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Hemostasis and inflammation: two of a kind?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hemostasis is a defense mechanism to stop bleeding. Activated by vessel wall injury, it consists of intertwined activation of platelets and the coagulation cascade, tightly controlled by natural anticoagulants and the fibrinolytic system. Inflammation aims at restoring the integrity of damaged or threatened tissues, most frequently because of injury or infectious pathogens. Both are intimately coupled. (Source: Thrombosis Journal)
Source: Thrombosis Journal - November 18, 2009 Category: Hematology Authors: Peter VerhammeMarc Hoylaerts Source Type: journals

Application of basic and composite Thrombelastography parameters in monitoring of the antithrombotic effect of the low molecular weight heparin dalteparin: An in vivo study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The TEG reaction time R and TDR are the most suitable TEG parameters for evaluation of the antithrombotic effect of dalteparin with a highly significant correlation with antiXa levels in healthy male volunteers. Measures for uniform clinical use of these parameters are proposed. Larger clinical trials are needed to correlate R and TDR with clinical outcomes. (Source: Thrombosis Journal)
Source: Thrombosis Journal - November 10, 2009 Category: Hematology Authors: Ramin ArtangNiels FrandsenJorn Dalsgaard Nielsen Source Type: journals

Annexin V and anti-Annexin V Antibodies: two interesting aspects in acute myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings suggest that low plasma ANV levels along with positive aANVAs tests in patients with AMI are indicative of hypercoagulable state that is not related to the traditional cardiovascular risk factors. (Source: Thrombosis Journal)
Source: Thrombosis Journal - July 20, 2009 Category: Hematology Authors: Mohammad ShojaieAbdoreza SotoodahShohre RoozmehEnsieh KholoosiSamira Dana Source Type: journals

The impact of platelet function or C-reactive protein, on cardiovascular events after an acute myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In patients with myocardial infarction, measured peak CRP is associated with new cardiovascular events. Despite an association with peak CRP neither more pronounced platelet aggregation nor PFA-100 closure times independently predict new cardiovascular events. (Source: Thrombosis Journal)
Source: Thrombosis Journal - July 6, 2009 Category: Hematology Authors: Angelo ModicaFredrik KarlssonThomas Mooe Source Type: journals

Plasma TF activity predicts cardiovascular mortality in patients with acute myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objectives and Background: Tissue factor (TF) contributes to thrombosis following plaque disruption in acute coronary syndromes (ACS). Aim of the study was to investigate the impact of plasma TF activity on prognosis in patients with ACS.Methods and Results: 174 patients with unstable Angina pectoris (uAP) and 112 patients with acute myocardial infarction (AMI) were included with a mean follow up time of 3.26 years. On admission, plasma TF activity was assessed. Patients were categorized into 2 groups: a high-TF activity group with TF >24 pmol/L and low TF activity group with TF (Source: Thrombosis Journal)
Source: Thrombosis Journal - July 1, 2009 Category: Hematology Authors: Birgit SteppichSiegmund Lorenz BraunAndreas SteinGabriele DemetzPhilip GrohaAlbert SchomigNicolas von BeckerathAdnan KastratiIlka Ott Source Type: journals

Plasma fibrinolysis is related to the degree of organ dysfunction but not to the concentration of von Willebrand Factor in critically ill patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Endothelial cell dysfunction, by promoting fibrin deposition, has been implicated in the development of multiple organ failure. Altered fibrinolysis during inflammation may participate in microvascular alterations. We sought to determine whether plasma fibrinolysis was related to the severity of organ dysfunction and/or to the levels of von Willebrand factor (vWF antigen), as a marker of endothelium dysfunction, in critically ill patients. Methods: Forty-nine consecutive patients admitted to an adult medico-surgical intensive care unit (ICU) with (18) or without sepsis (31) were included. C-reactive protein and...
Source: Thrombosis Journal - June 18, 2009 Category: Hematology Authors: Karim Zouaoui BoudjeltiaSandra OllieuzMichael PiagnerelliPatrick BistonPhilippe CauchieJean-Louis VincentDany BroheeMichel Vanhaeverbeek Source Type: journals

Thrombotic genetic risk factors and warfarin pharmacogenetic variants in Sao Miguel's healthy population (Azores)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The Azorean population presents the highest standardized mortality rate for cardiovascular diseases (CVD) when compared to mainland Portugal and other populations. Since thrombosis is a common cause of CVD, we assessed four polymorphisms in three thrombotic risk genes - F5 (G1691A), F2 (G20210A) and MTHFR (C677T, A1298C), in 469 healthy blood donors from Sao Miguel Island (Azores). We also analysed the CYP2C9 (C430T, A1075C) and VKORC1 (G1639A) variants in fifty-eight individuals with predisposition to thrombosis (possessing at least one variation in F5 or F2 genes and one in MTHFR) to evaluate their warfarin d...
Source: Thrombosis Journal - June 17, 2009 Category: Hematology Authors: Claudia BrancoTania PereirinhaRita CabralPaula PachecoLuisa Mota-Vieira Source Type: journals

Aminaphtone in the control of Schamberg's DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a case of a 28-year-old patient who presented with multiple purpuric lesions on the lower extremities which appeared spontaneously. A biopsy of the skin was then performed that showed a perivascular T-cell lymphocytic infiltrate is centered on the superficial small blood vessels of the skin and so the hypothesis of Schamberg's disease was reached. The patient started to use corticoids which controlled the appearance of lesions however on suspension of the medication the lesions reappeared in three days to one week. The attempt to control with corticoids was made during more than one year without success. Anoth...
Source: Thrombosis Journal - June 11, 2009 Category: Hematology Authors: Jose Maria Pereira de GodoyBatigalia Fernando Source Type: journals

Delayed formation of pulmonary artery stump thrombus: a case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 68 year-old man who presented with chest pain nearly ten years after undergoing a right pneumonectomy for lung cancer. Workup identified a pulmonary artery stump thrombosis. Due to the acute onset of his symptoms, the patient was anticoagulated, and his chest pain resolved. While the literature suggests that anticoagulation is not generally required for stump thromboses, we highlight features of this case that may indicate an increased risk of clinically important sequelae. Taking previous reports into account, we argue that a specific subset of patients with stump thrombosis may benefit from system...
Source: Thrombosis Journal - June 10, 2009 Category: Hematology Authors: Monika JoshiUmar FarooqSandeep MehrokNadine Srouji Source Type: journals

Clopidogrel resistance "Live" - the risk of stent thrombosis should be evaluated before proceduresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Every year, millions of people undergo percutaneous coronary intervention (PCI) with intracoronary stent implantation. A patient from the PRAGUE-8 trial (Optimal pre-PCI clopidogrel loading: 600mg before every coronary angiography vs. 600mg in the cath-lab only for PCI patients) is described who suffered from acute stent thrombosis. This patient did not have any relevant inhibition of platelet activation even after the 600mg dose of clopidogrel. Dose uptitration would have been ineffective. New P2Y12 receptor inhibitors are desperately needed. In the light of recently published data, the use of prasugrel may be considered ...
Source: Thrombosis Journal - May 19, 2009 Category: Hematology Authors: Zuzana Motovska, Petr Widimsky, Iuri Marinov, Robert Petr, Jaroslava Hajkova, Jan Kvasnicka and Prague-8 study Investigators Source Type: journals

Acute myocardial infarction and pulmonary embolism in a young man with pernicious anemia-induced severe hyperhomocysteinemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 27 year-old man who presented to the hospital with progressive lower extremity weakness, developed an acute ST elevation myocardial infarction on his second hospital day. Primary angioplasty to the left anterior descending coronary artery was performed. Due to persistent dyspnea, the patient underwent a diagnostic chest computed tomography which confirmed multiple small pulmonary emboli. Laboratory analysis revealed a megaloblastic anemia with a reduced vitamin B12 level and positive titers for antibodies against intrinsic factor, establishing a diagnosis of pernicious anemia. Screening for hypercoaguable markers documen...
Source: Thrombosis Journal - May 13, 2009 Category: Hematology Authors: Ayyash Melhem, Ankit Desai and Marion A Hofmann Source Type: journals

Comparison of VerifyNow-P2Y12 test and Flow Cytometry for monitoring individual platelet response to clopidogrel. What is the cut-off value for identifying patients who are low responders to clopidogrel therapy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In conclusion our findings show that a cut-off value of [less than or equal to] 15% inhibition in the VerifyNow-P2Y12test may provide the best accuracy for the identification of patients with LR. (Source: Thrombosis Journal)
Source: Thrombosis Journal - May 6, 2009 Category: Hematology Authors: Cosmo Godino, Loredana Mendolicchio, Filippo Figini, Azeem Latib, Andrew SP Sharp, John Cosgrave, Giliola Calori, Michela Cera, Alaide Chieffo, Alfredo Castelli, Attilio Maseri, Zaverio M Ruggeri and Antonio Colombo Source Type: journals

Editorial on hypothesis and objectives in clinical trials: superiority, equivalence and non-inferiorityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Randomized clinical trial is often considered as the Gold Standard method for comparing treatment effects. In practice, taking into consideration their main objectives, the majority of clinical trials are aimed to establish the superiority of an intervention regarding to an active control or placebo. But neither equivalence nor non-inferiority should be from definitively concluded from superiority trials exhibiting non-significant results.To evaluate equivalence or non-inferiority between treatments, specific trials should be designed. These designs have strengths and weaknesses dicussed in this Editorial. In spite of the ...
Source: Thrombosis Journal - March 21, 2009 Category: Hematology Authors: Claudio D Gonzalez, Ricardo Bolaños and Martha de Sereday Source Type: journals

Mild hypothermia does not attenuate platelet aggregation and may even increase ADP-stimulated platelet aggregation after clopidogrel treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Mild hypothermia did not attenuate platelet aggregation, instead it even increased ADP-stimulated platelet aggregation after clopidogrel treatment. Dual platelet inhibition with aspirin and a P2Y12 receptor antagonist is probably needed for patients with acute coronary syndromes treated with mild hypothermia, and it is possible that future ADP blockers could be of benefit. (Source: Thrombosis Journal)
Source: Thrombosis Journal - February 23, 2009 Category: Hematology Authors: Carl Hogberg, David Erlinge and Oscar O Braun Source Type: journals

Non ST-segment Elevation Myocardial Infarction in Patient with Essential ThrombocythemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 68-year-old woman presented with acute chest pain and a greatly increased platelet count. Cardiac catheterization revealed subtotal occlusion and a thrombus-like filling defect in the right coronary artery. The patient was successfully treated with intravenous tirofiban. Essential thrombocythemia was diagnosed based on bone marrow findings, clinical presentation and laboratory analysis. The relationship between intracoronary thrombus and essential thrombocythemia is discussed. (Source: Thrombosis Journal)
Source: Thrombosis Journal - February 20, 2009 Category: Hematology Authors: Emin Alioglu, Nurullah Tuzun, Fahri Sahin, Buket Kosova, Serkan Saygi, Istemihan Tengiz, Ugur O Turk, Nazan Ozsan and Ertugrul Ercan Source Type: journals

Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac deathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results suggest that the allelic variants (SREBF-2 1784G>C and SCAP 2386A>G) in the cholesterol homeostasis regulating SREBF-SCAP pathway may contribute to SCD in early middle-aged men. (Source: Thrombosis Journal)
Source: Thrombosis Journal - December 30, 2008 Category: Hematology Authors: Yue-Mei Fan, Pekka J Karhunen, Mari Levula, Erkki Ilveskoski, Jussi Mikkelsson, Olli A Kajander, Otso Järvinen, Niku Oksala, Janita Thusberg, Mauno Vihinen, Juha-Pekka Salenius, Leena Kytömäki, Juhani T Soini, Reijo Laaksonen and Terho Lehtimäki Source Type: journals

Expression of sterol regulatory element binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac deathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results suggest that the allelic variants (SREBF-2 1784G>C and SCAP 2386A>G) in the cholesterol homeostasis regulating SREBF-SCAP pathway may contribute to SCD in early middle-aged men. (Source: Thrombosis Journal)
Source: Thrombosis Journal - December 30, 2008 Category: Hematology Authors: Yue-Mei Fan, Pekka J Karhunen, Mari Levula, Erkki Ilveskoski, Jussi Mikkelsson, Olli A Kajander, Otso Jarvinen, Niku Oksala, Janita Thusberg, Mauno Vihinen, Juha-Pekka Salenius, Leena Kytomaki, Juhani T Soini, Reijo Laaksonen and Terho Lehtimaki Source Type: journals

Human Activated Protein C Variants in a Rat model of Arterial ThrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In conclusion, administration of human APC variants having enhanced anticoagulant efficacy together with human PS in a rat model of arterial thrombosis did not give an efficient antithrombotic effect. The lack of effect may be due to species-specific differences between the human protein C system and the rat hemostatic system. (Source: Thrombosis Journal)
Source: Thrombosis Journal - October 29, 2008 Category: Hematology Authors: Karl Malm, Bjorn Arnljots and Bjorn Dahlback Source Type: journals

Clinical factors influencing normalization of prothrombin time after stopping warfarin: a retrospective cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Baseline INR, but not the size of the maintenance dose, is associated with the rate of normalization of prothrombin time after stopping warfarin, but it has limited utility as predictor in clinical practice. Whenever normal hemostasis is considered crucial for the safety, the INR should be checked again before the invasive procedure. (Source: Thrombosis Journal)
Source: Thrombosis Journal - October 16, 2008 Category: Hematology Authors: Sam Schulman, Rajae Elbazi, Michelle Zondag and Martin O'Donnell Source Type: journals

A new method to determine tissue specific tissue factor thrombomodulin activities: endotoxin and particulate air pollution induced disbalance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to assess the consequences of inflammation-driven organ specific functional properties of the procoagulant response. Methods: Addition of lung from untreated animals to human plasma suppressed the endogenous thrombin potential (ETP) (175+/-61 vs. 1437+/-112 nM.min for control). This inhibitory effect was due to TM, because a) it was absent in protein C deficient plasma and b) lungs from TMpro/pro mice allowed full thrombin generation (ETP: 1686+/-209 nM.min). The inhibitory effect of TM was lost after lipopolysaccharide (LPS) administration to mice, which induced TF activity in lungs of C57Bl/6 mice...
Source: Thrombosis Journal - October 1, 2008 Category: Hematology Authors: Kim Frederix, Ingeborg M Kooter, Rene van Oerle, Diane Fens, Karly Hamulyak, Miriam E Gerlofs-Nijland, Hugo ten Cate and Henri MH Spronk Source Type: journals

Prevention and treatment of venous thromboembolism with low-molecular-weight heparins: clinical implications of the recent European guidelinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Venous thromboembolism (VTE) is an important cause of avoidable morbidity and mortality. However, routine prophylaxis for at-risk patients is underused. Recent guidelines issued by an international consensus group, including the International Union of Angiology (IUA), recommend use of low-molecular-weight heparins (LMWHs) for the treatment of acute VTE and prevention of recurrence, and for prophylaxis in surgical and medical patients. This review highlights current inadequacies in the provision of thromboprophylaxis, and considers the clinical implications of the European guidelines on the prevention and treatment of VTE. ...
Source: Thrombosis Journal - September 9, 2008 Category: Hematology Authors: Paolo Prandoni Source Type: journals

Use of rosiglitazone before and after vascular injury in hypercholesterolemic rabbits: assessment of neointimal formation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Pretreatment with rosiglitazone in hypercholesterolemic rabbits submitted to vascular injury significantly reduces neointimal formation. (Source: Thrombosis Journal)
Source: Thrombosis Journal - August 27, 2008 Category: Hematology Authors: Alexandre Alessi, Olimpio RIBEIRO Franca Neto, Paulo ROBERTO SLUD Brofman, Camila Prim, Lucia Noronha, Ruy FERNANDO KUENZER CAETANO Silva, Liz ANDREA VILLELA Baroncini and Dalton BERTOLIM Precoma Source Type: journals

Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study demonstrates that inflammatory gene SNPs are associated with early-onset ischemic stroke among African-American women (IL6) and that cigarette smoking may modulate stroke risk through a gene-environment interaction (IL6 and CD14). Our finding replicates a prior study showing an interaction with smoking and the C allele of CD14 SNP rs2569190. (Source: Thrombosis Journal)
Source: Thrombosis Journal - August 26, 2008 Category: Hematology Authors: John W Cole, David W Brown, Wayne H Giles, Oscar C Stine, Jeffrey R O'Connell, Braxton D Mitchell, John D Sorkin, Marcella A Wozniak, Barney J Stern, Mary J Sparks, Mark T Dobbins, Latasha T Shoffner, Nancy K Zappala, Laurie J Reinhart and Steven J Kittne Source Type: journals

Risk of myocardial infarction and overall mortality in survivors of venous thromboembolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Venous thromboembolism (VTE) and thromboembolic arterial diseases are usually considered to be distinct entities, but there is evidence to suggest that these disorders may be linked. The aim of this study was to determine whether a diagnosis of VTE increases the long-term risk of myocardial infarction (MI). The incidence rate (IR) and relative risk (RR) of MI in a cohort of patients with a diagnosis of VTE (n = 4890) compared with that of a control cohort without prior VTE (n = 43 382) were evaluated in the UK General Practice Research Database (GPRD). Death during follow-up was also determined. Patients were followed for ...
Source: Thrombosis Journal - August 18, 2008 Category: Hematology Authors: Consuelo Huerta, Saga Johansson, Mari-Ann Wallander and Luis Alberto Garcia Rodriguez Source Type: journals

Successful management of acute thromboembolic disease complicated with Heparin induced Thrombocytopenia type II (HIT II): a case seriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present two cases with massive pulmonary embolism and HIT, successfully treated with the administration of fondaparinux, an alternative anticoagulant, combined with the insertion of an inferior vena cava filter for the prevention of new thromboembolic events. The two cases supplement the available data of the use of fondaparinux in patients with HIT and pulmonary embolism, before further large studies establish its efficacy and safety in this group of patients. Moreover, the management of these patients reveals the need for future evaluation of the combined therapy of alternative anticoagulant agents with the placement ...
Source: Thrombosis Journal - July 2, 2008 Category: Hematology Authors: Eva Serasli, Maria Antoniadou, Venetia Tsara, Vasilis Kalpakidis, Angelos Megalopoulos, George Trellopoulos, Georgia Papaioannou and Pandora Christaki Source Type: journals

Venous thromboembolism prevention post neck of femur fractures - does it make a difference?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neck of femur fractures predispose patients to venous thromboembolism (VTE). NICE has issued guideline 46 to reduce this risk through the use of antithrombic agents. We audited our department's VTE practise by reviewing the clinical notes of 123 consecutive patients with no exclusions. We found our compliance to be a low 6%. We also found that patients were likely to be given low molecular heparin (LMWH) only during their hospital stay. Reasons for the low adherence were probably secondary to confusion caused by the multiple thromboprophylaxis protocols used in our department. The correlation between duration of heparin ad...
Source: Thrombosis Journal - June 26, 2008 Category: Hematology Authors: Radwane Faroug, Shireesha Konnuru, San S Min, Fazleenah Hussain and George Ampat Source Type: journals

Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: CYP2C9 and VKORC1 genotype frequencies in myocardial infarction patients appear similar to other patient groups and have similar impact on warfarin maintenance dose. (Source: Thrombosis Journal)
Source: Thrombosis Journal - June 17, 2008 Category: Hematology Authors: Kari Bente Foss Haug, Mohammad N Sharikabad, Marianne K Kringen, Sigrid Narum, Stine T Sjaatil, Per Wiik Johansen, Peter Kierulf, Ingebjorg Seljeflot, Harald Arnesen and Odd Brors Source Type: journals

Examining warfarin underutilization rates in patients with atrial fibrillation: Detailed chart review essential to capture contraindications to warfarin therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Consistent with previous reports, 45.4% of patients in this atrial fibrillation cohort were not prescribed warfarin. However, after reviewing medical charts for documented reasons why warfarin was not used, the inappropriate underutilization rate was only 7.1%. These findings suggest that studies utilizing administrative database and ICD-9 CM coding might overestimate warfarin underutilization. (Source: Thrombosis Journal)
Source: Thrombosis Journal - June 3, 2008 Category: Hematology Authors: Ajay Srivastava, Michael Hudson, Ihab Hamoud, Joao Cavalcante, Chetan Pai and Scott Kaatz Source Type: journals

The value of D-dimer in the detection of early deep-vein thrombosis after total knee arthroplasty in Asian patients: a cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: High plasma D-dimer level is a moderately sensitive, but less specific marker in the detection of early of DVT after TKA. Measurement of serum D-dimer alone is not accurate enough to detect DVT after TKA. Venography is recommended in patients with elevated D-dimer and clinically suspected but asymptomatic DVT after TKA. (Source: Thrombosis Journal)
Source: Thrombosis Journal - May 28, 2008 Category: Hematology Authors: Chung-Jen Chen, Ching-Jen Wang and Chung-Cheng Huang Source Type: journals

Effects of rosiglitazone on contralateral iliac artery after vascular injury in hypercholesterolemic rabbits.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings demonstrate that rosiglitazone given for 6 weeks did not prevent atherogenesis at a vessel distant from the injury site. (Source: Thrombosis Journal)
Source: Thrombosis Journal - May 16, 2008 Category: Hematology Authors: Olimpio RIBEIRO Franca, Dalton BERTOLIM Precoma, Alexandre Alessi, Camila Prim, Ruy FERNANDO KUENZER CAETANO Silva, Lucia Noronha and Liz ANDREA VILLELA Baroncini Source Type: journals

Pleural mesothelioma and venous thrombosis: the eosinophilia linkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a patient with mesothelioma who developed peripheral blood eosinophilia followed by deep vein thrombosis despite being on low molecular weight heparin prophylaxis. We discuss the genesis of peripheral blood eosinophilia and thrombosis in pleural mesothelioma. (Source: Thrombosis Journal)
Source: Thrombosis Journal - April 28, 2008 Category: Hematology Authors: Paul Richard JULIAN Ames and Win WIN Aye Source Type: journals

Stroke in inflammatory bowel disease: a report of two cases and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thrombosis is a recognised complication of inflammatory bowel disease (IBD), in particular venous thrombosis. Arterial thrombosis, especially stroke is rare. There is a paucity of information regarding stroke in IBD and its management. The authors describe two cases of stroke in patients with IBD during periods of increased disease activity. The literature regarding this devastating complication and the procoagulant state that exists in IBD is reviewed. (Source: Thrombosis Journal)
Source: Thrombosis Journal - March 21, 2008 Category: Hematology Authors: Deepak Joshi, Tobias Dickel, Rakesh Aga and Gray Smith-Laing Source Type: journals

Point-of-care platelet function assays demonstrate reduced responsiveness to clopidogrel, but not aspirin, in patients with Drug-Eluting Stent Thrombosis whilst on dual antiplatelet therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study demonstrates reduced platelet response to clopidogrel in some patients with DES ST compared to matched controls. The availability of point-of-care assays that can detect these responses raises the possibility of prospectively identifying DES patients at risk of ST and manipulating their subsequent risk. (Source: Thrombosis Journal)
Source: Thrombosis Journal - February 29, 2008 Category: Hematology Authors: Alex R Hobson, Graham Petley, Geraint Morton, Keith D Dawkins and Nick P Curzen Source Type: journals

Percutaneous mechanical thrombectomy for the treatment of acute massive pulmonary embolism: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We illustrate here that percutaneous mechanical thrombectomy can be a safe and effective method of treating massive pulmonary embolism when thrombolysis is relatively contraindicated. It may also be of use as an adjuvant therapy in those patients able to receive thrombolysis. In the future further evaluation involving a larger cohort of subjects is necessary to determine whether this treatment is superior to surgical embolectomy when thrombolysis cannot be performed. (Source: Thrombosis Journal)
Source: Thrombosis Journal - December 18, 2007 Category: Hematology Authors: Aung Myat and Arif Ahsan Source Type: journals

Effect of PlA1/A2 glycoprotein IIIa gene polymorphism on the long-term outcome after successful coronary stentingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The GP IIIa PlA1/A2 polymorphism does not influence the clinical long-term outcome in patients with symptomatic coronary disease undergoing percutaneous coronary intervention with stent implantation. (Source: Thrombosis Journal)
Source: Thrombosis Journal - November 16, 2007 Category: Hematology Authors: Claire Le Hello, Remy Morello, Agnes Lequerrec, Christine Duarte, John Riddell and Martial Hamon Source Type: journals

An unusual case of peripartum cardiomyopathy manifesting with multiple thrombo-embolic phenomena.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an unusual case of PPCM in a previously healthy postpartum woman who presented with an acute abdomen due to unrecognized thromboemboli of the abdominal organs. This case illustrates that abdominal pain in PPCM may not always result from hepatic congestion as previously reported, but may occur as a result of thromboemboli to abdominal organs. Further research is needed to determine the true incidence of thromboemboli in PPCM. (Source: Thrombosis Journal)
Source: Thrombosis Journal - October 29, 2007 Category: Hematology Authors: Uzoma N Ibebuogu, John W Thornton and Guy L Reed Source Type: journals

The 5, 10 methylenetetrahydrofolate reductase C677T mutation and risk of fetal loss: a case series and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We provide evidence to support the relationship between MTHFR C677T mutations and recurrent fetal loss, and to suggest that anticoagulation of these patients during pregnancy can lead to a successful pregnancy outcome. (Source: Thrombosis Journal)
Source: Thrombosis Journal - October 17, 2007 Category: Hematology Authors: Ivy Altomare, Alan Adler and Louis M Aledort Source Type: journals

Influenza infection and risk of acute pulmonary embolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this clinical study, influenza infection was not associated with an increased risk of acute pulmonary embolism. The ILI score is non-specific in this clinical setting. (Source: Thrombosis Journal)
Source: Thrombosis Journal - October 16, 2007 Category: Hematology Authors: Matthijs van Wissen, Tymen T Keller, Brechje Ronkes, Victor EA Gerdes, Hans L Zaaijer, Eric CM van Gorp, Dees PM Brandjes, Marcel Levi and Harry R Buller Source Type: journals

Dual antiplatelet therapy and drug eluting stents: a marriage of convenienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This is an editorial. No abstract or subheadings are provided (Source: Thrombosis Journal)
Source: Thrombosis Journal - October 1, 2007 Category: Hematology Authors: Juan Benezet-Mazuecos, Borja Ibanez and Juan J Badimon Source Type: journals

Relationship between ABO blood groups and von Willebrand factor levels: from biology to clinical implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although a number of studies have demonstrated the influence of ABO blood group on plasma levels of von Willebrand factor (VWF), the nature of this association and its clinical importance is still largely unknown. In this review, the most recent advances in our understanding of the mechanisms by which ABO blood group determines plasma VWF levels and their clinical impact will be discussed. (Source: Thrombosis Journal)
Source: Thrombosis Journal - September 25, 2007 Category: Hematology Authors: Massimo Franchini, Franco Capra, Giovanni Targher, Martina Montagnana and Giuseppe Lippi Source Type: journals

Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole bloodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of septic patients. There are indications, that fever reduces the mortality of sepsis, the effect on tissue factor activity on monocytes is unknown. Therefore, we investigated whether heat shock modulates LPS-induced tissue factor activity in human blood. Methods: Whole blood samples and leukocyte suspensions, respectively, from healthy probands (n=12) were incubated with LPS for 2 hours under heat shock condi...
Source: Thrombosis Journal - September 24, 2007 Category: Hematology Authors: Christoph Sucker, Kai Zacharowski, Matthias Thielmann and Matthias Hartmann Source Type: journals

Combining Taipan snake venom time/Ecarin time screening with the mixing studies of conventional assays increases detection rates of lupus anticoagulants in orally anticoagulated patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Addition of TSVT/ET screening for LA in orally anticoagulated patients could increase diagnostic efficacy either by detecting antibodies diluted in the mixing tests of conventional assays or those that do not react in DRVVT or DAPTT. Additionally, TSVT/ET can affirm the presence of a LA where conventional assay mixing tests may not have fully counteracted the oral anticoagulant effect but confirmatory test correction suggests the presence of a LA. (Source: Thrombosis Journal)
Source: Thrombosis Journal - September 6, 2007 Category: Hematology Authors: Gary W Moore Source Type: journals

Antithrombotic prevention in vascular disease. Bases for a new strategy in antithrombotic therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A tendency toward bleeding often undercuts the beneficial preventive effect of higher doses of a single antithrombotic drug or combined antithrombotic therapy. Although high doses of antithrombotic drugs may be necessary for optimal prevention, such therapy can also elicit more frequent bleeding. Although major bleeding could be a reversible event is likely to lead clinicians to discontinue antithrombotic therapy which in turn could increase the risk of myocardial infarction, stroke, and cardiovascular death. Thus, to prevent thrombotic events without frequent bleeding complications, the preferred approach might be to use ...
Source: Thrombosis Journal - August 29, 2007 Category: Hematology Authors: Raul Altman Source Type: journals

Hyperhomocysteinemia in women affected by unexplained sterility or recurrent early pregnancy loss from Southern Italy: a preliminary reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study sought to find out a possible relationship between sterility (primary sterility or secondary sterility due to recurrent pregnancy loss) and homocysteine metabolism. Patients and Methods. We selected 20 patients with recurrent pregnancy loss, 20 patients with unexplained female sterility and 20 healthy women as control group. Several whole blood samples were collected by venipuncture. Firstly homocysteinemia and other related variables were tested (i.e. folate and vitamin B12 levels); thereafter DNA was extracted by a further whole blood sample collected in EDTA in order to screen MTHFR C677T gene polymorphism. S...
Source: Thrombosis Journal - July 11, 2007 Category: Hematology Authors: Maristella D'Uva, Pierpaolo Di Micco, Ida Strina, Carlo Alviggi, Mariateresa Iannuzzo, Antonio Ranieri, Antonio Mollo and Giuseppe De Placido Source Type: journals

Deep venous thrombosis in the antenatal period in a large cohort of pregnancies from western IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Deep venous thrombosis (DVT) is an important complication in the peripartal and postpartal period. Methods: We followed up prospectively the prevalence of DVT in 34720 prenatal mothers between June 2002 and July 2006 attending the antenatal clinics of two major hospitals in Mumbai, India. Thirty two women (0.1%) presented for the first time with symptomatic DVT i.e. 17 in the first trimester, 6 in the second and 9 in the third trimester of pregnancy. Nine had history of fetal loss while in the remaining twenty three there was no history of fetal loss. Results: The evaluation of both acquired and heritable throm...
Source: Thrombosis Journal - July 4, 2007 Category: Hematology Authors: Sonal Vora, Kanjaksha Ghosh, Shrimati Shetty, Vinita Salvi and Purnima Satoskar Source Type: journals

Why differentiate low molecular weight heparins for venous thromboembolism?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Editorial (Source: Thrombosis Journal)
Source: Thrombosis Journal - June 19, 2007 Category: Hematology Authors: Jawed Fareed and Jeanine M. Walenga Source Type: journals

Increased platelet expression of FcGammaRIIa and its potential impact on platelet reactivity in patients with end stage renal diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Increased platelet reactivity has been implicated in cardiovascular disease -- the major cause of death in patients with end stage renal disease (ESRD). FcGammaRIIA is a component of glycoprotein VI and Ib-IX-V that mediate activation of platelets by collagen and von Willebrand factor. To determine whether expression of FcGammaRIIA impacts platelet reactivity we quantified its expression and platelet reactivity in 33 patients with ESRD who were undergoing hemodialysis. Methods: Blood samples were obtained from patients immediately before hemodialysis and before administration of heparin. Platelet expression o...
Source: Thrombosis Journal - June 4, 2007 Category: Hematology Authors: Feliciano A Serrano, Mohamed El-Shahawy, Richard J Solomon, Burton E Sobel and David J Schneider Source Type: journals

Clopidogrel in Orthopaedic patients: a review of current practice in ScotlandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionRecommendations on stopping clopidogrel have evolved from studies conducted on patients undergoing cardio-thoracic surgery. There is no data available on the effect of clopidogrel in orthopaedic practise. Our survey indicates that increased bleeding has not been found in patients who continue clopidogrel peri-operatively. Almost half of respondents complied with current recommendations, stopping clopidogrel 7 days pre-operatively. However there remains a lack of consensus amongst orthopaedic surgeons. Currently elective patients should stop clopidogrel 7 days pre-operatively, and emergency patients should stop c...
Source: Thrombosis Journal - May 25, 2007 Category: Hematology Authors: Jibu J Joseph, Anand Pillai and Diane Bramley Source Type: journals

Platelet adhesion onto immobilized fibrinogen under arterial and venous in-vitro flow conditions does not significantly differ between men and womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In our in vitro experimental system, hormonal differences between men and women did not influence platelet adhesion onto immobilized fibrinogen, neither under venous nor under arterial rheological conditions. (Source: Thrombosis Journal)
Source: Thrombosis Journal - April 26, 2007 Category: Hematology Authors: Robert Loncar, Reiner B Zotz, Christoph Sucker, Aleksandar Vodovnik, Mario Mihalj and Rudiger E Scharf Source Type: journals

Histological composition and progression of carotid plaqueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Asymptomatic and symptomatic patients could have the same histological components on their carotid plaques. Fibrotic and calcific plaques could become vulnerable as complex plaques with surface defect, hemorrhage and thrombus could remain silent. Asymptomatic carotid stenosis should be followed close with no invasive diagnostic methods and clinical evaluation. (Source: Thrombosis Journal)
Source: Thrombosis Journal - February 26, 2007 Category: Hematology Authors: Liz Andréa Villela Baroncini, Antonio Pazin Filho, Simone Gusmão Ramos, Antonio Roberto Martins and Luiz Otavio Murta Source Type: journals