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Higher HLA class I expression in renal cell carcinoma than in autologous normal tissueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A total of 93 frozen primary renal cell carcinoma (RCC) samples and 31 frozen samples of corresponding normal renal tissue were analyzed for human leukocyte antigen (HLA) class I and HLA-DR expression. Unexpectedly, HLA class I expression was much higher on RCC cells than on normal renal tubular cells. Immunohistochemistry analysis of frozen and paraffin-embedded tissue samples, applying an extended panel of specific anti-HLA monoclonal antibodies, showed elevated HLA class I antigen expression in 95.6% of the tumors vs only 12.9% of normal renal tissues. These findings were confirmed by molecular analysis of HLA heavy cha...
Source: Tissue Antigens - November 14, 2009 Category: Allergy & Immunology Authors: P. Sáenz-López, C. Gouttefangeas, J. Hennenlotter, A. Concha, I. Maleno, F. Ruiz-Cabello, J. M. Cózar, M. Tallada, A. Stenzl, H.-G. Rammensee, F. Garrido, T. Cabrera Source Type: journals

Nomenclature for factors of the HLA system, update September 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Tissue Antigens)
Source: Tissue Antigens - November 11, 2009 Category: Allergy & Immunology Authors: Steven G. E. Marsh Source Type: journals

Intercellular adhesion molecule 1 K469E gene polymorphism is associated with presence of skin lesions in Tunisian Behçet's disease patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intercellular adhesion molecule 1 (ICAM1) gene polymorphisms have been implicated in the susceptibility to inflammatory diseases. The expression of both soluble and tissue ICAM1 were increased in Behçet's disease (BD) but the contribution of ICAM1 gene polymorphisms to this disease remains unknown. We sought to establish the association of ICAM1 gene K469E polymorphism in exon 6 with susceptibility for BD. One hundred and thirty-five Tunisian patients who satisfied the International Study Group criteria for BD and 157 healthy blood donor controls from the same geographic area were genotyped by polymerase chain reaction me...
Source: Tissue Antigens - November 10, 2009 Category: Allergy & Immunology Authors: I. Ben Dhifallah, E. FakhFakh Karray, F. Sassi, K. Hamzaoui Source Type: journals

Nomenclature for factors of the HLA system, update August 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Tissue Antigens)
Source: Tissue Antigens - November 10, 2009 Category: Allergy & Immunology Authors: Steven G. E. Marsh Source Type: journals

Nomenclature for factors of the HLA system, update July 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Tissue Antigens)
Source: Tissue Antigens - November 10, 2009 Category: Allergy & Immunology Authors: Steven G. E. Marsh Source Type: journals

MICA polymorphisms and haplotypes with HLA-B and HLA-DRB1 in KoreansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Major histocompatibility complex (MHC) class I chain-related gene A (MICA) is located within the human MHC, centromeric to HLA-B and telomeric to HLA-DRB1. The location of MICA in the MHC indicates the presence of linkage disequilibrium with human leukocyte antigen (HLA). Like HLA, MICA is highly polymorphic; however, the information available for MICA polymorphisms is not as comprehensive as that for HLA polymorphisms. We estimated the allelic frequencies of MICA and haplotypes with HLA-B and HLA-DRB1 at high-resolution in a population of 139 unrelated Korean individuals by applying the newly developed method of sequence-...
Source: Tissue Antigens - November 6, 2009 Category: Allergy & Immunology Authors: Y.-H. Sohn, C.-H. Cha, H.-B. Oh, M. H. Kim, S.-E. Choi, O.-J. Kwon Source Type: journals

Conventional protein kinase C plays a critical role in negative regulation of CD98-induced homotypic aggregationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CD98, a heterodimeric type II transmembrane protein, is involved in many different cellular events, ranging from amino acid transport to cell[ndash]cell adhesion. Little is known about the positive and negative signalling pathways involved in these responses. Therefore, we examined the role of conventional protein kinase C (PKC) isoforms during CD98-induced intracellular signalling and homotypic aggregation of U937 cells. The CD98-induced aggregation was enhanced by the general protein kinase inhibitors GF109203X and staurosporin, and by specific PKC-[alpha]/-[beta] peptide inhibitor 19[ndash]27, but inhibited by PKC activ...
Source: Tissue Antigens - November 6, 2009 Category: Allergy & Immunology Authors: J. Y. Cho, D. R. Katz, K. M. Skubitz, B. M. Chain Source Type: journals

Identification of a novel HLA-DRB1*15 allele, DRB1*1533, in a recently registered stem cell donorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The new human leukocyte antigen (HLA)-DRB1 nucleotide sequence differs from HLA-DRB1*150101 in position 130 with an A instead of a T resulting in an amino acid change from Cysteine to Serine. (Source: Tissue Antigens)
Source: Tissue Antigens - November 6, 2009 Category: Allergy & Immunology Authors: A. Parkner, M. Mosebach, I. Halm-Heinrich, M. Heim Source Type: journals

Hypermethylation of HLA class I gene is associated with HLA class I down-regulation in human gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluated the expression and alteration of HLA class I molecules in a panel of 47 pairs of gastric cancer specimens with their noncancerous parts from Chinese patients by using immunohistochemistry (IHC), reverse transcription polymerase chain reaction (RT-PCR) and methylation-specific PCR (MSP) analysis. The expression of HLA-A, HLA-B/C and HLA class I complex was lost or down-regulated in human gastric cancer. The percentage of promoter methylation was 59.57% for HLA-A gene, 55.32% for HLA-B gene and 48.94% for HLA-C gene in gastric cancer, while it was decreased to 19.15%, 12.77% and 6.38% in the adjacent non...
Source: Tissue Antigens - October 30, 2009 Category: Allergy & Immunology Authors: Q. Ye, Y. Shen, X. Wang, J. Yang, F. Miao, C. Shen, J. Zhang Source Type: journals

No association of KIR3DL1 or KIR3DS1 or their alleles with ankylosing spondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We determined the alleles of KIR3DL1 and KIR3DS1 in a cohort of British Caucasian ankylosing spondylitis (AS) patients and HLA-B27-positive controls. We found no association in frequencies of the alleles of these genes in AS. In addition, no differences were found when the patients and controls were differentiated by gender. (Source: Tissue Antigens)
Source: Tissue Antigens - October 29, 2009 Category: Allergy & Immunology Authors: J. McCappin, D. Harvey, B. P. Wordsworth, D. Middleton Source Type: journals

Full length sequence of the HLA-Cw*0361 allele identified in a Chinese Han potential bone marrow donor from Northern ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HLA-Cw*0361 allele differs from Cw*030301 by one nucleotide substitution at nt 566 from T to A, resulting in an amino acid change at codon 165 from Val to Glu. (Source: Tissue Antigens)
Source: Tissue Antigens - October 21, 2009 Category: Allergy & Immunology Authors: L.-H. Cheng, S.-Z. Jin, W.-G. Zhu, Y.-X Lan, Z. Li Source Type: journals

Four-locus high-resolution HLA typing in a sample of Mexican AmericansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mexicans are the most common minority population of the United States. From a sample of 553 bone marrow donor registrants of self-described Mexican ancestry, human leukocyte antigen (HLA) loci A, C, B and DRB1 were typed by highresolution sequence based typing (SBT) methods. A total of 47, 34, 76 and 46 distinct alleles at A, C, B and DRB1 respectively were identified, including 3 new alleles. The four-locus haplotype frequency distribution was extremely skewed with only 53.9% of 1106 chromosomes present with more than one estimated copy. Haplotypes of Native American origin were identified. These data form an initial basi...
Source: Tissue Antigens - October 20, 2009 Category: Allergy & Immunology Authors: W. Klitz, L. Gragert, M. Maiers, B. Tu, A. Lazaro, R. Yang, Q. Xu, C. Masaberg, J. Ng, C. K. Hurley Source Type: journals

Molecular variation at the HLA-A, B, C, DRB1, DQA1, and DQB1 loci in full heritage American Indians in Arizona: private haplotypes and their evolutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A sample of 492 full heritage, unrelated residents of the Gila River Indian Community (GRIC) of Arizona were characterized for their high-resolution DNA alleles at the HLA-A, B, C, DRB1, DQA1, and DQB1 loci. Only five allelic categories are found at HLA-A, 10 at HLA-B, 8 at HLA-C and HLA-DR, and 4 at DQA1 and DQB1. There is little evidence for population structure at the 6 loci. Two 'private' alleles, B*5102 and B*4005, which are found nearly exclusively in American Indian populations in the desert southwest and northern Mexico, are likely new mutations after the first inhabitation of the area, the evolution of which are r...
Source: Tissue Antigens - October 20, 2009 Category: Allergy & Immunology Authors: R. Williams, Y.-F. Chen, R. Endres, D. Middleton, M. Trucco, J. Dunn Williams, W. Knowler Source Type: journals

Three new HLA-B alleles determined by sequence-based typing: B*9551, B*5161 and B*5317Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Three new alleles with polymorphisms located in exons 2 and 3. (Source: Tissue Antigens)
Source: Tissue Antigens - October 20, 2009 Category: Allergy & Immunology Authors: V. Dubois, I. Favre-Victoire, C. Giannoli Source Type: journals

Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Low-affinity IgE receptor gene (FCER2) rs3760687 polymorphism was found to be associated with differential binding affinity of transcription factors Sp1 and Sp3 leading to altered transcriptional activity. Haplotypic interaction of functional FCER2 polymorphisms (rs28364072, rs2228137 and rs3760687) might potentially provide a background for genotype[ndash]phenotype associations previously observed for some rather non-functional FCER2 variants. (Source: Tissue Antigens)
Source: Tissue Antigens - October 20, 2009 Category: Allergy & Immunology Authors: D. P. Potaczek, Q.-H. Wang, M. Sanak, T. Tokura, H. Matsuda, S. Dziedzina, N. Nakano, M. Hara, H. Ogawa, A. Szczeklik, K. Okumura, C. Nishiyama Source Type: journals

A novel HLA-Cw*0124 allele found in a Chinese Han patient from southern ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The sequence of novel HLA-Cw*0124 allele differs from Cw*0103 by one nucleotide change at nt 806 from C to A, resulting in an amino acid change at codon 245 from Ala to Glu. (Source: Tissue Antigens)
Source: Tissue Antigens - October 20, 2009 Category: Allergy & Immunology Authors: S.-Z. Jin, W.-G. Zhu, Y.-X Lan, H.-Y. Zou, L.-H. Cheng Source Type: journals

A high-throughput Taqman® approach for the discrimination of HLA-E allelesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An association between human leukocyte antigen (HLA) molecules and the incidence of various diseases has been recognized for years. Molecules of the HLA system also exert an important role on the clinical outcome after transplantation such as stem cell transplantation. The conventional HLA typing method is sequence based typing (SBT) which is reliable but laborious. The goal of this study was to develop a high-throughput Taqman® assay to screen large panels for HLA-E alleles. Two functional HLA-E alleles, *0101 and *0103, have been identified. We set up the Taqman® assay with genomic DNA as template to discriminate the t...
Source: Tissue Antigens - October 20, 2009 Category: Allergy & Immunology Authors: M. M. Paquay, J. Schellekens, M. G. J. Tilanus Source Type: journals

IL-21: roles in immunopathology and cancer therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cytokines are secreted signalling molecules with decisive effects on haematopoiesis, innate and adaptive immunity, and immunopathology. Interleukin (IL)-21 is a novel cytokine produced by activated CD4+ T cells and natural killer T (NKT) cells. IL-21 is part of a family of cytokines which include IL-2, -4, -7, -9 and -15 that all share the common IL-2 receptor [gamma] chain ([gamma]c) in their individual receptor complexes. IL-21 receptor (IL-21R) is widely expressed on both myeloid and lymphoid cell lineages and IL-21 actions include co-stimulation of B cell differentiation and immunoglobulin (Ig) production, co-mitogen o...
Source: Tissue Antigens - October 20, 2009 Category: Allergy & Immunology Authors: H. Søndergaard, K. Skak Source Type: journals

Identification of the HLA-Cw*0774 and DQB1*060105 allelesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cw*0774 differs from Cw*070201 by one nucleotide within the coding sequence of exons 2[ndash]4. DQB1*060105 differs from DQB1*060101 by one nucleotide within the coding sequence of exons 2[ndash]3. (Source: Tissue Antigens)
Source: Tissue Antigens - October 20, 2009 Category: Allergy & Immunology Authors: R.O. Endres, H. Redman, N. Marcus Source Type: journals

Successful implementation of a national HLA-B*5701 genetic testing service in CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) that is used in combination antiretroviral therapy in HIV-infected patients. It is currently recommended as a preferred or an alternative NRTI in antiretroviral-naïve patients. The major toxicity of abacavir is a hypersensitivity reaction (HSR), which occurs in approximately 5% of treated patients. There is a strong association between the human leukocyte antigen (HLA)-B*5701 allele and abacavir HSR, which has allowed for rapid acceptance of genetic screening for HLA-B*5701 in clinical use. Canadian clinicians working in hospital centers with HLA typing capac...
Source: Tissue Antigens - October 15, 2009 Category: Allergy & Immunology Authors: R. G. Lalonde, R. Thomas, A. Rachlis, M. J. Gill, M. Roger, J. B. Angel, G. Smith, N. Higgins, B. Trottier Source Type: journals

HLA-B*0777 allele differs from B*0707 by a single residue in the antigen binding grooveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human leukocyte antigen (HLA) class I sequence-based typing (SBT) for hematopoietic unrelated donor searching in a Romanian Caucasian patient showed the presence of a novel HLA-B allele defined as B*0777. HLA-B*0777 has two nucleotides changes at the same codon from B*0707, resulting an amino acid replacement 99Y > 99S. (Source: Tissue Antigens)
Source: Tissue Antigens - October 13, 2009 Category: Allergy & Immunology Authors: A. Balas, D. Planelles, G. F. Sanz, J. A. Montoro, J. L. Vicario Source Type: journals

Identification of a novel HLA-Cw*08 variant allele, Cw*0824Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel HLA-C allele, Cw*0824, which was identified from an individual of the Han Chinese, differs from Cw*080101 at codon 222 (GAG > AAG ) in exon 4, which results in an amino acid change Glu222Lys. In recent years, many human leukocyte antigen (HLA)-C alleles have been identified. Up to date, 23 different Cw*08 alleles have been identified according to the IMGT/HLA Database release 2.25.2 May 2009 (1). Here, we describe the identification of the novel allele HLA-Cw*0824 that was found during routine high resolution sequence-based typing (SBT) of a Chinese stem cell voluntary donor. The HLA alleles of the donor were typed...
Source: Tissue Antigens - October 12, 2009 Category: Allergy & Immunology Authors: D.-M. Wang, H.-Y. Zou, Z. Li Source Type: journals

A novel HLA-Cw*01 variant allele, HLA-Cw*0130Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The novel HLA-Cw*0130 variant allele differs from the closest allele Cw*010201 by single nucleotide change at genomic nt 959 T>C (CDS nt 583 T>C, codon 171 TAC>CAC) in exon 3, which causes an amino acid change Tyr171His. (Source: Tissue Antigens)
Source: Tissue Antigens - October 4, 2009 Category: Allergy & Immunology Authors: Z.-H. Deng, D.-M. Wang Source Type: journals

Genomic full-length sequence of HLA-Cw*140201, identified by cloning and sequencingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genomic full-length sequence of HLA-Cw*140201, differing from Cw*1403 by four nucleotide exchanges in exon 2 and intron 5, was identified by cloning and sequencing from a male Chinese donor. (Source: Tissue Antigens)
Source: Tissue Antigens - October 3, 2009 Category: Allergy & Immunology Authors: Y.-P. Xu, Z.-H. Deng, D.-M. Wang, J.-Q. Zeng, S.-Z. Jing Source Type: journals

Incidence of humoral sensitization in HLA partially mismatched hematopoietic stem cell transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As part of the 15th International Histocompatibility and Immunogenetics Workshop (IHIWS), seven centers participated in a collaborative project to determine whether any significant humoral sensitization occurred post-transplant among recipients of HLA partially mismatched hematopoietic cell transplants (HCTs). A total of 140 donor/recipient pairs were enrolled with a total of 367 pre-and post-transplant sera analyzed. The majority of the samples (69.1%) were obtained within 30[ndash]90 days post-HCT. HLA-specific antibodies were defined using single antigen bead assays on a Luminex[trade] platform with a positive cutoff va...
Source: Tissue Antigens - October 3, 2009 Category: Allergy & Immunology Authors: M. S. Leffell, K. Cao, M. Coppage, J. A. Hansen, J. M. Hart, N. Pereira, S. Pereira, N. L. Reinsmoen, D. Senitzer, A. Smith, M. Torres, R. Vega, E. Fuchs Source Type: journals

Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The HLA-B27 subtypes have a varied racial and ethnic prevalence throughout the world. However, the association of B27-subtypes with ankylosing spondylitis (AS) in the mainland China is unknown. To determine the association of B27-subtypes with AS in the Mainland Chinese Han population, a total of unrelated 153 patients with AS were enrolled in a large case-control association study, and 1545 unrelated, healthy, ethnically matched blood donors were included as controls. The genotyping of B27 and its subtypes was performed using the polymerase chain reaction with sequence specific primers (PCR-SSP). A total of 130 (84.97%) A...
Source: Tissue Antigens - October 3, 2009 Category: Allergy & Immunology Authors: Y. Liu, L. Jiang, Q. Cai, P. Danoy, M. C. N. M. Barnardo, M. A. Brown, H. Xu Source Type: journals

A novel HLA-Cw*08 allele, Cw*0822, identified by genomic full-length cloning and sequencingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel HLA-Cw*08 allele, Cw*0822, differing from the closest related allele Cw*080101 by one nucleotide exchange at nt2557 (G>A) in exon 6, was identified by genomic full-length cloning and sequencing from a male Chinese donor. (Source: Tissue Antigens)
Source: Tissue Antigens - October 3, 2009 Category: Allergy & Immunology Authors: Y.-P. Xu, Z.-H. Deng, D.-M. Wang, J.-Q. Zeng, S.-Q. Gao Source Type: journals

A bioinformatics approach to ascertaining the rarity of HLA allelesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A project of the 15th International Histocompatibility Workshop examined the rarity of human leukocyte antigen (HLA) alleles. A section was constructed in the website, www.allelefrequencies.net to contain this data from different sources. A mechanism to search the data was implemented for use by any individual. (Source: Tissue Antigens)
Source: Tissue Antigens - September 28, 2009 Category: Allergy & Immunology Authors: D. Middleton, F. Gonzalez, M. Fernandez-Vina, J.-M. Tiercy, S. G. E. Marsh, M. Aubrey, M. G. Bicalho, A. Canossi, V. Carter, S. Cate, F. R. Guerini, P. Loiseau, M. Martinetti, M. E. Moraes, V. Morales, J. Perasaari, M. Setterholm, M. Sprague, S. Tavoulari Source Type: journals

High resolution definition of HLA-DRB haplotypes by a simplified microsatellite typing techniqueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In humans, the region configurations DR1, DR8, DR51, DR52 and DR53 are known to display copy number as well as allelic variation, rendering high resolution typing of HLA-DRB haplotypes cumbersome. Advantage was taken of microsatellite D6S2878, present in all DRB genes/pseudogenes with an intact exon 2-intron 2 segment. This DRB-STR is highly polymorphic in composition and length. Recently, it was proven that all exon 2 sequences could be linked to a certain DRB-STR that segregates with the respective DRB allele. Because haplotypes show differential copy numbers and compositions of exon 2-positive DRB genes/pseudogenes, uni...
Source: Tissue Antigens - September 23, 2009 Category: Allergy & Immunology Authors: G. G. M. Doxiadis, N. de Groot, E. -M. Dauber, P. H. van Eede, I. Fae, R. Faner, G. Fischer, Z. Grubic, N. M. Lardy, W. Mayr, E. Palou, W. Swelsen, K. Stingl, I. I. N. Doxiadis, R. E. Bontrop Source Type: journals

Complete genomic sequence of a novel HLA-B*1325 allele observed in a Chinese Han individualEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The complete genomic sequence of HLA-B*1325 allele shows one nucleotide difference from B*130101 at nt 302 where A [rarr] G resulting in an amino acid substitution from Asn(AAC) to Ser(AGC) at codon 77 in exon 2. (Source: Tissue Antigens)
Source: Tissue Antigens - September 23, 2009 Category: Allergy & Immunology Authors: L.-H. Cheng, S.-Z. Jin, W.-G. Zhu, Z. Li, H.-Y. Zou Source Type: journals

Genomic sequence of HLA-Cw*1222 allele identified in a Chinese Han patient from southern ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The genomic sequence of HLA-Cw*1222 allele is identical to Cw*120202 except for a single-nucleotide substitution at codon 87 (CAG[rarr]CGG) resulting in an amino acid change from Gln to Arg. (Source: Tissue Antigens)
Source: Tissue Antigens - September 18, 2009 Category: Allergy & Immunology Authors: S.-Z. Jin, Z. Li, H.-Y. Zou, Y.-X Lan, W.-G. Zhu, L.-H. Cheng Source Type: journals

Full length sequence of a novel HLA-B*3818 allele differs from HLA-B*380201 allele in exon 4 and intron 5Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The full length sequence of HLA-B*3818 differs from HLA-B*380201 at nt 660 in exon 4 (C[rarr]A) and genomic position 2133 in intron 5 (A[rarr]C). (Source: Tissue Antigens)
Source: Tissue Antigens - September 17, 2009 Category: Allergy & Immunology Authors: L.-H. Cheng, W.-G. Zhu, Y.-X. Lan, S.-Z. Jin, H.-Y. Zou Source Type: journals

Genetic determinants of HIV-1 infection and progression to AIDS: immune response genesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genomic studies involving well-defined multicenter cohorts of HIV-1/AIDS covering multiple populations have led to a greater understanding of the role of host determinants in viral acquisition, disease progression, transmission, and response to anti-retroviral therapy. Similarly, recent knowledge on the virus genetic diversity has helped in elucidating mechanisms leading to the evolution of viral escape mutants and the role played by host immune determinants, in particular the major histocompatibility complex (MHC) associated genes. At least two alleles, HLA-B*27 and B*57, have been identified as 'protective' against HIV-1...
Source: Tissue Antigens - September 17, 2009 Category: Allergy & Immunology Authors: G. Kaur, N. Mehra Source Type: journals

Genomic full length sequence of HLA-Cw*030301, identified by cloning and sequencingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genomic full length sequence of human leukocyte antigen (HLA)-Cw*030301 that differs from Cw*030401 by two-nucleotide exchange at nt 473 (G>A) in exon 2 and nt 3033 (G>C) in 3'UTR, was identified by cloning and sequencing from a male Chinese donor. (Source: Tissue Antigens)
Source: Tissue Antigens - September 17, 2009 Category: Allergy & Immunology Authors: Y. Xu, Z. Deng, J. Zeng, S. Gao, B. Yang Source Type: journals

Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here comparison of the KIR gene content and genotypic structure of KIRs in 106 individuals from Eastern mainland Chinese Han and 97 from Taiwanese Han. All 17 KIR genes were observed in the two populations. Framework genes 2DL4, 3DL2, 3DL3 and 3DP1 were present in all individuals. The two populations had very similar frequencies in most loci, however, significant differences were noted in the frequencies of KIR3DS1 and KIR2DS4D (KIR2DS4 deletant variant). A total of 35 and 29 genotypes were identified in the individuals from the Eastern mainland Chinese and the Taiwanese Hans, respectively. Some pairs of KIRs sho...
Source: Tissue Antigens - September 16, 2009 Category: Allergy & Immunology Authors: G.-Q. Wu, Y.-M. Zhao, X.-Y. Lai, K.-L. Yang, F.-M. Zhu, W. Zhang, W. Wang, Y. Luo, Y.-M. Tan, Y.-J Wang, W.-J. Cao, H. Huang Source Type: journals

New HLA polymorphism detection by molecular and serologic typing procedures. Complete coding region characterization of Cw*0525, Cw*0825, B*3950 and A*3219N allelesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Four new HLA class I alleles, Cw*0525, Cw*0825, B*3950 and A*3219N, have been characterized. (Source: Tissue Antigens)
Source: Tissue Antigens - September 16, 2009 Category: Allergy & Immunology Authors: A. Balas, L. Bustamante, F. García-Sánchez, J. L. Vicario Source Type: journals

IL7RA polymorphisms and chronic inflammatory arthropathiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin-7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes. We analysed 13 SNPs in the IL7RA gene in a combined cohort of patients with chronic inflammatory arthropathies (rheumatoid arthritis and juvenile idiopathic arthritis; 368 patients and 532 unaffected subjects). No significant associations with disease were found with the exception of the non-synonymous SNP rs6897932. This SNP showed modest enrichment of the TT genotype in arthritic patients compared with controls [P = 0....
Source: Tissue Antigens - September 8, 2009 Category: Allergy & Immunology Authors: C. O'Doherty, I. Alloza, M. Rooney, K. Vandenbroeck Source Type: journals

Thirty-six novel HLA alleles: 7 HLA-A, 11 HLA-B, 15 HLA-C and 3 HLA-DRB1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thirty-six novel human leukocyte antigen (HLA) alleles are described in this article: A*9225N, A*9234, A*030106, A*0337, A*2317, A*2480, A*3023; B*070206, B*0759, B*0761, B*0765, B*150106, B*1827, B*352002, B*3585, B*3943, B*4082, B*5151; Cw*0342, Cw*0343, Cw*0344, Cw*0428, Cw*0430, Cw*0433, Cw*050104, Cw*0519, Cw*060203, Cw*070109, Cw*070202, Cw*0750, Cw*0815, Cw*120306, Cw*1409; DRB1*0336, DRB1*0473 and DRB1*1382. (Source: Tissue Antigens)
Source: Tissue Antigens - September 7, 2009 Category: Allergy & Immunology Authors: J. D. H. Anholts, M. Aneq, H. L. J. M. Dirks, A. Tas, W. Verduyn, M. Oudshoorn Source Type: journals

A novel HLA-DRB1*120204 allele found in a Chinese individualEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The HLA-DRB1*120204 allele differs by a single synonymous nucleotide change from the DRB1*120201 allele at position 203 in exon 2 from C to G. (Source: Tissue Antigens)
Source: Tissue Antigens - September 7, 2009 Category: Allergy & Immunology Authors: Y. Ji, Y. Sun, J. H. Xie, J. H. Yang, Y. Liu, K. M. Du Source Type: journals

Identification of a new HLA-Cw*01 variant, Cw*0121, by sequence-based typing in a Chinese patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HLA-Cw*0121 allele was identified in a Chinese patient. It is identical to Cw*0104 except for five nucleotides changes. (Source: Tissue Antigens)
Source: Tissue Antigens - September 7, 2009 Category: Allergy & Immunology Authors: Z. Li, H. Zhang, S.-Z. Jin Source Type: journals

Cytotoxic T lymphocyte-associated antigen-4 polymorphism in patients with rheumatic heart diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study included a total of 98 patients with RHD as a sequela of ARF, who fulfilled the revised classification criteria of Jones and 154 healthy unrelated controls. CTLA-4 +49 A/G polymorphism was genotyped by using PCR-RLFP technique. Data was analyzed by binary logistic regression models. The frequencies of GG, GA and AA genotypes were found to be 14%, 47% and 39%, respectively, in patients and 6%, 45% and 49%, respectively, in controls. The GG genotype was found to be significantly different between patients and controls (OR: 3.11; P = 0.016). GA and AA genotypes did not statistically differ between patients and cont...
Source: Tissue Antigens - September 7, 2009 Category: Allergy & Immunology Authors: N. Düzgün, T. Duman, F. E. Haydardedeoğlu, H. Tutkak Source Type: journals

Full-length sequence of a novel allele, HLA-Cw*070205Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The full-length sequences of exons 1[ndash]8 of this novel HLA-Cw*070205 allele are identical to those of HLA-Cw*07020101, except for one nucleotide change at nt 498 in exon 3 from C to T, which result in a synonymous amino acid substitution from ATC to ATT at codon 142 in exon 3. (Source: Tissue Antigens)
Source: Tissue Antigens - September 7, 2009 Category: Allergy & Immunology Authors: H.-Y. Zou, S.-Z. Jin, Z. Li, L.-H. Cheng Source Type: journals

Identification of HLA-B*9521 in TaiwanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We here report a new HLA-B allele, B*9521, which differs from B*1544 at codon 67 (TCC[rarr]TGC). (Source: Tissue Antigens)
Source: Tissue Antigens - September 7, 2009 Category: Allergy & Immunology Authors: C.-C. Chu, Y.-F. Chen, H.-L. Lee, C.-Y. Lin, M. Lin Source Type: journals

A novel HLA-Cw*04 allele, Cw*04010103, identified by genomic full length cloning and sequencingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel human leukocyte antigen-Cw*04 allele, Cw*04010103, was identified by genomic full length cloning and sequencing from a male Chinese donor. It differs from the closest related allele Cw*04010101 by one nucleotide exchange at nt 1111 (G>A) in intron 3. (Source: Tissue Antigens)
Source: Tissue Antigens - September 7, 2009 Category: Allergy & Immunology Authors: Y. Xu, Z. Deng, J. Zeng, S. Gao, D. Wang Source Type: journals

Human neutrophil alloantigen-1a, -1b, -2, -3a and -4a frequencies in BraziliansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human neutrophil reactive antibodies may cause clinical disorders such as transfusion-related acute lung injury, febrile transfusion reactions, alloimmune neonatal neutropenia, immune neutropenia after stem cell transplantation, refractoriness to granulocyte transfusion, drug-induced neutropenia and autoimmune neutropenia. Using the granulocyte immunofluorescence test by flow cytometry, the phenotypic frequencies of the human neutrophil alloantigens (HNA)-1a, -1b, -2, -3a and -4a were determined in 100 healthy Brazilian persons. Neutrophils were separated from blood samples by sedimentation, centrifugated and incubated wit...
Source: Tissue Antigens - September 7, 2009 Category: Allergy & Immunology Authors: A. M. M. I. Norcia, E. Y. K. Sugano, A. K. Chiba, E. Moritz, F. P. Guirao, M. Yamamoto, J. O. Bordin Source Type: journals

Full length sequence of a novel HLA-B*132202 alleleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Full length sequences of this novel HLA-B*132202 allele are identical to those of HLA-B*132201 allele, except for a synonymous amino acid substitution from ACG to ACC at codon 138 in exon 3. (Source: Tissue Antigens)
Source: Tissue Antigens - September 2, 2009 Category: Allergy & Immunology Authors: H.-Y. Zou, L.-H. Cheng, Z. Li, S.-Z. Jin Source Type: journals

Confirmation of the novel association at the BTNL2 locus with ulcerative colitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study using 58 single nucleotide polymorphisms (SNPs) with 616 UC cases, there was significant association with SNP rs2294881 of the (butyrophilin-like 2) BTNL2 gene with odds ratio (OR) = 2.80, confidence interval (CI) = 1.62[ndash]4.84 and P = 5.69 × 10[minus]4 (PBonferroni = 3.3 × 10[minus]2) and replication of SNP rs9268480. The missense SNP rs2076523 (K196E) showed novel association with a subset of UC cases with colectomy (n = 126), OR = 0.25, CI = 0.11[ndash]0.58 and P = 4.42 × 10[minus]4 (PBonferroni = 2.56 × 10[minus]2). These three associated variants within the BTNL2 gene were neither in linkage dise...
Source: Tissue Antigens - July 28, 2009 Category: Allergy & Immunology Authors: S. Pathan, R. E. Gowdy, R. Cooney, J. B. Beckly, L. Hancock, C. Guo, J. C. Barrett, A. Morris, D. P. Jewell Source Type: journals

No effects of a synonymous variant within the CD59 gene on its protein product in duodenal biopsies of coeliac individualsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel rare variant within the CD59 gene was linked with coeliac disease in a family with high incidence of disease. Functional analyses of this variant were performed using complementary DNA analysis and protein analysis in paraffin-embedded duodenal biopsies from affected individuals and controls. No effects on pre-mRNA or size of linear protein were observed, although these results do not exclude the possible effects of this variant on co-translational protein folding. (Source: Tissue Antigens)
Source: Tissue Antigens - July 20, 2009 Category: Allergy & Immunology Authors: C. A. Scerri, A. Xuereb-Anastasi, C. Vidal Source Type: journals

Characterization of a novel HLA-A*11 allele in a cord blood unit by sequence-based typing: HLA-A*1141Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The new allele HLA-A*1141 differs from HLA-A*110101 at the codon 120 by a substitution at the first nucleotide (GGC to CGC). (Source: Tissue Antigens)
Source: Tissue Antigens - July 20, 2009 Category: Allergy & Immunology Authors: Silvia Manfroi, Ornella Buffi, Michela Amadei, Andrea Bontadini, Sonia Nesci Source Type: journals

The HLA-G 14 bp insertion/deletion polymorphism is a putative susceptible factor for active human cytomegalovirus infection in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human leukocyte antigen-G (HLA-G) expression is a potential factor for the pathogenesis of virus infection. A 14 bp insertion/deletion polymorphism (rs16375) in the 3'-untranslated region of the HLA-G gene is involved in the stability of HLA-G mRNA and HLA-G protein expression. Therefore, the HLA-G 14 bp polymorphism might be involved in human cytomegalovirus (hCMV) infection. To test a possible association between the HLA-G 14 bp deletion/insertion polymorphism and the active hCMV infection, in this study, a total of 54 patients with active hCMV infection and 165 age- and sex-matched, unrelated, normal Chinese Han populat...
Source: Tissue Antigens - July 18, 2009 Category: Allergy & Immunology Authors: X.-Q. Zheng, F. Zhu, W.-W. Shi, A. Lin, W.-H. Yan Source Type: journals