Non-interacting, Non-opioid, and Non-barbiturate Containing Acute Medication Combinations in Headache: A Pilot Combinatorics Approach Based on DrugBank Database
Conclusion: This list of headaches abortive medications without drug-drug interactions is a useful tool for clinicians seeking to more effectively manage refractory headaches by implementing a rational polypharmacy. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 17, 2021 Category: Neurology Source Type: research

Physiologically based pharmacokinetic modeling of altered tizanidine systemic exposure by CYP1A2 modulation: Impact of drug-drug interactions and cigarette consumption.
Authors: Jogiraju VK, Heimbach T, Toderika Y, Taft DR Abstract Tizanidine is an alpha2-adrenergic agonist, used to treat spasticity associated with multiple sclerosis and spinal injury. Tizanidine is primarily metabolized by CYP1A2 and is considered a sensitive index substrate for this enzyme. The physiologically based pharmacokinetic (PBPK) modeling platform Simcyp® was used to evaluate the impact of CYP1A2 modulation on tizanidine exposure through drug-drug interactions (DDIs) and host-dependent habits (cigarette smoking). A PBPK model was developed to predict tizanidine disposition in healthy volunteer...
Source: Drug Metabolism and Pharmacokinetics - February 11, 2021 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research

High dose naloxone for acute tizanidine overdose in the emergency department: a case report
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - January 6, 2021 Category: Toxicology Authors: Amber Adams Colton Copley Source Type: research

Coadministration of tizanidine and ciprofloxacin: a retrospective analysis of the WHO pharmacovigilance database
ConclusionDespite the existing formal contraindication, the concomitant use of tizanidine and ciprofloxacin can be observed in real-world clinical practice. Reactions mainly affected the central nervous and the cardiovascular system resulting in potentially severe adverse effects. The concomitant use of tizanidine and ciprofloxacin should absolutely be avoided. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 6, 2021 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 25, Pages 4930: A Critical Review of the Role of the Cannabinoid Compounds Δ9-Tetrahydrocannabinol (Δ9-THC) and Cannabidiol (CBD) and their Combination in Multiple Sclerosis Treatment
hou Many people with MS (pwMS) use unregulated cannabis or cannabis products to treat the symptoms associated with the disease. In line with this, Sativex, a synthetic combination of cannabidiol (CBD) and Δ9-tetrahydrocannabinol (Δ9-THC) has been approved to treat symptoms of spasticity. In animals, CBD is effective in reducing the amounts of T-cell infiltrates in the spinal cord, suggesting CBD has anti-inflammatory properties. By doing this, CBD has shown to delay symptom onset in animal models of multiple sclerosis and slow disease progression. Importantly, combinations of CBD and &am...
Source: Molecules - October 25, 2020 Category: Chemistry Authors: Éamon Jones Styliani Vlachou Tags: Review Source Type: research

Molecules, Vol. 25, Pages 4109: Development and Validation of an HPLC-UV Detection Assay for the Determination of Clonidine in Mouse Plasma and Its Application to a Pharmacokinetic Study
Mostafa An accurate and simple HPLC-UV method has been developed for the determination of clonidine in mouse plasma. A reversed phase C18 Nova Pack® column (125 mm × 4.6 mm i.d., × 3 μm particle size) was used as stationary phase. The mobile phase composition was a mixture of 0.1% diethylamine/acetonitrile (70:30, v/v) at pH 8 in an isocratic mode at flow rate was 1.0 mL/min. Detection was set at 210 nm. Tizanidine was used as an internal standard. The clonidine and tizanidine were extracted from plasma matrix using the deproteinization technique. The developed method ...
Source: Molecules - September 7, 2020 Category: Chemistry Authors: Haitham AlRabiah Sabry M. Attia Nasser S. Al-Shakliah Gamal A. E. Mostafa Tags: Article Source Type: research