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Treatment of venous thromboembolism in patients with cancer: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We describe the results of a systematic literature review and an explicit approach to consensus techniques which resulted in recommendations for the key therapeutic issues in cancer patients with VTE. (Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Davide Imberti, Marcello Di Nisio, Maria Benedetta Donati, Anna Falanga, Angelo Ghirarduzzi, Daniele Guarneri, Franco Piovella, Rita Carlotta Santoro, Edoardo Baldini, Stefania Zampogna, on behalf of the Italian Society for Thrombosis and Haemostasis (SIS Tags: On-line Guidelines of the Italian Society for Haemostasis and Thrombosis Source Type: journals

Prevention of venous thromboembolism in immobilized neurological patients: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Neurological disorders are often associated with immobilization, thus placing patients at increased risk for venous thromboembolism (VTE). This risk is very high in patients with acute ischemic stroke and spinal cord injuries, and it remains poorly defined in patients with peripheral nervous disorders or degenerative disorders of the central nervous system. The benefit of prophylactic strategies remains often unclear. The Italian Society for Studies on Haemostasis and Thrombosis promoted the development of evidence- and consensus-based guidelines to help physicians involved in the management of neurological patie...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Walter Ageno, Giancarlo Agnelli, Giovanni Checchia, Claudio Cimminiello, Maurizio Paciaroni, Gualtiero Palareti, Mario Pini, Franco Piovella, Enrico Pogliani, Sophie Testa Tags: On-line Guidelines of the Italian Society for Haemostasis and Thrombosis Source Type: journals

Screening for thrombophilia and antithrombotic prophylaxis in pregnancy: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The term thrombophilia describes an increased tendency to develop thrombosis and many laboratory markers with different strengths of association with thrombosis have been identified. The main causes of maternal mortality and morbidity in developed countries is venous thromboembolism (VTE) and obstetric complications. During pregnancy and puerperium the risk for VTE increases due to hemostatic imbalance towards a prothrombotic state, and it is further increased in women carriers of thrombophilia; recent studies have also demonstrated an association between thrombophilia and obstetric complications. These complicat...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Federico Lussana, Francesco Dentali, Rosanna Abbate, Ernesto d'Aloja, Armando D'Angelo, Valerio De Stefano, Elena M. Faioni, Elvira Grandone, Cristina Legnani, Ida Martinelli, Paolo Simioni, Daniela Tormene Tags: On-line Guidelines of the Italian Society for Haemostasis and Thrombosis Source Type: journals

Management of bleeding and of invasive procedures in patients with platelet disorders and/or thrombocytopenia: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The optimal management of bleeding or its prophylaxis in patients with disorders of platelet count or function is controversial. The bleeding diathesis of these patients is usually mild to moderate: therefore, transfusion of platelet concentrates may be inappropriate, as potential adverse effects might outweigh its benefit. The availability of several anti-hemorrhagic drugs further compounds this problem, mainly because the efficacy/suitability of the various treatment options in different clinical manifestations is not well defined. In these guidelines, promoted by the Italian Society for Studies on Haemostasis ...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: A. Tosetto, C.L. Balduini, M. Cattaneo, E. De Candia, G. Mariani, A.C. Molinari, E. Rossi, S. Siragusa Tags: On-line Guidelines of the Italian Society for Haemostasis and Thrombosis Source Type: journals

Assessment of the risk of bleeding in patients undergoing surgery or invasive procedures: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the present guidelines is to provide recommendations for the pre-operative and pre-procedural assessment of the bleeding risk with the aim of reducing the incidence of preventable bleeding complications and limiting laboratory tests to the those necessary.The predictive value of haemostatic tests for bleeding complications after surgery or invasive procedures has been evaluated in prospective or retrospective cohort studies only. All retrieved studies were of low methodological quality with a high potential for bias because none conducted a blinded outcome assessment. In addition, different criteria for th...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Benilde Cosmi, Adriano Alatri, Marco Cattaneo, Paolo Gresele, Marco Marietta, Francesco Rodeghiero, Armando Tripodi, Luca Ansaloni, Maurizio Fusari, Stefania Taddei Tags: On-line Guidelines of the Italian Society for Haemostasis and Thrombosis Source Type: journals

Objectives and methodology: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A current goal of the Italian Society for Thrombosis and Haemostasis (SISET) is the production of guidelines for clinical conditions related to haemostasis and thrombosis. In 2006, the Executive Committee of SISET adopted a new program for the production of methodologically and scientifically sound guidelines aimed at both addressing clinical practice and stimulating new research. The first major step for this program was to train methodologists to manage working groups that compose the guidelines, and to create a reference document that describes the development of the program. The aim of the present paper is to...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Alfonso Iorio, Walter Ageno, Benilde Cosmi, Davide Imberti, Federico Lussana, Sergio Siragusa, Daniela Tormene, Alberto Tosetto, Marco Cattaneo Tags: On-line Guidelines of the Italian Society for Haemostasis and Thrombosis Source Type: journals

A novel cholesterol absorption inhibitor, ezetimibe, decreases adipose-derived and vascular PAI-1 expression in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hypercholesterolemia is an independent risk factor for the development of atherosclerosis and cardiovascular/thrombotic diseases. The increased incidence of cardiovascular disease may be associated with elevated levels of coagulation factors and plasminogen activator inhibitor-1 (PAI-1) in plasma, which is the primary inhibitor of plasminogen activation in vivo . PAI-1 levels in plasma are elevated in hyperlipidemic and/or obese patients , and adipose tissue is one of primary sources of PAI-1 production in this condition . These observations suggest that PAI-1 expression could be substantially influenced by lipid metabolis...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Koji Yamamoto, Shuji Shibayama, Kyosuke Takeshita, Tetsuhito Kojima, Junki Takamatsu Tags: Letters to the Editors-in-Chief Source Type: journals

A clinical-laboratory approach contributing to a rapid and reliable diagnosis of heparin-induced thrombocytopenia: An updateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We recently published a clinical-laboratory approach for the diagnosis of heparin-induced thrombocytopenia (HIT) . Our study confirmed that the combination of the ID-heparin (H)/platelet factor 4 (PF4) PaGIA® (Diamed, Cressier sur Morat, Switzerland) with the clinical 4T's score is a reliable screening strategy to rule out or support rapidly the diagnosis of HIT. Yet, the flow cytometric measurement of the CD62p-expression (flowCD62p) remains necessary to confirm the presence of functional relevant antibodies in patients with clinical features of HIT, especially when the clinical situation is not straightforward (intermed...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Barbara Denys, Katrien Devreese Tags: Letters to the Editors-in-Chief Source Type: journals

What is blood borne tissue factor?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a recent letter to the Editors-in-Chief of Thrombosis Research we reported on blood borne TF . Microparticles and monocytes were isolated from non-stimulated and LPS- and LPS+PMA-stimulated whole blood and their TF antigen and activity quantified using an immunoblot technique and a specific two stage assay, respectively. This approach indicated that circulating microparticles had quite a high content of TF antigen, even though their TF activity turned out extremely low. Thus their specific TF activity was found to be very low compared to that of resting as well as stimulated monocytes of whole blood. (Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Bjarne Østerud, Jan Ole Olsen, Eirik Bjørklid Tags: Letters to the Editors-in-Chief Source Type: journals

Biochemical and Hemostatic Mechanism of A Novel Thrombin-Like EnzymeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Thrombin-like enzyme (TLE) plays a significant role in vessel injury hemostasis. A novel snake venom TLE (Agacutin) was purified from Agkistrodon Acutus snake venom. Structural analysis indicated that Agacutin is a heterodimer that has a MW of 29,402 Da, a pI value of 5.39, and optimum activity at 35 °C and pH 7.5. The N-terminal 15 amino acid sequences of Agacutin are DSSGWSSYEGHEYYV (small subunit) and DCSSGWSSYEEHQYY (large subunit). In vitro studies indicated that the coagulation activity of Agacutin was activated by Ca+2 or inhibited by phenylmethanesulfonyl fluoride, but not influenced by heparin or hiru...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Song-Shan Tang, Juan-Hui Zhang, Bai-Shan Tang, Zhi-Hua Tang, Hong-Zhi Li, Hao-Jia Yuan, Shu-Lian Chui, Er-Yao Zhao Tags: Regular Articles Source Type: journals

Long term administration of LMWH - pharmacodynamic parameters under therapeutic or prophylactic regimen of enoxaparin or tinzaparin in neurological rehabilitation patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, although marked differences between tinzaparin and enoxaparin based on anti-FXa-activity were seen, markers of in vivo biological activity such as TFPI and D-dimer were not different. Furthermore, BID tinzaparin is a feasible option for therapeutic anticoagulation in patients with high bleeding risk. (Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: K. Kuczka, K. Baum, B. Picard-Willems, S. Harder Tags: Regular Articles Source Type: journals

Gene polymorphisms and risk of adult early-onset ischemic stroke: A meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Genetic abnormalities specific to homocysteine and lipid metabolism increase the risk for ischemic stroke at an early age. These data may offer important implications for future genetic association studies for stroke. (Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Xiao-Yu Xin, Yan-Yan Song, Jian-Fang Ma, Cai-Ni Fan, Jian-Qing Ding, Guo-Yuan Yang, Sheng-Di Chen Tags: Regular Articles Source Type: journals

Thrombin-activatable fibrinolysis inhibitor genetic polymorphisms as markers of the type of acute coronary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Introduction: In patients with coronary disease at risk of acute coronary events it is unclear which biological factors could predict the type of acute coronary syndrome clinical presentation. The aim of the study was to investigate the role of genetic polymorphisms in key proteins in fibrinolysis in the type of acute coronary syndrome.Materials and methods: 248 patients with acute coronary syndrome (unstable angina or myocardial infarction) (77% male, mean age 60.75 SD 13.30years) were prospectively recruited. PAI-1 (type-1 plasminogen activator inhibitor) 4G/5G and TAFI (thrombin-activatable fibrinolysis inhibi...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Dolors Tàssies, Merce Roqué, Joan Monteagudo, Teresa Martorell, Alessandro Sionis, Dabit Arzamendi, Magda Heras, Joan-Carles Reverter Tags: Regular Articles Source Type: journals

Disseminated intravascular coagulation with a fibrinolytic phenotype at an early phase of trauma predicts mortalityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: DIC with a fibrinolytic phenotype modified through fibrinogenolysis at an early phase of trauma contributes to poor prognosis due to massive bleeding. Tissue hypoperfusion may be involved in the pathogenesis of this type of DIC. (Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Atsushi Sawamura, Mineji Hayakawa, Satoshi Gando, Nobuhiko Kubota, Masahiro Sugano, Takeshi Wada, Ken-ichi Katabami Tags: Regular Articles Source Type: journals

Factor VIII contributes to platelet-fibrin thrombus formation via thrombin generation under low shear conditionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that FVIII contributes to platelet aggregation and fibrin formation via thrombin generation under low shear conditions. (Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Chihiro Sugita, Atsushi Yamashita, Sayaka Moriguchi-Goto, Eiji Furukoji, Misaki Takahashi, Aya Harada, Tetsuhiro Soeda, Takehisa Kitazawa, Kunihiro Hattori, Shozo Tamura, Yujiro Asada Tags: Regular Articles Source Type: journals

Release of necrosis markers and cardiovascular magnetic resonance-derived microvascular perfusion in reperfused ST-elevation myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In ST-elevation myocardial infarction, a larger release of cardiac necrosis markers soon after reperfusion therapy relates to abnormal perfusion. Troponin appears as the most reliable necrosis marker for an early detection of cardiovascular magnetic resonance-derived abnormal microvascular reperfusion. (Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Oliver Husser, Vicente Bodi, Juan Sanchis, Julio Nunez, Luis Mainar, Eva Rumiz, Maria P. Lopez-Lereu, Jose V. Monmeneu, Maria J. Forteza, Ricardo Oltra, Günter A.J. Riegger, Francisco J. Chorro, Angel Llacer Tags: Regular Articles Source Type: journals

Smoking promotes clopidogrel-mediated platelet inhibition in patients receiving dual antiplatelet therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: By in vitro testing, cigarette smoking is associated with enhanced clopidogrel- but not aspirin-mediated platelet inhibition. The clinical implications have to be evaluated in large prospective trials. (Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Thomas Gremmel, Sabine Steiner, Daniela Seidinger, Renate Koppensteiner, Simon Panzer, Christoph W. Kopp Tags: Regular Articles Source Type: journals

Increase in proinflammatory cytokines in peripheral blood without haemostatic changes after LPS inhalationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study confirms that despite systemic release of proinflammatory cytokines, LPS inhalation does not induce systemic haemostatic response to LPS challenge. (Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Marc Fouassier, Bertrand Souweine, Anne-Françoise Sapin, Afshin Hashemzadeh, Alain Marquès-Verdier, Denis Caillaud Tags: Regular Articles Source Type: journals

Effect of tissue inhibitor of matrix metalloproteinases-1 on in vitro and in vivo adipocyte differentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a role in development of obesity by contributing to adipogenesis, angiogenesis and extracellular matrix degradation. We have evaluated a potential functional role of TIMP-1, which inhibits most MMPs, in early stages of in vitro and in vivo adipogenesis. Overexpression of human TIMP-1 (hTIMP-1) in 3T3-F442A preadipocytes resulted in a somewhat slower differentiation into mature adipocytes, without affecting the total extent of differentiation. Local overexpression by injection of 3T3-F442A preadipocytes expressing hTIMP-1 in the back of NUDE...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Ilse Scroyen, Leentje Cosemans, H. Roger Lijnen Tags: Regular Articles Source Type: journals

Platelet inhibition assessed with VerifyNow, flow cytometry and PlateletMapping in patients undergoing heart surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Introduction: A substantial number of patients with coronary artery disease undergo cardiac surgery within five days of discontinuing anti-platelet treatment with aspirin and clopidogrel. The aims of this study were to describe the degree of platelet inhibition in patients with dual anti-platelet treatment scheduled for coronary artery bypass graft (CABG) surgery and to investigate whether the measured platelet inhibition correlated to intra- and postoperative risk for bleeding and transfusion requirements.Material and Methods: Sixty patients were included. Platelet inhibition was analysed with flow cytometry inc...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Ulrica Alström, Fredrik Granath, Jonas Oldgren, Elisabeth Ståhle, Hans Tydén, Agneta Siegbahn Tags: Regular Articles Source Type: journals

Comparison of ticagrelor and thienopyridine P2Y12 binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Ticagrelor (AZD6140), the first reversibly binding oral P2Y12 receptor antagonist, blocks adenosine diphosphate (ADP)-induced platelet aggregation via a mode of action distinct from that of thienopyridine antiplatelet agents. The latter must be metabolically activated and binds irreversibly to P2Y12 for the life of the platelet, precluding restoration of hemostatic function without the generation of new platelets. In in vitro studies comparing binding characteristics of ticagrelor and compound 105, a chemical compound indistinguishable from the active metabolite of prasugrel, ticagrelor exhibited 1) an approximat...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: J.J.J. van Giezen, Pia Berntsson, Helen Zachrisson, Jan-Arne Björkman Tags: Regular Articles Source Type: journals

The profile of circulating metalloproteinases after PCI in patients with acute myocardial infarction or stable anginaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to investigate the time profiles of plasma matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinases (TIMP-1 and -2), and pregnancy associated plasma protein A (PAPP-A) in patients with acute myocardial infarction (AMI), compared to patients with stable angina pectoris (AP), all treated with percutaneous coronary intervention (PCI) with stent.Methods: Twenty patients with ST-elevation AMI and 10 patients with AP were included. Serum levels of the selected markers were measured before (only in the AP group) PCI, and 3 and 12 hours, 1,3,5,7 and 14 days after PCI in all patie...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Eline B. Furenes, Harald Arnesen, Svein Solheim, Haakon K. Grøgaard, Pavel Hoffmann, Ingebjørg Seljeflot Tags: Regular Articles Source Type: journals

Risk factors for unfavorable clinical outcome in patients with documented heparin-induced thrombocytopeniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study supports the recommendations concerning the management of HIT patients, namely discontinuation of all heparin administration once the diagnosis is suspected and prompt initiation of an alternative anticoagulant drug with a strict adherence to doses specifically recommended for these patients. (Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Ismail Elalamy, Brigitte Tardy-Poncet, Agnès Mulot, Emmanuel de Maistre, Claire Pouplard, Philippe Nguyen, Bénédicte Cleret, Yves Gruel, Thomas Lecompte, Bernard Tardy, GEHT HIT study group Tags: Regular Articles Source Type: journals

Insights into the interpretation of light transmission aggregometry for evaluation of platelet aggregation inhibition by clopidogrelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: When assessing platelet aggregation following clopidogrel, measurement of late aggregation after addition of ADP 20 µM should be preferred. Large clinical trials should be conducted to assess which parameter between residual aggregation or inhibition of platelet aggregation by clopidogrel best predicts clinical efficacy of the drug. (Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Marie Lordkipanidzé, Chantal Pharand, Donald A. Palisaitis, Erick Schampaert, Jean G. Diodati Tags: Regular Articles Source Type: journals

Decreased ADAMTS13 Levels in Patients after Living Donor Liver TransplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A significant reduction of ADAMTS13 and an increase of VWF were observed in the patients with TMALS. The ADAMTS13 activity in patients after LDLT was significantly reduced from day 1 to day 21, and it was significantly low in those with TMALS at day 14 and 28. The VWF levels in patients with LDLT were significantly high, and the VWF/ADAMTS13 ratio was significantly increased in patients at 7, 14 and 28 days after LDLT, especially in patients with TMALS at day 14 and 28 after LDLT. High molecular weight multimers of VWF were observed to have increased in patients with LDLT, and the high molecular weight multim...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Toshihiko Kobayashi, Hideo Wada, Masanobu Usui, Hiroyuki Sakurai, Takeshi Matsumoto, Tsutomu Nobori, Naoyuki Katayama, Sinji Uemoto, Hiromichi Ishizashi, Masanori Matsumoto, Yoshihiro Fujimura, Shuji Isaji Tags: Regular Articles Source Type: journals

Mean platelet volume predicts patency of the infarct-related artery before mechanical reperfusion and short-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary interventionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and aims: Patency of infarct-related artery (IRA) before mechanical reperfusion with primary percutaneous coronary intervention (PPCI) has been associated with better prognosis in patients with ST-Elevation myocardial infarction (STEMI). Mean platelet volume (MPV) increases in STEMI patients and may be associated with increased thrombotic potential. In STEMI patients scheduled for PPCI we sought to assess whether mean platelet volume (MPV), as measured at admission, correlates with “spontaneous” reperfusion of the IRA and short-term clinical outcome.Methods: Blood samples were obtained on hospital ...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Rodrigo Estévez-Loureiro, Jorge Salgado-Fernández, Raquel Marzoa-Rivas, Eduardo Barge-Caballero, Alberto Pérez-Pérez, Victor Noriega-Concepción, Ramón Calviño-Santos, José Manuel Vázquez-Rodríguez, Nicolás Vázquez-González, Alfonso Castro-Bei Tags: Regular Articles Source Type: journals

Venous thromboembolism in recurrent ovarian cancer-patients: A systematic evaluation of the North-Eastern German Society of Gynaecologic Oncology Ovarian Cancer Study Group (NOGGO)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: ROC-patients appear to have the highest risk for developing VTE when ascites exists and during the first 2 months following chemotherapy initiation. In contrast to primary ovarian cancer, VTE could not be identified to affect overall survival in relapsed malignant ovarian disease. (Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: C. Fotopoulou, A. Karavas, R. Trappe, R. Chekerov, W. Lichtenegger, J. Sehouli Tags: Regular Articles Source Type: journals

Prothrombin fragment 1+2 is associated with intima media thickness of the carotid artery in patients with myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and aim: Previous studies have shown that a decreased fibrinolytic activity or a hyperactivated coagulation system increase the risk of myocardial infarction. The aim of this study was to investigate the relationship between the presence of atherosclerotic lesions and coagulation and fibrinolysis factors and high sensitivity CRP (hs-CRP) in patients with myocardial infarction.Methods: In a cross-sectional study, 123 patients, aged 31-80 years, with a history of previous myocardial infarction were examined with B-mode ultrasound of the common carotid artery. Blood samples were collected for measurement...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Loghman Henareh, Tomas Jogestrand, Stefan Agewall Tags: Regular Articles Source Type: journals

Mechanisms of antiphospholipid antibody-associated pregnancy complicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Women with antiphospholipid syndrome (APS) and antiphospholipid antibodies (aPL) are at high risk for recurrent spontaneous miscarriage and late pregnancy complications, such as preeclampsia and preterm labor. Recent clinical and experimental observations suggest that the pathophysiology of pregnancy failure in patients with APS may involve inflammation at the maternal-fetal interface and disruption of normal trophoblast function and survival, rather than a pro-thrombotic event. While treatment with heparin and aspirin from early pregnancy has been shown to significantly increase the live birth rate in recurrent ...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Vikki M. Abrahams Tags: Reviews Source Type: journals

Involvement of human decidual cell-expressed tissue factor in uterine hemostasis and abruptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Vascular injury increases access and binding of plasma-derived factor VII to perivascular cell membrane-bound tissue factor (TF). The resulting TF/VIIa complex promotes hemostasis by cleaving pro-thrombin to thrombin leading to the fibrin clot. In human pregnancy, decidual cell-expressed TF prevents decidual hemorrhage (abruption). During placentation, trophoblasts remodel decidual spiral arteries into high conductance vessels. Shallow trophoblast invasion impedes decidual vascular conversion, producing an inadequate uteroplacental blood flow that elicits abruption-related placental ischemia. Thrombin induces sev...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: C.J. Lockwood, M. Paidas, W.K. Murk, U.A. Kayisli, A. Gopinath, S.J. Huang, G. Krikun, F. Schatz Tags: Reviews Source Type: journals

Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the current issue of Thrombosis Research, we publish the first series of six guidelines produced by the Italian Society for Haemostasis and Thrombosis (Società Italiana per lo Studio dell'Emostasi e della Trombosi — SISET) . These guidelines are the first articles to be published on-line only as part of a new publication strategy of Thrombosis Research . (Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Per Morten Sandset, Charlie Francis, Nigel Key Tags: Editorial Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Thrombosis Research)
Source: Thrombosis Research - October 20, 2009 Category: Hematology Source Type: journals

Inherited thrombophilia in patients with thrombotic thrombocytopenic purpuraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thrombotic thrombocytopenic purpura (TTP) is a rare, but life-threatening disorder, characterized by thrombi in the microvasculature, resulting in vascular occlusions that lead to tissue ischemia and end-organ injury . The presenting triad of microangiopathic hemolytic anemia, thrombocytopenia and neurologic symptoms is found in the majority of patients, while the pentad including fever and renal involvement is present in 40% of the patients. A severe deficiency of ADAMTS13, caused by a genetic mutation or inhibitory autoantibodies, is considered the underlying pathophysiological mechanism . Although the incidence of proth...
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Silvia Maria Trisolini, Saveria Capria, Arturo Cafolla, Patrizia Pignoloni, Roberto Foà, Maria Gabriella Mazzucconi, Giovanna Meloni Tags: Letters to the Editors-in Chief Source Type: journals

A rare case of MYH9 disorders presenting with macrothrombocytopenia and deafness caused by MYH9-R702C mutationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Giant platelets often appear in acquired thrombocytopenia, such as idiopathic thrombocytopenic purpura (ITP) and myelodysplastic syndrome1. Congenital macrothrombocytopenia is rare, and consists of a variety of diseases , including 4 autosomal dominant disorders, May-Hegglin anomaly, and Sebastian, Fechtner, and Epstein syndromes, which have neutrophil inclusion bodies (Döhle-like bodies), or Alport-like symptoms (nephritis, deafness, or cataract) . These diseases have been differentiated by expression pattern and morphology of neutrophil inclusion bodies, or the clinical features of Alport-like manifestations . Mutations...
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Rumi Kodama, Takeshi Taketani, Shinji Kunishima, Seiji Mishima, Yoko Yoshikawa, Rie Kanai, Tamiko Suyama, Isao Yoshino, Hiroyuki Kunishi, Hiroshi Shibata, Atsushi Nagai, Seiji Yamaguchi, Junichi Masuda Tags: Letters to the Editors-in Chief Source Type: journals

The effect of high circulating estradiol levels on thrombin generation during in vitro fertilizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In vitro fertilization (IVF) is a well-documented risk factor for thromboembolic complications . Suspected complications have included jugular venous thrombosis , carotid thrombosis , and fatal cerebral infarction . Possible plasma factor compositional reasons for the link between IVF and thrombotic events include activated protein C resistance , decreased protein S and antithrombin (AT) , and increased fibrinogen and factor (F) VIII . These factors could potentiate increased thrombin generation. (Source: Thrombosis Research)
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Kathleen E. Brummel-Ziedins, Matthew Gissel, Charles Francis, John Queenan, Kenneth G. Mann Tags: Letters to the Editors-in Chief Source Type: journals

Increased phosphatidylserine exposure on platelets from hospitalized patients with acute medical illnessesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Activated platelets expose pro-coagulant phospholipids which catalyze the generation of thrombin by several-folds . Phosphatidylserine (PS) is one of the platelet membrane phospholipids which contributes most to the assembly of tenase and prothrombinase complexes PS is expressed on the inner leaflet of the membrane of non-stimulated platelets while it becomes actively transported on the outer layer upon cell activation . The PS-dependent platelet pro-coagulant activity is partly antagonised by annexin-V which binds to and forms a protective shield over exposed phospholipids such as PS Changes in lipid distributions with th...
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Ettore Porreca, Marco Marchisio, Marcello Di Nisio, Valeria Moretta, Paola Lanuti, Laura Pierdomenico, Franco Cuccurullo, Sebastiano Miscia Tags: Letters to the Editors-in Chief Source Type: journals

The expression of 4 protease-activated receptors is associated with increased levels of TNF-α, tissue factor, and fibrin in the frontal cortex of endotoxemic ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sepsis produces brain dysfunction, termed sepsis-associated encephalopathy . Pathological examinations have revealed the cerebral cortex to be the most commonly involved site . The main pathologic signs found in the brain of patients with septic shock are hemorrhage, hypercoagulability syndrome, microabscess formation, leucoencephalopathy, and ischemia . The pathogenesis of sepsis-associated encephalopathy is multifactorial, involving microvascular disorder, endothelial activation, breakdown of the blood-brain barrier (BBB), brain inflammation, neuronal degeneration, and apoptosis . (Source: Thrombosis Research)
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Subrina Jesmin, Satoshi Gando, Sohel Zaedi, Atsushi Sawamura, Naoto Yamaguchi Tags: Letters to the Editors-in Chief Source Type: journals

Implementation of the ISTH classification of non-overt DIC in a thromboplastin induced rabbit modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we use rabbit brain thromboplastin (thromboplastin) to induce DIC in a rabbit model and test the applicability of the ISTH criteria for standardized diagnosis of DIC.Cardiovascular and haematological parameters from rabbits, either saline-injected or administered 0.625, 1.25, 2.5 or 5 mg thromboplastin/kg as a single bolus, were collected at four timepoints over a 90 minute period. All groups of rabbits were scored at each time point according to the ISTH diagnostic criteria for non-overt DIC.Injection of 5 mg thromboplastin/kg was lethal. For the remaining groups, a dose dependent decrease in blood press...
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Line Olrik Berthelsen, Annemarie Thuri Kristensen, Bo Wiinberg, Mikael Tranholm Tags: Regular Articles Source Type: journals

Hyperglycaemia impairs antithrombin secretion: Possible contribution to the thrombotic risk of diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Recent data support that diabetes might be a conformational disease. Certainly, hyperglycaemia causes a broad range of deleterious effects that might facilitate protein aggregation. We have evaluated the effects of hyperglycaemia on antithrombin, a conformationally sensitive serpin with a potent anticoagulant role. Moreover, these studies might also help to understand the thrombotic risk associated to diabetes. We incubated in vitro plasma and purified antithrombin and human hepatoma cells (HepG2) with methyl-glyoxal and glucose. Moreover, a mouse model of acute diabetes was generated with streptozotocin. Antigen...
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: David Hernández-Espinosa, Adriana Ordóñez, Antonia Miñano, Irene Martínez-Martínez, Vicente Vicente, Javier Corral Tags: Regular Articles Source Type: journals

Allicin and disulfiram enhance platelet integrin αIIbβ3-fibrinogen bindingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Allicin and disulfiram inhibit agonist-induced washed platelet activation probably via inhibition of platelet signaling, but enhance PT25-2 antibody-induced αIIbβ3 integrin activity most likely by preventing reformation of disulfide bridges thereby stabilizing the active conformation of the integrin. (Source: Thrombosis Research)
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Yoav Manaster, Boris Shenkman, Nurit Rosenberg, Naphtali Savion Tags: Regular Articles Source Type: journals

Immobilization and the risk of venous thromboembolism. A meta-analysis on epidemiological studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: The thrombogenic burden of immobilization remains unknown especially in the medical setting. Most of epidemiological studies estimating the link between risk factors and venous thromboembolism (VTE) have not been designed to evaluate immobilization. The aim of this work was to estimate the risk of VTE in medical bedridden patients by a systematic review and a meta-analysis.Methods: A research on PUBMED and EMBASE was carried out to retrieve case-control and cohort studies showing the proportion of bedridden patients with or without VTE. Included studies were assigned in six groups according to the fol...
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: P. Pottier, J.B. Hardouin, S. Lejeune, P. Jolliet, B. Gillet, B. Planchon Tags: Regular Articles Source Type: journals

Lipopolysaccharide-induced activation of coagulation in neonatal cord and adult blood monitored by thrombelastographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In summary, TEG proved to be a sensitive and reliable tool for the determination of LPS-induced tissue factor mediated activation of hemostasis in whole blood samples from adults and neonates. (Source: Thrombosis Research)
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Lutz Koch, Stefan Hofer, Markus A. Weigand, David Frommhold, Johannes Poeschl Tags: Regular Articles Source Type: journals

Association of the -757T>C polymorphism in the CRP gene with circulating C-reactive protein levels and carotid atherosclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present study provides evidence that a genetic variant of CRP gene is associated with carotid atherosclerosis, independently of traditional vascular risk factors. Further large-scale genomic studies are required, which may identify the genetic vulnerable subjects to develop atherosclerosis. (Source: Thrombosis Research)
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Einor Ben Assayag, Shani Shenhar-Tsarfaty, Irena Bova, Shlomo Berliner, Sali Usher, Hava Peretz, Itzhak Shapira, Natan M. Bornstein Tags: RegularArticles Source Type: journals

Kynurenines and oxidative status are independently associated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Introduction: Increased oxidative stress (SOX) is one of the most potent inductors of endothelial dysfunction in end-stage renal disease (ESRD) patients. Kynurenines are the metabolites of tryptophan (TRP) degradation in mammals. However, the role of kynurenines in the function of the endothelium is still not recognized.Materials and methods: We determined the plasma concentrations of TRP, kynurenine (KYN), 3-hydroxykynurenine (3-HKYN), quinolinic acid (QA); markers of SOX: Cu/Zn superoxide dismutase (Cu/Zn SOD), malondialdehyde (MDA); and endothelial dysfunction markers: thrombomodulin (TM) and von Willebrand fa...
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Krystyna Pawlak, Tomasz Domaniewski, Michal Mysliwiec, Dariusz Pawlak Tags: RegularArticles Source Type: journals

Shear-induced global thrombosis test of native blood: Pivotal role of ADP allows monitoring of P2Y12 antagonist therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: It is claimed that in shear-induced platelet function tests, shear-stress is the sole agonist causing platelet activation and resultant thrombosis. However, the fact that red blood cells (RBC) are essential to achieve platelet aggregation in these tests supports recent evidence that ADP makes an important contribution to shear-induced platelet reaction.Aim: To establish the role of ADP in shear-induced thrombosis, and investigate whether a shear-induced thrombosis test can assess ADP-receptor (P2Y12) antagonist medication.Methods: Blood from healthy volunteers was tested using the Global Thrombosis Te...
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: S. Saraf, D. Wellsted, S. Sharma, D.A. Gorog Tags: RegularArticles Source Type: journals

Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The NADPH oxidase inhibitors DPI and S 17834 as well as Nox4 silencing decreased PAI-1 synthesis in human cultured endothelial cells demonstrating the involvement of the constitutively active Nox4-containing NADPH oxidase in ROS-mediated PAI-1 transcription via p38 MAPK pathways. NADPH oxidase targeting with inhibitors such as S17834 could be an interesting strategy to decrease both oxidative stress and PAI-1 synthesis. (Source: Thrombosis Research)
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Amandine Jaulmes, Patricia Sansilvestri-Morel, Gaëlle Rolland-Valognes, Fabienne Bernhardt, Roger Gaertner, Brian P. Lockhart, Alex Cordi, Michel Wierzbicki, Alain Rupin, Tony J. Verbeuren Tags: RegularArticles Source Type: journals

Dependence of platelet function on underlying liver disease in orthotopic liver transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In the entire process of OLT, coagulation factors, maximum aggregation and rate of platelet aggregation depend on the surgical phases during transplantation and on the underlying liver disease. The data obtained in this study might contribute to a better understanding of the pathophysiology and assessment of bleeding risk in OLT. (Source: Thrombosis Research)
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Björn Jüttner, Jeanette Brock, Annette Weißig, Thomas Becker, Arthur Studzinski, Wilhelm A. Osthaus, Albrecht Bornscheuer, Dirk Scheinichen Tags: RegularArticles Source Type: journals

Procarboxypeptidase U (TAFI) contributes to the risk of thrombosis in patients with hereditary thrombophiliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The increased risk of thrombosis in thrombophilia patients is not only ascribable to an increased thrombin generation, but also high levels of proCPU and the presence of the 325Ile genotype tip the balance towards thrombotic tendency even further. (Source: Thrombosis Research)
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Evelien Heylen, Predrag Miljic, Johan Willemse, Valentina Djordjevic, Dragica Radojkovic, Milica Colovic, Ivo Elezovic, Dirk Hendriks Tags: Regular Articles Source Type: journals

Haemostatic markers in patients with abdominal aortic aneurysm and the impact of aneurysm sizeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present data indicate a state of activated coagulation in patients with abdominal aortic aneurysm which is dependent by aneurysm size. The activated coagulation in AAA patients could contribute to an increased cardiovascular risk in patients also with small AAA. The possible impact of secondary prevention apart from smoking cessation has to be further evaluated and is maybe as important as finding patients at risk of rupture. (Source: Thrombosis Research)
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Jonas Wallinder, David Bergqvist, Anders E. Henriksson Tags: Regular Articles Source Type: journals

Evaluation of the platelet count drop method for assessment of platelet function in comparison with “gold standard” light transmission aggregometryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Introduction: Hyporesponsiveness to antiplatelet agents has been linked to an increased risk of major adverse cardiovascular events. However, light transmission aggregometry (LTA), the gold standard methodology for assessing platelet function, requires expertise and is labour-intensive, which render its use in clinical settings impractical. We assessed whether platelet count drop (PCD), a technique widely available in any haematology laboratory, could replace LTA in testing for inhibition of platelet aggregation induced by antiplatelet agents.Materials and methods: One hundred and sixty-one coronary artery diseas...
Source: Thrombosis Research - August 31, 2009 Category: Hematology Authors: Marie Lordkipanidzé, Chantal Pharand, Erick Schampaert, Donald A. Palisaitis, Jean G. Diodati Tags: Regular Articles Source Type: journals