TERT RNAscope analysis of sub-centimetric papillary thyroid carcinomas and synchronous lymph node metastases
ConclusionsOur data indicate thatTERT expression is not involved in the development early lymph node metastasis in patients with sub-centimetric PTC. (Source: Thyroid Research)
Source: Thyroid Research - April 15, 2024 Category: Endocrinology Source Type: research
Novel molecular typing reveals the risk of recurrence in patients with early-stage papillary thyroid cancer
ConclusionsThese findings could help accurately and reliably identify PTC patients with high risk of recurrence so that they could receive more radical and aggressive treatment strategies and more rigorous surveillance practices. (Source: Thyroid Research)
Source: Thyroid Research - April 1, 2024 Category: Endocrinology Source Type: research
Evaluating the progression to abnormal thyrotropin in euthyroid preconception women: a population-based study
ConclusionsBoth low and high baseline thyrotropin were associated with a significantly increased risk of developing abnormal thyrotropin outcomes. The optimal preconception baseline thyrotropin levels may be between 1.43 mIU/L and 1.93 mIU/L or baseline thyrotropin MoM between 0.59 and 1.36 to minimize progression toward abnormal thyrotropin after 1.5 –3.0 years. These findings may help with counseling of preconception thyroid function monitoring. (Source: Thyroid Research)
Source: Thyroid Research - March 11, 2024 Category: Endocrinology Source Type: research
When to settle for SETTLE! A lesson learned from our cases
AbstractSpindle epithelial tumor with thymic like elements (SETTLE) is a biphasic tumor composed of epithelial and spindle cell components. It is an uncommon indolent tumor arising in the thyroid gland and most commonly affects the children and young adults. This entity is mostly overlooked because of its rarity and diagnostic difficulty on morphology. We discuss two cases of SETTLE with varied presentation, diagnostic challenges and lessons learnt from them.SETTLE should be considered as a differential especially when dealing with a thyroid lesion in young and adolescent. The article discusses the histologic details an...
Source: Thyroid Research - March 4, 2024 Category: Endocrinology Source Type: research
Ultrasound radiomics signature for predicting central lymph node metastasis in clinically node-negative papillary thyroid microcarcinoma
ConclusionsThe radiomics nomogram may be a clinically useful tool for the individual prediction of CLNM in patients with cN0 PTMC. (Source: Thyroid Research)
Source: Thyroid Research - February 19, 2024 Category: Endocrinology Source Type: research
Clinical characteristics and outcomes of patients with TSH-secreting pituitary adenoma and Graves ’ disease - a case report and systematic review
ConclusionTSHoma and GD can co-exist, and it is essential to identify this rare association as it can significantly impact treatment strategies. (Source: Thyroid Research)
Source: Thyroid Research - February 5, 2024 Category: Endocrinology Source Type: research
Thyroid storm in pregnancy: a review
ConclusionThere is a critical need to recognize thyroid storm during pregnancy and initiate proper medical interventions promptly. (Source: Thyroid Research)
Source: Thyroid Research - January 17, 2024 Category: Endocrinology Source Type: research
Radiofrequency ablation for thyroid nodules in Ecuador: a cross-sectional study
ConclusionsIn this first report from Ecuador, we found that RFA may be a feasible alternative for treating benign and malignant thyroid nodules in the short term. Long-term data are needed to evaluate oncologic outcomes in PTMC patients. (Source: Thyroid Research)
Source: Thyroid Research - January 3, 2024 Category: Endocrinology Source Type: research
Twice or thrice weekly levothyroxine provides similar rates of adherence and post-Ramadan euthyroidism compared to daily levothyroxine during Ramadan fasting
ConclusionTwice or thrice weekly levothyroxine results in similarly high rates of adherence (96.5%) and post-Ramadan euthyroidism (91.2%) compared to daily levothyroxine during Ramadan fasting. (Source: Thyroid Research)
Source: Thyroid Research - December 6, 2023 Category: Endocrinology Source Type: research
Assessing the cardiovascular effects of levothyroxine use in an ageing United Kingdom population (ACEL-UK) protocol: a cohort and target trial emulation study
This study aims to determine if receiving levothyroxine affects the cardiovascular and bone health outcomes of subclinical patients in primary care aged 50 years and over.MethodsThis project includes a retrospective cohort analysis and a target trial emulation study using electronic patient records collected between 2006 and 2021 and recorded in The Health Improvement Network database. The primary outcome of this study is to compare the cardiovascular outcomes of subclinical hypothyroid patients aged over 50 years treated with levothyroxine compared to those untreated. Secondary outcomes are bone health and all-cause morta...
Source: Thyroid Research - November 13, 2023 Category: Endocrinology Source Type: research
Differential expression of zinc finger CCHC-type superfamily proteins in thyroid carcinoma and their associations with tumor immunity
ConclusionTheZCCHC genes, represented byZCCHC12, are differentially expressed in THCA staging. These genes are associated with immune infiltration of THCA and identified as the potential therapeutic targets for immunotherapy in THCA patients, which are possible novel biomarkers for the treatment of THCA. (Source: Thyroid Research)
Source: Thyroid Research - October 17, 2023 Category: Endocrinology Source Type: research
Is nitric oxide a clue to endemic goitre in highlanders?
AbstractGoitre is commonly caused by a lack of iodine in the diet. This condition is particularly prevalent in high-altitude areas where iodine deficiency is common. Here we speculate that inorganic nitrate, the oxidation product of nitric oxide, which is generated endogenously at very high levels in highlanders, further increases the risk of goitre and thyroid dysfunction in this population by inhibiting the transport of iodide into the thyroid gland. Indeed, it is well-known that nitrate and iodide compete for such transport. While iodine scarcity is a primary cause of goitre, the excessive nitrate levels in highlanders ...
Source: Thyroid Research - October 2, 2023 Category: Endocrinology Source Type: research
Use of thyroid hormones in hypothyroid and euthyroid patients: a 2022 THESIS questionnaire survey of members of the Latin American Thyroid Society (LATS)
ConclusionLT4 tablets is the treatment of choice for hypothyroidism. A significant proportion of respondents would use LT4 in some groups of euthyroid individuals, contrasting the recommendations of the major clinical practice guideline indications. LT4 + LT3 combination treatment in euthyroid symptomatic patients was considered by nearly 50%. Practices based on weak or absent evidence included use of thyroid hormones for euthyroid subjects by 56.8% of respondents and use of LT4 + LT3 treatment by 60.5% of respondents for patients with per sistent symptoms. In contrast to many European countries, LATS respondents ...
Source: Thyroid Research - September 29, 2023 Category: Endocrinology Source Type: research
RET/PTC rearrangement in papillary thyroid carcinoma arising in malignant struma ovarii with abdominal wall metastasis and cervical thyroid gland: a case report and review of the literature
ConclusionsIn light of these findings, malignant struma ovarii might yield a clue to cervical thyroid carcinoma, and the molecular analysis could provide valuable information for understanding the underlying mechanism, tumor clinicopathological behaviors, and prognosis. (Source: Thyroid Research)
Source: Thyroid Research - September 27, 2023 Category: Endocrinology Source Type: research
Expressions of mitochondria-related genes in pregnant women with subclinical hypothyroidism, and expressions of miRNAs in maternal and cord blood
ConclusionsA trend towards decreased mitochondrial gene expressions in subclinical hypothyroidism were demonstrated. The miRNAs hsa-let-7d-3p and hsa-miR-345-5p might be potential markers of maternal subclinical hypothyroidism. However, larger studies are needed to verify the findings. (Source: Thyroid Research)
Source: Thyroid Research - September 18, 2023 Category: Endocrinology Source Type: research
