Clinical and serological characteristics of anti-Ro/SS-A and anti-La/SS-B negative primary Sj ögren's syndrome: a comparative study
CONCLUSIONS: We confirm the strong influence of immunological markers on the phenotype of primary SS at diagnosis.PMID:38497858 | DOI:10.26355/eurrev_202403_35589 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: E Bodak çi Source Type: research
Association between Parvovirus B19 and thyroid/celiac autoantibodies among T1DM pediatric patients
CONCLUSIONS: The prevalence of autoantibodies against the thyroid was higher among the seropositive Parvovirus B19 children with T1DM. A positive association between the prevalence of autoantibodies against thyroid disease and the increase in the duration of diabetes was also noted. Hence, periodic screening of T1DM patients for B19 antibodies and autoantibodies for thyroid is crucial.PMID:38497882 | DOI:10.26355/eurrev_202403_35614 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: H C Chandramoorthy A A Shati A A Aseeri A Subramanian A Alhanshani E A H Almohseny R Ram Mani A Kumar R A Ali Moosa A Al-Hakami K Chidambaram Source Type: research
Clinical and serological characteristics of anti-Ro/SS-A and anti-La/SS-B negative primary Sj ögren's syndrome: a comparative study
CONCLUSIONS: We confirm the strong influence of immunological markers on the phenotype of primary SS at diagnosis.PMID:38497858 | DOI:10.26355/eurrev_202403_35589 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: E Bodak çi Source Type: research
Inhibiting sEH suppresses NF- κB p65 signaling and reduces CXCL10 expression as a potential therapeutic target in HT
CONCLUSIONS: Our findings suggest that sEH/NF-κB p65/CXCL10-CXCR3 might be promising therapeutic targets for HT.PMID:38478377 | DOI:10.1210/clinem/dgae163 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 13, 2024 Category: Endocrinology Authors: Jing Feng Xianghong Xu Wei Cai Xingwen Yang Ruilan Niu Ziqi Han Limin Tian Source Type: research
Reassessing Selenium for the Management of Hashimoto's Thyroiditis: The Selini Shines Bright for Autoimmune Thyroiditis Patients
Thyroid ®,Volume 34, Issue 3, Page 292-294, March 2024. (Source: Thyroid)
Source: Thyroid - March 13, 2024 Category: Endocrinology Authors: Leonidas H. Duntas Source Type: research
Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Thyroid ®,Volume 34, Issue 3, Page 295-313, March 2024. (Source: Thyroid)
Source: Thyroid - March 13, 2024 Category: Endocrinology Authors: Valentina V. Huwiler Stephanie Maissen-Abgottspon Zeno Stanga Stefan M ühlebach Roman Trepp Lia Bally Arjola Bano Source Type: research
Thyrotoxicosis and thyroiditis
Thyrotoxicosis is a common condition resulting from excess of circulating thyroid hormones in the blood. The most frequent cause of thyrotoxicosis is Graves ’ disease and the clinical features include goitre and eye disease. The treatment strategies in Graves’ disease involve anti-thyroid drugs, radioiodine and thyroidectomy. Thyroiditis (inflammation of the thyroid) is caused by release of stored thyroid hormones and may also result in thyrotoxicos is. The aetiology, pathogenesis, diagnosis, investigation and management of conditions causing thyrotoxicosis and thyroiditis are reviewed in this chapter. (Source: Surgery...
Source: Surgery (Medicine Publishing) - March 12, 2024 Category: Surgery Authors: Pui San Yap, Oroog Ali, Peter Truran, Sebastian Aspinall Tags: Endocrine Surgery Source Type: research
Ultrasound-guided fine needle aspiration thyroglobulin in the diagnosis of lymph node metastasis of differentiated papillary thyroid carcinoma and its influencing factors
ConclusionThe findings of this study indicate that the utilization of FNA in conjunction with FNA-Tg is a crucial approach for detecting LNM in DTC. TNM stage indicated N1b, the presence of HVLNM, the presence of HT, lymph node L/S ratio, liquefaction, calcification, tumor diameter, sTg and sTgAb are factors that can impact FNA-Tg levels.In the context of clinical application, it is imperative to individualize the use of FNA-Tg. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
Treg cells as a protective factor for Hashimoto`s thyroiditis: a Mendelian randomization study
ConclusionOur study has demonstrated the close connection between Treg cells and HT by genetic means, thus providing foundational basis for future research. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 8, 2024 Category: Endocrinology Source Type: research
Chronic Lymphocytic Thyroiditis with Oncocytic Metaplasia Influences PD-L1 Expression in Papillary Thyroid Carcinoma
ConclusionsOur study underscores the intricate interplay between chronic lymphocytic thyroiditis with oncocytic metaplasia and PD-L1 expression in papillary thyroid carcinoma. The observed link suggests a potential avenue for therapeutic intervention using anti-PD-1/PD-L1 therapies in surgery-refractory PTC. Understanding the dynamics of immune checkpoint regulation in the context of the tumor microenvironment is crucial for devising effective treatment strategies. Future research endeavors should delve deeper into the molecular mechanisms underlying this interaction and explore its implications for patient outcomes. As th...
Source: Head and Neck Pathology - March 8, 2024 Category: Pathology Source Type: research
Thyroiditis and COVID-19: focus on pediatric age. A narrative review
ConclusionHowever, due to the limited evidence available, further prospective longitudinal studies are required to clarify the relationship between COVID-19 and thyroid disease in children and adolescents, as well as to investigate any potential long-term consequences. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 8, 2024 Category: Endocrinology Source Type: research
Thyroid dysfunction (TD) induced by PD-1/PD-L1 inhibitors in advanced lung cancer
CONCLUSION: TD resulting from PD-1/PD-L1 inhibitor treatment in advanced lung cancer may be associated with good clinical outcomes. The clarification of the molecular mechanisms underlying TD and the identification of reliable predictive biomarkers will guide clinicians in managing TD in this patient population.PMID:38449616 | PMC:PMC10915392 | DOI:10.1016/j.heliyon.2024.e27077 (Source: Cancer Control)
Source: Cancer Control - March 7, 2024 Category: Cancer & Oncology Authors: Yanling Wang Xiaoxuan Yang Jia Ma Shenglan Chen Ping Gong Ping Dai Source Type: research
Papillary thyroid carcinoma: ≤ 10 mm does not always mean pN0. A multicentric real-world study
AbstractThe incidence of papillary thyroid carcinoma (PTC) is increasing and PTC ≤ 10 mm (PTMC) accounts for most new diagnoses. PTMCs are not always low risk, as detection of lymph nodes metastasis (LNM) may occur. The purpose of the study was to analyze the clinical pattern, frequency, and independent risk factors of patients with PTMC and LNM. From January 2022 to Jun e 2023, PTCs managed at CTO Hospital, Rome; Policlinico Vanvitelli, Naples; and Garibaldi Nesima Hospital, Catania were included. PTC management followed the same diagnostic–therapeutic procedures according to the ATA guidelines. Variables such a...
Source: Updates in Surgery - March 6, 2024 Category: Surgery Source Type: research
The impact of gut microbiota on autoimmune thyroiditis and relationship with pregnancy outcomes: a review
This article reviews the characteristics of the gut microbiota in patients with AITD and the current research on its impact in pregnancy. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - March 5, 2024 Category: Microbiology Source Type: research
