Cardiac failure in a child with tuberculous meningitis as a complication of Paroxysmal sympathetic hyperactivity
CONCLUSIONS: PSH assessment tool has benefits such as monitoring the patient, evaluating response to treatment and early diagnosing PSH patients.PMID:35611428 | DOI:10.24953/turkjped.2020.3609 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - May 25, 2022 Category: Pediatrics Authors: P ınar Yazıcı Özkaya E şe Eda Turanlı Hatice Feray Ar ı Serap Kurt B ülent Karapınar Source Type: research
Development of biocompatible nanoparticles of tizanidine hydrochloride in orodispersible films: In vitro characterization, ex vivo permeation and cytotoxic study on carcinoma cells
CONCLUSION: A study of cytotoxic effect on the MCF-7 breast cancer cells and A549 lung carcinoma cells revealed that tizanidine hydrochloride nanoparticles at 2.3 mg/film exhibited an IC50 value of 65.1 % cytotoxicity on MCF-7, approximately 100% on HOP92, and 83.5 % on A549 lung carcinoma cells, thus paving the way for a new paradigm of research for cytotoxic study on MCF-7, HOP92 and A549 cell lines using the subject drug model prepared as oral films or biodegradable nanoparticles in oral films for site-specific targeting.PMID:35319369 | DOI:10.2174/1567201819666220321111338 (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 23, 2022 Category: Drugs & Pharmacology Authors: Suhani Sinha Sonia Thapa Shashank Singh Rohit Dutt Ravinder Verma Parijat Pandey Vineet Mittal Md Habibur Rahman Deepak Kaushik Source Type: research
Development of biocompatible nanoparticles of tizanidine hydrochloride in orodispersible films: In vitro characterization, ex vivo permeation and cytotoxic study on carcinoma cells
CONCLUSION: A study of cytotoxic effect on the MCF-7 breast cancer cells and A549 lung carcinoma cells revealed that tizanidine hydrochloride nanoparticles at 2.3 mg/film exhibited an IC50 value of 65.1 % cytotoxicity on MCF-7, approximately 100% on HOP92, and 83.5 % on A549 lung carcinoma cells, thus paving the way for a new paradigm of research for cytotoxic study on MCF-7, HOP92 and A549 cell lines using the subject drug model prepared as oral films or biodegradable nanoparticles in oral films for site-specific targeting.PMID:35319369 | DOI:10.2174/1567201819666220321111338 (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 23, 2022 Category: Drugs & Pharmacology Authors: Suhani Sinha Sonia Thapa Shashank Singh Rohit Dutt Ravinder Verma Parijat Pandey Vineet Mittal Md Habibur Rahman Deepak Kaushik Source Type: research
Sex-dependent antiallodynic effect of α < sub > 2 < /sub > adrenergic receptor agonist tizanidine in rats with experimental neuropathic pain
Eur J Pharmacol. 2022 Feb 25:174855. doi: 10.1016/j.ejphar.2022.174855. Online ahead of print.ABSTRACTThe purpose of this study was to investigate the mechanism of antiallodynic effect of tizanidine in neuropathic rats. Spinal nerve ligation reduced withdrawal threshold which was interpreted as tactile allodynia. Increasing doses of tizanidine induced a dose-dependent antiallodynic effect in nerve injured rats. Tizanidine was more effective in female than male neuropathic rats. This drug induced a lower antiallodynic effect in ovariectomized, compared with non-ovariectomized, neuropathic rats, while systemic reconstitution...
Source: European Journal of Pharmacology - March 1, 2022 Category: Drugs & Pharmacology Authors: Erick Josu é Rodríguez-Palma Dania Guadalupe Castelo-Flores Nadia Lizeth Caram-Salas Ana Belen Salinas-Abarca David Centuri ón Yarim Elideth De la Luz-Cuellar Vinicio Granados-Soto Source Type: research
Sex-dependent antiallodynic effect of α < sub > 2 < /sub > adrenergic receptor agonist tizanidine in rats with experimental neuropathic pain
Eur J Pharmacol. 2022 Feb 25:174855. doi: 10.1016/j.ejphar.2022.174855. Online ahead of print.ABSTRACTThe purpose of this study was to investigate the mechanism of antiallodynic effect of tizanidine in neuropathic rats. Spinal nerve ligation reduced withdrawal threshold which was interpreted as tactile allodynia. Increasing doses of tizanidine induced a dose-dependent antiallodynic effect in nerve injured rats. Tizanidine was more effective in female than male neuropathic rats. This drug induced a lower antiallodynic effect in ovariectomized, compared with non-ovariectomized, neuropathic rats, while systemic reconstitution...
Source: European Journal of Pharmacology - March 1, 2022 Category: Drugs & Pharmacology Authors: Erick Josu é Rodríguez-Palma Dania Guadalupe Castelo-Flores Nadia Lizeth Caram-Salas Ana Belen Salinas-Abarca David Centuri ón Yarim Elideth De la Luz-Cuellar Vinicio Granados-Soto Source Type: research
Sex-dependent antiallodynic effect of α < sub > 2 < /sub > adrenergic receptor agonist tizanidine in rats with experimental neuropathic pain
Eur J Pharmacol. 2022 Feb 25:174855. doi: 10.1016/j.ejphar.2022.174855. Online ahead of print.ABSTRACTThe purpose of this study was to investigate the mechanism of antiallodynic effect of tizanidine in neuropathic rats. Spinal nerve ligation reduced withdrawal threshold which was interpreted as tactile allodynia. Increasing doses of tizanidine induced a dose-dependent antiallodynic effect in nerve injured rats. Tizanidine was more effective in female than male neuropathic rats. This drug induced a lower antiallodynic effect in ovariectomized, compared with non-ovariectomized, neuropathic rats, while systemic reconstitution...
Source: European Journal of Pharmacology - March 1, 2022 Category: Drugs & Pharmacology Authors: Erick Josu é Rodríguez-Palma Dania Guadalupe Castelo-Flores Nadia Lizeth Caram-Salas Ana Belen Salinas-Abarca David Centuri ón Yarim Elideth De la Luz-Cuellar Vinicio Granados-Soto Source Type: research
Enhanced Recovery After Surgery: Opioid Sparing Strategies After Discharge: A Review
AbstractPurpose of ReviewMany surgical subspecialties have developed enhanced recovery after surgery (ERAS) protocols that focus on multimodal analgesia to limit opioid use during a hospital stay and improve patient recovery. Unfortunately, ERAS protocols do not extend to post-discharge patient care, and opioids continue to be over prescribed. The primary reason seems to be a lack of good quality research evaluating extended use of a multimodal analgesic approach. This review was undertaken to evaluate available evidence for non-opioid analgesics in the postoperative period after discharge, utilizing Pubmed, Scopus, and ...
Source: Current Pain and Headache Reports - January 24, 2022 Category: Neurology Source Type: research
Pediatric tizanidine toxicity reversed with naloxone: a case report
ConclusionsThis case report provides further evidence regarding the use of naloxone as a viable antidote for centrally acting α-2 receptor agonists and presents additional epidemiologic data on childhood tizanidine poisoning. (Source: International Journal of Emergency Medicine)
Source: International Journal of Emergency Medicine - December 14, 2021 Category: Emergency Medicine Source Type: research
Liquid chromatography –tandem mass spectrometry and confirmation by liquid chromatography–high‐resolution mass spectrometry hair tests to evidence use of tizanidine by racing cyclists
A short story about abuse of Tizanidine by athletes with evidence by using hair tests. AbstractTizanidine, an imidazoline derivative close to clonidine, is a central alpha-2 adrenergic receptor agonist. Therapeutically, the drug is used as a muscle relaxant under the trade names Sirdalud ™ or Zanaflex™. The drug is not prohibited by the World Anti-Doping Agency but, for therapeutic purposes, can only be obtained via a nominative temporary use authorization. The French public health police requested the laboratory to test for tizanidine in head hair specimens collected from inter national racing cyclists. Using Liquid c...
Source: Drug Testing and Analysis - October 5, 2021 Category: Drugs & Pharmacology Authors: Pascal Kintz,
Laurie Gheddar,
Jean ‐Sébastien Raul Tags: RESEARCH ARTICLE Source Type: research
LC/MS ‐MS and confirmation by LC/HRMS hair tests to evidence use of tizanidine by racing cyclists
AbstractTizanidine, an imidazoline derivative close to clonidine, is a central alpha-2 adrenergic receptor agonist. Therapeutically, the drug is used as a muscle relaxant under the trade names Sirdalud ™ or Zanaflex™. The drug is not prohibited by the World Anti-Doping Agency, but, for therapeutic purposes, can only be obtained via a nominative temporary use authorisation. The French public health police requested the laboratory to test for tizanidine in head hair specimens collected from inte rnational racing cyclists. Using LC/MS-MS and confirmation by LC/HRMS, after pH 9.5 borate buffer overnight incubation of 20 mg...
Source: Drug Testing and Analysis - September 22, 2021 Category: Drugs & Pharmacology Authors: Pascal Kintz,
Laurie Gheddar,
Jean ‐Sébastien Raul Tags: RESEARCH ARTICLE Source Type: research
Derma Roller Mediated Transdermal Delivery of Tizanidine Invasomes for the Management of Skeletal Muscle Spasms
Eur J Pharm Sci. 2021 Jun 27:105920. doi: 10.1016/j.ejps.2021.105920. Online ahead of print.ABSTRACTTizanidine hydrochloride (TIZ) is a skeletal muscle relaxant used to treat spasms, a sudden involuntary muscle contraction. The currently available oral dosage forms exhibit low oral bioavailability due to high first-pass metabolism. Frequent administration of the drug is thus necessary because of the short half-life of the drug. Transdermal delivery is an excellent alternative, but the skin's outer stratum corneum barrier prevents most drugs from being effectively delivered into the bloodstream. Here we present a pre-clinic...
Source: European Journal of Pharmaceutical Sciences - June 30, 2021 Category: Drugs & Pharmacology Authors: Leonna Dsouza Pinal Chaudhari Bheemisetty Brahmam Shaila A Lewis Source Type: research
Derma Roller Mediated Transdermal Delivery of Tizanidine Invasomes for the Management of Skeletal Muscle Spasms
Eur J Pharm Sci. 2021 Jun 27:105920. doi: 10.1016/j.ejps.2021.105920. Online ahead of print.ABSTRACTTizanidine hydrochloride (TIZ) is a skeletal muscle relaxant used to treat spasms, a sudden involuntary muscle contraction. The currently available oral dosage forms exhibit low oral bioavailability due to high first-pass metabolism. Frequent administration of the drug is thus necessary because of the short half-life of the drug. Transdermal delivery is an excellent alternative, but the skin's outer stratum corneum barrier prevents most drugs from being effectively delivered into the bloodstream. Here we present a pre-clinic...
Source: European Journal of Pharmaceutical Sciences - June 30, 2021 Category: Drugs & Pharmacology Authors: Leonna Dsouza Pinal Chaudhari Bheemisetty Brahmam Shaila A Lewis Source Type: research
Derma Roller Mediated Transdermal Delivery of Tizanidine Invasomes for the Management of Skeletal Muscle Spasms
Eur J Pharm Sci. 2021 Jun 27:105920. doi: 10.1016/j.ejps.2021.105920. Online ahead of print.ABSTRACTTizanidine hydrochloride (TIZ) is a skeletal muscle relaxant used to treat spasms, a sudden involuntary muscle contraction. The currently available oral dosage forms exhibit low oral bioavailability due to high first-pass metabolism. Frequent administration of the drug is thus necessary because of the short half-life of the drug. Transdermal delivery is an excellent alternative, but the skin's outer stratum corneum barrier prevents most drugs from being effectively delivered into the bloodstream. Here we present a pre-clinic...
Source: European Journal of Pharmaceutical Sciences - June 30, 2021 Category: Drugs & Pharmacology Authors: Leonna Dsouza Pinal Chaudhari Bheemisetty Brahmam Shaila A Lewis Source Type: research
Potassium wasting nephropathy in the setting of tizanidine overdose: a case report
ConclusionIn our patient with intentional tizanidine overdose, severe and refractory hypokalemia appears to have been due to a transient potassium wasting nephropathy. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 1, 2021 Category: General Medicine Source Type: research
