - March 26, 2009 Category: Hematology Authors: Janka Slatinska, Eva Honsova, Marcela Burgelova, Antonij Slavcev, Ondrej Viklicky Tags: Original Articles Source Type: journals

Risk Factors of Normal Ankle–Brachial Index and Low Toe–Brachial Index in Hemodialysis PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The prevalence of peripheral arterial occlusive disease is high in patients with terminal renal failure, and it is a major problem in those on dialysis. A low ankle[ndash]brachial index (ABI) suggests the presence of arterial stenotic lesions between the aorta and the ankle joint, while a low toe[ndash]brachial index (TBI) suggests stenotic lesions between the aorta and the toes. Therefore, a normal ABI ([ge]0.9) and a low TBI ( (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - March 26, 2009 Category: Hematology Authors: Satoshi Morimoto, Fumitaka Nakajima, Takatomi Yurugi, Tatsuyori Morita, Fusakazu Jo, Mitsushige Nishikawa, Toshiji Iwasaka, Kei Maki Tags: Original Articles Source Type: journals

Hypoglycemia in Diabetic Patients Undergoing Chronic HemodialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of our study was to determine if different hypoglycemic therapies are associated with more frequent episodes of hypoglycemia in diabetes patients undergoing long-term hemodialysis. We conducted a prospective cohort study that included 102 diabetes patients who were undergoing long-term hemodialysis. The frequency of symptomatic hypoglycemic episodes, intradialytic hypotension, antihypertension medication, hypoglycemic therapy regimens, dialysate contents, and laboratory data were reviewed. The duration of follow-up was three months. Fifty-four (52.9%) patients were categorized as hypoglycemic and 48 (47.1%) patient...
Source: Therapeutic Apheresis and Dialysis - March 26, 2009 Category: Hematology Authors: Chiao-Yin Sun, Chin-Chan Lee, Mai-Szu Wu Tags: Original Articles Source Type: journals

Corporate SponsorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The ISFA wishes to acknowledge the following 2009 Corporate Sponsors (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - March 9, 2009 Category: Hematology Tags: Corporate Sponsors Source Type: journals

Upcoming MeetingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Therapeutic Apheresis and Dialysis - March 9, 2009 Category: Hematology Tags: Communications Source Type: journals

A Case Report of a Bone Histomorphometrical Analysis After a Total ParathyroidectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A patient with secondary hyperparathyroidism (2° HPT) underwent a total parathyroidectomy (PTx) without autotransplantation and showed interesting changes in the morphology of his iliac bone before and after the surgery. A 70-year-old man had been on hemodialysis for chronic glomerulonephritis since 1987. He had been administered calcium carbonate 6.0 g daily to prevent reabsorption of phosphorus and alfacalcidol 1.0 µg three times weekly at the end of hemodialysis. In September 2000, his intact parathyroid hormone (iPTH; 1[ndash]84 PTH) was 610 pg/mL; therefore, from 2.5 µg to 10 µg 22-oxacalcitriol (maxacalcitol, a d...
Source: Therapeutic Apheresis and Dialysis - March 9, 2009 Category: Hematology Authors: Ibuki Yajima, Tatsuhiko Tanizawa, Noriyuki Yamamoto, Toyoshi Fukuda, Tokio Higashi, Sakuyoshi Tabata, Ryoji Yao, Hideyuki Yamato, Hisashi Murayama Tags: Case Reports, Clinical Treatment Guidelines and Protocols Source Type: journals

A Case Report of Darbepoetin Treatment in a Patient With Sickle Cell Disease and Chronic Renal Failure Undergoing Regular Hemodialysis Procedures That Induce a Dose-Dependent Extension of Blood Transfusion IntervalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this case, a female Nigerian patient suffered from sickle cell disease (SCD, hemoglobin SS)-induced chronic renal failure and was undergoing hemodialysis treatment. Due to SCD crisis and renal anemia the patient received regular blood transfusions when the hemoglobin concentration fell below 5.0 g/L. Blood transfusion associated iron-overload was noticed. To reduce the iron-overload side effects, we started an erythropoietin therapy (darbepoetin) to extend the blood transfusion interval, using 30[ndash]150 µg/week. As a result of our investigation we observed that darbepoetin can significantly extend blood transfusion ...
Source: Therapeutic Apheresis and Dialysis - March 9, 2009 Category: Hematology Authors: Volker Schettler, Eberhard Wieland Tags: Case Reports, Clinical Treatment Guidelines and Protocols Source Type: journals

A Case Report of Steroid-resistant Antineutrophil Cytoplasmic Antibody-related Vasculitis Successfully Treated by Mizoribine in a Hemodialysis PatientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mizoribine (MZR) has shown to be effective against antineutrophil cytoplasmic antibody (ANCA)-related vasculitis; however, no reports have described the successful treatment of steroid-resistant ANCA-related vasculitis with MZR in patients with renal insufficiency requiring hemodialysis. We herein report the case of a 39-year-old man undergoing hemodialysis in whom MZR successfully lowered the myeloperoxidase (MPO)[ndash]ANCA titer accompanied by remission of interstitial pneumonia, together with the pharmacokinetics of MZR. The patient developed severe renal insufficiency and interstitial pneumonia, and was started on hem...
Source: Therapeutic Apheresis and Dialysis - March 9, 2009 Category: Hematology Authors: Masaki Tokunaga, Masahito Tamura, Narutoshi Kabashima, Ryota Serino, Tatsuya Shibata, Mika Matsumoto, Tetsu Miyamoto, Mieko Miyazaki, Yumi Furuno, Shinji Fujimatsu, Toshiyuki Muta, Masaaki Takeuchi, Haruhiko Abe, Masahiro Okazaki, Yutaka Otsuji Tags: Case Reports, Clinical Treatment Guidelines and Protocols Source Type: journals

A Case Report of Successful Treatment With Plasma Exchange for Hemophagocytic Syndrome Associated With Severe Systemic Juvenile Idiopathic Arthritis in an Infant GirlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An infantile case of hemophagocytic syndrome (HPS) with systemic juvenile idiopathic arthritis (s-JIA), refractory to methylprednisolone pulse therapy and cyclosporine A administration, was successfully treated by plasma exchange. The patient was a one-year-old Japanese girl who had developed recurrent steroid-dependent signs, including fever, skin eruption, and hepatopathy, while in France, where she had been diagnosed as having s-JIA at eight months of age. As a high fever and rheumatoid rash were evident on arrival at our hospital, she was admitted and given intravenous methylprednisolone pulse therapy and cyclosporine ...
Source: Therapeutic Apheresis and Dialysis - March 9, 2009 Category: Hematology Authors: Hyogo Nakakura, Akira Ashida, Hideki Matsumura, Takuji Murata, Katsuyuki Nagatoya, Nobuhisa Shibahara, Toru Inoue, Hiroshi Tamai Tags: Case Reports, Clinical Treatment Guidelines and Protocols Source Type: journals

Hemofiltration With the Cascade System in an Experimental Porcine Model of Septic ShockEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to assess the technical feasibility of the Cascade system and to compare its hemodynamic impact to that of the standard HVHF system. Twenty sepsis-induced pigs were randomized in two groups: one group was hemofiltered with the standard HVHF system and the other with the Cascade system during a six-hour session. No technical problems were observed with the Cascade system during the experiment. At the end of the experiment, colloid requirements (989 ± 355 mL vs. 1913 ± 538 mL, P = 0.006), epinephrine requirements (0.82 ± 0.42 mg vs. 3.27 ± 3.02 mg, P < 0.001), lactic acidosis (pH = 7.33 ±...
Source: Therapeutic Apheresis and Dialysis - March 9, 2009 Category: Hematology Authors: Thomas Rimmelé, Pierre-François Wey, Nicolas Bernard, Mehran Monchi, Nicolas Semenzato, Farida Benatir, Emmanuel Boselli, Jérôme Etienne, Joëlle Goudable, Dominique Chassard, Giampiero Bricca, Bernard Allaouchiche Tags: Original Articles Source Type: journals

On-line Hemodiafiltration in Southeast Asia: A Three-year Prospective Study of a Single CenterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our three-year experience showed that on-line HDF is a well-tolerated treatment with a lower incidence of intradialytic undesired events. The potential benefits may include the effective removal of higher molecular weight uremic toxins and an improved nutritional status, along with a low inflammatory state. (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - March 9, 2009 Category: Hematology Authors: Khajohn Tiranathanagul, Kearkiat Praditpornsilpa, Pisut Katavetin, Nattachai Srisawat, Natavudh Townamchai, Paweena Susantitaphong, Kriang Tungsanga, Somchai Eiam-Ong Tags: Original Articles Source Type: journals

Regulatory Effect of Parathyroid Hormone on sRANKL-Osteoprotegerin in Hemodialysis Patients With Renal Bone DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the observation that PTH favors RANKL and inhibits OPG production was only demonstrated in the serum of hemodialysis patients in a low turnover state. The positive correlation between serum OPG and iPTH in normal or high turnover rates implies a homeostatic mechanism to limit bone resorption, probably associated with skeletal resistance to PTH. (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - March 9, 2009 Category: Hematology Authors: Konstantinos Doumouchtsis, Despoina Perrea, Stergios Doumouchtsis, Marios Tziamalis, Maria Poulakou, Ioannis Vlachos, Alkis Kostakis Tags: Original Articles Source Type: journals