A rational approach to the management of chronic migraine.
Abstract
About 2% of the adult population has chronic migraine with only 20% diagnosed with this disorder. Those with medication overuse may improve with withdrawal of overuse medications. The intravenous dihydroergotamine regimen usually produces short-term benefit for those with medically refractory chronic migraine. OnabotulinumtoxinA and topiramate have shown efficacy in large placebo-controlled randomized trials. Sodium valproate, gabapentin, tizanidine, amitriptyline, fluoxetine, zonisamide, and possibly memantine may be alternative or possibly combined treatment options but with lesser levels of evi...
Source: Headache - January 1, 2013 Category: Neurology Authors: Evans RW Tags: Headache Source Type: research
Tizanidine Increases Antinociceptive Effect and Prevents Gastric Damage Induced by Ketorolac in the Rat
In this study, we evaluated the potential synergistic effect of these drugs in the thermal paw stimulation model and their effect on gastric ulcer production in response in the rat. Dose‐response curves for ketorolac and tizanidine were constructed and from these, an ED40 value was obtained. Isobolographic analysis was carried out based on 0.5:0.5 proportions. In addition, protective effect of tizanidine against ketorolac‐induced gastric damage was evaluated. A synergistic interaction in thermal hyperalgesia and gastroprotective activity was observed, suggesting a good therapeutic potential of this combination in the t...
Source: Drug Development Research - November 21, 2012 Category: Drugs & Pharmacology Authors: Juan Rodríguez‐Silverio, María Elena Sánchez‐Mendoza, Jesús Arrieta‐Valencia, Héctor Isaac Rocha‐Gonzalez, Francisco Javier Flores‐Murrieta Tags: Research Article Source Type: research
